iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19687296

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.033	15.8	244	283

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           Ca+C e +   p++ +C Hvf+  C+     ++ +    f+CP C
   Q: 244  CALCGEWPTM-PHTIGCEHVFCYYCV----KSSFLFDIYFTCPKC 283
           ****998877.**************5....6668999999***99 PP

Organism

Mus musculus

Functional Description
(View)

Belongs to the pex2/pex10/pex12 family.

Protein Sequence
(Fasta)

MTGKEENMQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKAFL 60
WLFLWRFTIY SKNATVGQSV LNIQYKNDSS LNLIYQPPSK TQKLWYAVCT IGGKWLEERC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCCGGCTTT CCTCAGACCC GGTGTTGCTT CTGGGTGTAA TTCCCCGCTC TCTCTTCAGC 60
CACTTCCGGG TCTTCCGTCG CTCCGGAAGC CCGCAGATTC CGGAAGTGAG GGCGACCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0576--Peroxisome
KW-0962--Peroxisome biogenesis
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006845--Pex_N
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF04757--Pex2_Pex12
PF00097--zf-C3HC4

SMART

SM00184--RING

Gene Ontology

GO:0016593--C:Cdc73/Paf1 complex
GO:0005779--C:integral component of peroxisomal membrane
GO:0016020--C:membrane
GO:0005778--C:peroxisomal membrane
GO:0008270--F:zinc ion binding
GO:0006699--P:bile acid biosynthetic process
GO:0042632--P:cholesterol homeostasis
GO:0006635--P:fatty acid beta-oxidation
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:0048147--P:negative regulation of fibroblast proliferation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0007399--P:nervous system development
GO:0001764--P:neuron migration
GO:0007031--P:peroxisome organization
GO:0031648--P:protein destabilization
GO:0016558--P:protein import into peroxisome matrix
GO:0045540--P:regulation of cholesterol biosynthetic process
GO:0000038--P:very long-chain fatty acid metabolic process

KEGG

mmu:19302

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000106	Aegilops tauschii	29.02	2.00e-22	99.40
IUUC-Aml-001595	Ailuropoda melanoleuca	88.52	6.00e-160	556.00
IUUC-Atr-002766	Amborella trichopoda	30.17	1.00e-35	144.00
IUUC-Apl-004019	Anas platyrhynchos	73.03	2.00e-134	471.00
IUUC-Aca-004791	Anolis carolinensis	72.70	1.00e-121	429.00
IUUC-Aly-005607	Arabidopsis lyrata	30.00	2.00e-38	152.00
IUUC-Ath-006880	Arabidopsis thaliana	29.33	1.00e-36	147.00
IUUC-Ago-007841	Ashbya gossypii	24.32	3.00e-09	55.50
IUUC-Acl-008272	Aspergillus clavatus	29.22	1.00e-24	107.00
IUUC-Afl-008698	Aspergillus flavus	31.19	3.00e-25	109.00
IUUC-Afu-008859	Aspergillus fumigatus	30.33	2.00e-25	110.00
IUUC-Ani-009210	Aspergillus nidulans	30.58	2.00e-24	106.00
IUUC-Ang-009515	Aspergillus niger	29.76	7.00e-24	105.00
IUUC-Aor-009913	Aspergillus oryzae	31.19	3.00e-25	109.00
IUUC-Ate-010581	Aspergillus terreus	30.43	2.00e-24	106.00
IUUC-Ame-010951	Astyanax mexicanus	55.81	3.00e-90	325.00
IUUC-Bgr-012274	Blumeria graminis	27.60	7.00e-22	98.60
IUUC-Bta-012949	Bos taurus	86.51	9.00e-155	539.00
IUUC-Bci-013654	Botrytis cinerea	30.10	7.00e-18	85.50
IUUC-Bdi-014062	Brachypodium distachyon	31.88	2.00e-38	152.00
IUUC-Bra-016860	Brassica rapa	29.77	8.00e-36	144.00
IUUC-Cel-018250	Caenorhabditis elegans	25.69	1.00e-19	89.70
IUUC-Cja-019623	Callithrix jacchus	87.87	2.00e-162	564.00
IUUC-Cfa-020899	Canis familiaris	87.21	1.00e-160	558.00
IUUC-Cpo-021971	Cavia porcellus	88.37	6.00e-161	559.00
IUUC-Cre-022853	Chlamydomonas reinhardtii	36.07	8.00e-05	41.20
IUUC-Csa-023552	Chlorocebus sabaeus	88.85	1.00e-164	572.00
IUUC-Cho-024309	Choloepus hoffmanni	89.51	1.00e-165	575.00
IUUC-Csv-025909	Ciona savignyi	28.96	1.00e-26	113.00
IUUC-Cgl-026469	Colletotrichum gloeosporioides	25.75	8.00e-22	98.60
IUUC-Cne-027011	Cryptococcus neoformans	25.34	1.00e-15	77.80
IUUC-Cme-027206	Cyanidioschyzon merolae	29.08	3.00e-17	82.40
IUUC-Dre-027627	Danio rerio	60.56	2.00e-98	352.00
IUUC-Dno-029220	Dasypus novemcinctus	90.49	6.00e-167	579.00
IUUC-Dor-030828	Dipodomys ordii	87.54	8.00e-163	565.00
IUUC-Dse-031469	Dothistroma septosporum	29.78	2.00e-15	77.80
IUUC-Dme-031865	Drosophila melanogaster	29.07	9.00e-36	143.00
IUUC-Ete-033020	Echinops telfairi	68.20	6.00e-105	373.00
IUUC-Eca-034078	Equus caballus	87.54	2.00e-161	561.00
IUUC-Fca-036406	Felis catus	86.89	3.00e-159	553.00
IUUC-Fal-037365	Ficedula albicollis	72.04	3.00e-124	437.00
IUUC-Fox-037825	Fusarium oxysporum	33.33	3.00e-22	99.80
IUUC-Fso-038458	Fusarium solani	33.33	2.00e-21	96.70
IUUC-Gmo-038729	Gadus morhua	50.00	6.00e-24	104.00
IUUC-Ggr-039992	Gaeumannomyces graminis	30.64	2.00e-15	77.00
IUUC-Gga-040364	Gallus gallus	73.03	1.00e-134	472.00
IUUC-Gac-041501	Gasterosteus aculeatus	51.36	1.00e-69	256.00
IUUC-Gma-044174	Glycine max	30.26	5.00e-35	141.00
IUUC-Ggo-045248	Gorilla gorilla	87.54	9.00e-163	565.00
IUUC-Hsa-046307	Homo sapiens	87.87	2.00e-162	565.00
IUUC-Hvu-047618	Hordeum vulgare	32.21	1.00e-37	150.00
IUUC-Itr-048006	Ictidomys tridecemlineatus	87.50	2.00e-161	561.00
IUUC-Kpa-049382	Komagataella pastoris	22.12	2.00e-13	70.90
IUUC-Lch-049694	Latimeria chalumnae	69.96	2.00e-119	421.00
IUUC-Lpe-050779	Leersia perrieri	31.48	1.00e-29	124.00
IUUC-Loc-052253	Lepisosteus oculatus	57.14	1.00e-100	359.00
IUUC-Lma-053100	Leptosphaeria maculans	34.23	8.00e-13	68.20
IUUC-Laf-053543	Loxodonta africana	86.89	2.00e-160	558.00
IUUC-Mcc-055435	Macaca mulatta	88.52	1.00e-163	568.00
IUUC-Meu-056096	Macropus eugenii	83.55	3.00e-153	534.00
IUUC-Mor-057285	Magnaporthe oryzae	30.66	7.00e-24	105.00
IUUC-Mtr-058501	Medicago truncatula	30.54	3.00e-31	129.00
IUUC-Mla-059178	Melampsora laricipopulina	25.32	3.00e-13	69.30
IUUC-Mga-060125	Meleagris gallopavo	72.04	4.00e-134	470.00
IUUC-Mvi-060252	Microbotryum violaceum	28.98	5.00e-21	95.90
IUUC-Mmr-061696	Microcebus murinus	87.87	1.00e-161	561.00
IUUC-Mdo-062789	Monodelphis domestica	82.57	1.00e-151	528.00
IUUC-Mac-064555	Musa acuminata	31.97	1.00e-38	153.00
IUUC-Mpu-065832	Mustela putorius furo	88.20	2.00e-163	568.00
IUUC-Mlu-067811	Myotis lucifugus	85.90	3.00e-159	553.00
IUUC-Nfi-068362	Neosartorya fischeri	30.19	2.00e-20	93.60
IUUC-Ncr-068621	Neurospora crassa	27.57	2.00e-20	94.40
IUUC-Nle-069980	Nomascus leucogenys	87.87	1.00e-162	565.00
IUUC-Opr-070196	Ochotona princeps	88.85	1.00e-163	568.00
IUUC-Ont-071826	Oreochromis niloticus	51.64	3.00e-79	288.00
IUUC-Oan-072999	Ornithorhynchus anatinus	56.98	5.00e-26	109.00
IUUC-Ocu-074466	Oryctolagus cuniculus	89.84	1.00e-164	572.00
IUUC-Oba-075893	Oryza barthii	31.62	1.00e-30	127.00
IUUC-Obr-076621	Oryza brachyantha	31.88	2.00e-37	149.00
IUUC-Ogl-077881	Oryza glaberrima	31.21	1.00e-36	147.00
IUUC-Ogu-078407	Oryza glumaepatula	30.74	4.00e-37	148.00
IUUC-Oin-080063	Oryza indica	30.45	8.00e-37	147.00
IUUC-Olo-080529	Oryza longistaminata	30.14	3.00e-26	112.00
IUUC-Ome-081350	Oryza meridionalis	30.77	9.00e-31	127.00
IUUC-Oni-082647	Oryza nivara	30.14	3.00e-26	112.00
IUUC-Opu-083358	Oryza punctata	30.45	3.00e-30	125.00
IUUC-Oru-084263	Oryza rufipogon	29.81	6.00e-28	117.00
IUUC-Osa-085561	Oryza sativa	30.45	8.00e-37	147.00
IUUC-Ola-087048	Oryzias latipes	48.55	8.00e-68	250.00
IUUC-Olu-087782	Ostreococcus lucimarinus	23.22	3.00e-16	79.00
IUUC-Oga-088107	Otolemur garnettii	87.87	1.00e-161	561.00
IUUC-Oar-089967	Ovis aries	86.18	3.00e-154	537.00
IUUC-Ptr-091627	Pan troglodytes	87.54	2.00e-162	564.00
IUUC-Pan-091754	Papio anubis	88.20	2.00e-163	568.00
IUUC-Psi-093286	Pelodiscus sinensis	72.46	2.00e-127	448.00
IUUC-Pma-094543	Petromyzon marinus	46.69	2.00e-67	248.00
IUUC-Pno-094850	Phaeosphaeria nodorum	30.43	8.00e-17	82.00
IUUC-Ppa-095816	Physcomitrella patens	30.64	3.00e-31	129.00
IUUC-Pfo-097377	Poecilia formosa	49.34	5.00e-76	278.00
IUUC-Pab-097671	Pongo abelii	88.20	2.00e-162	564.00
IUUC-Pop-099692	Populus trichocarpa	33.22	1.00e-38	153.00
IUUC-Ppe-101194	Prunus persica	31.08	7.00e-32	130.00
IUUC-Pva-102697	Pteropus vampyrus	83.33	3.00e-152	530.00
IUUC-Pgr-103472	Puccinia graminis	50.00	2.00e-06	47.00
IUUC-Pte-104058	Pyrenophora teres	29.26	2.00e-23	103.00
IUUC-Pyt-104435	Pyrenophora triticirepentis	32.11	4.00e-20	93.20
IUUC-Rno-105925	Rattus norvegicus	93.44	9.00e-172	595.00
IUUC-Sce-106321	Saccharomyces cerevisiae	22.68	5.00e-07	48.10
IUUC-Sha-106928	Sarcophilus harrisii	81.58	2.00e-149	521.00
IUUC-Sja-107666	Schizosaccharomyces japonicus	27.14	2.00e-04	39.30
IUUC-Ssl-108434	Sclerotinia sclerotiorum	29.68	6.00e-18	85.50
IUUC-Smo-109238	Selaginella moellendorffii	28.62	1.00e-30	127.00
IUUC-Sit-110018	Setaria italica	31.09	7.00e-38	150.00
IUUC-Sly-111670	Solanum lycopersicum	32.43	2.00e-39	156.00
IUUC-Stu-112190	Solanum tuberosum	31.88	5.00e-39	155.00
IUUC-Sar-112920	Sorex araneus	82.33	4.00e-151	527.00
IUUC-Sbi-114300	Sorghum bicolor	31.09	1.00e-37	150.00
IUUC-Sre-115019	Sporisorium reilianum	45.00	1.00e-11	65.10
IUUC-Ssc-116289	Sus scrofa	84.92	1.00e-152	532.00
IUUC-Tgu-116936	Taeniopygia guttata	72.37	2.00e-134	471.00
IUUC-Tru-118611	Takifugu rubripes	47.85	2.00e-79	289.00
IUUC-Tsy-119073	Tarsius syrichta	87.54	9.00e-162	562.00
IUUC-Tni-119824	Tetraodon nigroviridis	47.19	2.00e-70	259.00
IUUC-Tca-121117	Theobroma cacao	31.79	5.00e-38	151.00
IUUC-Tre-122081	Trichoderma reesei	25.00	2.00e-24	107.00
IUUC-Tvi-122454	Trichoderma virens	25.30	1.00e-25	110.00
IUUC-Tae-123108	Triticum aestivum	32.21	1.00e-37	150.00
IUUC-Tur-125989	Triticum urartu	30.85	2.00e-20	92.40
IUUC-Tme-127082	Tuber melanosporum	29.21	2.00e-24	106.00
IUUC-Tbe-127229	Tupaia belangeri	88.52	3.00e-162	563.00
IUUC-Ttr-129251	Tursiops truncatus	86.56	4.00e-160	556.00
IUUC-Vda-130008	Verticillium dahliae	33.33	2.00e-15	77.00
IUUC-Vpa-130084	Vicugna pacos	85.90	3.00e-150	524.00
IUUC-Vvi-130953	Vitis vinifera	31.74	1.00e-38	153.00
IUUC-Xtr-132429	Xenopus tropicalis	67.32	1.00e-124	438.00
IUUC-Xma-133897	Xiphophorus maculatus	50.17	8.00e-74	270.00
IUUC-Yli-134504	Yarrowia lipolytica	25.63	1.00e-15	77.40
IUUC-Zma-135123	Zea mays	29.52	1.00e-35	143.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence