iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mlu-068202

Ensembl Protein ID

ENSMLUP00000007621.2

UniProt Accession

G1PBA7; G1PBA7_MYOLU

Genbank Protein ID

ENSMLUP00000007621

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AAPE02019186

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000008355.2	ENSMLUT00000008353.2	ENSMLUP00000007621.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.90e-17	62.4	81	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++ v++lydyea + ++L+++kGd++ v+   e++++W+k+ + ++ k+G +P+n+v++++
   Q: 81   KDNIVIALYDYEAIHHEDLSFQKGDQMAVL---EESGEWWKARSLATRKEGYIPSNYVARVD 139
           5799**************************...99*************************97 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

WNPASKTPLP GLRASRAHLP SLCRRMGCVK SKFLRDRDKV SKSEASANPH SPLYVPDPTS 60
TGKRRPDPNN GNPPGPRRGS KDNIVIALYD YEAIHHEDLS FQKGDQMAVL EESGEWWKAR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGAACCCAG CATCAAAGAC TCCCCTGCCT GGGCTCAGGG CCAGCAGGGC TCACCTCCCT 60
TCTCTCTGCC GCAGGATGGG GTGCGTGAAG TCCAAGTTCC TCCGGGATAG AGACAAGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	89.72	0.00e+00	932.00
IUUC-Apl-003285	Anas platyrhynchos	75.79	0.00e+00	780.00
IUUC-Aca-004724	Anolis carolinensis	75.20	0.00e+00	765.00
IUUC-Ame-011954	Astyanax mexicanus	73.12	0.00e+00	738.00
IUUC-Bta-013060	Bos taurus	89.68	0.00e+00	948.00
IUUC-Cja-019817	Callithrix jacchus	87.55	0.00e+00	903.00
IUUC-Cfa-020511	Canis familiaris	90.08	0.00e+00	951.00
IUUC-Cpo-022538	Cavia porcellus	86.17	0.00e+00	907.00
IUUC-Csa-024143	Chlorocebus sabaeus	86.06	0.00e+00	936.00
IUUC-Dre-028157	Danio rerio	73.86	0.00e+00	766.00
IUUC-Dno-029761	Dasypus novemcinctus	86.71	0.00e+00	911.00
IUUC-Eca-034090	Equus caballus	87.30	0.00e+00	915.00
IUUC-Fca-035937	Felis catus	85.60	0.00e+00	876.00
IUUC-Fal-036624	Ficedula albicollis	75.59	0.00e+00	783.00
IUUC-Gmo-039009	Gadus morhua	69.84	0.00e+00	729.00
IUUC-Gga-040296	Gallus gallus	71.97	0.00e+00	747.00
IUUC-Gac-042362	Gasterosteus aculeatus	71.51	0.00e+00	751.00
IUUC-Ggo-044570	Gorilla gorilla	87.75	0.00e+00	907.00
IUUC-Hsa-046378	Homo sapiens	87.55	0.00e+00	915.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	86.73	0.00e+00	909.00
IUUC-Loc-052904	Lepisosteus oculatus	75.54	0.00e+00	793.00
IUUC-Laf-053654	Loxodonta africana	87.10	0.00e+00	912.00
IUUC-Mcc-055317	Macaca mulatta	88.29	0.00e+00	923.00
IUUC-Mga-060194	Meleagris gallopavo	77.06	0.00e+00	731.00
IUUC-Mmr-061510	Microcebus murinus	86.90	0.00e+00	910.00
IUUC-Mdo-062035	Monodelphis domestica	79.73	0.00e+00	861.00
IUUC-Mmu-064037	Mus musculus	83.82	0.00e+00	910.00
IUUC-Mpu-066874	Mustela putorius furo	90.28	0.00e+00	947.00
IUUC-Nle-069222	Nomascus leucogenys	88.49	0.00e+00	919.00
IUUC-Opr-070705	Ochotona princeps	83.96	0.00e+00	890.00
IUUC-Ont-072347	Oreochromis niloticus	79.02	0.00e+00	734.00
IUUC-Ocu-074490	Oryctolagus cuniculus	83.50	0.00e+00	881.00
IUUC-Ola-086521	Oryzias latipes	78.35	0.00e+00	746.00
IUUC-Oga-088153	Otolemur garnettii	86.93	0.00e+00	914.00
IUUC-Oar-090184	Ovis aries	89.17	0.00e+00	946.00
IUUC-Ptr-090505	Pan troglodytes	83.79	0.00e+00	855.00
IUUC-Pan-092260	Papio anubis	88.10	0.00e+00	921.00
IUUC-Pma-094311	Petromyzon marinus	66.08	0.00e+00	707.00
IUUC-Pfo-096566	Poecilia formosa	73.19	0.00e+00	763.00
IUUC-Pva-103021	Pteropus vampyrus	91.07	0.00e+00	956.00
IUUC-Rno-105309	Rattus norvegicus	85.29	0.00e+00	902.00
IUUC-Sha-107099	Sarcophilus harrisii	81.10	0.00e+00	855.00
IUUC-Tgu-116912	Taeniopygia guttata	75.35	0.00e+00	774.00
IUUC-Tru-118449	Takifugu rubripes	78.33	0.00e+00	726.00
IUUC-Tbe-128144	Tupaia belangeri	83.33	0.00e+00	768.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence