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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063434
UUCD1 version UUC-MuM-01165
Ensembl Protein ID ENSMUSP00000055318.4
UniProt Accession Q8CB27; B2RSW9; Q8BPM9; Q8CB24; OTU1_MOUSE
Genbank Protein ID BAC29646.1; BAC29661.1; BAC35495.1; AAI39035.1
Protein Name Ubiquitin thioesterase OTU1
Genbank Nucleotide ID AK036938; AK036991; AK053730; BC139034
Gene Name Yod1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000046404.5 ENSMUST00000049813.5 ENSMUSP00000055318.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IID
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
DUB/OTU 33.09 3.00e-37 150.00 IUUC-Sce-106323
ULD/UDP/UFD/UBX 33.09 3.00e-37 150.00 IUUC-Sce-106323
Active Site
Position(s) Description Evidence
152 N/A {ECO:0000250|UniProtKB:Q96FW1}
155 Nucleophile {ECO:0000250|UniProtKB:Q5VVQ6}
262 {ECO:0000250|UniProtKB:Q5VVQ6}
337 {ECO:0000250|UniProtKB:Q96FW1}
Organism Mus musculus
Functional Description
(View)

Functional Description


     Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity).
 Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity).
Protein Sequence
(Fasta)
MFGGAKGGHF GVPPAGYSGA VPQSEAGTKA GPAGGRPADT MWRVRCKAKG GTHLLQGLSS 60
RTRLRELQGQ IAAITGIAPG SQRILVGYPP ECLDLSDRDI TLGDLPIQSG DMLIVEEDQT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063434|DUB,OTU;ULD,UBX|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACCGGAGCGC TCGGGAGAGC CGGCCGACCC CCAACCCTCA CCCGCGGCCG CCCTTGCCAC 60
TTTAAGAGCC CGCGCCGTTT TTGGAAGGAC CGAGGCCGAG TCCCCCCCAC CCCCCACCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063434|DUB,OTU;ULD,UBX|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003323--OTU_dom
IPR029071--Ubiquitin-rel_dom
IPR013087--Znf_C2H2_type
PROSITE

PS50802--OTU
PS00028--ZINC_FINGER_C2H2_1
Pfam

PF02338--OTU
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1904265--F:ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:1990167--P:protein K27-linked deubiquitination
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG mmu:226418
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000271 Aegilops tauschii 48.15 1.00e-44 172.00
IUUC-Aml-001860 Ailuropoda melanoleuca 88.22 3.00e-180 624.00
IUUC-Atr-002548 Amborella trichopoda 49.51 3.00e-50 191.00
IUUC-Apl-004025 Anas platyrhynchos 79.17 2.00e-104 371.00
IUUC-Aca-004505 Anolis carolinensis 73.62 1.00e-135 475.00
IUUC-Aly-005999 Arabidopsis lyrata 44.66 1.00e-46 179.00
IUUC-Ath-006774 Arabidopsis thaliana 45.63 3.00e-47 181.00
IUUC-Ago-007741 Ashbya gossypii 38.89 5.00e-38 151.00
IUUC-Acl-008278 Aspergillus clavatus 41.58 2.00e-41 162.00
IUUC-Afl-008710 Aspergillus flavus 44.06 8.00e-43 167.00
IUUC-Afu-009009 Aspergillus fumigatus 34.38 3.00e-43 169.00
IUUC-Ani-009430 Aspergillus nidulans 31.33 3.00e-39 155.00
IUUC-Ang-009508 Aspergillus niger 32.86 7.00e-36 144.00
IUUC-Aor-009992 Aspergillus oryzae 34.94 2.00e-43 169.00
IUUC-Ate-010440 Aspergillus terreus 34.51 5.00e-45 174.00
IUUC-Ame-011038 Astyanax mexicanus 68.98 3.00e-125 441.00
IUUC-Bgr-012262 Blumeria graminis 34.47 3.00e-34 139.00
IUUC-Bta-012864 Bos taurus 86.49 2.00e-176 611.00
IUUC-Bci-013986 Botrytis cinerea 34.93 2.00e-35 142.00
IUUC-Bdi-014194 Brachypodium distachyon 48.78 1.00e-50 192.00
IUUC-Bol-016166 Brassica oleracea 46.12 5.00e-48 183.00
IUUC-Bra-017783 Brassica rapa 46.60 2.00e-48 185.00
IUUC-Cja-019488 Callithrix jacchus 85.92 2.00e-175 608.00
IUUC-Cpo-021728 Cavia porcellus 86.21 8.00e-178 615.00
IUUC-Cre-022819 Chlamydomonas reinhardtii 45.59 3.00e-42 164.00
IUUC-Csa-024237 Chlorocebus sabaeus 91.42 7.00e-165 572.00
IUUC-Cho-024544 Choloepus hoffmanni 85.34 2.00e-175 607.00
IUUC-Cin-025549 Ciona intestinalis 44.26 5.00e-72 264.00
IUUC-Cgl-026552 Colletotrichum gloeosporioides 29.64 1.00e-32 134.00
IUUC-Cne-027022 Cryptococcus neoformans 44.06 7.00e-44 171.00
IUUC-Cme-027196 Cyanidioschyzon merolae 36.84 4.00e-46 178.00
IUUC-Dre-027799 Danio rerio 68.98 8.00e-120 423.00
IUUC-Dno-029863 Dasypus novemcinctus 84.48 1.00e-173 602.00
IUUC-Dor-030804 Dipodomys ordii 80.80 6.00e-159 553.00
IUUC-Dse-031494 Dothistroma septosporum 39.71 4.00e-39 155.00
IUUC-Dme-032065 Drosophila melanogaster 41.50 7.00e-68 250.00
IUUC-Ete-033193 Echinops telfairi 86.21 2.00e-172 598.00
IUUC-Eca-033993 Equus caballus 88.51 3.00e-180 624.00
IUUC-Fca-035949 Felis catus 88.22 2.00e-180 624.00
IUUC-Fal-037473 Ficedula albicollis 76.27 2.00e-100 357.00
IUUC-Fox-037779 Fusarium oxysporum 31.37 5.00e-28 118.00
IUUC-Fso-038370 Fusarium solani 35.56 2.00e-27 116.00
IUUC-Gmo-038778 Gadus morhua 56.91 7.00e-90 323.00
IUUC-Ggr-039940 Gaeumannomyces graminis 33.13 2.00e-35 143.00
IUUC-Gga-041102 Gallus gallus 71.71 1.00e-124 439.00
IUUC-Gac-041954 Gasterosteus aculeatus 68.83 2.00e-123 435.00
IUUC-Gma-043608 Glycine max 47.09 2.00e-48 185.00
IUUC-Ggo-044753 Gorilla gorilla 86.78 2.00e-176 611.00
IUUC-Hsa-045714 Homo sapiens 87.54 8.00e-157 546.00
IUUC-Hvu-047600 Hordeum vulgare 48.78 4.00e-51 194.00
IUUC-Itr-048026 Ictidomys tridecemlineatus 88.22 0.00e+00 626.00
IUUC-Kpa-049360 Komagataella pastoris 31.23 1.00e-38 153.00
IUUC-Lch-049900 Latimeria chalumnae 73.68 2.00e-124 438.00
IUUC-Lpe-050984 Leersia perrieri 40.20 1.00e-32 132.00
IUUC-Loc-052567 Lepisosteus oculatus 71.15 8.00e-130 456.00
IUUC-Lma-053247 Leptosphaeria maculans 30.28 7.00e-39 154.00
IUUC-Laf-053361 Loxodonta africana 86.49 5.00e-169 587.00
IUUC-Meu-056137 Macropus eugenii 73.41 6.00e-144 503.00
IUUC-Mor-057191 Magnaporthe oryzae 29.50 2.00e-26 113.00
IUUC-Mpo-057565 Magnaporthe poae 38.27 3.00e-31 128.00
IUUC-Mtr-058196 Medicago truncatula 46.60 9.00e-49 186.00
IUUC-Mla-059096 Melampsora laricipopulina 32.82 2.00e-39 155.00
IUUC-Mga-059489 Meleagris gallopavo 79.66 3.00e-111 394.00
IUUC-Mvi-060300 Microbotryum violaceum 36.73 2.00e-41 162.00
IUUC-Mmr-061618 Microcebus murinus 90.24 7.00e-160 556.00
IUUC-Mdo-061909 Monodelphis domestica 84.29 1.00e-157 549.00
IUUC-Mac-064676 Musa acuminata 48.54 2.00e-50 192.00
IUUC-Mpu-066733 Mustela putorius furo 87.93 7.00e-180 622.00
IUUC-Mlu-066990 Myotis lucifugus 83.57 4.00e-171 593.00
IUUC-Nfi-068249 Neosartorya fischeri 42.57 1.00e-42 166.00
IUUC-Ncr-068764 Neurospora crassa 39.13 1.00e-34 140.00
IUUC-Nle-069094 Nomascus leucogenys 87.07 5.00e-176 610.00
IUUC-Oan-073585 Ornithorhynchus anatinus 84.87 3.00e-155 540.00
IUUC-Oba-075949 Oryza barthii 49.03 2.00e-49 188.00
IUUC-Obr-076096 Oryza brachyantha 49.03 3.00e-50 191.00
IUUC-Ogl-077106 Oryza glaberrima 48.54 4.00e-49 187.00
IUUC-Ogu-078024 Oryza glumaepatula 49.03 2.00e-49 188.00
IUUC-Oin-079635 Oryza indica 48.06 2.00e-49 188.00
IUUC-Olo-080299 Oryza longistaminata 49.03 3.00e-49 187.00
IUUC-Ome-081359 Oryza meridionalis 49.03 2.00e-49 188.00
IUUC-Oni-082459 Oryza nivara 48.54 4.00e-49 187.00
IUUC-Opu-083167 Oryza punctata 50.00 7.00e-51 193.00
IUUC-Oru-084577 Oryza rufipogon 48.06 2.00e-49 188.00
IUUC-Osa-085746 Oryza sativa 52.94 1.00e-12 63.90
IUUC-Ola-086890 Oryzias latipes 69.51 7.00e-126 443.00
IUUC-Olu-087585 Ostreococcus lucimarinus 41.79 1.00e-42 165.00
IUUC-Oga-088190 Otolemur garnettii 88.46 1.00e-162 565.00
IUUC-Oar-089631 Ovis aries 87.36 4.00e-178 617.00
IUUC-Pan-091892 Papio anubis 87.36 5.00e-176 610.00
IUUC-Pma-094491 Petromyzon marinus 56.51 2.00e-87 315.00
IUUC-Pno-094993 Phaeosphaeria nodorum 31.80 3.00e-40 159.00
IUUC-Ppa-095791 Physcomitrella patens 50.49 5.00e-52 197.00
IUUC-Pfo-096301 Poecilia formosa 69.31 5.00e-126 443.00
IUUC-Pab-097873 Pongo abelii 87.36 2.00e-177 615.00
IUUC-Pop-099482 Populus trichocarpa 46.60 2.00e-49 188.00
IUUC-Pca-100817 Procavia capensis 87.54 1.00e-158 552.00
IUUC-Ppe-101624 Prunus persica 49.27 9.00e-52 196.00
IUUC-Pva-102120 Pteropus vampyrus 85.06 8.00e-173 599.00
IUUC-Pgr-103368 Puccinia graminis 31.38 6.00e-43 168.00
IUUC-Ptt-103923 Puccinia triticina 39.36 1.00e-42 167.00
IUUC-Pte-104199 Pyrenophora teres 39.20 1.00e-39 156.00
IUUC-Pyt-104502 Pyrenophora triticirepentis 38.38 5.00e-40 157.00
IUUC-Rno-105605 Rattus norvegicus 96.50 0.00e+00 654.00
IUUC-Sce-106323 Saccharomyces cerevisiae 33.09 2.00e-33 135.00
IUUC-Sha-107176 Sarcophilus harrisii 85.17 8.00e-135 472.00
IUUC-Sja-107812 Schizosaccharomyces japonicus 35.71 7.00e-37 147.00
IUUC-Spo-108085 Schizosaccharomyces pombe 29.94 7.00e-38 150.00
IUUC-Smo-109050 Selaginella moellendorffii 48.06 2.00e-49 188.00
IUUC-Sit-110056 Setaria italica 47.80 6.00e-50 190.00
IUUC-Sly-111869 Solanum lycopersicum 49.71 1.00e-43 169.00
IUUC-Stu-112452 Solanum tuberosum 48.29 6.00e-50 190.00
IUUC-Sar-113629 Sorex araneus 81.97 4.00e-56 211.00
IUUC-Sbi-114422 Sorghum bicolor 48.54 2.00e-50 191.00
IUUC-Sre-115105 Sporisorium reilianum 41.50 2.00e-31 129.00
IUUC-Ssc-115553 Sus scrofa 87.93 1.00e-179 622.00
IUUC-Tgu-116921 Taeniopygia guttata 77.37 3.00e-101 360.00
IUUC-Tru-117830 Takifugu rubripes 67.55 3.00e-123 434.00
IUUC-Tsy-119320 Tarsius syrichta 87.07 2.00e-176 611.00
IUUC-Tni-119706 Tetraodon nigroviridis 66.34 3.00e-117 414.00
IUUC-Tca-121238 Theobroma cacao 48.06 5.00e-50 190.00
IUUC-Tae-124711 Triticum aestivum 49.03 9.00e-51 193.00
IUUC-Tme-126966 Tuber melanosporum 35.12 8.00e-50 190.00
IUUC-Tbe-127712 Tupaia belangeri 93.43 4.00e-108 383.00
IUUC-Ttr-129168 Tursiops truncatus 85.63 1.00e-176 612.00
IUUC-Uma-129461 Ustilago maydis 40.00 2.00e-37 149.00
IUUC-Vda-129890 Verticillium dahliae 35.00 4.00e-25 108.00
IUUC-Vpa-130616 Vicugna pacos 87.64 3.00e-180 624.00
IUUC-Vvi-131250 Vitis vinifera 48.54 3.00e-50 191.00
IUUC-Xtr-132126 Xenopus tropicalis 70.72 6.00e-130 456.00
IUUC-Xma-133596 Xiphophorus maculatus 68.85 2.00e-125 441.00
IUUC-Yli-134562 Yarrowia lipolytica 31.16 7.00e-32 131.00
IUUC-Zma-135205 Zea mays 48.06 1.00e-49 189.00
Created Date 25-Jun-2017

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