iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090964

UUCD1 version

UUC-PaT-00904

Ensembl Protein ID

ENSPTRP00000051283.4

UniProt Accession

H2R875; H2R875_PANTR

Genbank Protein ID

JAA05906.1; JAA05907.1; JAA17620.1; JAA24851.1; JAA24852.1; JAA24853.1; JAA35128.1

Protein Name

Mdm4 p53 binding protein homolog

Genbank Nucleotide ID

AACZ03002252; GABC01005431; GABF01004525; GABD01008249; GABD01008248; GABD01008247; GABE01009611

Gene Name

MDM4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000001889.6	ENSPTRT00000058312.4	ENSPTRP00000051283.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	99.59	0.00e+00	898.00	IUUC-Hsa-046950

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK EVMHYLGQYI 60
MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD MLRKNLVTLA TATTDAAQTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGGGAGG CCGGAAGTTG CGGCTTCATT ACTCGCCATT TCAAAATGCT GCCGAGGCCC 60
TAGGACCTGT GACTGCCACC CCTCCCCCCA CCCGGGCTCG GCGGGGGAGC GACTCATGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR015458--MDM4
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2

Pfam

PF02201--SWIB
PF00641--zf-RanBP

Gene Ontology

GO:0005634--C:nucleus
GO:0008270--F:zinc ion binding
GO:0008283--P:cell proliferation
GO:0071456--P:cellular response to hypoxia
GO:0030330--P:DNA damage response, signal transduction by p53 class mediator
GO:0045023--P:G0 to G1 transition
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0042177--P:negative regulation of protein catabolic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0006461--P:protein complex assembly
GO:0050821--P:protein stabilization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001467	Ailuropoda melanoleuca	93.09	0.00e+00	806.00
IUUC-Apl-003800	Anas platyrhynchos	60.53	5.00e-155	540.00
IUUC-Aca-004608	Anolis carolinensis	57.43	1.00e-136	479.00
IUUC-Ame-010869	Astyanax mexicanus	46.45	2.00e-105	375.00
IUUC-Bta-013287	Bos taurus	90.22	0.00e+00	859.00
IUUC-Cja-019305	Callithrix jacchus	94.90	0.00e+00	853.00
IUUC-Cfa-020393	Canis familiaris	93.90	0.00e+00	830.00
IUUC-Cpo-022166	Cavia porcellus	89.27	0.00e+00	750.00
IUUC-Csa-023654	Chlorocebus sabaeus	98.37	0.00e+00	856.00
IUUC-Cho-024403	Choloepus hoffmanni	90.64	1.00e-129	455.00
IUUC-Cgl-026403	Colletotrichum gloeosporioides	32.56	1.50e+00	28.90
IUUC-Dre-027754	Danio rerio	49.01	1.00e-115	409.00
IUUC-Dno-029630	Dasypus novemcinctus	89.23	0.00e+00	821.00
IUUC-Dor-031064	Dipodomys ordii	69.45	0.00e+00	649.00
IUUC-Ete-032901	Echinops telfairi	79.07	0.00e+00	755.00
IUUC-Eca-034234	Equus caballus	94.91	0.00e+00	906.00
IUUC-Eeu-035015	Erinaceus europaeus	65.24	1.00e-158	552.00
IUUC-Fca-036587	Felis catus	93.48	0.00e+00	841.00
IUUC-Fal-036906	Ficedula albicollis	53.97	6.00e-138	483.00
IUUC-Gmo-038646	Gadus morhua	43.70	5.00e-95	341.00
IUUC-Gga-040124	Gallus gallus	59.71	5.00e-115	407.00
IUUC-Gac-042397	Gasterosteus aculeatus	46.03	3.00e-106	378.00
IUUC-Ggo-045505	Gorilla gorilla	99.59	0.00e+00	896.00
IUUC-Hsa-046950	Homo sapiens	99.59	0.00e+00	897.00
IUUC-Itr-048886	Ictidomys tridecemlineatus	91.04	0.00e+00	829.00
IUUC-Lch-050141	Latimeria chalumnae	54.29	2.00e-120	426.00
IUUC-Loc-051921	Lepisosteus oculatus	50.10	7.00e-115	407.00
IUUC-Laf-054281	Loxodonta africana	87.17	0.00e+00	781.00
IUUC-Mcc-055462	Macaca mulatta	94.50	0.00e+00	803.00
IUUC-Meu-056294	Macropus eugenii	70.59	3.00e-144	504.00
IUUC-Mga-059924	Meleagris gallopavo	60.65	3.00e-166	578.00
IUUC-Mmr-061428	Microcebus murinus	92.46	0.00e+00	867.00
IUUC-Mdo-062643	Monodelphis domestica	75.65	0.00e+00	716.00
IUUC-Mmu-063229	Mus musculus	83.71	0.00e+00	768.00
IUUC-Mpu-065782	Mustela putorius furo	91.48	0.00e+00	816.00
IUUC-Mlu-068105	Myotis lucifugus	81.50	0.00e+00	771.00
IUUC-Nle-069549	Nomascus leucogenys	99.59	0.00e+00	897.00
IUUC-Opr-070568	Ochotona princeps	90.11	0.00e+00	772.00
IUUC-Ont-072276	Oreochromis niloticus	47.00	7.00e-116	410.00
IUUC-Oan-072787	Ornithorhynchus anatinus	73.08	0.00e+00	647.00
IUUC-Ocu-074912	Oryctolagus cuniculus	90.22	0.00e+00	820.00
IUUC-Ola-087037	Oryzias latipes	44.51	2.00e-96	345.00
IUUC-Oga-088953	Otolemur garnettii	89.09	0.00e+00	814.00
IUUC-Oar-089202	Ovis aries	90.22	0.00e+00	863.00
IUUC-Pan-091975	Papio anubis	98.16	0.00e+00	872.00
IUUC-Psi-093558	Pelodiscus sinensis	60.49	3.00e-157	548.00
IUUC-Pfo-096454	Poecilia formosa	47.05	7.00e-109	387.00
IUUC-Pab-098123	Pongo abelii	98.98	0.00e+00	894.00
IUUC-Pca-101112	Procavia capensis	78.46	0.00e+00	720.00
IUUC-Pva-103098	Pteropus vampyrus	82.48	0.00e+00	768.00
IUUC-Rno-105930	Rattus norvegicus	83.74	0.00e+00	738.00
IUUC-Sha-107512	Sarcophilus harrisii	73.78	0.00e+00	639.00
IUUC-Sar-113584	Sorex araneus	83.10	0.00e+00	721.00
IUUC-Tgu-116766	Taeniopygia guttata	57.01	2.00e-101	361.00
IUUC-Tru-117829	Takifugu rubripes	47.33	3.00e-111	395.00
IUUC-Tsy-119268	Tarsius syrichta	78.41	0.00e+00	680.00
IUUC-Tni-120204	Tetraodon nigroviridis	46.56	2.00e-108	386.00
IUUC-Tbe-127840	Tupaia belangeri	85.71	1.00e-127	449.00
IUUC-Ttr-128863	Tursiops truncatus	90.02	0.00e+00	830.00
IUUC-Vpa-130718	Vicugna pacos	92.90	0.00e+00	806.00
IUUC-Xtr-132320	Xenopus tropicalis	47.39	5.00e-89	321.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence