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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063981
UUCD1 version UUC-MuM-00387
Ensembl Protein ID ENSMUSP00000146310.1
UniProt Accession Q3U319; Q6ZQ75; Q8BJA1; Q8BY03; Q8CHX4; BRE1B_MOUSE
Genbank Protein ID BAC97994.1; BAC31322.1; BAC40966.1; BAE32971.1; BAE42468.1; AAH38348.1
Protein Name E3 ubiquitin-protein ligase BRE1B; RING finger protein 40; RING-type E3 ubiquitin transferase BRE1B
Genbank Nucleotide ID AK129184; AK042654; AK089805; AK154982; AK171462; BC038348
Gene Name Rnf40; Bre1b; Kiaa0661
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000030816.8 ENSMUST00000205694.1 ENSMUSP00000146310.1
ENSMUSG00000030816.8 ENSMUST00000033088.7 ENSMUSP00000033088.7
ENSMUSG00000030816.8 ENSMUST00000206914.1 ENSMUSP00000146004.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 43.03 0.00e+00 708.00 IUUC-Dme-032034
E3 activity/RING/RING 92.51 0.00e+00 1653.00 IUUC-Hsa-045732
E3 activity/RING/RING 98.10 0.00e+00 1818.00 IUUC-Rno-105165
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
 Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Protein Sequence
(Fasta)
MSGLSNKRAA GDGGSGPPEK KMNREEKTTT TLIEPIRLGG ISSTEEMDSK VLQFKNKKLA 60
ERLEQRQACE DELRERIEKL EKRQATDDAT LLIVNRYWAQ LDETVEALLQ CYENQRELSS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063981|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
GACGTCCGGT GAAATCCAAG ATGGTGGCGC TTGGCTGACC CTACGGTAAG TGCGGACCCC 60
CGTCCGGCGG GGGCGGGGTC CGGGAGATAT GTCCAGGGGG ACGCTCAGGA CTGCGGAGCT 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063981|E3,RING|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
SMART

SM00184--RING
Gene Ontology

GO:0043679--C:axon terminus
GO:0005829--C:cytosol
GO:0019898--C:extrinsic component of membrane
GO:0033503--C:HULC complex
GO:0016020--C:membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0003730--F:mRNA 3'-UTR binding
GO:0042803--F:protein homodimerization activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0033523--P:histone H2B ubiquitination
GO:0010390--P:histone monoubiquitination
GO:1900364--P:negative regulation of mRNA polyadenylation
GO:2001168--P:positive regulation of histone H2B ubiquitination
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0043434--P:response to peptide hormone
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:233900
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001027 Aegilops tauschii 28.65 2.00e-12 68.20
IUUC-Aml-002295 Ailuropoda melanoleuca 93.91 0.00e+00 1666.00
IUUC-Atr-002836 Amborella trichopoda 31.12 6.00e-27 116.00
IUUC-Aca-004850 Anolis carolinensis 73.95 0.00e+00 662.00
IUUC-Aly-006055 Arabidopsis lyrata 28.42 2.00e-29 124.00
IUUC-Ath-007462 Arabidopsis thaliana 28.95 2.00e-29 124.00
IUUC-Ang-009601 Aspergillus niger 26.20 4.00e-16 80.10
IUUC-Ame-011745 Astyanax mexicanus 81.51 8.00e-152 531.00
IUUC-Bta-013173 Bos taurus 92.81 0.00e+00 1643.00
IUUC-Bci-013926 Botrytis cinerea 37.74 4.00e-08 53.50
IUUC-Bdi-015006 Brachypodium distachyon 51.52 2.00e-16 81.30
IUUC-Bol-015421 Brassica oleracea 28.93 2.00e-28 121.00
IUUC-Bra-016804 Brassica rapa 29.04 1.00e-34 142.00
IUUC-Cja-019042 Callithrix jacchus 91.91 0.00e+00 1592.00
IUUC-Cfa-020318 Canis familiaris 93.51 0.00e+00 1659.00
IUUC-Cpo-021539 Cavia porcellus 92.91 0.00e+00 1658.00
IUUC-Cre-022940 Chlamydomonas reinhardtii 37.93 1.00e-08 55.10
IUUC-Csa-024051 Chlorocebus sabaeus 93.01 0.00e+00 1565.00
IUUC-Cin-025174 Ciona intestinalis 43.18 0.00e+00 700.00
IUUC-Csv-025830 Ciona savignyi 54.52 1.00e-96 348.00
IUUC-Cgl-026569 Colletotrichum gloeosporioides 42.31 2.00e-09 58.20
IUUC-Cne-026878 Cryptococcus neoformans 26.57 2.00e-15 78.20
IUUC-Dre-028171 Danio rerio 80.67 8.00e-153 534.00
IUUC-Dno-028892 Dasypus novemcinctus 93.31 0.00e+00 1612.00
IUUC-Dor-030268 Dipodomys ordii 91.60 0.00e+00 761.00
IUUC-Dme-032034 Drosophila melanogaster 43.11 0.00e+00 725.00
IUUC-Ete-032505 Echinops telfairi 89.79 0.00e+00 627.00
IUUC-Eca-033436 Equus caballus 93.21 0.00e+00 1679.00
IUUC-Eeu-035291 Erinaceus europaeus 87.49 0.00e+00 1305.00
IUUC-Fca-035720 Felis catus 93.51 0.00e+00 1666.00
IUUC-Fox-038017 Fusarium oxysporum 27.39 2.00e-10 61.20
IUUC-Fso-038414 Fusarium solani 26.36 3.00e-10 60.50
IUUC-Gmo-039269 Gadus morhua 80.12 1.00e-142 501.00
IUUC-Gac-041303 Gasterosteus aculeatus 65.06 2.00e-151 530.00
IUUC-Gma-042797 Glycine max 28.10 2.00e-36 148.00
IUUC-Ggo-045426 Gorilla gorilla 92.71 0.00e+00 1634.00
IUUC-Hsa-045732 Homo sapiens 92.51 0.00e+00 1666.00
IUUC-Hvu-047689 Hordeum vulgare 28.10 6.00e-28 119.00
IUUC-Itr-048724 Ictidomys tridecemlineatus 93.61 0.00e+00 1650.00
IUUC-Kpa-049345 Komagataella pastoris 27.59 3.00e-10 60.80
IUUC-Lch-049429 Latimeria chalumnae 84.46 1.00e-161 563.00
IUUC-Lpe-051253 Leersia perrieri 31.58 4.00e-34 140.00
IUUC-Laf-054267 Loxodonta africana 93.01 0.00e+00 1645.00
IUUC-Mcc-055240 Macaca mulatta 93.01 0.00e+00 1565.00
IUUC-Meu-056750 Macropus eugenii 82.41 0.00e+00 1409.00
IUUC-Mor-057068 Magnaporthe oryzae 45.28 5.00e-12 66.60
IUUC-Mtr-057632 Medicago truncatula 28.85 3.00e-33 137.00
IUUC-Mla-059072 Melampsora laricipopulina 28.34 8.00e-27 115.00
IUUC-Mvi-060341 Microbotryum violaceum 29.93 6.00e-23 102.00
IUUC-Mmr-061177 Microcebus murinus 93.21 0.00e+00 1647.00
IUUC-Mdo-062415 Monodelphis domestica 82.74 0.00e+00 1412.00
IUUC-Mac-065103 Musa acuminata 30.85 3.00e-42 167.00
IUUC-Mpu-066498 Mustela putorius furo 93.21 0.00e+00 1590.00
IUUC-Mlu-067242 Myotis lucifugus 92.61 0.00e+00 1631.00
IUUC-Nle-069320 Nomascus leucogenys 93.32 0.00e+00 827.00
IUUC-Opr-070286 Ochotona princeps 88.05 0.00e+00 1027.00
IUUC-Ont-071299 Oreochromis niloticus 80.28 2.00e-153 536.00
IUUC-Oan-073538 Ornithorhynchus anatinus 75.56 5.00e-176 611.00
IUUC-Ocu-073799 Oryctolagus cuniculus 93.31 0.00e+00 1651.00
IUUC-Oba-075000 Oryza barthii 28.50 6.00e-30 126.00
IUUC-Obr-076532 Oryza brachyantha 29.72 1.00e-32 135.00
IUUC-Ogl-077200 Oryza glaberrima 30.21 2.00e-32 134.00
IUUC-Ogu-078279 Oryza glumaepatula 28.50 5.00e-30 126.00
IUUC-Oin-079097 Oryza indica 30.21 2.00e-32 134.00
IUUC-Olo-080612 Oryza longistaminata 53.33 4.00e-15 77.40
IUUC-Ome-081304 Oryza meridionalis 30.08 2.00e-31 130.00
IUUC-Oni-082162 Oryza nivara 28.50 5.00e-30 126.00
IUUC-Opu-083683 Oryza punctata 51.52 2.00e-16 81.30
IUUC-Oru-084382 Oryza rufipogon 28.50 5.00e-30 126.00
IUUC-Osa-085839 Oryza sativa 51.52 3.00e-16 80.90
IUUC-Ola-086435 Oryzias latipes 66.67 3.00e-153 536.00
IUUC-Oga-089016 Otolemur garnettii 87.12 0.00e+00 1519.00
IUUC-Oar-089589 Ovis aries 93.11 0.00e+00 1651.00
IUUC-Ptr-090530 Pan troglodytes 91.46 0.00e+00 1243.00
IUUC-Pan-092502 Papio anubis 93.01 0.00e+00 1568.00
IUUC-Psi-093155 Pelodiscus sinensis 72.94 2.00e-140 493.00
IUUC-Pno-095079 Phaeosphaeria nodorum 27.52 2.00e-13 70.90
IUUC-Ppa-095735 Physcomitrella patens 34.16 2.00e-42 167.00
IUUC-Pfo-097527 Poecilia formosa 52.77 0.00e+00 754.00
IUUC-Pab-098619 Pongo abelii 93.21 0.00e+00 1648.00
IUUC-Pop-099376 Populus trichocarpa 30.00 6.00e-36 146.00
IUUC-Pca-100544 Procavia capensis 92.21 0.00e+00 1633.00
IUUC-Ppe-102065 Prunus persica 29.68 1.00e-31 132.00
IUUC-Pva-102479 Pteropus vampyrus 94.37 0.00e+00 1387.00
IUUC-Pgr-103536 Puccinia graminis 27.51 9.00e-22 99.40
IUUC-Ptt-104014 Puccinia triticina 26.98 4.00e-05 43.50
IUUC-Pte-104415 Pyrenophora teres 33.33 3.00e-13 70.90
IUUC-Pyt-104762 Pyrenophora triticirepentis 30.39 2.00e-13 71.20
IUUC-Rno-105165 Rattus norvegicus 98.10 0.00e+00 1790.00
IUUC-Sce-106384 Saccharomyces cerevisiae 24.63 3.00e-16 80.50
IUUC-Sha-107602 Sarcophilus harrisii 83.93 0.00e+00 1451.00
IUUC-Ssl-108546 Sclerotinia sclerotiorum 37.74 2.00e-08 54.70
IUUC-Smo-109550 Selaginella moellendorffii 30.19 1.00e-38 155.00
IUUC-Sit-109889 Setaria italica 29.53 8.00e-32 132.00
IUUC-Sly-111490 Solanum lycopersicum 33.61 1.00e-41 164.00
IUUC-Sar-113755 Sorex araneus 90.84 0.00e+00 1308.00
IUUC-Sbi-114734 Sorghum bicolor 30.43 4.00e-24 104.00
IUUC-Sre-115087 Sporisorium reilianum 24.91 6.00e-16 79.70
IUUC-Ssc-116134 Sus scrofa 92.01 0.00e+00 1646.00
IUUC-Tru-117867 Takifugu rubripes 80.28 7.00e-154 538.00
IUUC-Tsy-119065 Tarsius syrichta 88.67 0.00e+00 1427.00
IUUC-Tca-121060 Theobroma cacao 33.06 6.00e-40 159.00
IUUC-Tre-122150 Trichoderma reesei 41.51 3.00e-10 60.50
IUUC-Tvi-122431 Trichoderma virens 41.51 4.00e-10 60.10
IUUC-Tae-124308 Triticum aestivum 29.83 3.00e-31 130.00
IUUC-Tur-126160 Triticum urartu 50.00 8.00e-16 79.30
IUUC-Tme-127177 Tuber melanosporum 23.27 1.00e-12 68.60
IUUC-Tbe-127597 Tupaia belangeri 85.63 0.00e+00 1035.00
IUUC-Ttr-128303 Tursiops truncatus 92.53 0.00e+00 1598.00
IUUC-Uma-129488 Ustilago maydis 27.68 1.00e-18 89.00
IUUC-Vda-129815 Verticillium dahliae 40.38 2.00e-09 57.40
IUUC-Vvi-131316 Vitis vinifera 32.36 2.00e-35 144.00
IUUC-Xtr-132906 Xenopus tropicalis 67.91 0.00e+00 651.00
IUUC-Xma-133365 Xiphophorus maculatus 52.57 0.00e+00 748.00
IUUC-Yli-134445 Yarrowia lipolytica 40.62 1.00e-12 68.60
Created Date 25-Jun-2017

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