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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046385
Ensembl Protein ID ENSP00000225941.1
UniProt Accession Q9P2A4; C9IZN8; Q9H0P6; ABI3_HUMAN
Genbank Protein ID BAA90667.1; CAB66644.1; AAH07780.1
Protein Name ABI gene family member 3; New molecule including SH3
Genbank Nucleotide ID AB037886; AL136709; AC004797
Gene Name ABI3; NESH
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000108798.8 ENST00000225941.5 ENSP00000225941.1
ENSG00000108798.8 ENST00000419580.6 ENSP00000406651.2
ENSG00000108798.8 ENST00000573347.5 ENSP00000460776.1
ENSG00000108798.8 ENST00000571035.1 ENSP00000459171.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProt
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.10e-11 46.2 310 363
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           +ekv +ly+y++q+d+eL++ +G v+ v      + gW++g    ++  G+fP n+ve
   Q: 310  LEKVVTLYPYTSQKDNELSFSEGTVICVT--RRYSDGWCEG--VSSEGTGFFPGNYVE 363
           589*************************7..999*******..688899********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
 May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility.
Protein Sequence
(Fasta)
MAELQQLQEF EIPTGREALR GNHSALLRVA DYCEDNYVQA TDKRKALEET MAFTTQALAS 60
VAYQVGNLAG HTLRMLDLQG AALRQVEARV STLGQMVNMH MEKVARREIG TLATVQRLPP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046385|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCCTATCCAC CCTCCACTCC CCTGTCCCTT GGTGACTCAT CCCTGAGCTT CCCAAGGAAG 60
CCCCCACCCT CTGCCCTTTC CTCCCGCCTT CCATGAGTGG AAAATCCACC TCCGCCCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046385|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR028457--ABI
IPR028455--ABI3
IPR012849--Abl-interactor_HHR_dom
IPR001452--SH3_domain
PROSITE

PS50002--SH3
Pfam

PF07815--Abi_HHR
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005622--C:intracellular
GO:0030027--C:lamellipodium
GO:0016020--C:membrane
GO:0042802--F:identical protein binding
GO:0006928--P:movement of cell or subcellular component
GO:0030334--P:regulation of cell migration
KEGG hsa:51225
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002253 Ailuropoda melanoleuca 92.04 7.00e-107 380.00
IUUC-Apl-003887 Anas platyrhynchos 61.69 6.00e-46 178.00
IUUC-Aca-005073 Anolis carolinensis 55.88 1.00e-54 207.00
IUUC-Bta-012731 Bos taurus 95.02 6.00e-109 387.00
IUUC-Cja-019927 Callithrix jacchus 94.17 1.00e-109 389.00
IUUC-Cfa-021246 Canis familiaris 94.81 7.00e-75 274.00
IUUC-Csa-023170 Chlorocebus sabaeus 97.27 4.00e-151 527.00
IUUC-Dno-030080 Dasypus novemcinctus 96.65 1.00e-89 323.00
IUUC-Dor-030777 Dipodomys ordii 95.54 8.00e-102 363.00
IUUC-Ete-032324 Echinops telfairi 90.91 9.00e-80 290.00
IUUC-Eca-034219 Equus caballus 80.09 2.00e-86 312.00
IUUC-Eeu-034475 Erinaceus europaeus 85.89 2.00e-74 272.00
IUUC-Fca-036479 Felis catus 93.03 1.00e-97 349.00
IUUC-Ggo-045520 Gorilla gorilla 99.45 2.00e-154 538.00
IUUC-Itr-048846 Ictidomys tridecemlineatus 94.76 2.00e-115 409.00
IUUC-Laf-053905 Loxodonta africana 93.56 7.00e-108 384.00
IUUC-Mcc-055351 Macaca mulatta 97.54 1.00e-151 529.00
IUUC-Meu-056867 Macropus eugenii 79.78 1.00e-83 303.00
IUUC-Mga-060205 Meleagris gallopavo 59.14 1.00e-52 200.00
IUUC-Mmr-060684 Microcebus murinus 94.55 1.00e-101 363.00
IUUC-Mdo-062899 Monodelphis domestica 81.68 6.00e-95 340.00
IUUC-Mmu-063703 Mus musculus 90.21 7.00e-101 360.00
IUUC-Mpu-066022 Mustela putorius furo 94.54 1.00e-90 326.00
IUUC-Mlu-067886 Myotis lucifugus 93.56 5.00e-107 380.00
IUUC-Nle-069030 Nomascus leucogenys 98.09 2.00e-151 528.00
IUUC-Opr-070747 Ochotona princeps 92.54 6.00e-106 377.00
IUUC-Ocu-073874 Oryctolagus cuniculus 92.08 1.00e-97 349.00
IUUC-Oga-088294 Otolemur garnettii 90.39 2.00e-109 388.00
IUUC-Oar-089285 Ovis aries 96.75 8.00e-85 307.00
IUUC-Ptr-090972 Pan troglodytes 99.18 4.00e-154 537.00
IUUC-Pan-092463 Papio anubis 97.27 1.00e-142 499.00
IUUC-Pab-098655 Pongo abelii 98.63 7.00e-152 530.00
IUUC-Pca-100627 Procavia capensis 64.63 1.00e-64 240.00
IUUC-Pva-103217 Pteropus vampyrus 86.29 5.00e-75 274.00
IUUC-Rno-105415 Rattus norvegicus 91.24 1.00e-103 369.00
IUUC-Sha-107113 Sarcophilus harrisii 80.20 2.00e-93 336.00
IUUC-Ssc-115938 Sus scrofa 90.45 9.00e-95 340.00
Created Date 25-Jun-2017

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