iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000054863.1	ENSRNOT00000083046.1	ENSRNOP00000071463.1
ENSRNOG00000054863.1	ENSRNOT00000085609.1	ENSRNOP00000069514.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.50e-112	374.9	302	921
ULD/UDP/UBQ/UBQ_Other	1.50e-16	60.4	143	221

Active Site

Position(s)	Description	Evidence
311	N/A	{ECO:0000250}
879		{ECO:0000250}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l+e++l+ +++ ++n++np ++kge+++++++l++++w++++++v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTGPLTEYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDTHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laf+ld+l+e+l++ k+kp+ e ++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFILDGLHEDLNRVKKKPYLEPKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           *******************999999999987777..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRIMEvflvpadphcrpiqyrvtvplmgaisdlcealsklsgiaaenmvvtdvynhrfhkifqmdeglshitprddifvye 566
           ********99888**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  icttpmdgseyitlpvyfrekksrpsstssgavlygqpllvsvpkhrltleslyqavcerisryikqplpeeflssplepgacngsrgs 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  yegdeeemdhqeegkeqlseveesgedsqggdptettqkakgpprhkrlftfslvnscgtadinslatdgkllklnsrstlaidwdset 744
           ***************************************************************************************** PP
   S: 186  ..............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqk 244
                                          l++c+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++  
   Q: 745  rslyfdeqeseacekhtsmsqpqkkkkaaiALRECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY-- 831
           **********************************************************************************99885.. PP
   S: 245  srekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaY 331
            r k+++ vefp + L++s+f++++     +++ Y+Liav +H+G ++ GHY+ay+kn  +gkW++fdDs+V+  +e+++++   + aY
   Q: 832  WRDKLDTVVEFPVRaLNMSEFVCDRAA---RPYVYDLIAVSNHYGAMGVGHYTAYAKNrLNGKWYYFDDSSVSLASEDQIVT---KAAY 914
           567*****************9999554...49**************************55677*******************...**** PP
   S: 332  vlfYkrr 338
           vlfY+rr
   Q: 915  VLFYQRR 921
           *****96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTIQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Rattus norvegicus

Functional Description
(View)

Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.

Protein Sequence
(Fasta)

MAEGRGTHER PDVETQKTEL GALMGTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTGGGCCC GGGCGGCGGA CGAGATGGCG GAAGGCCGGG GCACCCATGA GCGACCGGAT 60
GTGGAGACCC AGAAGACGGA GCTCGGAGCC TTGATGGGGA CCACGCTCCA GCGTGGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:290864

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	88.69	0.00e+00	1619.00
IUUC-Atr-002991	Amborella trichopoda	35.91	5.00e-146	511.00
IUUC-Apl-004068	Anas platyrhynchos	71.08	0.00e+00	1253.00
IUUC-Aca-004459	Anolis carolinensis	68.59	0.00e+00	1267.00
IUUC-Ago-007911	Ashbya gossypii	39.13	2.00e-63	237.00
IUUC-Acl-008284	Aspergillus clavatus	39.82	2.00e-56	214.00
IUUC-Afu-008878	Aspergillus fumigatus	36.49	3.00e-58	221.00
IUUC-Ani-009479	Aspergillus nidulans	42.76	6.00e-54	206.00
IUUC-Ang-009562	Aspergillus niger	43.46	4.00e-57	217.00
IUUC-Ate-010323	Aspergillus terreus	42.66	5.00e-55	210.00
IUUC-Bgr-012277	Blumeria graminis	39.60	1.00e-63	239.00
IUUC-Bta-012929	Bos taurus	89.42	0.00e+00	1665.00
IUUC-Bci-013993	Botrytis cinerea	35.76	1.00e-65	246.00
IUUC-Bdi-014013	Brachypodium distachyon	37.10	6.00e-154	538.00
IUUC-Bol-015244	Brassica oleracea	37.11	2.00e-155	543.00
IUUC-Bra-016885	Brassica rapa	36.38	7.00e-153	534.00
IUUC-Cja-018798	Callithrix jacchus	87.64	0.00e+00	1614.00
IUUC-Cfa-020599	Canis familiaris	89.94	0.00e+00	1660.00
IUUC-Cpo-022144	Cavia porcellus	87.85	0.00e+00	1630.00
IUUC-Csa-023770	Chlorocebus sabaeus	89.54	0.00e+00	1536.00
IUUC-Cho-024595	Choloepus hoffmanni	80.85	0.00e+00	1053.00
IUUC-Cin-025292	Ciona intestinalis	43.71	0.00e+00	763.00
IUUC-Cne-026852	Cryptococcus neoformans	40.22	2.00e-73	271.00
IUUC-Dno-029316	Dasypus novemcinctus	89.20	0.00e+00	1659.00
IUUC-Dse-031432	Dothistroma septosporum	41.22	1.00e-58	222.00
IUUC-Ete-032970	Echinops telfairi	79.45	0.00e+00	1046.00
IUUC-Eca-034012	Equus caballus	89.62	0.00e+00	1640.00
IUUC-Eeu-035158	Erinaceus europaeus	74.81	0.00e+00	757.00
IUUC-Fca-035373	Felis catus	85.17	0.00e+00	1606.00
IUUC-Fal-037634	Ficedula albicollis	75.14	0.00e+00	1340.00
IUUC-Fox-037986	Fusarium oxysporum	42.67	3.00e-65	244.00
IUUC-Fso-038291	Fusarium solani	30.52	3.00e-72	268.00
IUUC-Gmo-038866	Gadus morhua	64.56	0.00e+00	1180.00
IUUC-Ggr-039740	Gaeumannomyces graminis	43.96	2.00e-62	234.00
IUUC-Gga-040729	Gallus gallus	70.90	0.00e+00	1279.00
IUUC-Gac-042631	Gasterosteus aculeatus	68.20	0.00e+00	1253.00
IUUC-Gma-043077	Glycine max	36.98	1.00e-156	547.00
IUUC-Ggo-045337	Gorilla gorilla	89.29	0.00e+00	1486.00
IUUC-Hsa-045669	Homo sapiens	89.62	0.00e+00	1648.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	90.86	0.00e+00	1705.00
IUUC-Lpe-051424	Leersia perrieri	36.73	9.00e-153	534.00
IUUC-Lma-052981	Leptosphaeria maculans	34.00	4.00e-67	251.00
IUUC-Laf-053803	Loxodonta africana	88.36	0.00e+00	1691.00
IUUC-Mcc-055556	Macaca mulatta	85.67	0.00e+00	1540.00
IUUC-Meu-056742	Macropus eugenii	70.14	0.00e+00	1301.00
IUUC-Mor-056985	Magnaporthe oryzae	43.22	3.00e-62	234.00
IUUC-Mpo-057486	Magnaporthe poae	44.33	1.00e-62	235.00
IUUC-Mtr-058138	Medicago truncatula	38.16	2.00e-160	559.00
IUUC-Mla-058848	Melampsora laricipopulina	32.65	2.00e-81	298.00
IUUC-Mga-059300	Meleagris gallopavo	71.72	0.00e+00	1249.00
IUUC-Mdo-061848	Monodelphis domestica	81.92	0.00e+00	1527.00
IUUC-Mmu-063960	Mus musculus	95.43	0.00e+00	1794.00
IUUC-Mac-064956	Musa acuminata	38.34	7.00e-160	557.00
IUUC-Mpu-066920	Mustela putorius furo	89.94	0.00e+00	1656.00
IUUC-Mlu-068088	Myotis lucifugus	88.80	0.00e+00	1646.00
IUUC-Nfi-068330	Neosartorya fischeri	28.59	7.00e-62	233.00
IUUC-Ncr-068879	Neurospora crassa	31.58	4.00e-70	260.00
IUUC-Nle-070010	Nomascus leucogenys	89.93	0.00e+00	1648.00
IUUC-Opr-070740	Ochotona princeps	86.73	0.00e+00	1170.00
IUUC-Ont-072573	Oreochromis niloticus	66.97	0.00e+00	1281.00
IUUC-Oan-073363	Ornithorhynchus anatinus	74.87	0.00e+00	1416.00
IUUC-Ocu-074242	Oryctolagus cuniculus	84.64	0.00e+00	1550.00
IUUC-Oba-075553	Oryza barthii	40.23	1.00e-130	461.00
IUUC-Obr-076902	Oryza brachyantha	36.38	3.00e-150	526.00
IUUC-Ogl-077583	Oryza glaberrima	40.23	1.00e-130	461.00
IUUC-Ogu-078422	Oryza glumaepatula	34.16	5.00e-134	472.00
IUUC-Oin-079300	Oryza indica	40.38	8.00e-132	464.00
IUUC-Olo-080315	Oryza longistaminata	35.58	2.00e-148	520.00
IUUC-Ome-081271	Oryza meridionalis	35.61	4.00e-150	525.00
IUUC-Oni-082834	Oryza nivara	34.26	1.00e-134	473.00
IUUC-Opu-083691	Oryza punctata	34.66	6.00e-145	508.00
IUUC-Oru-084820	Oryza rufipogon	34.16	4.00e-134	472.00
IUUC-Osa-086139	Oryza sativa	35.41	8.00e-149	521.00
IUUC-Ola-086553	Oryzias latipes	67.19	0.00e+00	1287.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.46	2.00e-126	446.00
IUUC-Oga-088562	Otolemur garnettii	83.57	0.00e+00	1446.00
IUUC-Oar-090439	Ovis aries	88.58	0.00e+00	1634.00
IUUC-Ptr-090801	Pan troglodytes	89.92	0.00e+00	1657.00
IUUC-Pan-092717	Papio anubis	84.65	0.00e+00	1511.00
IUUC-Psi-093942	Pelodiscus sinensis	73.90	0.00e+00	1303.00
IUUC-Pfo-097060	Poecilia formosa	64.80	0.00e+00	1269.00
IUUC-Pab-098522	Pongo abelii	87.21	0.00e+00	1179.00
IUUC-Pop-099313	Populus trichocarpa	37.66	1.00e-157	550.00
IUUC-Pca-100161	Procavia capensis	79.67	0.00e+00	1439.00
IUUC-Ppe-101587	Prunus persica	38.08	2.00e-154	540.00
IUUC-Sce-106170	Saccharomyces cerevisiae	37.50	2.00e-60	228.00
IUUC-Sha-106937	Sarcophilus harrisii	81.26	0.00e+00	1487.00
IUUC-Sit-109948	Setaria italica	36.76	2.00e-142	500.00
IUUC-Sly-111746	Solanum lycopersicum	38.22	6.00e-158	551.00
IUUC-Stu-112671	Solanum tuberosum	38.10	1.00e-155	543.00
IUUC-Sar-113542	Sorex araneus	83.20	0.00e+00	1557.00
IUUC-Sbi-114874	Sorghum bicolor	36.45	1.00e-146	513.00
IUUC-Ssc-115637	Sus scrofa	89.42	0.00e+00	1646.00
IUUC-Tgu-117267	Taeniopygia guttata	72.31	0.00e+00	1332.00
IUUC-Tru-118634	Takifugu rubripes	67.06	0.00e+00	1208.00
IUUC-Tca-121001	Theobroma cacao	36.85	4.00e-160	558.00
IUUC-Tae-125295	Triticum aestivum	36.05	3.00e-153	536.00
IUUC-Tur-126478	Triticum urartu	40.83	4.00e-120	425.00
IUUC-Tme-127062	Tuber melanosporum	33.56	1.00e-79	291.00
IUUC-Tbe-127669	Tupaia belangeri	71.36	0.00e+00	872.00
IUUC-Ttr-128778	Tursiops truncatus	87.86	0.00e+00	1632.00
IUUC-Uma-129498	Ustilago maydis	41.74	4.00e-73	270.00
IUUC-Vda-129781	Verticillium dahliae	30.14	1.00e-71	265.00
IUUC-Vpa-130571	Vicugna pacos	94.04	0.00e+00	1141.00
IUUC-Vvi-131010	Vitis vinifera	39.98	3.00e-160	559.00
IUUC-Xtr-132305	Xenopus tropicalis	69.95	0.00e+00	1314.00
IUUC-Yli-134392	Yarrowia lipolytica	44.44	5.00e-63	236.00
IUUC-Zma-135699	Zea mays	36.12	2.00e-146	513.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence