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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046889
UUCD1 version UUC-HoS-00088
Ensembl Protein ID ENSP00000381567.2
UniProt Accession P82094; B7ZLJ2; Q17R87; Q59GK0; TMF1_HUMAN
Genbank Protein ID AAD54608.1; BAD92346.1; EAW65468.1; AAI17419.1; AAI26124.1; AAI43841.1
Protein Name TATA element modulatory factor; Androgen receptor coactivator 160 kDa protein; Androgen receptor-associated protein of 160 kDa
Genbank Nucleotide ID L01042; AB209109; AC109587; BC117418; BC126123; BC143840
Gene Name TMF1; ARA160
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000144747.15 ENST00000398559.6 ENSP00000381567.2
ENSG00000144747.15 ENST00000488010.5 ENSP00000419330.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 15467733
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).
 Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP).
Protein Sequence
(Fasta)
MSWFNASQLS SFAKQALSQA QKSIDRVLDI QEEEPSIWAE TIPYGEPGIS SPVSGGWDTS 60
TWGLKSNTEP QSPPIASPKA ITKPVRRTVV DESENFFSAF LSPTDVQTIQ KSPVVSKPPA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046889|E3,SOCS|Homo sapiens
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Nucleotide Sequence
(Fasta)
GCAAGCGCAT GCGCACATGG GCCCCCTTCG TCTCAGCTGT GCGGGAACGG CCGAGGGTAA 60
CATCCCGGGC TCGCGGGAGG CTGTCGGGGT AATGGCCACA CGCTGACAGA ACCAGCCGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046889|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
Interpro

IPR022092--TMF_DNA-bd
IPR022091--TMF_TATA-bd
Pfam

PF12329--TMF_DNA_bd
PF12325--TMF_TATA_bd
Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0003712--F:transcription cofactor activity
GO:0001675--P:acrosome assembly
GO:0071407--P:cellular response to organic cyclic compound
GO:0042742--P:defense response to bacterium
GO:0030317--P:flagellated sperm motility
GO:0033327--P:Leydig cell differentiation
GO:0032275--P:luteinizing hormone secretion
GO:0043066--P:negative regulation of apoptotic process
GO:0010629--P:negative regulation of gene expression
GO:0001819--P:positive regulation of cytokine production
GO:2000845--P:positive regulation of testosterone secretion
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0007289--P:spermatid nucleus differentiation
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG hsa:7110
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000973 Aegilops tauschii 31.94 1.00e-17 85.90
IUUC-Aml-001448 Ailuropoda melanoleuca 92.69 0.00e+00 1736.00
IUUC-Atr-003092 Amborella trichopoda 30.97 6.00e-40 159.00
IUUC-Apl-003546 Anas platyrhynchos 74.66 0.00e+00 1315.00
IUUC-Aca-004234 Anolis carolinensis 71.74 0.00e+00 1310.00
IUUC-Ath-007364 Arabidopsis thaliana 29.92 1.00e-36 149.00
IUUC-Acl-008271 Aspergillus clavatus 28.57 1.00e-11 65.90
IUUC-Afl-008405 Aspergillus flavus 27.45 2.00e-07 51.60
IUUC-Afu-009059 Aspergillus fumigatus 28.57 4.00e-12 67.40
IUUC-Ani-009416 Aspergillus nidulans 28.97 8.00e-11 62.80
IUUC-Ang-009857 Aspergillus niger 28.77 2.00e-11 64.30
IUUC-Aor-009910 Aspergillus oryzae 27.45 2.00e-07 51.60
IUUC-Ate-010427 Aspergillus terreus 32.74 5.00e-09 56.60
IUUC-Ame-011270 Astyanax mexicanus 66.30 0.00e+00 889.00
IUUC-Bgr-012100 Blumeria graminis 29.46 3.00e-08 54.30
IUUC-Bta-012337 Bos taurus 92.42 0.00e+00 1680.00
IUUC-Bci-013775 Botrytis cinerea 30.77 5.00e-06 47.00
IUUC-Bdi-014582 Brachypodium distachyon 33.42 7.00e-24 106.00
IUUC-Cel-018635 Caenorhabditis elegans 34.15 1.20e-01 30.80
IUUC-Cja-019803 Callithrix jacchus 97.26 0.00e+00 1821.00
IUUC-Cfa-020451 Canis familiaris 92.55 0.00e+00 1691.00
IUUC-Cpo-021327 Cavia porcellus 90.56 0.00e+00 1594.00
IUUC-Cre-022628 Chlamydomonas reinhardtii 28.40 3.00e-03 37.40
IUUC-Csa-023803 Chlorocebus sabaeus 98.63 0.00e+00 1843.00
IUUC-Cho-024293 Choloepus hoffmanni 88.86 0.00e+00 756.00
IUUC-Cin-025461 Ciona intestinalis 40.62 3.00e-38 152.00
IUUC-Cgl-026669 Colletotrichum gloeosporioides 27.03 3.00e-09 57.80
IUUC-Cme-027311 Cyanidioschyzon merolae 33.77 6.00e-04 39.70
IUUC-Dre-028098 Danio rerio 59.30 0.00e+00 978.00
IUUC-Dno-029535 Dasypus novemcinctus 91.50 0.00e+00 1650.00
IUUC-Dor-031120 Dipodomys ordii 88.22 0.00e+00 1658.00
IUUC-Dse-031548 Dothistroma septosporum 30.30 2.00e-07 51.20
IUUC-Dme-031658 Drosophila melanogaster 30.25 5.00e-22 100.00
IUUC-Ete-032764 Echinops telfairi 84.94 0.00e+00 1095.00
IUUC-Eca-034312 Equus caballus 93.61 0.00e+00 1692.00
IUUC-Eeu-034967 Erinaceus europaeus 84.37 0.00e+00 978.00
IUUC-Fca-036312 Felis catus 93.05 0.00e+00 1724.00
IUUC-Fal-036979 Ficedula albicollis 74.30 0.00e+00 1228.00
IUUC-Fox-037833 Fusarium oxysporum 43.18 4.00e-06 47.40
IUUC-Gmo-039175 Gadus morhua 66.04 0.00e+00 695.00
IUUC-Ggr-039752 Gaeumannomyces graminis 32.74 1.00e-10 62.40
IUUC-Gga-041252 Gallus gallus 74.57 0.00e+00 1322.00
IUUC-Gac-042186 Gasterosteus aculeatus 67.76 0.00e+00 679.00
IUUC-Gma-042878 Glycine max 30.36 3.00e-32 134.00
IUUC-Ggo-045127 Gorilla gorilla 99.09 0.00e+00 1853.00
IUUC-Hvu-047231 Hordeum vulgare 34.17 9.00e-25 109.00
IUUC-Itr-048895 Ictidomys tridecemlineatus 83.82 0.00e+00 1377.00
IUUC-Kpa-049375 Komagataella pastoris 34.65 2.00e-08 54.70
IUUC-Lch-049701 Latimeria chalumnae 68.97 0.00e+00 1214.00
IUUC-Lpe-051071 Leersia perrieri 31.12 6.00e-16 80.10
IUUC-Loc-052900 Lepisosteus oculatus 61.95 0.00e+00 1077.00
IUUC-Lma-053189 Leptosphaeria maculans 25.04 9.00e-13 69.30
IUUC-Laf-054583 Loxodonta africana 90.85 0.00e+00 1593.00
IUUC-Meu-056215 Macropus eugenii 69.23 3.00e-117 416.00
IUUC-Mor-057227 Magnaporthe oryzae 26.54 3.00e-07 51.20
IUUC-Mpo-057315 Magnaporthe poae 42.31 6.00e-07 50.10
IUUC-Mtr-058276 Medicago truncatula 27.63 2.00e-23 105.00
IUUC-Mga-059916 Meleagris gallopavo 74.74 0.00e+00 1271.00
IUUC-Mmr-061789 Microcebus murinus 81.71 0.00e+00 1180.00
IUUC-Mdo-062174 Monodelphis domestica 80.97 0.00e+00 1488.00
IUUC-Mmu-063422 Mus musculus 86.68 0.00e+00 1505.00
IUUC-Mac-065498 Musa acuminata 28.59 1.00e-30 129.00
IUUC-Mpu-065744 Mustela putorius furo 92.32 0.00e+00 1757.00
IUUC-Mlu-066925 Myotis lucifugus 90.74 0.00e+00 1573.00
IUUC-Nfi-068254 Neosartorya fischeri 28.57 2.00e-12 68.20
IUUC-Ncr-068887 Neurospora crassa 27.81 6.00e-10 60.10
IUUC-Nle-070100 Nomascus leucogenys 98.63 0.00e+00 1845.00
IUUC-Opr-071131 Ochotona princeps 84.52 0.00e+00 1183.00
IUUC-Ont-071378 Oreochromis niloticus 61.63 0.00e+00 978.00
IUUC-Oan-073705 Ornithorhynchus anatinus 80.92 0.00e+00 1533.00
IUUC-Ocu-074158 Oryctolagus cuniculus 92.17 0.00e+00 1743.00
IUUC-Oba-075498 Oryza barthii 30.87 5.00e-17 84.00
IUUC-Obr-076136 Oryza brachyantha 31.75 2.00e-32 135.00
IUUC-Ogl-077020 Oryza glaberrima 33.93 2.00e-25 112.00
IUUC-Ogu-078875 Oryza glumaepatula 30.87 4.00e-20 94.00
IUUC-Oin-079223 Oryza indica 33.93 2.00e-25 111.00
IUUC-Olo-080859 Oryza longistaminata 31.27 8.00e-18 86.30
IUUC-Ome-081621 Oryza meridionalis 30.61 4.00e-17 84.30
IUUC-Oni-082628 Oryza nivara 30.87 9.00e-17 82.80
IUUC-Opu-083825 Oryza punctata 30.87 1.00e-19 92.80
IUUC-Oru-084959 Oryza rufipogon 30.61 3.00e-16 81.30
IUUC-Osa-086104 Oryza sativa 33.93 2.00e-25 112.00
IUUC-Ola-087148 Oryzias latipes 59.26 0.00e+00 1001.00
IUUC-Olu-087856 Ostreococcus lucimarinus 33.06 4.00e-15 76.60
IUUC-Oga-088598 Otolemur garnettii 91.50 0.00e+00 1690.00
IUUC-Oar-090450 Ovis aries 91.25 0.00e+00 1659.00
IUUC-Ptr-091659 Pan troglodytes 99.45 0.00e+00 1862.00
IUUC-Pan-091964 Papio anubis 96.57 0.00e+00 1345.00
IUUC-Psi-093585 Pelodiscus sinensis 80.59 0.00e+00 984.00
IUUC-Pma-094379 Petromyzon marinus 50.54 0.00e+00 747.00
IUUC-Pno-095032 Phaeosphaeria nodorum 25.91 7.00e-10 59.70
IUUC-Ppa-095425 Physcomitrella patens 32.32 2.00e-53 204.00
IUUC-Pfo-096386 Poecilia formosa 65.12 0.00e+00 857.00
IUUC-Pab-098042 Pongo abelii 97.68 0.00e+00 983.00
IUUC-Pop-099005 Populus trichocarpa 37.65 4.00e-14 72.80
IUUC-Pca-100308 Procavia capensis 92.56 0.00e+00 1185.00
IUUC-Ppe-101449 Prunus persica 28.44 8.00e-26 112.00
IUUC-Pva-103119 Pteropus vampyrus 87.53 0.00e+00 1198.00
IUUC-Pte-104335 Pyrenophora teres 25.97 1.00e-08 55.50
IUUC-Pyt-104547 Pyrenophora triticirepentis 26.62 1.00e-09 58.90
IUUC-Rno-105578 Rattus norvegicus 86.22 0.00e+00 1498.00
IUUC-Sha-106612 Sarcophilus harrisii 80.53 0.00e+00 1434.00
IUUC-Sja-107911 Schizosaccharomyces japonicus 25.19 8.00e-04 38.50
IUUC-Spo-108059 Schizosaccharomyces pombe 29.92 5.00e-08 52.80
IUUC-Ssl-108390 Sclerotinia sclerotiorum 26.23 6.00e-15 76.60
IUUC-Smo-108781 Selaginella moellendorffii 29.36 3.00e-17 82.80
IUUC-Sit-109754 Setaria italica 31.63 2.00e-25 112.00
IUUC-Sly-111573 Solanum lycopersicum 30.61 1.00e-34 142.00
IUUC-Stu-112843 Solanum tuberosum 27.71 2.00e-02 31.20
IUUC-Sar-113118 Sorex araneus 85.64 0.00e+00 1522.00
IUUC-Sbi-114519 Sorghum bicolor 32.40 7.00e-24 106.00
IUUC-Ssc-115826 Sus scrofa 88.21 0.00e+00 1590.00
IUUC-Tgu-116702 Taeniopygia guttata 74.79 0.00e+00 1237.00
IUUC-Tru-117915 Takifugu rubripes 65.05 0.00e+00 830.00
IUUC-Tsy-119224 Tarsius syrichta 94.05 0.00e+00 1732.00
IUUC-Tni-120157 Tetraodon nigroviridis 59.59 0.00e+00 926.00
IUUC-Tca-121361 Theobroma cacao 28.91 3.00e-18 87.00
IUUC-Tre-122066 Trichoderma reesei 31.43 6.00e-09 56.60
IUUC-Tvi-122562 Trichoderma virens 32.29 7.00e-09 56.60
IUUC-Tae-123602 Triticum aestivum 33.42 1.00e-21 99.40
IUUC-Tme-126895 Tuber melanosporum 31.66 3.00e-07 50.40
IUUC-Tbe-128074 Tupaia belangeri 85.54 0.00e+00 1266.00
IUUC-Ttr-128190 Tursiops truncatus 92.86 0.00e+00 1727.00
IUUC-Vda-129710 Verticillium dahliae 30.97 9.00e-11 62.40
IUUC-Vpa-130072 Vicugna pacos 92.26 0.00e+00 1568.00
IUUC-Vvi-130853 Vitis vinifera 36.50 2.00e-10 62.00
IUUC-Xtr-131969 Xenopus tropicalis 65.36 0.00e+00 1109.00
IUUC-Xma-133623 Xiphophorus maculatus 64.73 0.00e+00 896.00
IUUC-Yli-134550 Yarrowia lipolytica 24.87 5.00e-14 73.20
Created Date 25-Jun-2017

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