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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-106039
Ensembl Protein ID ENSRNOP00000024021.4
UniProt Accession D3ZDI6; MYLIP_RAT
Protein Name E3 ubiquitin-protein ligase MYLIP; Inducible degrader of the LDL-receptor; Myosin regulatory light chain interacting protein; RING-type E3 ubiquitin transferase MYLIP
Gene Name Mylip
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000017579.6 ENSRNOT00000024021.6 ENSRNOP00000024021.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 96.40 0.00e+00 844.00 IUUC-Hsa-046869
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Protein Sequence
(Fasta)
MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN 60
RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KESLLAGHLQ CSPEQAVELS 120
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Protein Fasta Sequence


>IUUC-Rno-106039|E3,RING|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
CAGTGGGGCT GTCGGAGCGG CGCGGCCGTG TAGCTCCCGG GAACTGGCTG TCGTGGGGGG 60
TGGCGGGGAC GCGAGTGGCG GCTGCGTGGG GTGCAGGGCG GGTGACCGCA CGGCTGCACC 120
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Nucleotide Fasta Sequence


>IUUC-Rno-106039|E3,RING|Rattus norvegicus
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Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0408--Iron
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR019749--Band_41_domain
IPR001370--BIR_rpt
IPR000798--Ez/rad/moesin-like
IPR014352--FERM/acyl-CoA-bd_prot_3-hlx
IPR019748--FERM_central
IPR000299--FERM_domain
IPR018979--FERM_N
IPR018980--FERM_PH-like_C
IPR011993--PH_dom-like
IPR029071--Ubiquitin-rel_dom
IPR001841--Znf_RING
PROSITE

PS50057--FERM_3
PS50089--ZF_RING_2
Pfam

PF09380--FERM_C
PF00373--FERM_M
PF09379--FERM_N
PRINTS

PR00935--BAND41
PR00661--ERMFAMILY
SMART

SM00295--B41
SM01196--FERM_C
Gene Ontology

GO:0005737--C:cytoplasm
GO:0019898--C:extrinsic component of membrane
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0042632--P:cholesterol homeostasis
GO:0010989--P:negative regulation of low-density lipoprotein particle clearance
GO:0007399--P:nervous system development
GO:0045732--P:positive regulation of protein catabolic process
GO:0031648--P:protein destabilization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032803--P:regulation of low-density lipoprotein particle receptor catabolic process
KEGG rno:306825
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001425 Ailuropoda melanoleuca 94.47 0.00e+00 786.00
IUUC-Apl-003704 Anas platyrhynchos 89.74 0.00e+00 763.00
IUUC-Aca-004645 Anolis carolinensis 88.54 0.00e+00 754.00
IUUC-Ame-011401 Astyanax mexicanus 74.10 0.00e+00 650.00
IUUC-Bta-012752 Bos taurus 93.16 0.00e+00 699.00
IUUC-Cja-019734 Callithrix jacchus 94.83 0.00e+00 839.00
IUUC-Cfa-020145 Canis familiaris 94.47 0.00e+00 714.00
IUUC-Cpo-021436 Cavia porcellus 95.00 0.00e+00 714.00
IUUC-Csa-024248 Chlorocebus sabaeus 95.51 0.00e+00 844.00
IUUC-Cho-024528 Choloepus hoffmanni 82.92 0.00e+00 672.00
IUUC-Cin-025748 Ciona intestinalis 36.33 3.00e-47 181.00
IUUC-Csv-025837 Ciona savignyi 38.85 4.00e-91 328.00
IUUC-Dre-027847 Danio rerio 74.55 0.00e+00 657.00
IUUC-Dno-029860 Dasypus novemcinctus 92.89 0.00e+00 670.00
IUUC-Dor-030664 Dipodomys ordii 82.70 0.00e+00 683.00
IUUC-Dse-031509 Dothistroma septosporum 45.10 8.00e-10 59.30
IUUC-Dme-031990 Drosophila melanogaster 29.57 6.00e-34 139.00
IUUC-Ete-032496 Echinops telfairi 75.54 2.00e-144 505.00
IUUC-Eca-033674 Equus caballus 93.76 0.00e+00 842.00
IUUC-Eeu-035048 Erinaceus europaeus 86.07 0.00e+00 755.00
IUUC-Fca-036547 Felis catus 94.95 0.00e+00 789.00
IUUC-Fal-037504 Ficedula albicollis 90.41 0.00e+00 751.00
IUUC-Fox-037905 Fusarium oxysporum 27.85 1.30e-02 32.30
IUUC-Gmo-038660 Gadus morhua 74.71 1.00e-153 536.00
IUUC-Gga-040123 Gallus gallus 90.56 0.00e+00 800.00
IUUC-Gac-042073 Gasterosteus aculeatus 71.97 0.00e+00 630.00
IUUC-Ggo-045387 Gorilla gorilla 95.96 0.00e+00 848.00
IUUC-Hsa-046869 Homo sapiens 96.40 0.00e+00 856.00
IUUC-Itr-047917 Ictidomys tridecemlineatus 94.83 0.00e+00 829.00
IUUC-Lch-049990 Latimeria chalumnae 81.57 0.00e+00 764.00
IUUC-Lpe-051271 Leersia perrieri 39.62 1.00e-07 54.30
IUUC-Loc-051908 Lepisosteus oculatus 75.89 0.00e+00 661.00
IUUC-Lma-053223 Leptosphaeria maculans 52.50 2.00e-08 55.80
IUUC-Laf-053915 Loxodonta africana 93.26 0.00e+00 826.00
IUUC-Mcc-054865 Macaca mulatta 95.28 0.00e+00 842.00
IUUC-Meu-056826 Macropus eugenii 84.42 2.00e-73 270.00
IUUC-Mga-059827 Meleagris gallopavo 89.70 0.00e+00 720.00
IUUC-Mmr-060734 Microcebus murinus 95.51 0.00e+00 845.00
IUUC-Mdo-062988 Monodelphis domestica 93.26 0.00e+00 834.00
IUUC-Mmu-064415 Mus musculus 99.33 0.00e+00 826.00
IUUC-Mpu-066118 Mustela putorius furo 94.47 0.00e+00 711.00
IUUC-Mlu-067131 Myotis lucifugus 93.93 0.00e+00 804.00
IUUC-Nle-070112 Nomascus leucogenys 95.73 0.00e+00 844.00
IUUC-Opr-071193 Ochotona princeps 92.48 0.00e+00 790.00
IUUC-Ont-072635 Oreochromis niloticus 74.05 0.00e+00 648.00
IUUC-Oan-073266 Ornithorhynchus anatinus 89.42 0.00e+00 746.00
IUUC-Ocu-074903 Oryctolagus cuniculus 92.58 0.00e+00 816.00
IUUC-Ola-087533 Oryzias latipes 71.36 5.00e-176 610.00
IUUC-Oga-087979 Otolemur garnettii 95.96 0.00e+00 849.00
IUUC-Oar-089747 Ovis aries 93.27 0.00e+00 771.00
IUUC-Ptr-090732 Pan troglodytes 96.18 0.00e+00 850.00
IUUC-Pan-092032 Papio anubis 95.51 0.00e+00 844.00
IUUC-Psi-093296 Pelodiscus sinensis 89.74 0.00e+00 761.00
IUUC-Pma-094351 Petromyzon marinus 48.60 6.00e-32 129.00
IUUC-Pfo-097183 Poecilia formosa 73.29 1.00e-175 609.00
IUUC-Pab-098177 Pongo abelii 95.73 0.00e+00 846.00
IUUC-Pca-100734 Procavia capensis 91.69 0.00e+00 818.00
IUUC-Ppe-101272 Prunus persica 44.83 3.00e-10 59.70
IUUC-Pva-102778 Pteropus vampyrus 95.19 0.00e+00 793.00
IUUC-Sha-106869 Sarcophilus harrisii 92.79 0.00e+00 774.00
IUUC-Sar-113587 Sorex araneus 64.66 9.00e-141 493.00
IUUC-Ssc-116212 Sus scrofa 94.38 0.00e+00 832.00
IUUC-Tgu-116871 Taeniopygia guttata 90.17 0.00e+00 749.00
IUUC-Tru-117925 Takifugu rubripes 73.26 0.00e+00 666.00
IUUC-Tsy-118815 Tarsius syrichta 93.51 0.00e+00 766.00
IUUC-Tni-120007 Tetraodon nigroviridis 73.42 0.00e+00 638.00
IUUC-Tbe-127381 Tupaia belangeri 92.05 0.00e+00 635.00
IUUC-Ttr-129025 Tursiops truncatus 92.24 7.00e-115 407.00
IUUC-Vpa-130164 Vicugna pacos 77.30 1.00e-175 608.00
IUUC-Xtr-132800 Xenopus tropicalis 82.70 0.00e+00 732.00
Created Date 25-Jun-2017

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