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Tag Content
UUCD2 ID IUUC-Mlu-066976
UUCD1 version UUC-MyL-00675
Ensembl Protein ID ENSMLUP00000013351.2
UniProt Accession G1PQJ1; G1PQJ1_MYOLU
Genbank Protein ID ENSMLUP00000013351
Protein Name Uncharacterized protein
Genbank Nucleotide ID AAPE02001583
Gene Name FBXW7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMLUG00000014672.2 ENSMLUT00000014674.2 ENSMLUP00000013351.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 8.60e-61 199.2 624 657
UBD/Beta-Prp 1.10e-102 343.3 375 657
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 624  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 657
           9*********449******************976 PP
   

   UBD/Beta-Prp
   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 375  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 459
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 460  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 542
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 543  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 627
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 628  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 657
           *************************98776 PP
   
Organism Myotis lucifugus
Protein Sequence
(Fasta)
MNQELLSVGS KRRRTGGSVR GNPSASQADE EQMNRVVEEE QQQQQLRQQE EEHTARNGEV 60
VGAEPRPGDQ NDSQQGQLEE NNNRFISVDE DSSGNQEEPE EDEEHAEEQD EEDEEEEEMD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mlu-066976|E3,WD_repeat;UBD,Beta-Prp|Myotis lucifugus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAATCAGG AACTGCTCTC TGTGGGCAGC AAAAGACGAC GAACTGGAGG CTCTGTGAGA 60
GGTAACCCTT CCGCAAGCCA GGCAGATGAG GAACAGATGA ATCGTGTGGT GGAGGAGGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mlu-066976|E3,WD_repeat;UBD,Beta-Prp|Myotis lucifugus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002406 Ailuropoda melanoleuca 98.16 0.00e+00 1234.00
IUUC-Apl-003489 Anas platyrhynchos 89.69 0.00e+00 1191.00
IUUC-Aca-005318 Anolis carolinensis 97.82 0.00e+00 1100.00
IUUC-Ago-007794 Ashbya gossypii 31.07 6.00e-62 231.00
IUUC-Acl-008123 Aspergillus clavatus 32.40 6.00e-75 275.00
IUUC-Afl-008730 Aspergillus flavus 31.33 6.00e-74 272.00
IUUC-Afu-009014 Aspergillus fumigatus 32.53 2.00e-75 277.00
IUUC-Ani-009332 Aspergillus nidulans 33.47 2.00e-80 293.00
IUUC-Ang-009790 Aspergillus niger 31.52 2.00e-75 276.00
IUUC-Aor-010215 Aspergillus oryzae 30.71 1.00e-74 274.00
IUUC-Ate-010535 Aspergillus terreus 32.09 2.00e-76 280.00
IUUC-Ame-010898 Astyanax mexicanus 94.82 0.00e+00 1047.00
IUUC-Bgr-012075 Blumeria graminis 33.40 1.00e-79 290.00
IUUC-Bta-012391 Bos taurus 98.55 0.00e+00 1110.00
IUUC-Bci-013725 Botrytis cinerea 33.20 2.00e-78 286.00
IUUC-Cel-018495 Caenorhabditis elegans 48.73 2.00e-131 462.00
IUUC-Cja-018902 Callithrix jacchus 97.74 0.00e+00 1222.00
IUUC-Cfa-020237 Canis familiaris 97.19 0.00e+00 1228.00
IUUC-Cpo-022234 Cavia porcellus 98.55 0.00e+00 1112.00
IUUC-Cre-022837 Chlamydomonas reinhardtii 37.54 6.00e-49 188.00
IUUC-Csa-023532 Chlorocebus sabaeus 97.60 0.00e+00 1196.00
IUUC-Cho-025026 Choloepus hoffmanni 83.40 0.00e+00 768.00
IUUC-Cin-025516 Ciona intestinalis 70.34 2.00e-141 494.00
IUUC-Csv-026312 Ciona savignyi 75.47 0.00e+00 756.00
IUUC-Cgl-026492 Colletotrichum gloeosporioides 34.82 4.00e-85 308.00
IUUC-Cne-027018 Cryptococcus neoformans 33.08 3.00e-73 270.00
IUUC-Cme-027168 Cyanidioschyzon merolae 31.10 3.00e-31 130.00
IUUC-Dre-028303 Danio rerio 93.90 0.00e+00 1049.00
IUUC-Dno-029576 Dasypus novemcinctus 95.62 0.00e+00 1203.00
IUUC-Dor-030196 Dipodomys ordii 92.94 0.00e+00 1215.00
IUUC-Dse-031558 Dothistroma septosporum 38.98 1.00e-70 261.00
IUUC-Dme-031702 Drosophila melanogaster 76.61 0.00e+00 804.00
IUUC-Ete-032791 Echinops telfairi 90.93 0.00e+00 1005.00
IUUC-Eca-033424 Equus caballus 98.55 0.00e+00 1110.00
IUUC-Eeu-034996 Erinaceus europaeus 93.52 0.00e+00 1189.00
IUUC-Fca-036422 Felis catus 96.62 0.00e+00 1241.00
IUUC-Fal-037267 Ficedula albicollis 99.45 0.00e+00 1100.00
IUUC-Fox-037800 Fusarium oxysporum 34.07 2.00e-84 306.00
IUUC-Fso-038258 Fusarium solani 34.21 2.00e-83 303.00
IUUC-Gmo-039119 Gadus morhua 83.12 0.00e+00 902.00
IUUC-Ggr-039781 Gaeumannomyces graminis 34.66 2.00e-85 309.00
IUUC-Gga-040667 Gallus gallus 89.55 0.00e+00 1191.00
IUUC-Gac-042423 Gasterosteus aculeatus 74.82 0.00e+00 805.00
IUUC-Ggo-044422 Gorilla gorilla 97.60 0.00e+00 1199.00
IUUC-Hsa-045898 Homo sapiens 97.46 0.00e+00 1199.00
IUUC-Itr-048241 Ictidomys tridecemlineatus 99.79 0.00e+00 976.00
IUUC-Kpa-049097 Komagataella pastoris 32.06 2.00e-76 280.00
IUUC-Lch-050414 Latimeria chalumnae 94.53 0.00e+00 1090.00
IUUC-Loc-052348 Lepisosteus oculatus 95.83 0.00e+00 1073.00
IUUC-Lma-053185 Leptosphaeria maculans 32.40 3.00e-72 266.00
IUUC-Laf-054054 Loxodonta africana 96.62 0.00e+00 1239.00
IUUC-Mcc-055056 Macaca mulatta 97.60 0.00e+00 1196.00
IUUC-Meu-056778 Macropus eugenii 92.83 0.00e+00 741.00
IUUC-Mor-057133 Magnaporthe oryzae 39.13 4.00e-74 273.00
IUUC-Mpo-057542 Magnaporthe poae 39.13 2.00e-74 273.00
IUUC-Mla-059081 Melampsora laricipopulina 32.57 1.00e-76 280.00
IUUC-Mga-059255 Meleagris gallopavo 89.83 0.00e+00 1181.00
IUUC-Mvi-060490 Microbotryum violaceum 38.75 2.00e-67 251.00
IUUC-Mmr-061292 Microcebus murinus 97.74 0.00e+00 1226.00
IUUC-Mdo-062304 Monodelphis domestica 92.90 0.00e+00 1205.00
IUUC-Mmu-063610 Mus musculus 92.69 0.00e+00 1260.00
IUUC-Mpu-065931 Mustela putorius furo 98.16 0.00e+00 1231.00
IUUC-Nfi-068428 Neosartorya fischeri 31.93 2.00e-75 277.00
IUUC-Ncr-068688 Neurospora crassa 35.97 2.00e-87 316.00
IUUC-Nle-070174 Nomascus leucogenys 97.32 0.00e+00 1198.00
IUUC-Opr-070851 Ochotona princeps 86.32 0.00e+00 653.00
IUUC-Ont-071997 Oreochromis niloticus 93.10 0.00e+00 1072.00
IUUC-Oan-072936 Ornithorhynchus anatinus 92.67 0.00e+00 1243.00
IUUC-Ocu-074742 Oryctolagus cuniculus 99.82 0.00e+00 1141.00
IUUC-Obr-076806 Oryza brachyantha 31.52 9.00e-30 126.00
IUUC-Oin-079809 Oryza indica 31.52 6.00e-30 126.00
IUUC-Ola-087098 Oryzias latipes 93.90 0.00e+00 1061.00
IUUC-Olu-087837 Ostreococcus lucimarinus 34.47 4.00e-38 151.00
IUUC-Oga-088884 Otolemur garnettii 100.00 0.00e+00 788.00
IUUC-Oar-090220 Ovis aries 95.22 0.00e+00 1208.00
IUUC-Ptr-090492 Pan troglodytes 97.46 0.00e+00 1199.00
IUUC-Pan-091770 Papio anubis 97.32 0.00e+00 1196.00
IUUC-Psi-093207 Pelodiscus sinensis 98.55 0.00e+00 1110.00
IUUC-Pma-094749 Petromyzon marinus 83.67 0.00e+00 946.00
IUUC-Pno-095026 Phaeosphaeria nodorum 38.83 4.00e-71 263.00
IUUC-Pfo-096493 Poecilia formosa 95.38 0.00e+00 1058.00
IUUC-Pab-098141 Pongo abelii 98.55 0.00e+00 1111.00
IUUC-Pca-100571 Procavia capensis 97.18 0.00e+00 849.00
IUUC-Pva-102988 Pteropus vampyrus 97.88 0.00e+00 1236.00
IUUC-Pgr-103612 Puccinia graminis 35.66 4.00e-62 233.00
IUUC-Ptt-103698 Puccinia triticina 35.55 1.00e-41 164.00
IUUC-Pte-104275 Pyrenophora teres 32.36 9.00e-74 271.00
IUUC-Pyt-104438 Pyrenophora triticirepentis 39.09 5.00e-70 259.00
IUUC-Rno-105706 Rattus norvegicus 91.46 0.00e+00 1224.00
IUUC-Sce-106314 Saccharomyces cerevisiae 29.39 7.00e-61 228.00
IUUC-Sha-107653 Sarcophilus harrisii 95.76 0.00e+00 1248.00
IUUC-Sja-107840 Schizosaccharomyces japonicus 33.83 2.00e-79 290.00
IUUC-Spo-108115 Schizosaccharomyces pombe 32.14 9.00e-63 234.00
IUUC-Sar-113600 Sorex araneus 92.37 0.00e+00 1118.00
IUUC-Sre-114901 Sporisorium reilianum 44.21 1.00e-67 252.00
IUUC-Ssc-115787 Sus scrofa 95.76 0.00e+00 1196.00
IUUC-Tgu-117510 Taeniopygia guttata 90.25 0.00e+00 1186.00
IUUC-Tru-117819 Takifugu rubripes 93.61 0.00e+00 1082.00
IUUC-Tsy-118828 Tarsius syrichta 98.45 0.00e+00 1245.00
IUUC-Tni-120468 Tetraodon nigroviridis 93.47 0.00e+00 1072.00
IUUC-Tre-122193 Trichoderma reesei 36.25 3.00e-85 309.00
IUUC-Tvi-122615 Trichoderma virens 35.03 6.00e-84 305.00
IUUC-Tme-127021 Tuber melanosporum 34.55 7.00e-84 304.00
IUUC-Tbe-127925 Tupaia belangeri 96.12 0.00e+00 1104.00
IUUC-Ttr-128899 Tursiops truncatus 97.74 0.00e+00 1225.00
IUUC-Uma-129449 Ustilago maydis 46.89 7.00e-67 249.00
IUUC-Vda-129802 Verticillium dahliae 36.20 9.00e-88 317.00
IUUC-Vpa-130082 Vicugna pacos 96.93 0.00e+00 1047.00
IUUC-Xtr-132213 Xenopus tropicalis 87.66 0.00e+00 1165.00
IUUC-Xma-133646 Xiphophorus maculatus 94.02 0.00e+00 1054.00
IUUC-Yli-134429 Yarrowia lipolytica 34.27 1.00e-86 314.00
Created Date 25-Jun-2017

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