iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-086413

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

BAAF04047500

Gene Name

usp49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000000269.1	ENSORLT00000000330.1	ENSORLP00000000330.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	6.00e-97	325.1	202	613

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenp........................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+    +++e l+++n+                                           
   Q: 202  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlcETEELLAKTNHsppvtgavvgggnallserplgatdktgcwnvpigqkesappp 290
           7******************************999744444444444777********************************99999999 PP
   S: 43   ...............kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpke 116
                            +k +l+++l++lf+ +w+++++ vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         
   Q: 291  sksaelvqpkeprcsARQKMSLCHELHTLFRVMWSGRWSLVSPFAMLHSVWNLIPAFRGYDQQDAQEFLCELLDKVQQEL--------- 370
           99999999988888888888************************************************************......... PP
   S: 117  eeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...........slqdcLesf 194
           ++e+++++    + ++k  k+  ++++++F+gql sq++cl+c+++s++ epf+dlsl++p++ +++ +           +l+++L++f
   Q: 371  DTEGSKRRIVIPITKRKLSKQVLKVLNTIFHGQLLSQVTCLSCKHKSNTVEPFWDLSLEFPERYHSADKgsastafhrscTLTEMLSKF 459
           7888999999999**************************************************9988889******************* PP
   S: 195  tkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekq 272
           t+ e leg+  y c++c+++++           a k+l + +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c++++  +
   Q: 460  TEMEALEGRI-YACNHCNRRRRksshkplvlseACKQLLIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVAFDQVLKIQPYCCTDSGHS 546
           *******965.*******999899999999999***********************997.8889*******************977665 PP
   S: 273  ke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
            +   + Y+L+avv+H+G +++sGHY+ay+ n++g+ W++++Ds+ ++++ eev++   ++aY+lfY++r
   Q: 547  VHrgGYVYDLSAVVMHHGkGFGSGHYTAYCFNTEGGfWVHCNDSEMRVCSVEEVCN---TQAYILFYTQR 613
           446799**************************9999********************...********985 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MDRCKHVGRL RLGQDHSILN PQKWRCVECS TTDSVWACLK CSHVACGRFM EEHSLKHFQE 60
SQHPLAMEVR ELDVFCFACV AVRHRRKALL GKMLQTWIGK HQEVQSRRRE KLEEARRQKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCGCT GTAAGCACGT GGGACGCCTG CGTCTGGGTC AGGACCATTC CATCCTCAAT 60
CCGCAGAAAT GGCGCTGTGT GGAATGCAGC ACGACAGACT CGGTGTGGGC CTGCCTGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	59.49	0.00e+00	703.00
IUUC-Apl-003658	Anas platyrhynchos	65.34	0.00e+00	662.00
IUUC-Aca-005278	Anolis carolinensis	57.45	0.00e+00	688.00
IUUC-Ame-011403	Astyanax mexicanus	74.47	0.00e+00	646.00
IUUC-Bta-012911	Bos taurus	68.94	1.00e-170	593.00
IUUC-Cja-019171	Callithrix jacchus	60.66	5.00e-180	624.00
IUUC-Cfa-020408	Canis familiaris	71.12	4.00e-173	601.00
IUUC-Cpo-022233	Cavia porcellus	70.64	8.00e-173	600.00
IUUC-Csa-024272	Chlorocebus sabaeus	64.13	3.00e-139	488.00
IUUC-Cho-025051	Choloepus hoffmanni	64.35	1.00e-128	453.00
IUUC-Cin-025587	Ciona intestinalis	47.02	8.00e-106	378.00
IUUC-Csv-025814	Ciona savignyi	49.65	2.00e-106	379.00
IUUC-Dre-027577	Danio rerio	65.39	0.00e+00	798.00
IUUC-Dno-029856	Dasypus novemcinctus	69.98	1.00e-172	600.00
IUUC-Ete-032627	Echinops telfairi	55.32	1.00e-164	573.00
IUUC-Eca-033851	Equus caballus	55.43	5.00e-155	541.00
IUUC-Eeu-035225	Erinaceus europaeus	50.18	3.00e-147	515.00
IUUC-Fca-036288	Felis catus	54.45	2.00e-164	572.00
IUUC-Fal-037290	Ficedula albicollis	69.06	9.00e-179	620.00
IUUC-Gmo-039249	Gadus morhua	88.71	2.00e-169	589.00
IUUC-Gga-040383	Gallus gallus	65.70	0.00e+00	632.00
IUUC-Gac-042595	Gasterosteus aculeatus	77.99	0.00e+00	1005.00
IUUC-Ggo-044979	Gorilla gorilla	65.85	0.00e+00	628.00
IUUC-Hsa-046743	Homo sapiens	65.85	0.00e+00	627.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	60.58	7.00e-177	613.00
IUUC-Lch-050294	Latimeria chalumnae	65.76	0.00e+00	644.00
IUUC-Loc-051961	Lepisosteus oculatus	76.06	0.00e+00	716.00
IUUC-Laf-054491	Loxodonta africana	54.38	3.00e-161	561.00
IUUC-Mcc-055048	Macaca mulatta	66.05	0.00e+00	631.00
IUUC-Meu-055971	Macropus eugenii	44.26	4.00e-85	308.00
IUUC-Mga-059720	Meleagris gallopavo	69.04	0.00e+00	637.00
IUUC-Mmr-060885	Microcebus murinus	55.31	4.00e-166	578.00
IUUC-Mdo-062073	Monodelphis domestica	60.52	0.00e+00	770.00
IUUC-Mmu-064095	Mus musculus	64.96	2.00e-177	615.00
IUUC-Mpu-066318	Mustela putorius furo	71.26	1.00e-176	613.00
IUUC-Mlu-067090	Myotis lucifugus	69.98	6.00e-174	604.00
IUUC-Nle-069486	Nomascus leucogenys	66.26	0.00e+00	632.00
IUUC-Opr-070563	Ochotona princeps	60.29	2.00e-175	608.00
IUUC-Ont-072103	Oreochromis niloticus	79.97	0.00e+00	1044.00
IUUC-Oan-073245	Ornithorhynchus anatinus	76.31	4.00e-145	507.00
IUUC-Ocu-074836	Oryctolagus cuniculus	54.50	3.00e-166	578.00
IUUC-Oga-088862	Otolemur garnettii	60.92	1.00e-174	606.00
IUUC-Oar-089462	Ovis aries	68.26	2.00e-163	568.00
IUUC-Ptr-091525	Pan troglodytes	64.69	3.00e-162	565.00
IUUC-Pan-092363	Papio anubis	66.05	0.00e+00	628.00
IUUC-Psi-093353	Pelodiscus sinensis	66.06	0.00e+00	672.00
IUUC-Pma-094155	Petromyzon marinus	68.60	4.00e-78	284.00
IUUC-Pfo-096413	Poecilia formosa	79.94	0.00e+00	1040.00
IUUC-Pab-098592	Pongo abelii	64.37	2.00e-139	489.00
IUUC-Pca-100449	Procavia capensis	59.82	2.00e-177	615.00
IUUC-Pva-102868	Pteropus vampyrus	71.43	2.00e-176	612.00
IUUC-Rno-105190	Rattus norvegicus	65.16	0.00e+00	629.00
IUUC-Sha-107337	Sarcophilus harrisii	59.74	0.00e+00	767.00
IUUC-Sar-113561	Sorex araneus	79.71	1.00e-65	243.00
IUUC-Ssc-115735	Sus scrofa	70.95	3.00e-174	604.00
IUUC-Tgu-117025	Taeniopygia guttata	62.90	9.00e-157	546.00
IUUC-Tru-117585	Takifugu rubripes	77.86	0.00e+00	974.00
IUUC-Tsy-118814	Tarsius syrichta	65.58	3.00e-180	625.00
IUUC-Tni-120600	Tetraodon nigroviridis	80.65	0.00e+00	749.00
IUUC-Tbe-128084	Tupaia belangeri	53.66	1.00e-159	556.00
IUUC-Ttr-128928	Tursiops truncatus	55.13	3.00e-167	582.00
IUUC-Vpa-130706	Vicugna pacos	54.31	4.00e-166	578.00
IUUC-Xtr-132090	Xenopus tropicalis	65.52	0.00e+00	648.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence