iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033963

UUCD1 version

UUC-EqC-00225

Ensembl Protein ID

ENSECAP00000018471.1

UniProt Accession

F6TIX2; F6TIX2_HORSE

Protein Name

Uncharacterized protein

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000020895.1	ENSECAT00000022357.1	ENSECAP00000018471.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.70e-41	141.2	388	696

Active Site

Position(s)	Description	Evidence
666	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           +++ev +v+E+   g +++G+++efl+ll+++l+n+   lf  + + +++l+ n+++      + +l++ +G++l+++l++g + + ++
   Q: 388  YSIEVVYVNENdnfGREHPGSKQEFLSLLMQHLENSP--LF--EGSLSKNLSLNSQAL-----KDNLYYEAGKMLAISLVHGGPSPGFF 467
           67899999988888*********************99..56..677778888888885.....56899********************* PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk+++ +l+  +   e+++ + +++ ++ + +i  ++  +  + ++dl++       +e +++  + g+ +i    ++k++  k++++y
   Q: 468  SKTLFDCLVYGP---ENTQPILDDVSDFdVAQIVMRV--NAATNTADLNSI-----TNEFYNYLELIGCLRIITSLSDKYMLAKDILDY 546
           ***********8...*************999999875..455555777765.....56677888889********************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ ++++  +e+f++G++++  le+++++ e   +l++++ e+++++ l++   ++ ++ +d +a+  Fw+ + +++++ + ++ ++  
   Q: 547  HVIKRVQAPFESFKQGLKTLGVLEKIQSYPEAFYSLFCHKPENLSAKVLSD--LFTVHTLSDVQAL-GFWNSYlQAVEDGKSATTVEdi 632
           *************************************************99..7888889999998.8998775777766665543333 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
             F+Tg++++P++Gf++ + +l +++      ++P  n+C n+L LP  +++++++e++ +Ai++t ++e
   Q: 633  lsFTTGCNSIPPAGFKPTP-SLECLHM-----DFPVGNKCNNCLALPITNTYKEFQENMDFAIRNTLRLE 696
           33****************9.99****9.....********************************987665 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MNEKKPGDSQ NLACVFCRKN DDCPNKYGEK KTNEKWNLTV HYYCLLMSSG IWQRGKEEEG 60
VYGFLIEDIR KEVTRASKLK CCICKKTGAS IGCVAPRCKR SYHFPCGLQR ECIFQFTGNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGGAGTGC GGCGCAGCGT GAGAAGGCAG AAGTGACACG GCCGCTCTGG AACTTCTGCC 60
CAGTGCGCCT TGGTGAGTGG ACGGGAAACG AGAAGAAACG GCGTATTCCA GGGAGAGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

ecb:100049939

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	91.93	0.00e+00	1375.00
IUUC-Apl-003763	Anas platyrhynchos	58.77	0.00e+00	841.00
IUUC-Aca-004328	Anolis carolinensis	58.90	0.00e+00	854.00
IUUC-Ame-011288	Astyanax mexicanus	40.85	4.00e-165	574.00
IUUC-Bta-012496	Bos taurus	87.50	0.00e+00	1312.00
IUUC-Cja-019756	Callithrix jacchus	88.78	0.00e+00	1331.00
IUUC-Cfa-020806	Canis familiaris	91.78	0.00e+00	1373.00
IUUC-Cpo-022519	Cavia porcellus	85.55	0.00e+00	1277.00
IUUC-Csa-023957	Chlorocebus sabaeus	89.38	0.00e+00	1350.00
IUUC-Cho-024375	Choloepus hoffmanni	82.68	0.00e+00	1189.00
IUUC-Cin-025325	Ciona intestinalis	41.89	9.00e-67	246.00
IUUC-Csv-026262	Ciona savignyi	42.23	1.00e-68	253.00
IUUC-Dre-027829	Danio rerio	40.20	2.00e-155	542.00
IUUC-Dno-029362	Dasypus novemcinctus	88.83	0.00e+00	1314.00
IUUC-Dor-030710	Dipodomys ordii	82.29	0.00e+00	1248.00
IUUC-Dse-031248	Dothistroma septosporum	38.46	1.00e-03	38.90
IUUC-Dme-031692	Drosophila melanogaster	34.32	4.00e-43	169.00
IUUC-Ete-032282	Echinops telfairi	79.52	0.00e+00	1138.00
IUUC-Eeu-035029	Erinaceus europaeus	86.79	0.00e+00	1306.00
IUUC-Fca-036229	Felis catus	92.35	0.00e+00	1385.00
IUUC-Fal-037015	Ficedula albicollis	57.34	0.00e+00	855.00
IUUC-Gmo-039715	Gadus morhua	41.24	5.00e-81	294.00
IUUC-Gga-040298	Gallus gallus	58.03	0.00e+00	888.00
IUUC-Gac-041444	Gasterosteus aculeatus	38.91	4.00e-142	498.00
IUUC-Ggo-045456	Gorilla gorilla	89.52	0.00e+00	1347.00
IUUC-Hsa-046297	Homo sapiens	89.80	0.00e+00	1355.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	87.28	0.00e+00	925.00
IUUC-Lch-050287	Latimeria chalumnae	66.54	5.00e-105	375.00
IUUC-Loc-052839	Lepisosteus oculatus	58.59	5.00e-32	129.00
IUUC-Laf-053581	Loxodonta africana	87.63	0.00e+00	1305.00
IUUC-Mcc-055615	Macaca mulatta	89.38	0.00e+00	1350.00
IUUC-Meu-056753	Macropus eugenii	48.47	1.00e-129	456.00
IUUC-Mga-059902	Meleagris gallopavo	57.76	0.00e+00	888.00
IUUC-Mmr-061522	Microcebus murinus	91.36	0.00e+00	1365.00
IUUC-Mdo-063022	Monodelphis domestica	65.27	0.00e+00	905.00
IUUC-Mmu-063609	Mus musculus	76.62	0.00e+00	1175.00
IUUC-Mpu-066656	Mustela putorius furo	91.22	0.00e+00	1375.00
IUUC-Mlu-067011	Myotis lucifugus	91.07	0.00e+00	1336.00
IUUC-Nle-069949	Nomascus leucogenys	89.38	0.00e+00	1347.00
IUUC-Opr-071224	Ochotona princeps	83.08	5.00e-131	461.00
IUUC-Ont-072174	Oreochromis niloticus	36.71	5.00e-135	474.00
IUUC-Oan-072712	Ornithorhynchus anatinus	66.62	0.00e+00	964.00
IUUC-Ocu-073776	Oryctolagus cuniculus	89.52	0.00e+00	1336.00
IUUC-Ola-087247	Oryzias latipes	37.39	4.00e-130	458.00
IUUC-Oga-088094	Otolemur garnettii	86.52	0.00e+00	1225.00
IUUC-Oar-090248	Ovis aries	88.07	0.00e+00	1313.00
IUUC-Ptr-090634	Pan troglodytes	89.66	0.00e+00	1354.00
IUUC-Pan-092876	Papio anubis	89.52	0.00e+00	1350.00
IUUC-Psi-093580	Pelodiscus sinensis	60.11	0.00e+00	866.00
IUUC-Pma-094295	Petromyzon marinus	53.57	1.00e-73	269.00
IUUC-Pfo-096351	Poecilia formosa	37.26	1.00e-144	506.00
IUUC-Pab-097596	Pongo abelii	90.23	0.00e+00	1356.00
IUUC-Pca-100309	Procavia capensis	81.44	0.00e+00	1210.00
IUUC-Pva-102526	Pteropus vampyrus	93.84	0.00e+00	873.00
IUUC-Rno-105432	Rattus norvegicus	80.82	0.00e+00	1221.00
IUUC-Sha-107089	Sarcophilus harrisii	65.37	0.00e+00	1020.00
IUUC-Sar-113667	Sorex araneus	67.80	0.00e+00	977.00
IUUC-Ssc-116200	Sus scrofa	90.79	0.00e+00	1357.00
IUUC-Tgu-116467	Taeniopygia guttata	57.22	0.00e+00	846.00
IUUC-Tru-117690	Takifugu rubripes	38.83	1.00e-154	540.00
IUUC-Tsy-119481	Tarsius syrichta	87.20	0.00e+00	921.00
IUUC-Tni-119669	Tetraodon nigroviridis	37.71	6.00e-133	468.00
IUUC-Tbe-127241	Tupaia belangeri	81.53	0.00e+00	1160.00
IUUC-Ttr-129057	Tursiops truncatus	81.30	0.00e+00	1168.00
IUUC-Vpa-130685	Vicugna pacos	88.62	0.00e+00	1291.00
IUUC-Xtr-132555	Xenopus tropicalis	52.38	0.00e+00	749.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence