iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
miRNAMap	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.80e-08	35.2	535	573

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 535  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 573
           ********999******************......********** PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MAQQQVWAAL EVALRVPCLY IIDAIFNSYY DSSQSRFCIG LQIFLRLLGI VVSSIVLILS 60
QRSLFKFYMY SSAFLLAATS VLVNYYAALH IDFYGAYNTS AFGIELLPRK GPSLWMALIV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCCCCGCA GCAGCAGGTG CGGATGGCCC AGCAGCAGGT CTGGGCGGCG CTCGAAGTGG 60
CGCTCCGGGT GCCCTGCCTC TACATCATCG ACGCCATCTT CAACTCCTAC TACGATTCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

KEGG

rno:315000

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	94.36	0.00e+00	1180.00
IUUC-Apl-004214	Anas platyrhynchos	85.48	0.00e+00	958.00
IUUC-Aca-005326	Anolis carolinensis	78.09	0.00e+00	956.00
IUUC-Ame-011687	Astyanax mexicanus	74.08	0.00e+00	864.00
IUUC-Bta-013394	Bos taurus	93.90	0.00e+00	1211.00
IUUC-Bci-013813	Botrytis cinerea	42.11	7.00e-08	51.60
IUUC-Cja-019499	Callithrix jacchus	92.84	0.00e+00	1215.00
IUUC-Cfa-020357	Canis familiaris	94.21	0.00e+00	1182.00
IUUC-Cpo-021924	Cavia porcellus	94.14	0.00e+00	1169.00
IUUC-Csa-023513	Chlorocebus sabaeus	94.36	0.00e+00	1207.00
IUUC-Cho-024285	Choloepus hoffmanni	87.67	0.00e+00	1056.00
IUUC-Cin-025223	Ciona intestinalis	53.18	5.00e-73	267.00
IUUC-Csv-026018	Ciona savignyi	46.69	1.00e-62	233.00
IUUC-Dre-028660	Danio rerio	72.12	0.00e+00	786.00
IUUC-Dno-029463	Dasypus novemcinctus	93.50	6.00e-156	544.00
IUUC-Dor-030728	Dipodomys ordii	93.79	0.00e+00	1129.00
IUUC-Dse-031284	Dothistroma septosporum	43.40	4.00e-09	55.10
IUUC-Dme-032186	Drosophila melanogaster	42.86	4.00e-98	352.00
IUUC-Ete-032368	Echinops telfairi	86.59	0.00e+00	1117.00
IUUC-Eca-034325	Equus caballus	93.61	0.00e+00	1145.00
IUUC-Fca-035537	Felis catus	95.44	0.00e+00	1167.00
IUUC-Fal-037459	Ficedula albicollis	85.63	0.00e+00	937.00
IUUC-Gmo-039442	Gadus morhua	77.61	1.00e-97	350.00
IUUC-Ggr-039921	Gaeumannomyces graminis	31.91	8.00e-08	52.80
IUUC-Gga-041071	Gallus gallus	82.91	0.00e+00	976.00
IUUC-Gac-042483	Gasterosteus aculeatus	66.62	0.00e+00	895.00
IUUC-Ggo-044672	Gorilla gorilla	94.05	0.00e+00	1205.00
IUUC-Hsa-045836	Homo sapiens	93.29	0.00e+00	1174.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	95.13	0.00e+00	1234.00
IUUC-Lch-050073	Latimeria chalumnae	73.36	0.00e+00	966.00
IUUC-Loc-052908	Lepisosteus oculatus	75.37	0.00e+00	943.00
IUUC-Lma-053202	Leptosphaeria maculans	42.59	3.00e-08	52.40
IUUC-Laf-053519	Loxodonta africana	91.46	0.00e+00	1211.00
IUUC-Mcc-054674	Macaca mulatta	91.98	2.00e-93	334.00
IUUC-Mor-057262	Magnaporthe oryzae	32.93	3.00e-08	53.90
IUUC-Mga-059922	Meleagris gallopavo	84.66	0.00e+00	951.00
IUUC-Mmr-061452	Microcebus murinus	92.84	0.00e+00	1164.00
IUUC-Mdo-062412	Monodelphis domestica	88.99	0.00e+00	1152.00
IUUC-Mmu-063147	Mus musculus	97.99	0.00e+00	1273.00
IUUC-Mpu-065929	Mustela putorius furo	94.21	0.00e+00	1179.00
IUUC-Mlu-067899	Myotis lucifugus	90.85	0.00e+00	1156.00
IUUC-Nle-070083	Nomascus leucogenys	94.05	0.00e+00	1203.00
IUUC-Opr-070461	Ochotona princeps	89.95	0.00e+00	1192.00
IUUC-Ont-072256	Oreochromis niloticus	70.20	0.00e+00	911.00
IUUC-Oan-073150	Ornithorhynchus anatinus	83.21	0.00e+00	932.00
IUUC-Ocu-073748	Oryctolagus cuniculus	92.39	0.00e+00	1152.00
IUUC-Oga-088565	Otolemur garnettii	94.22	0.00e+00	1206.00
IUUC-Oar-089432	Ovis aries	93.74	0.00e+00	1144.00
IUUC-Ptr-091422	Pan troglodytes	93.90	0.00e+00	1204.00
IUUC-Pan-092331	Papio anubis	94.21	0.00e+00	1206.00
IUUC-Psi-092933	Pelodiscus sinensis	82.88	0.00e+00	934.00
IUUC-Pfo-097466	Poecilia formosa	69.80	0.00e+00	911.00
IUUC-Pab-098702	Pongo abelii	93.90	0.00e+00	1203.00
IUUC-Pca-100125	Procavia capensis	89.39	0.00e+00	1164.00
IUUC-Pva-102628	Pteropus vampyrus	93.89	0.00e+00	1174.00
IUUC-Sha-106702	Sarcophilus harrisii	87.12	0.00e+00	1128.00
IUUC-Ssc-116164	Sus scrofa	93.14	0.00e+00	1204.00
IUUC-Tgu-116829	Taeniopygia guttata	83.67	0.00e+00	973.00
IUUC-Tru-118557	Takifugu rubripes	65.22	0.00e+00	867.00
IUUC-Tsy-119399	Tarsius syrichta	88.32	0.00e+00	662.00
IUUC-Tni-120006	Tetraodon nigroviridis	63.76	0.00e+00	751.00
IUUC-Tbe-127664	Tupaia belangeri	92.52	0.00e+00	1174.00
IUUC-Ttr-129144	Tursiops truncatus	92.99	0.00e+00	1233.00
IUUC-Vpa-130226	Vicugna pacos	93.90	0.00e+00	1208.00
IUUC-Xtr-132461	Xenopus tropicalis	73.19	0.00e+00	903.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence