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Tag Content
UUCD2 ID IUUC-Sha-107482
UUCD1 version UUC-SaH-00804
Ensembl Protein ID ENSSHAP00000019119.1
UniProt Accession G3WUL4; G3WUL4_SARHA
Genbank Protein ID ENSSHAP00000019119
Protein Name Uncharacterized protein
Genbank Nucleotide ID AEFK01059989
Gene Name NEDD4L
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSHAG00000016231.1 ENSSHAT00000019275.1 ENSSHAP00000019119.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.60e-133 443.6 544 878
Active Site
Position(s) Description Evidence
848 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 544  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 632
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilge...tkeeeLkpgGenipVtneNkeeYvkl 176
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+   t++++Lkp+G++i+VtneNk+eY++l
   Q: 633  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQkiqTYQVDLKPNGSEIMVTNENKREYIDL 716
           ***********************************99...6666..7*********977422266777********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafL 265
           v+++r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d+++++ yk+gy +++p+iqwFw+++  +++e+r ++L
   Q: 717  VIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHAIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLL 805
           ***************************************************************************************** PP
   S: 266  qFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           qFvTg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 806  QFVTGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 878
           ************************************************************************8 PP
   
Organism Sarcophilus harrisii
Protein Sequence
(Fasta)
TRDDFLGQVD VPLSHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEENNDQRED LEHGWEVVDS NDSASQHQEE LPPPPLPPGW EEKVDNLGRT YYVNHNNRTT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sha-107482|E3,HECT|Sarcophilus harrisii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACAAGAGACG ACTTCCTTGG ACAAGTAGAC GTTCCTCTTA GTCATCTCCC GGTAAGGAAG 60
TTTAAGTTAC CTATATTTTA TGTGATGGAA AATAATTTTT AACTTGTGCC CTTTGATAAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sha-107482|E3,HECT|Sarcophilus harrisii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00632--HECT
PF00397--WW
SMART

SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001314 Ailuropoda melanoleuca 94.67 0.00e+00 1563.00
IUUC-Apl-003893 Anas platyrhynchos 94.32 0.00e+00 1583.00
IUUC-Aca-004744 Anolis carolinensis 91.16 0.00e+00 1527.00
IUUC-Acl-008273 Aspergillus clavatus 48.37 4.00e-162 565.00
IUUC-Afl-008713 Aspergillus flavus 46.17 6.00e-160 557.00
IUUC-Afu-009103 Aspergillus fumigatus 48.78 1.00e-162 566.00
IUUC-Ani-009259 Aspergillus nidulans 48.75 7.00e-160 557.00
IUUC-Ang-009738 Aspergillus niger 48.92 2.00e-160 559.00
IUUC-Aor-010053 Aspergillus oryzae 57.48 4.00e-100 357.00
IUUC-Ate-010529 Aspergillus terreus 46.82 1.00e-162 566.00
IUUC-Ame-010810 Astyanax mexicanus 70.30 0.00e+00 1139.00
IUUC-Bgr-012148 Blumeria graminis 47.52 2.00e-152 532.00
IUUC-Bta-012679 Bos taurus 96.14 0.00e+00 1598.00
IUUC-Bci-013785 Botrytis cinerea 47.60 3.00e-154 538.00
IUUC-Cel-018564 Caenorhabditis elegans 52.74 3.00e-180 625.00
IUUC-Cja-018732 Callithrix jacchus 97.16 0.00e+00 1641.00
IUUC-Cfa-021226 Canis familiaris 96.25 0.00e+00 1612.00
IUUC-Cpo-021671 Cavia porcellus 94.10 0.00e+00 1573.00
IUUC-Csa-023344 Chlorocebus sabaeus 94.77 0.00e+00 1613.00
IUUC-Cho-024832 Choloepus hoffmanni 98.87 0.00e+00 737.00
IUUC-Cin-025157 Ciona intestinalis 63.17 0.00e+00 781.00
IUUC-Csv-026098 Ciona savignyi 58.80 0.00e+00 648.00
IUUC-Dre-027770 Danio rerio 78.76 0.00e+00 1288.00
IUUC-Dno-029466 Dasypus novemcinctus 96.94 0.00e+00 1635.00
IUUC-Dor-030138 Dipodomys ordii 92.71 0.00e+00 1535.00
IUUC-Dse-031241 Dothistroma septosporum 48.37 3.00e-159 555.00
IUUC-Dme-032166 Drosophila melanogaster 66.67 0.00e+00 708.00
IUUC-Ete-033145 Echinops telfairi 87.78 0.00e+00 1276.00
IUUC-Eca-033445 Equus caballus 96.94 0.00e+00 1576.00
IUUC-Eeu-035247 Erinaceus europaeus 89.22 0.00e+00 1403.00
IUUC-Fca-035489 Felis catus 94.23 0.00e+00 1554.00
IUUC-Fal-037604 Ficedula albicollis 91.00 0.00e+00 1549.00
IUUC-Fox-037774 Fusarium oxysporum 48.52 1.00e-157 550.00
IUUC-Gmo-039674 Gadus morhua 76.07 0.00e+00 1236.00
IUUC-Ggr-040107 Gaeumannomyces graminis 47.51 8.00e-155 540.00
IUUC-Gga-040703 Gallus gallus 93.42 0.00e+00 1576.00
IUUC-Gac-042020 Gasterosteus aculeatus 79.71 0.00e+00 1286.00
IUUC-Ggo-045332 Gorilla gorilla 95.01 0.00e+00 1605.00
IUUC-Hsa-045968 Homo sapiens 96.82 0.00e+00 1625.00
IUUC-Lch-050443 Latimeria chalumnae 87.30 0.00e+00 1455.00
IUUC-Loc-052662 Lepisosteus oculatus 80.99 0.00e+00 1290.00
IUUC-Laf-053850 Loxodonta africana 95.35 0.00e+00 1612.00
IUUC-Mcc-055821 Macaca mulatta 96.71 0.00e+00 1623.00
IUUC-Meu-056712 Macropus eugenii 86.38 0.00e+00 729.00
IUUC-Mor-057097 Magnaporthe oryzae 47.51 1.00e-155 543.00
IUUC-Mpo-057442 Magnaporthe poae 51.84 3.00e-144 505.00
IUUC-Mla-058996 Melampsora laricipopulina 46.47 2.00e-154 539.00
IUUC-Mga-059264 Meleagris gallopavo 74.02 0.00e+00 1071.00
IUUC-Mvi-060395 Microbotryum violaceum 53.37 3.00e-148 519.00
IUUC-Mmr-060798 Microcebus murinus 92.19 0.00e+00 1503.00
IUUC-Mdo-062173 Monodelphis domestica 96.56 0.00e+00 1655.00
IUUC-Mmu-064136 Mus musculus 95.92 0.00e+00 1595.00
IUUC-Mpu-066765 Mustela putorius furo 96.48 0.00e+00 1600.00
IUUC-Mlu-067565 Myotis lucifugus 95.24 0.00e+00 1576.00
IUUC-Nfi-068427 Neosartorya fischeri 48.78 1.00e-162 566.00
IUUC-Ncr-068918 Neurospora crassa 47.50 6.00e-155 541.00
IUUC-Nle-069070 Nomascus leucogenys 93.08 0.00e+00 1534.00
IUUC-Opr-071044 Ochotona princeps 95.23 0.00e+00 1190.00
IUUC-Ont-072044 Oreochromis niloticus 78.13 0.00e+00 1324.00
IUUC-Oan-073032 Ornithorhynchus anatinus 93.51 0.00e+00 1446.00
IUUC-Ocu-074160 Oryctolagus cuniculus 92.97 0.00e+00 1551.00
IUUC-Ola-087467 Oryzias latipes 78.68 0.00e+00 1301.00
IUUC-Oga-088460 Otolemur garnettii 92.18 0.00e+00 1562.00
IUUC-Oar-090198 Ovis aries 95.35 0.00e+00 1581.00
IUUC-Ptr-090939 Pan troglodytes 96.82 0.00e+00 1625.00
IUUC-Pan-092284 Papio anubis 96.94 0.00e+00 1628.00
IUUC-Psi-093645 Pelodiscus sinensis 94.67 0.00e+00 1584.00
IUUC-Pma-094364 Petromyzon marinus 82.34 0.00e+00 862.00
IUUC-Pno-095118 Phaeosphaeria nodorum 47.65 2.00e-162 566.00
IUUC-Pfo-096768 Poecilia formosa 90.29 0.00e+00 957.00
IUUC-Pab-098088 Pongo abelii 96.59 0.00e+00 1622.00
IUUC-Pca-100714 Procavia capensis 77.98 0.00e+00 1262.00
IUUC-Pva-102354 Pteropus vampyrus 94.44 0.00e+00 1562.00
IUUC-Pgr-103620 Puccinia graminis 53.20 2.00e-146 513.00
IUUC-Ptt-103806 Puccinia triticina 53.00 2.00e-121 429.00
IUUC-Pte-104016 Pyrenophora teres 48.43 1.00e-160 560.00
IUUC-Pyt-104550 Pyrenophora triticirepentis 48.43 1.00e-160 560.00
IUUC-Rno-105318 Rattus norvegicus 96.15 0.00e+00 1596.00
IUUC-Sce-106289 Saccharomyces cerevisiae 49.00 7.00e-163 567.00
IUUC-Sja-107786 Schizosaccharomyces japonicus 48.67 2.00e-150 526.00
IUUC-Ssl-108514 Sclerotinia sclerotiorum 48.09 7.00e-156 544.00
IUUC-Ssc-115950 Sus scrofa 71.04 0.00e+00 1175.00
IUUC-Tgu-117130 Taeniopygia guttata 93.64 0.00e+00 1578.00
IUUC-Tru-118610 Takifugu rubripes 79.44 0.00e+00 1330.00
IUUC-Tsy-119492 Tarsius syrichta 94.78 0.00e+00 1598.00
IUUC-Tni-120113 Tetraodon nigroviridis 74.12 0.00e+00 1265.00
IUUC-Tre-122203 Trichoderma reesei 44.51 4.00e-151 528.00
IUUC-Tvi-122595 Trichoderma virens 47.04 1.00e-152 533.00
IUUC-Tme-126897 Tuber melanosporum 52.16 1.00e-145 510.00
IUUC-Tbe-127441 Tupaia belangeri 91.37 0.00e+00 727.00
IUUC-Ttr-128235 Tursiops truncatus 86.54 0.00e+00 1380.00
IUUC-Vda-129753 Verticillium dahliae 47.45 2.00e-155 542.00
IUUC-Xtr-132859 Xenopus tropicalis 89.91 0.00e+00 1509.00
IUUC-Xma-133797 Xiphophorus maculatus 80.09 0.00e+00 1317.00
Created Date 25-Jun-2017

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