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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Ath-007148
UUCD1 version UUC-ArT-01398
Ensembl Protein ID AT5G02310.1
UniProt Accession F4KCC2; Q96248; Q9LZ94; Q9LZ95; PRT6_ARATH
Genbank Protein ID CAB85535.1; CAB85536.1; AED90457.1; ANM70335.1; CAA65198.1
Protein Name E3 ubiquitin-protein ligase PRT6; Protein PROTEOLYSIS 6; RING-type E3 ubiquitin transferase PRT6
Genbank Nucleotide ID AL162874; AL162874; CP002688; CP002688; X95962
Gene Name PRT6; CER3; At5g02310/At5g02300; T1E22.70/T1E22.60
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
AT5G02310 AT5G02310.1 AT5G02310.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/N-recognin/Other E3 activity/N-recognin/Other 17572409; 19255443
E3 activity/RING/RING RING 17572409
Classification
Family E-value Score Start End
E3 activity/RING/RING 6.20e-07 30.7 1387 1440
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 9    kdgplvlpCgHvfhadClqkw................pglknssskefrCPlCr 46
           +dg+++ +CgH+ h++Cl+++                 +  ++++kef+CP+Cr
   Q: 1387 CDGVYLSSCGHAVHQSCLERYlkslkersgrrtvfegAHIVDLKKKEFLCPVCR 1440
           567999******************************98888888*********8 PP
   
Organism Arabidopsis thaliana
Functional Description
(View)

Functional Description


     Ubiquitin ligase protein which is a component of the N-end rule pathway with the arginyltransferases ATE1 and ATE2. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:17572409, PubMed:19255443, PubMed:19620738, PubMed:22020282). Does not participate in degradation of proteins with N-terminal Phe or Leu (PubMed:17572409). The N-end rule pathway regulates seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination (PubMed:19255443). The end-rule pathway regulates various aspects of leaf and shoot development (PubMed:19620738). Involved in the ubiquitination and subsequent degradation of RAP2-12, an activator of hypoxic gene expression. The ubiquitination occurs after the N-arginylation of RAP2-12 by ATE1 or ATE2 under aerobic conditions (PubMed:22020282).
 Ubiquitin ligase protein which is a component of the N-end rule pathway with the arginyltransferases ATE1 and ATE2. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (PubMed:17572409, PubMed:19255443, PubMed:19620738, PubMed:22020282). Does not participate in degradation of proteins with N-terminal Phe or Leu (PubMed:17572409). The N-end rule pathway regulates seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination (PubMed:19255443). The end-rule pathway regulates various aspects of leaf and shoot development (PubMed:19620738). Involved in the ubiquitination and subsequent degradation of RAP2-12, an activator of hypoxic gene expression. The ubiquitination occurs after the N-arginylation of RAP2-12 by ATE1 or ATE2 under aerobic conditions (PubMed:22020282).
Protein Sequence
(Fasta)
METNSSLFGL VSPSSHDLVI ERLASVGVPK KYRSKRGLVE FVRANPAKIS ELVSALLPTD 60
DDVKLGLKEA RERPRKSAVS PTMKKRFRES MNMLQWLMFQ DEPDVSLRNL AKLNLDQRGV 120
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Protein Fasta Sequence


>IUUC-Ath-007148|E3,N-recognin/Other;E3,RING|Arabidopsis thaliana
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Nucleotide Sequence
(Fasta)
GTGACTTATT CTTCGTTCGT ATCACAATTG GTAAAGAGAC TTGCCGAGCT CCGCAAACCG 60
CCATGCCTTT AACCAATCTT CACCTATAAA CTCTTTCGTA TTTGGTGCAA TCGGAGAAAT 120
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Nucleotide Fasta Sequence


>IUUC-Ath-007148|E3,N-recognin/Other;E3,RING|Arabidopsis thaliana
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR
PROSITE

PS51157--ZF_UBR
Pfam

PF02207--zf-UBR
SMART

SM00396--ZnF_UBR1
Gene Ontology

GO:0005737--C:cytoplasm
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0050994--P:regulation of lipid catabolic process
GO:0010029--P:regulation of seed germination
GO:0009737--P:response to abscisic acid
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0071596--P:ubiquitin-dependent protein catabolic process via the N-end rule pathway
KEGG ath:AT5G02310
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000949 Aegilops tauschii 39.54 6.00e-179 621.00
IUUC-Aml-001876 Ailuropoda melanoleuca 30.24 3.00e-21 97.80
IUUC-Atr-002501 Amborella trichopoda 49.92 4.00e-134 473.00
IUUC-Apl-003828 Anas platyrhynchos 30.52 2.00e-19 91.70
IUUC-Aca-005189 Anolis carolinensis 25.11 3.00e-24 107.00
IUUC-Aly-005901 Arabidopsis lyrata 91.07 0.00e+00 3376.00
IUUC-Ago-007752 Ashbya gossypii 24.64 6.00e-11 63.50
IUUC-Acl-008055 Aspergillus clavatus 25.26 1.00e-17 85.90
IUUC-Afl-008479 Aspergillus flavus 28.79 4.00e-18 87.40
IUUC-Afu-008929 Aspergillus fumigatus 24.60 2.00e-16 82.00
IUUC-Ani-009334 Aspergillus nidulans 28.57 2.00e-18 88.60
IUUC-Ang-009550 Aspergillus niger 24.41 3.00e-18 87.80
IUUC-Aor-010124 Aspergillus oryzae 28.79 4.00e-18 87.80
IUUC-Ate-010550 Aspergillus terreus 27.80 4.00e-19 90.90
IUUC-Ame-011917 Astyanax mexicanus 31.75 1.00e-25 112.00
IUUC-Bgr-011999 Blumeria graminis 26.40 2.00e-14 75.90
IUUC-Bta-012768 Bos taurus 32.39 3.00e-20 94.70
IUUC-Bci-013834 Botrytis cinerea 31.55 5.00e-18 87.40
IUUC-Bdi-014635 Brachypodium distachyon 42.16 0.00e+00 1310.00
IUUC-Bol-016004 Brassica oleracea 80.51 0.00e+00 2970.00
IUUC-Bra-017776 Brassica rapa 80.23 0.00e+00 2996.00
IUUC-Cel-018476 Caenorhabditis elegans 27.54 9.00e-16 79.70
IUUC-Cja-019797 Callithrix jacchus 29.58 6.00e-20 92.80
IUUC-Cfa-020950 Canis familiaris 30.52 2.00e-20 95.10
IUUC-Cpo-022385 Cavia porcellus 30.05 1.00e-20 95.50
IUUC-Csa-024082 Chlorocebus sabaeus 30.05 2.00e-20 95.10
IUUC-Cho-025029 Choloepus hoffmanni 29.95 7.00e-18 86.70
IUUC-Cin-025110 Ciona intestinalis 38.94 2.00e-21 98.20
IUUC-Csv-026033 Ciona savignyi 40.59 3.00e-19 86.70
IUUC-Cgl-026605 Colletotrichum gloeosporioides 30.06 2.00e-15 78.60
IUUC-Cne-026823 Cryptococcus neoformans 30.21 4.00e-15 77.40
IUUC-Dre-028343 Danio rerio 26.97 1.00e-22 102.00
IUUC-Dno-029345 Dasypus novemcinctus 41.30 8.00e-24 105.00
IUUC-Dor-030207 Dipodomys ordii 27.70 1.00e-19 92.40
IUUC-Dse-031531 Dothistroma septosporum 28.51 2.00e-17 85.90
IUUC-Dme-031910 Drosophila melanogaster 29.59 2.00e-21 98.20
IUUC-Ete-033162 Echinops telfairi 30.99 7.00e-21 96.70
IUUC-Eca-033454 Equus caballus 30.05 3.00e-20 94.70
IUUC-Eeu-034664 Erinaceus europaeus 41.53 5.00e-22 100.00
IUUC-Fca-036588 Felis catus 24.45 6.00e-27 116.00
IUUC-Fal-036919 Ficedula albicollis 24.26 2.00e-25 111.00
IUUC-Fox-037984 Fusarium oxysporum 30.77 2.00e-15 79.00
IUUC-Fso-038463 Fusarium solani 31.47 1.00e-15 79.30
IUUC-Gmo-039698 Gadus morhua 29.38 9.00e-21 95.90
IUUC-Ggr-040070 Gaeumannomyces graminis 22.30 8.00e-16 80.10
IUUC-Gga-041123 Gallus gallus 24.26 1.00e-24 109.00
IUUC-Gac-042622 Gasterosteus aculeatus 32.43 5.00e-25 110.00
IUUC-Gma-043622 Glycine max 50.07 0.00e+00 1701.00
IUUC-Ggo-045583 Gorilla gorilla 30.05 2.00e-20 95.10
IUUC-Hsa-046343 Homo sapiens 30.05 2.00e-20 94.70
IUUC-Hvu-047707 Hordeum vulgare 42.40 0.00e+00 915.00
IUUC-Itr-048464 Ictidomys tridecemlineatus 28.65 1.00e-23 105.00
IUUC-Kpa-049088 Komagataella pastoris 20.94 4.00e-13 70.90
IUUC-Lch-050205 Latimeria chalumnae 44.20 6.00e-26 113.00
IUUC-Lpe-051516 Leersia perrieri 41.25 0.00e+00 1341.00
IUUC-Loc-052818 Lepisosteus oculatus 28.15 1.00e-25 112.00
IUUC-Lma-053059 Leptosphaeria maculans 26.77 7.00e-19 90.50
IUUC-Laf-054142 Loxodonta africana 31.63 2.00e-19 91.70
IUUC-Mcc-055677 Macaca mulatta 24.85 1.00e-21 99.00
IUUC-Meu-056858 Macropus eugenii 43.40 2.00e-15 78.20
IUUC-Mor-057051 Magnaporthe oryzae 24.40 1.00e-16 83.20
IUUC-Mpo-057372 Magnaporthe poae 35.77 2.00e-15 78.20
IUUC-Mtr-058538 Medicago truncatula 49.76 0.00e+00 1689.00
IUUC-Mla-058963 Melampsora laricipopulina 26.63 2.00e-13 71.60
IUUC-Mga-059698 Meleagris gallopavo 23.83 2.00e-24 108.00
IUUC-Mvi-060535 Microbotryum violaceum 25.73 1.00e-14 76.30
IUUC-Mmr-060901 Microcebus murinus 29.11 3.00e-21 97.40
IUUC-Mdo-062014 Monodelphis domestica 24.30 1.00e-24 109.00
IUUC-Mmu-063699 Mus musculus 30.05 2.00e-20 95.10
IUUC-Mac-064773 Musa acuminata 43.29 0.00e+00 1308.00
IUUC-Mpu-066153 Mustela putorius furo 30.05 2.00e-20 95.50
IUUC-Mlu-068151 Myotis lucifugus 28.50 4.00e-19 90.50
IUUC-Nfi-068403 Neosartorya fischeri 28.63 2.00e-17 85.50
IUUC-Ncr-068864 Neurospora crassa 34.91 7.00e-15 77.00
IUUC-Nle-069529 Nomascus leucogenys 30.05 3.00e-20 94.70
IUUC-Opr-071107 Ochotona princeps 23.93 7.00e-18 86.70
IUUC-Ont-072189 Oreochromis niloticus 32.00 6.00e-23 103.00
IUUC-Oan-072893 Ornithorhynchus anatinus 27.23 7.00e-19 89.70
IUUC-Ocu-074082 Oryctolagus cuniculus 24.34 3.00e-25 110.00
IUUC-Oba-075295 Oryza barthii 39.26 0.00e+00 1130.00
IUUC-Obr-076117 Oryza brachyantha 42.04 0.00e+00 1316.00
IUUC-Ogl-077571 Oryza glaberrima 40.52 0.00e+00 1216.00
IUUC-Ogu-078497 Oryza glumaepatula 39.51 0.00e+00 1145.00
IUUC-Oin-079343 Oryza indica 38.46 0.00e+00 1079.00
IUUC-Olo-081056 Oryza longistaminata 39.93 0.00e+00 1147.00
IUUC-Ome-081738 Oryza meridionalis 38.17 0.00e+00 1051.00
IUUC-Oni-083099 Oryza nivara 39.26 0.00e+00 1133.00
IUUC-Opu-083202 Oryza punctata 42.60 0.00e+00 884.00
IUUC-Oru-084471 Oryza rufipogon 39.09 0.00e+00 1125.00
IUUC-Osa-085336 Oryza sativa 39.83 6.00e-157 547.00
IUUC-Ola-087460 Oryzias latipes 29.24 2.00e-27 118.00
IUUC-Olu-087635 Ostreococcus lucimarinus 28.89 9.20e-02 30.40
IUUC-Oga-088432 Otolemur garnettii 24.67 7.00e-26 113.00
IUUC-Oar-090206 Ovis aries 23.65 2.00e-23 105.00
IUUC-Ptr-091180 Pan troglodytes 30.05 2.00e-20 94.70
IUUC-Pan-092375 Papio anubis 23.81 1.00e-23 105.00
IUUC-Psi-093049 Pelodiscus sinensis 23.07 6.00e-23 103.00
IUUC-Pma-094152 Petromyzon marinus 28.80 2.00e-16 80.90
IUUC-Pno-094877 Phaeosphaeria nodorum 27.64 3.00e-19 91.70
IUUC-Ppa-095715 Physcomitrella patens 40.80 9.00e-104 372.00
IUUC-Pfo-096524 Poecilia formosa 29.35 3.00e-24 107.00
IUUC-Pab-097989 Pongo abelii 30.05 3.00e-20 94.40
IUUC-Pop-099496 Populus trichocarpa 47.62 0.00e+00 1260.00
IUUC-Pca-101009 Procavia capensis 41.30 1.00e-23 105.00
IUUC-Ppe-101802 Prunus persica 52.40 0.00e+00 1635.00
IUUC-Pva-102538 Pteropus vampyrus 30.52 2.00e-21 98.60
IUUC-Pgr-103372 Puccinia graminis 33.10 2.00e-15 79.00
IUUC-Ptt-103878 Puccinia triticina 26.60 1.00e-09 58.90
IUUC-Pte-104174 Pyrenophora teres 30.17 2.00e-21 98.20
IUUC-Pyt-104431 Pyrenophora triticirepentis 28.46 9.00e-21 96.70
IUUC-Rno-105567 Rattus norvegicus 30.05 3.00e-20 94.70
IUUC-Sce-106272 Saccharomyces cerevisiae 37.93 9.00e-10 59.70
IUUC-Sha-106980 Sarcophilus harrisii 24.26 7.00e-27 116.00
IUUC-Sja-107980 Schizosaccharomyces japonicus 27.73 3.00e-17 84.70
IUUC-Spo-108183 Schizosaccharomyces pombe 27.07 4.00e-19 90.90
IUUC-Smo-108719 Selaginella moellendorffii 37.14 0.00e+00 635.00
IUUC-Sit-110716 Setaria italica 42.47 0.00e+00 1372.00
IUUC-Sly-111286 Solanum lycopersicum 48.16 0.00e+00 1654.00
IUUC-Sar-113332 Sorex araneus 31.46 5.00e-25 110.00
IUUC-Sbi-114577 Sorghum bicolor 42.09 0.00e+00 905.00
IUUC-Sre-115045 Sporisorium reilianum 33.33 2.00e-14 75.10
IUUC-Ssc-115525 Sus scrofa 31.92 5.00e-20 93.60
IUUC-Tgu-116943 Taeniopygia guttata 24.38 4.00e-25 110.00
IUUC-Tru-117673 Takifugu rubripes 31.84 3.00e-24 107.00
IUUC-Tsy-119032 Tarsius syrichta 30.05 2.00e-20 95.50
IUUC-Tni-119987 Tetraodon nigroviridis 32.34 8.00e-24 106.00
IUUC-Tca-121077 Theobroma cacao 54.01 0.00e+00 1866.00
IUUC-Tre-122137 Trichoderma reesei 31.88 1.00e-15 79.70
IUUC-Tvi-122272 Trichoderma virens 24.60 1.00e-16 82.80
IUUC-Tae-125358 Triticum aestivum 42.48 0.00e+00 1318.00
IUUC-Tur-126562 Triticum urartu 41.29 0.00e+00 802.00
IUUC-Tme-127156 Tuber melanosporum 24.63 3.00e-18 88.20
IUUC-Tbe-127964 Tupaia belangeri 41.30 2.00e-23 103.00
IUUC-Ttr-128253 Tursiops truncatus 32.39 2.00e-20 95.10
IUUC-Uma-129344 Ustilago maydis 43.04 3.00e-16 81.60
IUUC-Vda-129778 Verticillium dahliae 31.71 2.00e-14 75.50
IUUC-Vpa-130540 Vicugna pacos 32.86 4.00e-22 100.00
IUUC-Vvi-131290 Vitis vinifera 48.77 0.00e+00 1373.00
IUUC-Xtr-132690 Xenopus tropicalis 25.04 5.00e-24 107.00
IUUC-Xma-133748 Xiphophorus maculatus 31.75 2.00e-23 105.00
IUUC-Yli-134662 Yarrowia lipolytica 32.32 2.00e-09 58.50
IUUC-Zma-135553 Zea mays 39.85 0.00e+00 1196.00
Created Date 25-Jun-2017

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