iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010697

Ensembl Protein ID

ENSAMXP00000019650.1

UniProt Accession

W5LII8; W5LII8_ASTMX

Genbank Protein ID

ENSAMXP00000019650

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

APWO01090963

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000019073.1	ENSAMXT00000019650.1	ENSAMXP00000019650.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-96	324.2	397	659

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 129  e..............aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.................. 185
                           ++k ++k++s+isd+F+g++ s+++cl+cd+vs++ e+f+d+slp+pgke+ +k+                  
   Q: 397  FmfsclflsvtsfapPKSKRQRKHRSVISDVFDGTIVSSVQCLTCDRVSVTLENFQDISLPIPGKEDLAKLhsashqtalvkagscgea 485
           0555555555555555678899999*****************************************99888****************** PP
   S: 186  ...........................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
                                      +lqdcL++f++++el+g+n+y+cekckk+++ +k +k+++lPe+L++hLkRf  ++e ++++
   Q: 486  yapqgwiafvmeyiksalfswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQSLPEILCIHLKRF--RHELMFST 572
           *******************************************************************************..9999**** PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlf 334
           ki+++v+fpl  Ldl+pf+++++++q   ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e+ v++   ++aYvlf
   Q: 573  KISTHVSFPLDgLDLQPFLAKDSSAQ--ITTYDLLSVICHHGTASSGHYIAYCRNDLNQlWYEFDDQSVTEVSESCVQN---AEAYVLF 656
           *********************88877..9**************************98889*******************...******* PP
   S: 335  Ykr 337
           Yk+
   Q: 657  YKK 659
           *98 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

EMTNTMNVLW FQGQCQDCKV GGPNLWACLE NGCSYVGCGE SHADHSTVHS QETRHNLTVN 60
LTTLRVWCYA CAKEVFLDRK LGPPNLLPSA VKPISPLQTP SQEPAAPGSP TSLRVPPAGA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAATGACTA ATACAATGAA TGTGTTGTGG TTTCAGGGCC AGTGCCAGGA CTGCAAAGTC 60
GGGGGACCAA ACCTCTGGGC CTGTCTGGAA GTAAGTGAAC TCATATTAGC ATTATTTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004713	Anolis carolinensis	81.33	0.00e+00	816.00
IUUC-Cpo-021910	Cavia porcellus	69.98	0.00e+00	717.00
IUUC-Csv-025889	Ciona savignyi	42.17	1.00e-35	141.00
IUUC-Eeu-035357	Erinaceus europaeus	68.97	0.00e+00	628.00
IUUC-Opr-070606	Ochotona princeps	80.79	0.00e+00	806.00
IUUC-Ocu-074457	Oryctolagus cuniculus	63.33	0.00e+00	1092.00
IUUC-Pca-100598	Procavia capensis	74.78	0.00e+00	703.00
IUUC-Rno-104894	Rattus norvegicus	81.82	0.00e+00	851.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence