iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mtr-058128

Ensembl Protein ID

KEH31408

UniProt Accession

A0A072UQW1; A0A072UQW1_MEDTR

Genbank Protein ID

KEH31408.1

Protein Name

E3 ubiquitin-protein ligase UPL1-like protein

Genbank Nucleotide ID

CM001220

Gene Name

MTR_4g094705

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MTR_4g094705	KEH31408	KEH31408

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-119	399.6	3398	3736
UBD/Alpha-Helix/UBA	6.00e-08	34.0	1287	1326
UBD/Alpha-Helix/UBM	2.10e-13	50.9	2682	2706

Active Site

Position(s)	Description	Evidence
3704	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklll 101
           +dlk rl+v+f+gEeg+d+gG+tre+++lls+ ++++ + lf ++ ++++t+qpnp+s ++ +ehl++F+f+Gr++gkal+dg+lld+ +++sfyk++l
   Q: 3398 QDLKGRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLF-TTVGNNATFQPNPNSVYQ-TEHLSYFKFVGRVVGKALFDGQLLDVYFTRSFYKHIL 3494
           799***********************************9999.566688999******986.5************************************ PP
   S: 102  gkklsledleevdpelykslkeikenaesdieelgldltfsvseei.....lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafre 195
           g+k++++d+e+vdp++yk+lk+++en+ sdi +l++ +   ++ee+      +e++++eLkpgG+ni+Vt+e k+eYv+lv+e+ l++ i+ q+++f e
   Q: 3495 GVKVTYHDIEAVDPDYYKNLKWMLENDVSDIPDLTFSMD--ADEEKlilyeKNEVTDYELKPGGRNIRVTEETKHEYVDLVAEHLLTNAIRPQINSFLE 3591
           **************************6666666533333..444446786677888999**************************************** PP
   S: 196  GfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvir 290
           Gf+e++p el+s+F+ +elelli+G +eid++dlk++t+y+g yt  s+++qwFwev+++fs+e+ +++LqFvTg+s++Pl+Gf++l+    p++f+i+
   Q: 3592 GFSEMVPRELISIFNDKELELLISGLPEIDLDDLKANTEYTG-YTVASNVVQWFWEVVKSFSKEDMARLLQFVTGTSKVPLEGFKALQgisgPQRFQIH 3689
           ****************************************66.******************************************************** PP
   S: 291  k.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kgFel 335
           k ++++drlPs++TCfn+L+LPeY+ske+l+++Ll+Ai+e+ +gF++
   Q: 3690 KaYGAPDRLPSAHTCFNQLDLPEYTSKEQLQDRLLLAIHEAsEGFGF 3736
           *99999***********************************9***85 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           de  +  +veMGF+r +a +aLr+   n++e A+e+L+++
   Q: 1287 DEATISTIVEMGFSRARAEEALRRVeTNSVELAMEWLFSH 1326
           7888999*****************66************97 PP

UBD/Alpha-Helix/UBM

   S: 4    qvDpeVfsqLPeeiQeEvmaelrqq 28
           ++Dpe++++LP++iQ+Ev+a +r q
   Q: 2682 DIDPEFLAALPPDIQAEVLAQQRAQ 2706
           79******************99976 PP

Organism

Medicago truncatula

Protein Sequence
(Fasta)

MKLKRKRALE VPPKIRCFIN CVTAVPLENI QEPLNNFAWE FDKGDFHHWA DLFNHFDSFF 60
EKYVKPRKDL QVDDGFLDSD PPFPREAVLQ ILRVIRIILD NCPNKHFYSS YEQHLSLLLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTATACTTC CTTCTTCTCT TCTCTTTTCT TCCTCACTTG GTTTTTCTCT CTTTCTCTCA 60
CTACTTTCTC TCTCTACCTT CACTCCATCG ATAAACCAAT CCTCTCATTC TCCTCAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR003903--UIM_dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50330--UIM

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mtr:MTR_4g094705

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003044	Amborella trichopoda	58.41	0.00e+00	3643.00
IUUC-Aly-006083	Arabidopsis lyrata	60.98	0.00e+00	3903.00
IUUC-Ate-010253	Aspergillus terreus	41.14	2.00e-140	494.00
IUUC-Cgl-026647	Colletotrichum gloeosporioides	39.85	1.00e-140	495.00
IUUC-Cne-027095	Cryptococcus neoformans	31.12	5.00e-111	396.00
IUUC-Mla-058888	Melampsora laricipopulina	46.96	5.00e-115	406.00
IUUC-Mvi-060320	Microbotryum violaceum	33.83	7.00e-127	449.00
IUUC-Ome-081289	Oryza meridionalis	67.91	0.00e+00	1095.00
IUUC-Olu-087813	Ostreococcus lucimarinus	52.80	3.00e-128	451.00
IUUC-Spo-108024	Schizosaccharomyces pombe	32.66	9.00e-139	489.00
IUUC-Smo-109428	Selaginella moellendorffii	42.86	0.00e+00	1581.00
IUUC-Sbi-113794	Sorghum bicolor	52.16	0.00e+00	3095.00
IUUC-Tvi-122370	Trichoderma virens	40.03	4.00e-142	500.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence