iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108381

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase 2; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2

Genbank Nucleotide ID

CU329670

Gene Name

ubp2; SPAC328.06

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPAC328.06	SPAC328.06.1	SPAC328.06.1:pep

Annotation

mRNA Expression
GEO
Protein-protein Interaction
HINT	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/UCH	UCH	11473321; 20542005
DUB/USP	USP	11473321; 20542005

Classification

Family	E-value	Score	Start	End
DUB/USP	2.10e-46	156.7	783	1123

Active Site

Position(s)	Description	Evidence
623	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1076	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 62   kskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlks 152
           ++ +++++p+ +  + ++++++++  +qqD+ E++ ++l qle +l +                   +++e+   + ++li +lF g+lk+
   Q: 783  TNGESQTQPHYFEVSEEEINSSMDLGRQQDVLECIDHVLFQLEASLGR------------------ISNSEDRLGSDNDLIRRLFSGKLKQ 855
           667789999999999*******************************33..................2234567788889***********8 PP
   S: 153  qikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeq 243
           ++   + + v s +e f  l +++ ++++    +l d+L+  +++ +++           ++ +a+++l +++lP +L l+++R++f++++
   Q: 856  TLND-ASQGVRSNYEIFSHLIVDLFEEKQ----TLYDALDGVFETVNIDM----------GSETAQRSLCITELPIILQLQIQRVQFDRTT 931
           8775.66777789************9996....7**************94..........555699************************* PP
   S: 244  ksrekinkkvefpleLdlspfctspeekqke............................................................ 274
           +++ k n  vef +eL++++++++++ k +                                                             
   Q: 932  GQPFKSNAFVEFGKELSMDRYVEDTDGKMAPllqrywdlkreiinlqkrqqlllttnsnlmssvdtlsilskwaaqqqdsrlpinpklpdi 1022
           ************************5554444666666666666666666666666666666666777777777777777777777777777 PP
   S: 275  ..................................kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg... 327
                                             +++Y+L+av vH G++s GHY++y+ + +++ + +++D++Vt+v+e+e+  +t    
   Q: 1023 lqeeinnvvaevdmlkkqeaslkeerthlfdnyiSHSYDLLAVFVHRGQASFGHYWTYIHDFENNvYRKYNDEYVTVVDESEIFADTTgnn 1113
           77778888888888888888899999***********************************99999******************9998999 PP
   S: 328  staYvlfYkr 337
           +++Y+l Y r
   Q: 1114 ANPYMLTYIR 1123
           ********87 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MATVKNLRIG KSPNRLIQDL DVFDSPSAGW NDPWSPHSSR YHWQLHSNLG ESAVFDENDF 60
WCVCQKTRKH LHVKVRRDRG KPLIEEPEEN YGIKDRIPVY YEEEELPEPH VTSPTKSEFA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGAGTCCT TTACTCATGA AAAATCCTTC AATCTGTACG TTCTTTCCGT TTGGACGTTT 60
TTTCAAGTAT TTTTCATAAT AAAAAATTTA AATTTCTTTA TTAAAATTAT TTACATCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR025305--UCH_repeat_domain
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF13446--RPT
PF00443--UCH

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

spo:SPAC328.06

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007865	Ashbya gossypii	35.15	3.00e-49	188.00
IUUC-Acl-008164	Aspergillus clavatus	31.52	2.00e-40	159.00
IUUC-Afl-008717	Aspergillus flavus	26.75	3.00e-37	149.00
IUUC-Afu-008871	Aspergillus fumigatus	29.86	2.00e-37	149.00
IUUC-Ani-009503	Aspergillus nidulans	30.68	1.00e-37	150.00
IUUC-Ang-009577	Aspergillus niger	27.94	9.00e-83	300.00
IUUC-Aor-009928	Aspergillus oryzae	26.57	1.00e-37	150.00
IUUC-Ate-010275	Aspergillus terreus	33.14	1.00e-49	190.00
IUUC-Ame-011910	Astyanax mexicanus	47.95	2.00e-12	67.40
IUUC-Bgr-011993	Blumeria graminis	27.08	1.00e-65	243.00
IUUC-Bci-013999	Botrytis cinerea	33.14	1.00e-42	167.00
IUUC-Cel-018346	Caenorhabditis elegans	32.35	5.00e-08	52.00
IUUC-Cho-024343	Choloepus hoffmanni	44.59	7.00e-12	64.30
IUUC-Cgl-026575	Colletotrichum gloeosporioides	26.69	2.00e-13	69.70
IUUC-Cne-026803	Cryptococcus neoformans	31.02	1.00e-29	124.00
IUUC-Cme-027167	Cyanidioschyzon merolae	24.90	4.00e-10	58.50
IUUC-Dor-030948	Dipodomys ordii	43.24	5.00e-11	61.60
IUUC-Dse-031290	Dothistroma septosporum	27.06	2.00e-47	182.00
IUUC-Ete-032323	Echinops telfairi	31.71	7.00e-12	64.70
IUUC-Eca-033214	Equus caballus	44.59	2.00e-11	62.00
IUUC-Fox-037752	Fusarium oxysporum	25.55	1.00e-14	73.90
IUUC-Fso-038114	Fusarium solani	27.95	2.00e-15	77.00
IUUC-Gmo-039593	Gadus morhua	33.60	2.00e-12	66.20
IUUC-Ggr-039843	Gaeumannomyces graminis	22.70	1.00e-14	74.30
IUUC-Gac-041867	Gasterosteus aculeatus	37.86	6.00e-12	64.70
IUUC-Itr-048276	Ictidomys tridecemlineatus	41.67	3.00e-10	58.20
IUUC-Kpa-049349	Komagataella pastoris	30.56	3.00e-92	331.00
IUUC-Lma-053078	Leptosphaeria maculans	26.05	7.00e-53	201.00
IUUC-Meu-056416	Macropus eugenii	31.58	3.00e-11	62.00
IUUC-Mor-057281	Magnaporthe oryzae	34.12	4.00e-10	58.90
IUUC-Mpo-057451	Magnaporthe poae	22.30	2.00e-14	73.20
IUUC-Mla-058944	Melampsora laricipopulina	34.38	2.00e-46	179.00
IUUC-Nfi-068458	Neosartorya fischeri	30.86	7.00e-41	160.00
IUUC-Ncr-068739	Neurospora crassa	24.13	3.00e-24	105.00
IUUC-Opr-070214	Ochotona princeps	43.24	9.00e-11	60.80
IUUC-Oan-073054	Ornithorhynchus anatinus	46.43	1.00e-11	63.50
IUUC-Ola-086393	Oryzias latipes	46.58	2.00e-12	66.20
IUUC-Pno-095093	Phaeosphaeria nodorum	30.48	6.00e-32	131.00
IUUC-Pca-100718	Procavia capensis	32.34	2.00e-12	65.90
IUUC-Pva-103150	Pteropus vampyrus	43.59	1.00e-11	63.50
IUUC-Pgr-103515	Puccinia graminis	38.94	9.00e-32	130.00
IUUC-Ptt-103803	Puccinia triticina	36.32	5.00e-18	84.00
IUUC-Pte-104300	Pyrenophora teres	25.54	1.00e-48	187.00
IUUC-Pyt-104434	Pyrenophora triticirepentis	27.59	8.00e-26	110.00
IUUC-Sce-106441	Saccharomyces cerevisiae	29.29	2.00e-76	278.00
IUUC-Sja-107936	Schizosaccharomyces japonicus	45.74	0.00e+00	846.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	33.43	7.00e-43	167.00
IUUC-Sar-113097	Sorex araneus	31.71	1.00e-11	63.90
IUUC-Sre-115145	Sporisorium reilianum	27.56	3.00e-44	172.00
IUUC-Tsy-119471	Tarsius syrichta	42.31	5.00e-11	61.60
IUUC-Tre-122145	Trichoderma reesei	26.69	8.00e-15	74.30
IUUC-Tvi-122548	Trichoderma virens	26.32	8.00e-14	71.20
IUUC-Tme-126928	Tuber melanosporum	36.23	6.00e-58	217.00
IUUC-Tbe-127549	Tupaia belangeri	42.31	7.00e-11	61.20
IUUC-Ttr-128896	Tursiops truncatus	43.59	2.00e-11	63.20
IUUC-Uma-129338	Ustilago maydis	27.06	4.00e-33	135.00
IUUC-Vda-129742	Verticillium dahliae	25.28	1.00e-17	84.00
IUUC-Vpa-130500	Vicugna pacos	47.83	3.00e-11	62.40
IUUC-Yli-134560	Yarrowia lipolytica	30.10	1.00e-81	296.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence