iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088867

Ensembl Protein ID

ENSOGAP00000009828.2

UniProt Accession

H0X3U6; H0X3U6_OTOGA

Genbank Protein ID

ENSOGAP00000009828

Protein Name

E3 ubiquitin-protein ligase parkin

Genbank Nucleotide ID

AAQR03090138

Gene Name

PARK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000010979.2	ENSOGAT00000010983.2	ENSOGAP00000009828.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.00e-23	83.1	1	72

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 3    ltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkks 74
           ++v++++++ f++ev++d+++ +lKe +ak++gvp++q+++I+aGk+L++d+t+++++++++s+vh+v+k+ 
   Q: 1    VFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQKPW 72
           789**99999**********************************************************9975 PP

Organism

Otolemur garnettii

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

VFVRFNSSHG FPVEVDSDTS IFQLKEVVAK RQGVPADQLR VIFAGKELRN DWTVQNCDLD 60
QQSIVHIVQK PWRKGHEMAA TGGDGPRSTT GGPGREPQSL TRVDLSSSLL PADSVGLAVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTTTGTCA GGTTCAACTC CAGCCATGGT TTCCCAGTGG AGGTCGATTC TGACACCAGC 60
ATCTTCCAGC TCAAGGAGGT GGTTGCTAAG CGACAGGGGG TTCCAGCTGA CCAGTTGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0071797--C:LUBAC complex
GO:0005739--C:mitochondrion
GO:0099073--C:mitochondrion-derived vesicle
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0043234--C:protein complex
GO:0046872--F:metal ion binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008344--P:adult locomotory behavior
GO:0070842--P:aggresome assembly
GO:0097237--P:cellular response to toxic substance
GO:0042417--P:dopamine metabolic process
GO:0051583--P:dopamine uptake involved in synaptic transmission
GO:0010994--P:free ubiquitin chain polymerization
GO:0007612--P:learning
GO:0000423--P:macromitophagy
GO:0099074--P:mitochondrion to lysosome transport
GO:0044828--P:negative regulation by host of viral genome replication
GO:0032232--P:negative regulation of actin filament bundle assembly
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:1903382--P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542--P:negative regulation of exosomal secretion
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion
GO:1905366--P:negative regulation of intralumenal vesicle formation
GO:1902254--P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1903377--P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1902283--P:negative regulation of primary amine oxidase activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:1904049--P:negative regulation of spontaneous neurotransmitter secretion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042415--P:norepinephrine metabolic process
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:0043388--P:positive regulation of DNA binding
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010636--P:positive regulation of mitochondrial fusion
GO:0051582--P:positive regulation of neurotransmitter uptake
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:1902530--P:positive regulation of protein linear polyubiquitination
GO:1905477--P:positive regulation of protein localization to membrane
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0050821--P:protein stabilization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042053--P:regulation of dopamine metabolic process
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0034976--P:response to endoplasmic reticulum stress
GO:0001964--P:startle response
GO:0035249--P:synaptic transmission, glutamatergic

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	82.64	1.00e-141	495.00
IUUC-Apl-003304	Anas platyrhynchos	77.44	2.00e-159	554.00
IUUC-Aca-004908	Anolis carolinensis	78.70	2.00e-49	186.00
IUUC-Ame-011856	Astyanax mexicanus	62.93	4.00e-171	594.00
IUUC-Bta-013014	Bos taurus	84.31	0.00e+00	688.00
IUUC-Cel-018687	Caenorhabditis elegans	28.41	1.00e-45	177.00
IUUC-Cja-019274	Callithrix jacchus	87.85	4.00e-151	526.00
IUUC-Cfa-020461	Canis familiaris	81.31	5.00e-140	490.00
IUUC-Cpo-022251	Cavia porcellus	84.38	7.00e-145	506.00
IUUC-Csa-023112	Chlorocebus sabaeus	87.50	3.00e-143	500.00
IUUC-Cho-024504	Choloepus hoffmanni	61.90	5.00e-155	540.00
IUUC-Dre-028202	Danio rerio	61.85	9.00e-158	549.00
IUUC-Dno-028946	Dasypus novemcinctus	70.48	6.00e-41	158.00
IUUC-Dor-030508	Dipodomys ordii	73.26	2.00e-141	495.00
IUUC-Dme-031980	Drosophila melanogaster	42.77	1.00e-105	376.00
IUUC-Ete-032281	Echinops telfairi	64.81	3.00e-86	311.00
IUUC-Eca-033228	Equus caballus	82.01	4.00e-141	493.00
IUUC-Fca-036045	Felis catus	61.90	7.00e-22	94.70
IUUC-Fal-037507	Ficedula albicollis	72.75	0.00e+00	705.00
IUUC-Gmo-038744	Gadus morhua	59.65	4.00e-95	341.00
IUUC-Gga-040353	Gallus gallus	72.20	0.00e+00	684.00
IUUC-Gac-042519	Gasterosteus aculeatus	49.15	4.00e-128	451.00
IUUC-Hsa-046016	Homo sapiens	89.20	0.00e+00	842.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	83.37	0.00e+00	763.00
IUUC-Loc-052389	Lepisosteus oculatus	67.74	5.00e-175	607.00
IUUC-Laf-053412	Loxodonta africana	66.67	9.00e-29	117.00
IUUC-Mcc-054933	Macaca mulatta	89.20	0.00e+00	837.00
IUUC-Meu-055963	Macropus eugenii	60.78	8.00e-133	466.00
IUUC-Mga-059626	Meleagris gallopavo	76.00	8.00e-31	124.00
IUUC-Mmr-061566	Microcebus murinus	93.18	7.00e-101	359.00
IUUC-Mdo-061952	Monodelphis domestica	88.14	3.00e-30	122.00
IUUC-Mmu-063561	Mus musculus	83.59	0.00e+00	812.00
IUUC-Mpu-065799	Mustela putorius furo	81.66	1.00e-136	479.00
IUUC-Mlu-068134	Myotis lucifugus	78.06	6.00e-156	543.00
IUUC-Nle-070078	Nomascus leucogenys	86.62	8.00e-155	539.00
IUUC-Opr-070541	Ochotona princeps	83.77	0.00e+00	753.00
IUUC-Ont-071743	Oreochromis niloticus	53.78	1.00e-129	456.00
IUUC-Oan-073700	Ornithorhynchus anatinus	88.89	3.00e-25	105.00
IUUC-Ola-086426	Oryzias latipes	63.22	8.00e-61	225.00
IUUC-Oar-089365	Ovis aries	82.45	5.00e-174	603.00
IUUC-Ptr-091371	Pan troglodytes	89.20	0.00e+00	839.00
IUUC-Pan-092443	Papio anubis	87.50	4.00e-150	523.00
IUUC-Psi-093851	Pelodiscus sinensis	64.98	1.00e-91	328.00
IUUC-Pfo-097194	Poecilia formosa	51.73	2.00e-130	459.00
IUUC-Pab-097999	Pongo abelii	73.35	1.00e-140	492.00
IUUC-Pca-100410	Procavia capensis	77.88	0.00e+00	659.00
IUUC-Pva-102300	Pteropus vampyrus	74.03	0.00e+00	662.00
IUUC-Rno-105556	Rattus norvegicus	83.33	2.00e-142	498.00
IUUC-Sha-106992	Sarcophilus harrisii	94.44	2.00e-26	110.00
IUUC-Sar-113121	Sorex araneus	89.66	2.00e-59	223.00
IUUC-Ssc-116435	Sus scrofa	80.20	2.00e-135	474.00
IUUC-Tgu-117489	Taeniopygia guttata	71.86	0.00e+00	701.00
IUUC-Tru-117927	Takifugu rubripes	52.25	1.00e-139	489.00
IUUC-Tsy-119372	Tarsius syrichta	90.21	5.00e-174	603.00
IUUC-Tni-120043	Tetraodon nigroviridis	50.83	1.00e-128	452.00
IUUC-Tvi-122588	Trichoderma virens	40.00	3.00e-09	57.40
IUUC-Tbe-127539	Tupaia belangeri	77.27	0.00e+00	702.00
IUUC-Ttr-129149	Tursiops truncatus	80.99	0.00e+00	780.00
IUUC-Vpa-130439	Vicugna pacos	62.37	8.00e-159	553.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence