iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Afu-008884

Ensembl Protein ID

CADAFUAP00000420

UniProt Accession

Q4WDD7; BRE1_ASPFU

Genbank Protein ID

EAL85601.1

Protein Name

E3 ubiquitin-protein ligase bre1; RING-type E3 ubiquitin transferase bre1

Genbank Nucleotide ID

AAHF01000012

Gene Name

AFUA_6G04390; bre1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADAFUAG00000420	CADAFUAT00000420	CADAFUAP00000420

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	27.88	5.00e-17	84.70	IUUC-Sce-106384
E3 activity/RING/RING	28.70	1.00e-10	63.50	IUUC-Spo-108279

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Aspergillus fumigatus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.

Protein Sequence
(Fasta)

MQKSRLDARS SSELWGEVGS VTWEALGDAK PPRPKILLAF QVLLITTTCT ATSSNVTQIL 60
LPTRAGTAAP LMPATEASPV VCSESAIVKM EDRKRPATHD HNDSAPPLKK QATSVNGGSK 120

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Nucleotide Sequence
(Fasta)

ATGCAGAAGT CTAGACTAGA TGCCAGGAGT TCGTCTGAAC TCTGGGGGGA AGTGGGCTCG 60
GTCACGTGGG AGGCGCTAGG CGACGCTAAA CCTCCCAGGC CGAAAATCCT CCTGGCTTTC 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR013956--E3_ubiquit_lig_BRE1
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF08647--BRE1

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0016567--P:protein ubiquitination

KEGG

afm:AFUA_6G04390

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007988	Ashbya gossypii	30.41	9.00e-10	57.00
IUUC-Acl-008319	Aspergillus clavatus	87.79	0.00e+00	1121.00
IUUC-Afl-008679	Aspergillus flavus	81.40	0.00e+00	1056.00
IUUC-Ani-009487	Aspergillus nidulans	77.44	0.00e+00	969.00
IUUC-Ang-009601	Aspergillus niger	78.29	0.00e+00	1021.00
IUUC-Aor-010142	Aspergillus oryzae	77.56	0.00e+00	1032.00
IUUC-Ate-010547	Aspergillus terreus	78.66	0.00e+00	934.00
IUUC-Bgr-012245	Blumeria graminis	44.55	5.00e-129	453.00
IUUC-Bci-013926	Botrytis cinerea	46.30	5.00e-139	486.00
IUUC-Cgl-026569	Colletotrichum gloeosporioides	37.09	7.00e-96	343.00
IUUC-Cne-026878	Cryptococcus neoformans	25.05	1.00e-14	73.90
IUUC-Dse-031300	Dothistroma septosporum	44.97	2.00e-130	457.00
IUUC-Ete-032330	Echinops telfairi	40.62	9.30e-02	29.60
IUUC-Fox-038017	Fusarium oxysporum	40.21	3.00e-114	404.00
IUUC-Fso-038414	Fusarium solani	41.54	2.00e-96	345.00
IUUC-Ggr-040117	Gaeumannomyces graminis	39.62	6.00e-108	383.00
IUUC-Kpa-049345	Komagataella pastoris	31.01	4.00e-09	55.10
IUUC-Lma-053312	Leptosphaeria maculans	43.67	2.00e-141	494.00
IUUC-Mor-057068	Magnaporthe oryzae	38.89	5.00e-101	360.00
IUUC-Mpo-057568	Magnaporthe poae	40.73	8.00e-110	389.00
IUUC-Mla-059072	Melampsora laricipopulina	25.67	5.00e-15	74.70
IUUC-Mvi-060341	Microbotryum violaceum	24.13	4.00e-16	78.60
IUUC-Nfi-068269	Neosartorya fischeri	97.16	0.00e+00	1268.00
IUUC-Ncr-068695	Neurospora crassa	41.61	1.00e-124	438.00
IUUC-Ont-072370	Oreochromis niloticus	26.73	7.40e-02	30.00
IUUC-Oni-082966	Oryza nivara	26.98	7.50e-02	29.60
IUUC-Pno-095079	Phaeosphaeria nodorum	46.36	6.00e-140	489.00
IUUC-Pgr-103536	Puccinia graminis	25.95	2.00e-17	83.20
IUUC-Ptt-104014	Puccinia triticina	25.56	1.00e-11	63.90
IUUC-Pte-104415	Pyrenophora teres	41.98	4.00e-128	450.00
IUUC-Pyt-104762	Pyrenophora triticirepentis	43.42	8.00e-133	466.00
IUUC-Sce-106384	Saccharomyces cerevisiae	28.00	3.00e-17	82.00
IUUC-Sja-108010	Schizosaccharomyces japonicus	29.00	2.00e-10	59.30
IUUC-Spo-108279	Schizosaccharomyces pombe	28.70	1.00e-09	57.00
IUUC-Ssl-108546	Sclerotinia sclerotiorum	43.44	2.00e-124	437.00
IUUC-Sar-113659	Sorex araneus	33.78	1.10e-01	28.90
IUUC-Sre-115087	Sporisorium reilianum	33.11	4.00e-12	65.10
IUUC-Tre-122150	Trichoderma reesei	40.52	2.00e-114	404.00
IUUC-Tvi-122431	Trichoderma virens	41.49	3.00e-127	447.00
IUUC-Tme-127177	Tuber melanosporum	40.48	3.00e-113	400.00
IUUC-Uma-129488	Ustilago maydis	41.51	1.00e-12	67.00
IUUC-Vda-129815	Verticillium dahliae	37.67	1.00e-98	352.00
IUUC-Xma-133786	Xiphophorus maculatus	27.27	4.20e-02	30.80
IUUC-Yli-134445	Yarrowia lipolytica	28.81	2.00e-37	149.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence