iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
iRefIndex	PINA	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	16236769

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	4.30e-129	431.0	460	791

Active Site

Position(s)	Description	Evidence
760	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklll 101
            dl++rl+++f+gEegld+gGv+re+++lls+e+ np+++lf+y  n++++lq+np+s++ np+hlk+Fe++Gr++++al++g+++   ++ +fyk++l
   Q: 460  VDLRRRLYIQFRGEEGLDYGGVAREWFFLLSHEVLNPMYCLFMYAGNNNYSLQINPASFV-NPDHLKYFEYIGRFIAMALFHGKFIYSGFTMPFYKKML 557
           5899*******************************************************9.89************************************ PP
   S: 102  gkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnev 200
           +kk+ l+d+e+vd+e+y+sl++ik+n   +i+e++++l f ++ e+lge k++eLk+gG +i Vt+eNk eY++l+ve+r+++g+++q++af  Gfn+v
   Q: 558  NKKIVLKDIEQVDSEIYNSLMWIKDN---NIDECDMELYFVADYELLGELKTYELKEGGTEIAVTEENKLEYIELLVEWRFNRGVEQQTKAFFTGFNSV 653
           ************************99...9********************************************************************* PP
   S: 201  iplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasd 295
           +ple++++F+e+elell+cG++++dv+d++++t y++ y ++s+++ wFw+ ++++++e+r+++LqFvTg++r+P+gGf el+    p+lf+i++ +++
   Q: 654  FPLEWMQYFDERELELLLCGMQDVDVDDWQRNTVYRH-YAPQSKQVTWFWQWVRSLDQEKRARLLQFVTGTCRVPVGGFSELMgstgPQLFCIERVGKE 751
           ***********************************99.************************************************************* PP
   S: 296  drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           ++lP+s+TCfn+L+LP+Y s+++l ekL +Aie+t+gF+ 
   Q: 752  NWLPRSHTCFNRLDLPPYRSYDQLVEKLSMAIEMTEGFGN 791
           **************************************85 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MARNEPSSQQ PSSSGSNGTP AQQNGSAKPS KVTVKVVNAS FTKAADCYVE ITSDTSSAAP 60
KKTTVKKKTM APEWNEHLNV HANESSTISF RLLQKAKLFD DTCLGMAKLK LSSLTRNENG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGTTTCAT GATCGAATGG CTCGTAATGA ACCATCATCT CAGCAGCCGA GTAGTTCCGG 60
GAGTAATGGA ACTCCAGCAC AACAAAACGG GTCGGCAAAA CCATCAAAAG TCACAGTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005737--C:cytoplasm
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008340--P:determination of adult lifespan
GO:0016567--P:protein ubiquitination
GO:0042176--P:regulation of protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	67.13	0.00e+00	830.00
IUUC-Apl-003310	Anas platyrhynchos	68.05	0.00e+00	829.00
IUUC-Aca-005388	Anolis carolinensis	67.36	0.00e+00	820.00
IUUC-Ago-007742	Ashbya gossypii	45.98	1.00e-147	515.00
IUUC-Acl-008273	Aspergillus clavatus	45.71	8.00e-150	523.00
IUUC-Afl-008713	Aspergillus flavus	45.71	2.00e-148	518.00
IUUC-Afu-009103	Aspergillus fumigatus	45.88	1.00e-150	525.00
IUUC-Ani-009259	Aspergillus nidulans	45.76	1.00e-149	522.00
IUUC-Ang-009738	Aspergillus niger	45.56	2.00e-147	515.00
IUUC-Aor-010053	Aspergillus oryzae	52.33	5.00e-93	332.00
IUUC-Ate-010529	Aspergillus terreus	45.45	3.00e-148	517.00
IUUC-Ame-010601	Astyanax mexicanus	65.30	0.00e+00	804.00
IUUC-Bgr-012148	Blumeria graminis	43.17	6.00e-142	496.00
IUUC-Bta-012857	Bos taurus	67.53	0.00e+00	823.00
IUUC-Bci-013785	Botrytis cinerea	44.20	3.00e-145	508.00
IUUC-Cja-019448	Callithrix jacchus	67.53	0.00e+00	827.00
IUUC-Cfa-020728	Canis familiaris	67.53	0.00e+00	827.00
IUUC-Cpo-021988	Cavia porcellus	67.18	0.00e+00	835.00
IUUC-Csa-023805	Chlorocebus sabaeus	67.30	0.00e+00	813.00
IUUC-Cho-024695	Choloepus hoffmanni	64.27	0.00e+00	803.00
IUUC-Cin-025212	Ciona intestinalis	63.86	0.00e+00	789.00
IUUC-Csv-026256	Ciona savignyi	63.86	0.00e+00	781.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	43.42	1.00e-142	499.00
IUUC-Cne-026849	Cryptococcus neoformans	44.97	5.00e-147	513.00
IUUC-Dre-028245	Danio rerio	67.01	0.00e+00	838.00
IUUC-Dno-029618	Dasypus novemcinctus	67.36	0.00e+00	825.00
IUUC-Dor-030176	Dipodomys ordii	67.25	0.00e+00	820.00
IUUC-Dse-031241	Dothistroma septosporum	45.19	2.00e-146	511.00
IUUC-Dme-032041	Drosophila melanogaster	67.51	0.00e+00	842.00
IUUC-Ete-032779	Echinops telfairi	64.40	0.00e+00	760.00
IUUC-Eca-033949	Equus caballus	67.42	0.00e+00	832.00
IUUC-Eeu-035259	Erinaceus europaeus	59.41	0.00e+00	696.00
IUUC-Fca-035420	Felis catus	67.53	0.00e+00	827.00
IUUC-Fal-037335	Ficedula albicollis	68.05	0.00e+00	832.00
IUUC-Fox-037774	Fusarium oxysporum	43.27	3.00e-141	494.00
IUUC-Fso-038393	Fusarium solani	43.00	3.00e-138	484.00
IUUC-Gmo-038842	Gadus morhua	65.27	0.00e+00	774.00
IUUC-Ggr-040107	Gaeumannomyces graminis	43.61	3.00e-143	501.00
IUUC-Gga-040246	Gallus gallus	68.05	0.00e+00	830.00
IUUC-Gac-042211	Gasterosteus aculeatus	67.94	0.00e+00	850.00
IUUC-Ggo-045278	Gorilla gorilla	67.60	0.00e+00	831.00
IUUC-Hsa-046148	Homo sapiens	67.60	0.00e+00	831.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	67.36	0.00e+00	825.00
IUUC-Kpa-049273	Komagataella pastoris	47.09	2.00e-152	531.00
IUUC-Lch-050398	Latimeria chalumnae	67.88	0.00e+00	827.00
IUUC-Loc-052116	Lepisosteus oculatus	67.41	0.00e+00	842.00
IUUC-Laf-053551	Loxodonta africana	67.18	0.00e+00	821.00
IUUC-Mcc-055655	Macaca mulatta	67.42	0.00e+00	828.00
IUUC-Meu-055953	Macropus eugenii	58.72	0.00e+00	698.00
IUUC-Mor-057097	Magnaporthe oryzae	43.90	7.00e-144	503.00
IUUC-Mpo-057442	Magnaporthe poae	42.93	2.00e-133	469.00
IUUC-Mla-058996	Melampsora laricipopulina	50.00	1.00e-139	489.00
IUUC-Mga-059986	Meleagris gallopavo	68.05	0.00e+00	832.00
IUUC-Mvi-060395	Microbotryum violaceum	47.54	1.00e-135	476.00
IUUC-Mmr-060896	Microcebus murinus	67.77	0.00e+00	832.00
IUUC-Mdo-062536	Monodelphis domestica	67.18	0.00e+00	831.00
IUUC-Mmu-063202	Mus musculus	67.53	0.00e+00	825.00
IUUC-Mpu-065773	Mustela putorius furo	67.30	0.00e+00	822.00
IUUC-Mlu-067623	Myotis lucifugus	65.51	0.00e+00	795.00
IUUC-Nfi-068427	Neosartorya fischeri	45.88	2.00e-150	525.00
IUUC-Ncr-068918	Neurospora crassa	43.57	7.00e-141	493.00
IUUC-Nle-069188	Nomascus leucogenys	67.53	0.00e+00	827.00
IUUC-Opr-070965	Ochotona princeps	66.67	0.00e+00	806.00
IUUC-Ont-072226	Oreochromis niloticus	67.59	0.00e+00	847.00
IUUC-Oan-073497	Ornithorhynchus anatinus	67.59	0.00e+00	824.00
IUUC-Ocu-074271	Oryctolagus cuniculus	67.94	0.00e+00	833.00
IUUC-Ola-087438	Oryzias latipes	67.07	0.00e+00	840.00
IUUC-Oga-087922	Otolemur garnettii	67.13	0.00e+00	821.00
IUUC-Oar-089429	Ovis aries	67.36	0.00e+00	818.00
IUUC-Ptr-090484	Pan troglodytes	67.18	0.00e+00	825.00
IUUC-Pan-092117	Papio anubis	67.53	0.00e+00	827.00
IUUC-Psi-093338	Pelodiscus sinensis	68.22	0.00e+00	832.00
IUUC-Pma-094279	Petromyzon marinus	58.62	0.00e+00	653.00
IUUC-Pno-095118	Phaeosphaeria nodorum	44.56	1.00e-147	515.00
IUUC-Pfo-096171	Poecilia formosa	67.94	0.00e+00	848.00
IUUC-Pab-098494	Pongo abelii	67.19	0.00e+00	824.00
IUUC-Pca-100596	Procavia capensis	68.29	0.00e+00	702.00
IUUC-Pva-102811	Pteropus vampyrus	67.36	0.00e+00	817.00
IUUC-Pgr-103620	Puccinia graminis	49.79	2.00e-138	484.00
IUUC-Ptt-103806	Puccinia triticina	48.19	1.00e-111	396.00
IUUC-Pte-104016	Pyrenophora teres	45.27	5.00e-149	520.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	45.27	5.00e-149	520.00
IUUC-Rno-106125	Rattus norvegicus	67.53	0.00e+00	823.00
IUUC-Sce-106289	Saccharomyces cerevisiae	45.73	5.00e-148	516.00
IUUC-Sha-106781	Sarcophilus harrisii	67.47	0.00e+00	835.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	47.32	1.00e-145	508.00
IUUC-Spo-108171	Schizosaccharomyces pombe	45.53	2.00e-145	508.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	43.93	2.00e-144	504.00
IUUC-Sar-113761	Sorex araneus	63.57	0.00e+00	792.00
IUUC-Sre-114929	Sporisorium reilianum	45.32	3.00e-148	517.00
IUUC-Ssc-115368	Sus scrofa	67.30	0.00e+00	820.00
IUUC-Tgu-117079	Taeniopygia guttata	68.05	0.00e+00	830.00
IUUC-Tru-118062	Takifugu rubripes	67.24	0.00e+00	845.00
IUUC-Tsy-119507	Tarsius syrichta	62.46	0.00e+00	754.00
IUUC-Tni-120151	Tetraodon nigroviridis	66.96	0.00e+00	832.00
IUUC-Tre-122203	Trichoderma reesei	43.03	4.00e-138	484.00
IUUC-Tvi-122595	Trichoderma virens	42.24	4.00e-137	481.00
IUUC-Tbe-127793	Tupaia belangeri	60.28	0.00e+00	709.00
IUUC-Ttr-128275	Tursiops truncatus	67.25	0.00e+00	827.00
IUUC-Uma-129332	Ustilago maydis	45.48	2.00e-140	491.00
IUUC-Vda-129753	Verticillium dahliae	43.20	2.00e-142	498.00
IUUC-Vpa-130103	Vicugna pacos	55.38	0.00e+00	662.00
IUUC-Xtr-132866	Xenopus tropicalis	66.03	0.00e+00	806.00
IUUC-Xma-133778	Xiphophorus maculatus	67.76	0.00e+00	848.00
IUUC-Yli-134668	Yarrowia lipolytica	43.53	3.00e-146	511.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence