iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053654

Ensembl Protein ID

ENSLAFP00000009342.2

UniProt Accession

G3T700; G3T700_LOXAF

Protein Name

Tyrosine-protein kinase

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011161.2	ENSLAFT00000029537.1	ENSLAFP00000028715.1
ENSLAFG00000011161.2	ENSLAFT00000011162.2	ENSLAFP00000009342.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.00e-16	59.5	57	114

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++v +lydyea + ++L+++kGd++ v+   e++++W+++ +  ++k+G +P+n+v++++
   Q: 57   DFVVVALYDYEAIHREDLSFQKGDQMVVL---EESGEWWRARSLVTQKEGYIPSNYVARVN 114
           6789*************************...99*************************97 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

RMGCMKSKFL RSGGKVSKTE PSSTQQSPTY VPDPTSSGKR VVGTPSHVPP FPAGAEDFVV 60
VALYDYEAIH REDLSFQKGD QMVVLEESGE WWRARSLVTQ KEGYIPSNYV ARVNSLETEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGATGGGGT GCATGAAGTC CAAGTTCCTC CGGTCAGGAG GCAAGGTCTC AAAAACTGAG 60
CCCAGTTCCA CCCAGCAGAG CCCCACGTAC GTGCCGGATC CCACGTCCTC GGGCAAGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	91.30	0.00e+00	961.00
IUUC-Apl-003285	Anas platyrhynchos	79.33	0.00e+00	815.00
IUUC-Aca-004724	Anolis carolinensis	78.35	0.00e+00	795.00
IUUC-Ame-011954	Astyanax mexicanus	75.35	0.00e+00	770.00
IUUC-Bta-013060	Bos taurus	90.87	0.00e+00	956.00
IUUC-Bdi-014122	Brachypodium distachyon	31.01	7.00e-21	95.90
IUUC-Cja-019817	Callithrix jacchus	89.53	0.00e+00	937.00
IUUC-Cfa-020511	Canis familiaris	90.14	0.00e+00	951.00
IUUC-Cpo-022538	Cavia porcellus	89.88	0.00e+00	946.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	24.83	3.00e-17	82.80
IUUC-Csa-024143	Chlorocebus sabaeus	89.11	0.00e+00	931.00
IUUC-Dre-028157	Danio rerio	74.26	0.00e+00	776.00
IUUC-Dno-029761	Dasypus novemcinctus	89.66	0.00e+00	944.00
IUUC-Eca-034090	Equus caballus	87.90	0.00e+00	919.00
IUUC-Fca-035937	Felis catus	89.90	0.00e+00	924.00
IUUC-Fal-036624	Ficedula albicollis	79.17	0.00e+00	815.00
IUUC-Gmo-039009	Gadus morhua	72.82	0.00e+00	759.00
IUUC-Gga-040296	Gallus gallus	75.54	0.00e+00	788.00
IUUC-Gac-042362	Gasterosteus aculeatus	73.48	0.00e+00	776.00
IUUC-Ggo-044570	Gorilla gorilla	89.53	0.00e+00	933.00
IUUC-Hsa-046378	Homo sapiens	89.96	0.00e+00	939.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	89.68	0.00e+00	941.00
IUUC-Loc-052904	Lepisosteus oculatus	78.11	0.00e+00	827.00
IUUC-Mcc-055317	Macaca mulatta	89.68	0.00e+00	937.00
IUUC-Mga-060194	Meleagris gallopavo	81.78	0.00e+00	776.00
IUUC-Mmr-061510	Microcebus murinus	87.50	0.00e+00	924.00
IUUC-Mdo-062035	Monodelphis domestica	84.55	0.00e+00	893.00
IUUC-Mmu-064037	Mus musculus	89.29	0.00e+00	952.00
IUUC-Mpu-066874	Mustela putorius furo	90.67	0.00e+00	956.00
IUUC-Mlu-068202	Myotis lucifugus	86.90	0.00e+00	900.00
IUUC-Nle-069222	Nomascus leucogenys	89.48	0.00e+00	931.00
IUUC-Opr-070705	Ochotona princeps	87.13	0.00e+00	930.00
IUUC-Ont-072347	Oreochromis niloticus	81.84	0.00e+00	763.00
IUUC-Ocu-074490	Oryctolagus cuniculus	87.67	0.00e+00	929.00
IUUC-Ola-086521	Oryzias latipes	80.94	0.00e+00	773.00
IUUC-Oga-088153	Otolemur garnettii	88.32	0.00e+00	926.00
IUUC-Oar-090184	Ovis aries	90.34	0.00e+00	952.00
IUUC-Ptr-090505	Pan troglodytes	85.77	0.00e+00	882.00
IUUC-Pan-092260	Papio anubis	89.29	0.00e+00	936.00
IUUC-Pma-094311	Petromyzon marinus	68.24	0.00e+00	736.00
IUUC-Pfo-096566	Poecilia formosa	75.69	0.00e+00	793.00
IUUC-Pva-103021	Pteropus vampyrus	91.07	0.00e+00	958.00
IUUC-Rno-105309	Rattus norvegicus	88.67	0.00e+00	942.00
IUUC-Sha-107099	Sarcophilus harrisii	83.66	0.00e+00	883.00
IUUC-Sly-111528	Solanum lycopersicum	32.73	1.00e-22	102.00
IUUC-Stu-112831	Solanum tuberosum	32.27	7.00e-22	99.40
IUUC-Tgu-116912	Taeniopygia guttata	78.85	0.00e+00	806.00
IUUC-Tru-118449	Takifugu rubripes	80.67	0.00e+00	756.00
IUUC-Tae-123706	Triticum aestivum	31.54	9.00e-22	99.00
IUUC-Tur-126022	Triticum urartu	31.54	9.00e-22	99.00
IUUC-Tbe-128144	Tupaia belangeri	86.67	0.00e+00	803.00
IUUC-Xma-133902	Xiphophorus maculatus	75.30	0.00e+00	790.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence