iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-088565

Ensembl Protein ID

ENSOGAP00000019574.1

UniProt Accession

H0XTY2; H0XTY2_OTOGA

Genbank Protein ID

ENSOGAP00000019574

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03010438

Gene Name

RNF139

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000027959.1	ENSOGAT00000029385.1	ENSOGAP00000019574.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.30e-08	35.2	539	577

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 539  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 577
           ********999******************......********** PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

QQVRMAHQQV WVALEVALRV PCLYIIDAIF NSYYDSSQSR FCIVLQIFLR LLGIFVSSIV 60
LILSQRSLFK FYMYSSAFLL AATSVLVNYY AALHIDFYGA YNTSAFGIEL LPRKGPSLWM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGCTCAGA GACCTCCTGG GAAGCCGCCG CCGCCGCTGC CTCAGCCATC GCCGCCGCCG 60
CCGCCTGCTC CAGCTCGGGA GACGCGAGCG GGCGGCGGGG CGGGCGGTGA GAGAGACAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0016021--C:integral component of membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	96.96	0.00e+00	1227.00
IUUC-Apl-004214	Anas platyrhynchos	86.24	0.00e+00	968.00
IUUC-Aca-005326	Anolis carolinensis	79.33	0.00e+00	969.00
IUUC-Ame-011687	Astyanax mexicanus	68.50	0.00e+00	868.00
IUUC-Bta-013394	Bos taurus	97.11	0.00e+00	1261.00
IUUC-Bci-013813	Botrytis cinerea	41.38	7.00e-08	51.60
IUUC-Cja-019499	Callithrix jacchus	96.19	0.00e+00	1270.00
IUUC-Cfa-020357	Canis familiaris	96.80	0.00e+00	1227.00
IUUC-Cpo-021924	Cavia porcellus	95.11	0.00e+00	1177.00
IUUC-Csa-023513	Chlorocebus sabaeus	96.96	0.00e+00	1250.00
IUUC-Cho-024285	Choloepus hoffmanni	89.95	0.00e+00	1092.00
IUUC-Cin-025223	Ciona intestinalis	53.93	2.00e-74	272.00
IUUC-Csv-026018	Ciona savignyi	47.00	2.00e-63	235.00
IUUC-Dre-028660	Danio rerio	68.13	0.00e+00	793.00
IUUC-Dno-029463	Dasypus novemcinctus	96.33	4.00e-160	558.00
IUUC-Dor-030728	Dipodomys ordii	94.44	0.00e+00	1137.00
IUUC-Dse-031284	Dothistroma septosporum	43.40	6.00e-09	54.70
IUUC-Dme-032186	Drosophila melanogaster	44.93	5.00e-99	355.00
IUUC-Ete-032368	Echinops telfairi	88.32	0.00e+00	1161.00
IUUC-Eca-034325	Equus caballus	96.35	0.00e+00	1202.00
IUUC-Fca-035537	Felis catus	95.99	0.00e+00	1190.00
IUUC-Fal-037459	Ficedula albicollis	85.74	0.00e+00	946.00
IUUC-Gmo-039442	Gadus morhua	78.28	1.00e-97	350.00
IUUC-Ggr-039921	Gaeumannomyces graminis	31.91	1.00e-07	52.00
IUUC-Gga-041071	Gallus gallus	83.83	0.00e+00	984.00
IUUC-Gac-042483	Gasterosteus aculeatus	67.02	0.00e+00	906.00
IUUC-Ggo-044672	Gorilla gorilla	96.65	0.00e+00	1248.00
IUUC-Hsa-045836	Homo sapiens	95.89	0.00e+00	1210.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	96.50	0.00e+00	1266.00
IUUC-Lch-050073	Latimeria chalumnae	74.24	0.00e+00	981.00
IUUC-Loc-052908	Lepisosteus oculatus	70.21	0.00e+00	945.00
IUUC-Lma-053202	Leptosphaeria maculans	42.59	3.00e-08	52.40
IUUC-Laf-053519	Loxodonta africana	93.61	0.00e+00	1252.00
IUUC-Mcc-054674	Macaca mulatta	97.38	1.00e-102	365.00
IUUC-Mor-057262	Magnaporthe oryzae	32.93	3.00e-08	54.30
IUUC-Mga-059922	Meleagris gallopavo	85.92	0.00e+00	958.00
IUUC-Mmr-061452	Microcebus murinus	95.44	0.00e+00	1206.00
IUUC-Mdo-062412	Monodelphis domestica	90.36	0.00e+00	1182.00
IUUC-Mmu-063147	Mus musculus	94.29	0.00e+00	1218.00
IUUC-Mpu-065929	Mustela putorius furo	97.11	0.00e+00	1228.00
IUUC-Mlu-067899	Myotis lucifugus	93.01	0.00e+00	1182.00
IUUC-Nle-070083	Nomascus leucogenys	96.65	0.00e+00	1245.00
IUUC-Opr-070461	Ochotona princeps	91.20	0.00e+00	1211.00
IUUC-Ont-072256	Oreochromis niloticus	70.00	0.00e+00	912.00
IUUC-Oan-073150	Ornithorhynchus anatinus	84.72	0.00e+00	947.00
IUUC-Ocu-073748	Oryctolagus cuniculus	93.32	0.00e+00	1179.00
IUUC-Oar-089432	Ovis aries	97.19	0.00e+00	1191.00
IUUC-Ptr-091422	Pan troglodytes	96.50	0.00e+00	1246.00
IUUC-Pan-092331	Papio anubis	96.80	0.00e+00	1248.00
IUUC-Psi-092933	Pelodiscus sinensis	83.90	0.00e+00	938.00
IUUC-Pfo-097466	Poecilia formosa	64.76	0.00e+00	914.00
IUUC-Pab-098702	Pongo abelii	96.50	0.00e+00	1245.00
IUUC-Pca-100125	Procavia capensis	91.14	0.00e+00	1191.00
IUUC-Ppe-101613	Prunus persica	32.35	2.00e-10	58.20
IUUC-Pva-102628	Pteropus vampyrus	96.34	0.00e+00	1223.00
IUUC-Rno-104886	Rattus norvegicus	94.22	0.00e+00	1234.00
IUUC-Sha-106702	Sarcophilus harrisii	88.20	0.00e+00	1155.00
IUUC-Ssc-116164	Sus scrofa	95.89	0.00e+00	1247.00
IUUC-Tgu-116829	Taeniopygia guttata	83.78	0.00e+00	979.00
IUUC-Tru-118557	Takifugu rubripes	66.37	0.00e+00	883.00
IUUC-Tsy-119399	Tarsius syrichta	91.00	0.00e+00	668.00
IUUC-Tni-120006	Tetraodon nigroviridis	61.48	0.00e+00	767.00
IUUC-Tca-121057	Theobroma cacao	39.73	2.00e-10	58.90
IUUC-Tbe-127664	Tupaia belangeri	95.27	0.00e+00	1234.00
IUUC-Ttr-129144	Tursiops truncatus	96.35	0.00e+00	1284.00
IUUC-Vpa-130226	Vicugna pacos	96.50	0.00e+00	1252.00
IUUC-Xtr-132461	Xenopus tropicalis	71.56	0.00e+00	918.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence