iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.20e-80	270.0	123	421

Active Site

Position(s)	Description	Evidence
131	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
382	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           Gl+NlgNtC++NS++QcL+ +p+l+++ll+ ++ ++++     +   ++l+ +q+ + +   ++ +a++p ++++ lkk+a++f+  +q
   Q: 123  GLHNLGNTCFLNSTIQCLTYTPPLANYLLSkEHARSCH-----QGGFCMLCLMQNHMVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQ 206
           9*****************************33333333.....456799999999999999**************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da+Efl++ +d++++++                  l+  a+ + +++ ++l++++F+g l+s++kc  c++vs +++p ld+ l++++
   Q: 207  EDAHEFLRYTIDAMQKAC------------------LNGYAKLDRQTQATTLVHQIFGGYLRSRVKCSVCKSVSDTYDPYLDIALEIRQ 277
           ******************..................444556788999***************************************** PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
                  ++  +Le f+k + l gen+y c kckkk+ a+k++++++ ++vL+l LkRf    ++ s  ki+k v +p+ L+++p++++
   Q: 278  AA-----NIVRALELFVKSDVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRF----ANFSGGKITKDVGYPEFLNIRPYMSQ 357
           **.....9***************************************************....668899******************** PP
   S: 268  peekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           ++ +   ++ Y L+av+vHsG s++ GHY++yvk ++g+W++++Ds V++++ + vl+   ++aYvlfY 
   Q: 358  SSGD---PVMYGLYAVLVHSGySCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLN---QQAYVLFYL 421
           5544...9**************************************************...********6 PP

Organism

Mus musculus

Functional Description
(View)

May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).

Protein Sequence
(Fasta)

MPIVDKLKEA LKPGRKDSAE DGDLGRLLAA SAKKVLLQRI EFEPASKSFS YQLESLKSKY 60
VLLSARAEGA SRHRSGDELQ ARKPGTERVS GSGGDGVPAP QKVLFPVERL SLRWERVFRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCTCTTAA GGCGAACGTG CCCTTCACGC GGACTCAGGG AGCACATTGC AGTGCGGCTC 60
CTTTAAACGT CGTGGTGACA CGTGTGTGAG GCTCTGGAGG CCCGGATGGT GCGCATGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016607--C:nuclear speck
GO:0005730--C:nucleolus
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:1903146--P:regulation of mitophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:72344

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002092	Ailuropoda melanoleuca	66.93	0.00e+00	1202.00
IUUC-Aca-005360	Anolis carolinensis	76.55	0.00e+00	867.00
IUUC-Aly-006389	Arabidopsis lyrata	38.58	1.00e-77	284.00
IUUC-Bta-013047	Bos taurus	65.60	0.00e+00	1136.00
IUUC-Bdi-014036	Brachypodium distachyon	45.57	4.00e-85	310.00
IUUC-Bra-016634	Brassica rapa	44.90	6.00e-83	302.00
IUUC-Cja-019203	Callithrix jacchus	69.88	0.00e+00	1220.00
IUUC-Cfa-020586	Canis familiaris	68.71	0.00e+00	1253.00
IUUC-Cpo-021804	Cavia porcellus	69.26	0.00e+00	1290.00
IUUC-Cre-022988	Chlamydomonas reinhardtii	47.53	4.00e-53	201.00
IUUC-Csa-023137	Chlorocebus sabaeus	71.59	0.00e+00	1308.00
IUUC-Cin-025230	Ciona intestinalis	52.42	1.00e-97	349.00
IUUC-Cne-027049	Cryptococcus neoformans	33.69	3.00e-39	156.00
IUUC-Cme-027339	Cyanidioschyzon merolae	37.33	3.00e-62	232.00
IUUC-Dre-028587	Danio rerio	72.43	0.00e+00	804.00
IUUC-Dno-029149	Dasypus novemcinctus	66.19	0.00e+00	1190.00
IUUC-Dor-030836	Dipodomys ordii	71.62	0.00e+00	1025.00
IUUC-Dme-032119	Drosophila melanogaster	34.01	2.00e-70	260.00
IUUC-Ete-032567	Echinops telfairi	68.08	0.00e+00	862.00
IUUC-Eca-033600	Equus caballus	70.05	0.00e+00	1281.00
IUUC-Eeu-035206	Erinaceus europaeus	50.68	5.00e-107	382.00
IUUC-Fca-036392	Felis catus	53.79	3.00e-160	558.00
IUUC-Fal-036852	Ficedula albicollis	69.93	1.00e-163	570.00
IUUC-Gmo-039033	Gadus morhua	72.34	0.00e+00	804.00
IUUC-Gga-040664	Gallus gallus	78.17	0.00e+00	766.00
IUUC-Gac-042176	Gasterosteus aculeatus	71.45	0.00e+00	793.00
IUUC-Ggo-045437	Gorilla gorilla	72.10	0.00e+00	1294.00
IUUC-Hsa-046863	Homo sapiens	72.21	0.00e+00	1303.00
IUUC-Itr-048655	Ictidomys tridecemlineatus	71.81	0.00e+00	1365.00
IUUC-Lch-050120	Latimeria chalumnae	60.44	0.00e+00	756.00
IUUC-Lpe-051574	Leersia perrieri	42.50	5.00e-80	292.00
IUUC-Loc-052796	Lepisosteus oculatus	71.55	0.00e+00	789.00
IUUC-Laf-054243	Loxodonta africana	65.44	0.00e+00	1205.00
IUUC-Mcc-055762	Macaca mulatta	71.59	0.00e+00	1280.00
IUUC-Meu-056697	Macropus eugenii	63.29	0.00e+00	1161.00
IUUC-Mtr-058537	Medicago truncatula	44.62	3.00e-86	313.00
IUUC-Mla-059049	Melampsora laricipopulina	42.19	6.00e-59	222.00
IUUC-Mga-059359	Meleagris gallopavo	80.29	2.00e-159	556.00
IUUC-Mmr-060966	Microcebus murinus	67.97	0.00e+00	1198.00
IUUC-Mdo-062733	Monodelphis domestica	70.75	0.00e+00	1025.00
IUUC-Mac-064815	Musa acuminata	41.67	4.00e-87	315.00
IUUC-Mpu-065759	Mustela putorius furo	66.52	0.00e+00	1138.00
IUUC-Mlu-067371	Myotis lucifugus	66.31	0.00e+00	1145.00
IUUC-Nle-070087	Nomascus leucogenys	71.06	0.00e+00	1262.00
IUUC-Opr-070729	Ochotona princeps	65.07	0.00e+00	951.00
IUUC-Ont-071346	Oreochromis niloticus	75.10	0.00e+00	804.00
IUUC-Oan-072931	Ornithorhynchus anatinus	67.16	0.00e+00	831.00
IUUC-Ocu-074823	Oryctolagus cuniculus	70.90	0.00e+00	918.00
IUUC-Oba-075866	Oryza barthii	41.94	1.00e-83	304.00
IUUC-Obr-076408	Oryza brachyantha	42.98	2.00e-85	311.00
IUUC-Ogl-077559	Oryza glaberrima	45.57	3.00e-84	307.00
IUUC-Ogu-078064	Oryza glumaepatula	42.22	1.00e-84	308.00
IUUC-Oin-079471	Oryza indica	45.57	2.00e-84	307.00
IUUC-Olo-080231	Oryza longistaminata	43.67	2.00e-76	281.00
IUUC-Ome-081746	Oryza meridionalis	42.86	4.00e-84	306.00
IUUC-Oni-082339	Oryza nivara	43.31	7.00e-85	308.00
IUUC-Opu-083194	Oryza punctata	41.96	1.00e-84	309.00
IUUC-Oru-085083	Oryza rufipogon	43.02	1.00e-84	308.00
IUUC-Osa-085395	Oryza sativa	45.57	2.00e-84	307.00
IUUC-Ola-087255	Oryzias latipes	72.25	0.00e+00	815.00
IUUC-Olu-087773	Ostreococcus lucimarinus	44.76	8.00e-72	263.00
IUUC-Oga-088818	Otolemur garnettii	71.04	0.00e+00	1099.00
IUUC-Oar-089410	Ovis aries	64.08	0.00e+00	1120.00
IUUC-Ptr-090680	Pan troglodytes	72.73	0.00e+00	1123.00
IUUC-Pan-092482	Papio anubis	71.50	0.00e+00	1298.00
IUUC-Pma-094591	Petromyzon marinus	57.61	5.00e-54	203.00
IUUC-Ppa-095853	Physcomitrella patens	46.18	4.00e-93	336.00
IUUC-Pfo-096807	Poecilia formosa	73.10	0.00e+00	825.00
IUUC-Pab-098724	Pongo abelii	71.53	0.00e+00	1316.00
IUUC-Pop-099693	Populus trichocarpa	46.58	2.00e-83	304.00
IUUC-Pca-100117	Procavia capensis	74.78	3.00e-147	516.00
IUUC-Pva-102883	Pteropus vampyrus	66.50	0.00e+00	827.00
IUUC-Pgr-103270	Puccinia graminis	45.94	4.00e-69	256.00
IUUC-Ptt-103887	Puccinia triticina	45.31	9.00e-69	254.00
IUUC-Rno-105340	Rattus norvegicus	91.24	0.00e+00	1481.00
IUUC-Sha-107019	Sarcophilus harrisii	62.43	0.00e+00	1147.00
IUUC-Sja-107805	Schizosaccharomyces japonicus	41.58	2.00e-77	282.00
IUUC-Spo-108119	Schizosaccharomyces pombe	45.78	2.00e-84	306.00
IUUC-Sit-110536	Setaria italica	42.35	3.00e-79	290.00
IUUC-Sly-111722	Solanum lycopersicum	38.84	3.00e-79	290.00
IUUC-Stu-112912	Solanum tuberosum	39.41	6.00e-80	292.00
IUUC-Sbi-114477	Sorghum bicolor	43.05	1.00e-86	314.00
IUUC-Sre-114924	Sporisorium reilianum	41.37	2.00e-66	246.00
IUUC-Ssc-116022	Sus scrofa	81.72	0.00e+00	855.00
IUUC-Tgu-116976	Taeniopygia guttata	72.52	6.00e-163	566.00
IUUC-Tru-118391	Takifugu rubripes	68.73	0.00e+00	816.00
IUUC-Tsy-119253	Tarsius syrichta	57.93	0.00e+00	774.00
IUUC-Tni-120064	Tetraodon nigroviridis	77.28	0.00e+00	798.00
IUUC-Tae-125259	Triticum aestivum	47.95	3.00e-88	320.00
IUUC-Tur-126014	Triticum urartu	47.39	2.00e-84	308.00
IUUC-Tbe-127377	Tupaia belangeri	56.26	0.00e+00	716.00
IUUC-Ttr-129259	Tursiops truncatus	80.61	0.00e+00	738.00
IUUC-Uma-129416	Ustilago maydis	43.50	3.00e-68	253.00
IUUC-Vpa-130568	Vicugna pacos	65.81	1.00e-43	172.00
IUUC-Xtr-132944	Xenopus tropicalis	76.54	0.00e+00	672.00
IUUC-Xma-133735	Xiphophorus maculatus	70.83	0.00e+00	822.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence