iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053519

UUCD1 version

UUC-LoA-00809

Ensembl Protein ID

ENSLAFP00000023007.1

UniProt Accession

G3U599; G3U599_LOXAF

Protein Name

Uncharacterized protein

Gene Name

RNF139

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000030934.1	ENSLAFT00000028935.1	ENSLAFP00000023007.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.70e-08	35.2	547	585

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 547  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 585
           ********999******************......********** PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MAAVGPPQQQ VRMARQQVWA ALEVALRVPC LYIIDAIFNS YYDSSQSRFC IALQVVLRLL 60
GIFISSIVLI LSQRSLFKFY MYSSAILLAA TSVLVNYYAA LHIDFYGAYN TSAFGIELLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGCGG TGGGGCCCCC GCAGCAGCAG GTGCGGATGG CCCGTCAGCA GGTCTGGGCG 60
GCGCTCGAAG TGGCGCTCCG GGTGCCCTGC CTCTACATCA TCGACGCCAT CTTCAACTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

KEGG

lav:100664451

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	94.56	0.00e+00	1244.00
IUUC-Apl-004214	Anas platyrhynchos	84.40	0.00e+00	952.00
IUUC-Aca-005326	Anolis carolinensis	76.55	0.00e+00	956.00
IUUC-Ame-011687	Astyanax mexicanus	68.50	0.00e+00	875.00
IUUC-Bta-013394	Bos taurus	93.98	0.00e+00	1273.00
IUUC-Bci-013813	Botrytis cinerea	42.37	3.00e-08	52.80
IUUC-Cja-019499	Callithrix jacchus	92.93	0.00e+00	1271.00
IUUC-Cfa-020357	Canis familiaris	94.44	0.00e+00	1251.00
IUUC-Cpo-021924	Cavia porcellus	92.48	0.00e+00	1162.00
IUUC-Csa-023513	Chlorocebus sabaeus	93.68	0.00e+00	1259.00
IUUC-Cho-024285	Choloepus hoffmanni	87.82	0.00e+00	1108.00
IUUC-Cin-025223	Ciona intestinalis	53.93	2.00e-74	271.00
IUUC-Csv-026018	Ciona savignyi	47.00	8.00e-64	236.00
IUUC-Dre-028660	Danio rerio	67.47	0.00e+00	792.00
IUUC-Dno-029463	Dasypus novemcinctus	93.73	1.00e-162	566.00
IUUC-Dor-030728	Dipodomys ordii	92.47	0.00e+00	1106.00
IUUC-Dse-031284	Dothistroma septosporum	43.86	3.00e-09	55.50
IUUC-Dme-032186	Drosophila melanogaster	44.27	2.00e-99	357.00
IUUC-Ete-032368	Echinops telfairi	89.06	0.00e+00	1187.00
IUUC-Eca-034325	Equus caballus	93.68	0.00e+00	1219.00
IUUC-Fca-035537	Felis catus	92.96	0.00e+00	1192.00
IUUC-Fal-037459	Ficedula albicollis	84.36	0.00e+00	929.00
IUUC-Gmo-039442	Gadus morhua	78.28	6.00e-98	351.00
IUUC-Ggr-039921	Gaeumannomyces graminis	32.56	9.00e-08	52.80
IUUC-Gga-041071	Gallus gallus	80.29	0.00e+00	977.00
IUUC-Gac-042483	Gasterosteus aculeatus	67.42	0.00e+00	914.00
IUUC-Ggo-044672	Gorilla gorilla	93.38	0.00e+00	1256.00
IUUC-Hsa-045836	Homo sapiens	92.78	0.00e+00	1222.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	93.30	0.00e+00	1253.00
IUUC-Lch-050073	Latimeria chalumnae	72.65	0.00e+00	976.00
IUUC-Lpe-051487	Leersia perrieri	35.48	5.00e-10	59.30
IUUC-Loc-052908	Lepisosteus oculatus	69.61	0.00e+00	949.00
IUUC-Lma-053202	Leptosphaeria maculans	44.44	7.00e-09	54.30
IUUC-Mcc-054674	Macaca mulatta	92.46	2.00e-102	364.00
IUUC-Mor-057262	Magnaporthe oryzae	34.15	7.00e-09	56.20
IUUC-Mga-059922	Meleagris gallopavo	83.57	0.00e+00	939.00
IUUC-Mmr-061452	Microcebus murinus	93.09	0.00e+00	1200.00
IUUC-Mdo-062412	Monodelphis domestica	87.80	0.00e+00	1190.00
IUUC-Mmu-063147	Mus musculus	91.47	0.00e+00	1223.00
IUUC-Mpu-065929	Mustela putorius furo	94.44	0.00e+00	1249.00
IUUC-Mlu-067899	Myotis lucifugus	90.99	0.00e+00	1193.00
IUUC-Nle-070083	Nomascus leucogenys	93.38	0.00e+00	1254.00
IUUC-Opr-070461	Ochotona princeps	89.07	0.00e+00	1227.00
IUUC-Ont-072256	Oreochromis niloticus	70.33	0.00e+00	917.00
IUUC-Oan-073150	Ornithorhynchus anatinus	83.45	0.00e+00	939.00
IUUC-Ocu-073748	Oryctolagus cuniculus	90.87	0.00e+00	1187.00
IUUC-Oga-088565	Otolemur garnettii	93.61	0.00e+00	1246.00
IUUC-Oar-089432	Ovis aries	94.54	0.00e+00	1186.00
IUUC-Ptr-091422	Pan troglodytes	93.38	0.00e+00	1254.00
IUUC-Pan-092331	Papio anubis	93.68	0.00e+00	1258.00
IUUC-Psi-092933	Pelodiscus sinensis	82.76	0.00e+00	927.00
IUUC-Pfo-097466	Poecilia formosa	64.82	0.00e+00	925.00
IUUC-Pab-098702	Pongo abelii	93.23	0.00e+00	1254.00
IUUC-Pca-100125	Procavia capensis	91.71	0.00e+00	1232.00
IUUC-Pva-102628	Pteropus vampyrus	94.57	0.00e+00	1246.00
IUUC-Rno-104886	Rattus norvegicus	91.46	0.00e+00	1233.00
IUUC-Sha-106702	Sarcophilus harrisii	85.07	0.00e+00	1162.00
IUUC-Ssc-116164	Sus scrofa	93.68	0.00e+00	1267.00
IUUC-Tgu-116829	Taeniopygia guttata	82.35	0.00e+00	964.00
IUUC-Tru-118557	Takifugu rubripes	66.51	0.00e+00	881.00
IUUC-Tsy-119399	Tarsius syrichta	90.27	0.00e+00	667.00
IUUC-Tni-120006	Tetraodon nigroviridis	60.54	0.00e+00	762.00
IUUC-Tbe-127664	Tupaia belangeri	92.01	0.00e+00	1213.00
IUUC-Ttr-129144	Tursiops truncatus	92.33	0.00e+00	1259.00
IUUC-Vpa-130226	Vicugna pacos	93.98	0.00e+00	1268.00
IUUC-Xtr-132461	Xenopus tropicalis	70.47	0.00e+00	904.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence