iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090801

UUCD1 version

UUC-PaT-01077

Ensembl Protein ID

ENSPTRP00000025757.3

UniProt Accession

H2QML3; H2QML3_PANTR

Genbank Protein ID

JAA11173.1; JAA17898.1; JAA23458.1; JAA43499.1

Protein Name

Ubiquitin specific peptidase 4 (Proto-oncogene)

Genbank Nucleotide ID

AACZ03025925; GABF01004247; GABD01009642; GABE01001240

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000014920.5	ENSPTRT00000027927.3	ENSPTRP00000025757.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.80e-114	380.2	302	922
ULD/UDP/UBQ/UBQ_Other	2.20e-18	65.9	143	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++ +v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           ******************************8888..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRVMEvflvpadphcrptqyrvtvplmgavsdlcealsrlsgiaaenmvvadvynhrfhkifqmdeglnhimprddifvye 566
           ********99999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  vcstsvdgsecvtlpvyfrerksrpsstssasalygqplllsvpkhkltleslyqavcdrisryvkqplpdefgssplepgacngsrns 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  cegedeeemehqeegkeqlsetegsgedepgndpsettqkikgqpcpkrlftfslvnsygtadinslaadgkllklnsrstlamdwdse 744
           ***************************************************************************************** PP
   S: 186  ...............................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeq 243
                                           l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++ 
   Q: 745  trrlyydeqeseayekhvsmlqpqkkkkttvALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY- 832
           ***********************************************************************************99885. PP
   S: 244  ksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkne.kgkWllfdDskVtevkeeevleetgsta 330
             r k+++ vefp++ L++s+f+++ +    +++ Y+Liav +H+G ++ GHY+ay+kn+ +gkW++fdDs+V+  +e+++++   + a
   Q: 833  -WRDKLDTVVEFPIRgLNMSEFVCNLSA---RPYVYDLIAVSNHYGAMGVGHYTAYAKNKlNGKWYYFDDSNVSLASEDQIVT---KAA 914
           .567******************999443...49**************************52666*******************...*** PP
   S: 331  YvlfYkrr 338
           YvlfY+rr
   Q: 915  YVLFYQRR 922
           ******96 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAEGGGCRER PDAETQKSEL GALMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYNVG 60
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGCGTGCGT GGGCGCGGTC TATAGCACGC CGCGCGCGGG GCGGATGTCC GGGCCGGCTG 60
GGCCGGGGCC GCGGACGAGA TGGCGGAAGG TGGAGGCTGC CGTGAGCGAC CGGATGCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	93.78	0.00e+00	1672.00
IUUC-Atr-002991	Amborella trichopoda	35.63	4.00e-144	505.00
IUUC-Apl-004068	Anas platyrhynchos	71.13	0.00e+00	1205.00
IUUC-Aca-004459	Anolis carolinensis	68.88	0.00e+00	1230.00
IUUC-Aly-006044	Arabidopsis lyrata	36.91	9.00e-150	524.00
IUUC-Ath-007288	Arabidopsis thaliana	36.28	3.00e-151	529.00
IUUC-Ago-007911	Ashbya gossypii	37.43	3.00e-63	237.00
IUUC-Ani-009479	Aspergillus nidulans	43.06	9.00e-52	199.00
IUUC-Ang-009562	Aspergillus niger	45.16	2.00e-55	211.00
IUUC-Bta-012929	Bos taurus	94.08	0.00e+00	1717.00
IUUC-Bdi-014013	Brachypodium distachyon	36.72	4.00e-152	531.00
IUUC-Cja-018798	Callithrix jacchus	96.16	0.00e+00	1709.00
IUUC-Cfa-020599	Canis familiaris	95.02	0.00e+00	1712.00
IUUC-Cpo-022144	Cavia porcellus	90.22	0.00e+00	1620.00
IUUC-Csa-023770	Chlorocebus sabaeus	98.13	0.00e+00	1657.00
IUUC-Cho-024595	Choloepus hoffmanni	84.43	0.00e+00	1079.00
IUUC-Csv-026109	Ciona savignyi	46.57	1.00e-148	520.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	43.75	1.00e-60	229.00
IUUC-Dno-029316	Dasypus novemcinctus	92.01	0.00e+00	1714.00
IUUC-Ete-032970	Echinops telfairi	82.88	0.00e+00	1063.00
IUUC-Eca-034012	Equus caballus	95.22	0.00e+00	1707.00
IUUC-Eeu-035158	Erinaceus europaeus	77.69	0.00e+00	799.00
IUUC-Fca-035373	Felis catus	91.18	0.00e+00	1676.00
IUUC-Fal-037634	Ficedula albicollis	74.95	0.00e+00	1297.00
IUUC-Fox-037986	Fusarium oxysporum	44.49	4.00e-64	240.00
IUUC-Fso-038291	Fusarium solani	44.49	8.00e-64	239.00
IUUC-Gmo-038866	Gadus morhua	68.39	0.00e+00	853.00
IUUC-Ggr-039740	Gaeumannomyces graminis	44.32	1.00e-62	235.00
IUUC-Gga-040729	Gallus gallus	67.88	0.00e+00	1256.00
IUUC-Gac-042631	Gasterosteus aculeatus	67.33	0.00e+00	1246.00
IUUC-Ggo-045337	Gorilla gorilla	97.35	0.00e+00	1598.00
IUUC-Hsa-045669	Homo sapiens	99.69	0.00e+00	1800.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	94.81	0.00e+00	1731.00
IUUC-Lch-050533	Latimeria chalumnae	68.88	0.00e+00	1182.00
IUUC-Lpe-051424	Leersia perrieri	36.85	2.00e-148	520.00
IUUC-Loc-051800	Lepisosteus oculatus	65.69	0.00e+00	1301.00
IUUC-Laf-053803	Loxodonta africana	94.08	0.00e+00	1709.00
IUUC-Mcc-055556	Macaca mulatta	94.29	0.00e+00	1669.00
IUUC-Meu-056742	Macropus eugenii	72.65	0.00e+00	1312.00
IUUC-Mor-056985	Magnaporthe oryzae	43.22	5.00e-62	233.00
IUUC-Mpo-057486	Magnaporthe poae	45.05	2.00e-62	235.00
IUUC-Mtr-058138	Medicago truncatula	44.57	4.00e-139	488.00
IUUC-Mga-059300	Meleagris gallopavo	71.06	0.00e+00	1227.00
IUUC-Mdo-061848	Monodelphis domestica	84.19	0.00e+00	1550.00
IUUC-Mmu-063960	Mus musculus	90.96	0.00e+00	1667.00
IUUC-Mpu-066920	Mustela putorius furo	95.02	0.00e+00	1716.00
IUUC-Mlu-068088	Myotis lucifugus	92.84	0.00e+00	1691.00
IUUC-Ncr-068879	Neurospora crassa	32.19	2.00e-68	254.00
IUUC-Nle-070010	Nomascus leucogenys	98.96	0.00e+00	1788.00
IUUC-Opr-070740	Ochotona princeps	90.15	0.00e+00	1204.00
IUUC-Ont-072573	Oreochromis niloticus	64.22	0.00e+00	1253.00
IUUC-Oan-073363	Ornithorhynchus anatinus	76.88	0.00e+00	1408.00
IUUC-Ocu-074242	Oryctolagus cuniculus	89.48	0.00e+00	1591.00
IUUC-Olo-080315	Oryza longistaminata	36.35	1.00e-146	513.00
IUUC-Osa-086139	Oryza sativa	35.89	4.00e-147	515.00
IUUC-Ola-086553	Oryzias latipes	69.31	0.00e+00	1273.00
IUUC-Olu-087717	Ostreococcus lucimarinus	40.03	2.00e-122	433.00
IUUC-Oga-088562	Otolemur garnettii	86.94	0.00e+00	1498.00
IUUC-Oar-090439	Ovis aries	93.56	0.00e+00	1698.00
IUUC-Pan-092717	Papio anubis	93.26	0.00e+00	1641.00
IUUC-Psi-093942	Pelodiscus sinensis	74.19	0.00e+00	1300.00
IUUC-Pab-098522	Pongo abelii	99.05	0.00e+00	1312.00
IUUC-Pca-100161	Procavia capensis	91.62	0.00e+00	1115.00
IUUC-Ptt-103847	Puccinia triticina	37.76	4.00e-60	227.00
IUUC-Rno-106081	Rattus norvegicus	89.92	0.00e+00	1669.00
IUUC-Sha-106937	Sarcophilus harrisii	82.78	0.00e+00	1508.00
IUUC-Sit-109948	Setaria italica	36.85	2.00e-142	499.00
IUUC-Sly-111746	Solanum lycopersicum	38.07	2.00e-153	536.00
IUUC-Stu-112671	Solanum tuberosum	37.86	2.00e-151	529.00
IUUC-Sar-113542	Sorex araneus	87.54	0.00e+00	1600.00
IUUC-Sbi-114874	Sorghum bicolor	36.36	6.00e-144	504.00
IUUC-Ssc-115637	Sus scrofa	94.91	0.00e+00	1703.00
IUUC-Tgu-117267	Taeniopygia guttata	72.03	0.00e+00	1297.00
IUUC-Tca-121001	Theobroma cacao	36.10	2.00e-154	539.00
IUUC-Tbe-127669	Tupaia belangeri	76.16	0.00e+00	904.00
IUUC-Ttr-128778	Tursiops truncatus	93.35	0.00e+00	1686.00
IUUC-Uma-129498	Ustilago maydis	40.90	9.00e-70	259.00
IUUC-Vda-129781	Verticillium dahliae	44.60	4.00e-65	243.00
IUUC-Vpa-130571	Vicugna pacos	96.46	0.00e+00	1135.00
IUUC-Vvi-131010	Vitis vinifera	38.11	4.00e-150	525.00
IUUC-Xtr-132305	Xenopus tropicalis	69.15	0.00e+00	1279.00
IUUC-Yli-134392	Yarrowia lipolytica	43.01	9.00e-62	232.00
IUUC-Zma-135699	Zea mays	36.51	8.00e-144	504.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence