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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045782
UUCD1 version UUC-HoS-00305
Ensembl Protein ID ENSP00000264658.6
UniProt Accession Q96IG2; A8K729; Q38J52; FXL20_HUMAN
Genbank Protein ID ABB03906.1; BAF84533.1; AAH07557.2
Protein Name F-box/LRR-repeat protein 20; F-box and leucine-rich repeat protein 20; F-box/LRR-repeat protein 2-like
Genbank Nucleotide ID DQ223959; AK291844; BC007557
Gene Name FBXL20; FBL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000108306.11 ENST00000264658.10 ENSP00000264658.6
ENSG00000108306.11 ENST00000394294.7 ENSP00000377832.3
ENSG00000108306.11 ENST00000577399.5 ENSP00000462878.1
ENSG00000108306.11 ENST00000581781.1 ENSP00000463132.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDMenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 23316391
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 7.80e-05 24.4 20 68
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 98   pdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
            +a + ++lp+e+l++i+++ld  +l+r+a+v+r w+ la + + w+++
   Q: 20   DEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRI 68
           5677889******************************887778888865 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
 Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
Protein Sequence
(Fasta)
MRRDVNGVTK SRFEMFSNSD EAVINKKLPK ELLLRIFSFL DVVTLCRCAQ VSRAWNVLAL 60
DGSNWQRIDL FDFQRDIEGR VVENISKRCG GFLRKLSLRG CLGVGDNALR TFAQNCRNIE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045782|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCAAAGGAA GGGTTGCCCG GCTCCAGCCC TGCACCCCCG ACCCCCGGCC TCAGGTGCAG 60
CTCCGCAGCC ATCCCCGGAC CAGGGCGGGC ACTTGGCCTG TTGCTCAGCG CAACCACCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045782|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR006553--Leu-rich_rpt_Cys-con_subtyp
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF13516--LRR_6
SMART

SM00256--FBOX
SM00367--LRR_CC
Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
GO:0001662--P:behavioral fear response
GO:0000209--P:protein polyubiquitination
KEGG hsa:84961
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001686 Ailuropoda melanoleuca 100.00 0.00e+00 884.00
IUUC-Atr-002749 Amborella trichopoda 32.89 4.00e-34 139.00
IUUC-Apl-003807 Anas platyrhynchos 93.93 0.00e+00 763.00
IUUC-Aca-004693 Anolis carolinensis 97.94 0.00e+00 869.00
IUUC-Ago-007921 Ashbya gossypii 26.32 2.00e-22 102.00
IUUC-Afu-009050 Aspergillus fumigatus 28.22 3.00e-39 157.00
IUUC-Ame-011441 Astyanax mexicanus 91.76 0.00e+00 813.00
IUUC-Bta-012431 Bos taurus 100.00 0.00e+00 884.00
IUUC-Bci-013687 Botrytis cinerea 28.16 1.00e-30 128.00
IUUC-Bdi-015021 Brachypodium distachyon 29.23 4.00e-38 152.00
IUUC-Cel-018603 Caenorhabditis elegans 49.16 2.00e-121 429.00
IUUC-Cja-019691 Callithrix jacchus 100.00 0.00e+00 884.00
IUUC-Cfa-020128 Canis familiaris 100.00 0.00e+00 884.00
IUUC-Cpo-021658 Cavia porcellus 100.00 0.00e+00 884.00
IUUC-Csa-024001 Chlorocebus sabaeus 100.00 0.00e+00 884.00
IUUC-Cho-024747 Choloepus hoffmanni 91.94 0.00e+00 778.00
IUUC-Cin-025116 Ciona intestinalis 58.70 3.00e-137 481.00
IUUC-Csv-025897 Ciona savignyi 57.77 6.00e-144 504.00
IUUC-Cne-027024 Cryptococcus neoformans 24.73 6.00e-21 96.70
IUUC-Cme-027303 Cyanidioschyzon merolae 26.21 6.00e-29 122.00
IUUC-Dre-027642 Danio rerio 92.20 0.00e+00 825.00
IUUC-Dno-029404 Dasypus novemcinctus 99.08 0.00e+00 877.00
IUUC-Dor-030309 Dipodomys ordii 75.64 2.00e-109 389.00
IUUC-Dme-032125 Drosophila melanogaster 58.75 4.00e-141 495.00
IUUC-Eca-033855 Equus caballus 99.76 0.00e+00 855.00
IUUC-Eeu-035124 Erinaceus europaeus 83.18 0.00e+00 668.00
IUUC-Fca-035529 Felis catus 99.51 0.00e+00 811.00
IUUC-Fal-037266 Ficedula albicollis 96.92 0.00e+00 827.00
IUUC-Gmo-039470 Gadus morhua 91.76 0.00e+00 818.00
IUUC-Ggr-039761 Gaeumannomyces graminis 28.54 1.00e-36 148.00
IUUC-Gac-041522 Gasterosteus aculeatus 92.22 0.00e+00 822.00
IUUC-Gma-043454 Glycine max 31.86 1.00e-35 144.00
IUUC-Ggo-044918 Gorilla gorilla 98.83 0.00e+00 839.00
IUUC-Itr-048431 Ictidomys tridecemlineatus 100.00 0.00e+00 854.00
IUUC-Lpe-051035 Leersia perrieri 30.37 4.00e-38 152.00
IUUC-Loc-052210 Lepisosteus oculatus 85.23 0.00e+00 731.00
IUUC-Laf-054025 Loxodonta africana 99.54 0.00e+00 880.00
IUUC-Mcc-055833 Macaca mulatta 100.00 0.00e+00 854.00
IUUC-Meu-056907 Macropus eugenii 80.53 2.00e-131 462.00
IUUC-Mpo-057434 Magnaporthe poae 27.85 8.00e-35 142.00
IUUC-Mtr-058542 Medicago truncatula 28.69 1.00e-31 131.00
IUUC-Mla-058932 Melampsora laricipopulina 26.79 2.00e-25 110.00
IUUC-Mga-060160 Meleagris gallopavo 95.40 0.00e+00 839.00
IUUC-Mvi-060464 Microbotryum violaceum 25.71 2.00e-22 101.00
IUUC-Mmr-060909 Microcebus murinus 100.00 0.00e+00 854.00
IUUC-Mdo-062490 Monodelphis domestica 99.08 0.00e+00 877.00
IUUC-Mmu-063739 Mus musculus 99.77 0.00e+00 882.00
IUUC-Mpu-066176 Mustela putorius furo 99.76 0.00e+00 855.00
IUUC-Mlu-068097 Myotis lucifugus 98.15 0.00e+00 855.00
IUUC-Nfi-068415 Neosartorya fischeri 27.45 2.00e-38 154.00
IUUC-Nle-070106 Nomascus leucogenys 96.10 0.00e+00 825.00
IUUC-Ont-071380 Oreochromis niloticus 92.89 0.00e+00 829.00
IUUC-Oan-073599 Ornithorhynchus anatinus 99.05 0.00e+00 848.00
IUUC-Ocu-073864 Oryctolagus cuniculus 99.53 0.00e+00 851.00
IUUC-Oba-075119 Oryza barthii 28.53 1.00e-36 147.00
IUUC-Obr-076836 Oryza brachyantha 28.25 2.00e-33 137.00
IUUC-Ogl-077393 Oryza glaberrima 28.53 2.00e-36 147.00
IUUC-Ogu-078431 Oryza glumaepatula 28.83 2.00e-37 150.00
IUUC-Oin-079837 Oryza indica 28.68 3.00e-37 149.00
IUUC-Olo-080891 Oryza longistaminata 28.80 1.00e-36 147.00
IUUC-Ome-082008 Oryza meridionalis 31.35 2.00e-35 144.00
IUUC-Oni-082538 Oryza nivara 27.98 5.00e-38 152.00
IUUC-Opu-083682 Oryza punctata 29.06 5.00e-37 149.00
IUUC-Oru-084309 Oryza rufipogon 31.79 1.00e-38 154.00
IUUC-Ola-086829 Oryzias latipes 91.97 0.00e+00 819.00
IUUC-Olu-087859 Ostreococcus lucimarinus 24.08 2.00e-08 53.90
IUUC-Oga-088755 Otolemur garnettii 99.29 0.00e+00 853.00
IUUC-Oar-089707 Ovis aries 100.00 0.00e+00 881.00
IUUC-Ptr-090904 Pan troglodytes 100.00 0.00e+00 884.00
IUUC-Pan-092252 Papio anubis 100.00 0.00e+00 854.00
IUUC-Psi-093859 Pelodiscus sinensis 97.88 0.00e+00 843.00
IUUC-Pma-094114 Petromyzon marinus 77.63 0.00e+00 697.00
IUUC-Ppa-096002 Physcomitrella patens 28.29 7.00e-27 115.00
IUUC-Pfo-097333 Poecilia formosa 91.74 0.00e+00 819.00
IUUC-Pab-098166 Pongo abelii 95.18 0.00e+00 829.00
IUUC-Pca-100608 Procavia capensis 95.87 0.00e+00 826.00
IUUC-Ppe-101524 Prunus persica 31.43 4.00e-35 142.00
IUUC-Pva-102787 Pteropus vampyrus 93.35 0.00e+00 814.00
IUUC-Pgr-103540 Puccinia graminis 25.75 1.00e-19 92.40
IUUC-Ptt-103850 Puccinia triticina 23.11 5.00e-07 50.10
IUUC-Rno-105909 Rattus norvegicus 99.77 0.00e+00 882.00
IUUC-Sce-106382 Saccharomyces cerevisiae 25.42 6.00e-24 107.00
IUUC-Sha-107652 Sarcophilus harrisii 99.26 0.00e+00 813.00
IUUC-Sja-107860 Schizosaccharomyces japonicus 27.10 7.00e-27 115.00
IUUC-Spo-108376 Schizosaccharomyces pombe 25.70 2.00e-14 74.30
IUUC-Ssl-108637 Sclerotinia sclerotiorum 29.19 2.00e-28 120.00
IUUC-Sly-111002 Solanum lycopersicum 30.00 5.00e-34 139.00
IUUC-Stu-112043 Solanum tuberosum 31.82 1.00e-34 140.00
IUUC-Sar-113053 Sorex araneus 99.48 0.00e+00 772.00
IUUC-Sbi-114065 Sorghum bicolor 31.95 1.00e-38 154.00
IUUC-Sre-115053 Sporisorium reilianum 25.35 2.00e-28 121.00
IUUC-Ssc-115902 Sus scrofa 100.00 0.00e+00 884.00
IUUC-Tru-117535 Takifugu rubripes 92.66 0.00e+00 828.00
IUUC-Tsy-119203 Tarsius syrichta 93.60 0.00e+00 769.00
IUUC-Tni-120555 Tetraodon nigroviridis 90.83 0.00e+00 819.00
IUUC-Tca-121600 Theobroma cacao 29.37 3.00e-38 153.00
IUUC-Tae-123291 Triticum aestivum 29.82 2.00e-31 130.00
IUUC-Ttr-128324 Tursiops truncatus 100.00 0.00e+00 884.00
IUUC-Uma-129602 Ustilago maydis 26.16 2.00e-27 118.00
IUUC-Vpa-130267 Vicugna pacos 99.05 0.00e+00 842.00
IUUC-Vvi-130903 Vitis vinifera 31.49 3.00e-32 133.00
IUUC-Xtr-131847 Xenopus tropicalis 89.39 0.00e+00 773.00
IUUC-Xma-133204 Xiphophorus maculatus 91.74 0.00e+00 819.00
Created Date 25-Jun-2017

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