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Tag Content
iUUCD ID IUUC-Bta-012845
Ensembl Protein ID ENSBTAP00000045295.3
UniProt Accession O97902; ASAP1_BOVIN
Genbank Protein ID AAD19965.1
Protein Name Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1; 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein; ADP-ribosylation factor-directed GTPase-activating protein 1; Development and differentiation-enhancing factor 1; PIP2-dependent ARF1 GAP
Genbank Nucleotide ID AF112886
Gene Name ASAP1; DDEF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000003185.5 ENSBTAT00000048214.3 ENSBTAP00000045295.3
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 2.40e-12 46.7 1050 1107
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk.elegkrGlfPenFvekl 62
           ++v+++yd +a nddeLt+ +G+v+ v    e+d++W+ g      +++G+fP  Fv+ l
   Q: 1050 RRVKTIYDCQADNDDELTFMEGEVIVVT--GEEDQEWWIGHIeGQPERKGVFPVSFVHIL 1107
           689**********************996..999*******763455789*******9866 PP
   
Organism Bos taurus
Functional Description
(View)

Functional Description


     Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Plays a role in ciliogenesis (By similarity). May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types.
 Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Plays a role in ciliogenesis (By similarity). May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types.
Protein Sequence
(Fasta)
MPDQISVSEF IAETTEDYNS PTTSSFTTRL HNCRNTVTLL EEALDQDRTA LQKVKKSVKA 60
IYNSGQDHVQ NEENYAQVLD KFGSNFLSRD NPDLGTAFVK FSTLTKELST LLKNLLQGLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-012845|UBD,SH3|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCGGCCCGC GCCTCCCGCC CGCCGGCTGC TCCCGCCGCC GCCGCCGCCG CCTCCCGCTT 60
TCCGCTGCGA GAGCCGCGAT CGGCCGGCCG AGGGGAGCCG GGGCGCGGGC GTCTGCGCCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-012845|UBD,SH3|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0343--GTPase activation
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR027267--AH/BAR-dom
IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001164--ArfGAP
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50115--ARFGAP
PS50003--PH_DOMAIN
PS50002--SH3
Pfam

PF12796--Ank_2
PF01412--ArfGap
PF00169--PH
PF00018--SH3_1
PRINTS

PR00405--REVINTRACTNG
SMART

SM00248--ANK
SM00105--ArfGap
SM00233--PH
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005096--F:GTPase activator activity
GO:0046872--F:metal ion binding
GO:0060271--P:cilium assembly
KEGG bta:327705
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001715 Ailuropoda melanoleuca 96.14 0.00e+00 1769.00
IUUC-Apl-004017 Anas platyrhynchos 89.21 0.00e+00 1581.00
IUUC-Aca-004813 Anolis carolinensis 84.58 0.00e+00 1727.00
IUUC-Ani-009433 Aspergillus nidulans 38.75 1.00e-16 81.60
IUUC-Ang-009739 Aspergillus niger 37.50 2.00e-15 77.80
IUUC-Aor-010082 Aspergillus oryzae 39.78 6.00e-18 85.90
IUUC-Ame-011148 Astyanax mexicanus 66.67 0.00e+00 1322.00
IUUC-Bgr-012127 Blumeria graminis 31.53 2.00e-12 67.80
IUUC-Bci-013879 Botrytis cinerea 38.64 9.00e-16 78.60
IUUC-Cja-019378 Callithrix jacchus 95.96 0.00e+00 1725.00
IUUC-Cfa-020871 Canis familiaris 96.23 0.00e+00 1833.00
IUUC-Cpo-021882 Cavia porcellus 94.53 0.00e+00 1733.00
IUUC-Csa-023903 Chlorocebus sabaeus 95.78 0.00e+00 1733.00
IUUC-Cho-024955 Choloepus hoffmanni 97.79 0.00e+00 835.00
IUUC-Csv-026103 Ciona savignyi 51.70 0.00e+00 711.00
IUUC-Cgl-026399 Colletotrichum gloeosporioides 32.14 3.00e-17 83.60
IUUC-Cne-026976 Cryptococcus neoformans 37.08 5.00e-19 89.00
IUUC-Dre-027777 Danio rerio 74.67 0.00e+00 1473.00
IUUC-Dno-029662 Dasypus novemcinctus 95.16 0.00e+00 1741.00
IUUC-Dse-031303 Dothistroma septosporum 34.86 3.00e-16 80.50
IUUC-Dme-032141 Drosophila melanogaster 50.28 0.00e+00 660.00
IUUC-Ete-032263 Echinops telfairi 90.36 0.00e+00 1291.00
IUUC-Eca-034304 Equus caballus 94.33 0.00e+00 1598.00
IUUC-Eeu-035275 Erinaceus europaeus 82.38 0.00e+00 757.00
IUUC-Fal-036825 Ficedula albicollis 88.63 0.00e+00 1621.00
IUUC-Fox-037687 Fusarium oxysporum 32.17 1.00e-17 84.70
IUUC-Gmo-039588 Gadus morhua 79.58 0.00e+00 1024.00
IUUC-Ggr-039997 Gaeumannomyces graminis 29.36 2.00e-13 70.90
IUUC-Gga-041168 Gallus gallus 89.52 0.00e+00 1667.00
IUUC-Gac-041493 Gasterosteus aculeatus 80.83 0.00e+00 1050.00
IUUC-Ggo-045273 Gorilla gorilla 93.36 0.00e+00 1647.00
IUUC-Hsa-045946 Homo sapiens 95.78 0.00e+00 1718.00
IUUC-Itr-048570 Ictidomys tridecemlineatus 93.06 0.00e+00 1566.00
IUUC-Kpa-049331 Komagataella pastoris 45.76 2.00e-12 66.20
IUUC-Lch-050495 Latimeria chalumnae 54.59 0.00e+00 997.00
IUUC-Loc-052152 Lepisosteus oculatus 82.18 0.00e+00 1589.00
IUUC-Lma-053193 Leptosphaeria maculans 40.82 5.00e-09 55.80
IUUC-Laf-053716 Loxodonta africana 93.74 0.00e+00 1673.00
IUUC-Mcc-054921 Macaca mulatta 95.61 0.00e+00 1733.00
IUUC-Meu-056172 Macropus eugenii 67.77 0.00e+00 1224.00
IUUC-Mor-057115 Magnaporthe oryzae 39.36 6.00e-18 85.90
IUUC-Mpo-057623 Magnaporthe poae 36.49 2.00e-13 70.90
IUUC-Mla-059095 Melampsora laricipopulina 46.99 3.00e-19 90.10
IUUC-Mga-059751 Meleagris gallopavo 87.79 0.00e+00 1606.00
IUUC-Mvi-060310 Microbotryum violaceum 42.19 4.00e-14 73.60
IUUC-Mmr-060919 Microcebus murinus 96.23 0.00e+00 1744.00
IUUC-Mdo-062814 Monodelphis domestica 88.18 0.00e+00 1723.00
IUUC-Mmu-063683 Mus musculus 90.64 0.00e+00 1752.00
IUUC-Mpu-066167 Mustela putorius furo 96.14 0.00e+00 1795.00
IUUC-Mlu-067593 Myotis lucifugus 91.26 0.00e+00 1630.00
IUUC-Ncr-068796 Neurospora crassa 41.94 4.00e-17 83.20
IUUC-Nle-069303 Nomascus leucogenys 95.45 0.00e+00 1665.00
IUUC-Opr-070730 Ochotona princeps 88.14 0.00e+00 834.00
IUUC-Ont-071978 Oreochromis niloticus 74.81 0.00e+00 1473.00
IUUC-Oan-073362 Ornithorhynchus anatinus 75.69 3.00e-58 216.00
IUUC-Ocu-074259 Oryctolagus cuniculus 90.81 0.00e+00 1740.00
IUUC-Oba-075644 Oryza barthii 40.78 1.00e-15 77.40
IUUC-Ogl-077781 Oryza glaberrima 40.78 1.00e-15 77.40
IUUC-Oin-079062 Oryza indica 40.78 9.00e-16 77.40
IUUC-Oni-082151 Oryza nivara 40.78 1.00e-15 77.00
IUUC-Oru-084368 Oryza rufipogon 40.78 1.00e-15 77.40
IUUC-Osa-085311 Oryza sativa 39.81 4.00e-15 75.50
IUUC-Ola-087435 Oryzias latipes 59.74 0.00e+00 908.00
IUUC-Oga-088179 Otolemur garnettii 94.44 0.00e+00 1577.00
IUUC-Oar-090066 Ovis aries 84.62 0.00e+00 1597.00
IUUC-Ptr-091408 Pan troglodytes 95.78 0.00e+00 1718.00
IUUC-Pan-092196 Papio anubis 95.70 0.00e+00 1732.00
IUUC-Psi-093612 Pelodiscus sinensis 84.82 0.00e+00 1703.00
IUUC-Pma-094175 Petromyzon marinus 52.05 0.00e+00 728.00
IUUC-Ppa-095411 Physcomitrella patens 40.54 1.00e-14 73.20
IUUC-Pfo-096707 Poecilia formosa 73.54 0.00e+00 1459.00
IUUC-Pab-098254 Pongo abelii 90.79 0.00e+00 1619.00
IUUC-Pca-100662 Procavia capensis 87.17 0.00e+00 1638.00
IUUC-Pva-102540 Pteropus vampyrus 91.57 0.00e+00 1656.00
IUUC-Pte-104047 Pyrenophora teres 39.08 1.00e-17 83.60
IUUC-Pyt-104690 Pyrenophora triticirepentis 35.63 2.00e-13 71.20
IUUC-Rno-105530 Rattus norvegicus 90.38 0.00e+00 1669.00
IUUC-Sha-106473 Sarcophilus harrisii 91.05 0.00e+00 1723.00
IUUC-Sja-107965 Schizosaccharomyces japonicus 32.73 1.00e-15 78.20
IUUC-Spo-108088 Schizosaccharomyces pombe 37.04 5.00e-16 79.30
IUUC-Ssl-108437 Sclerotinia sclerotiorum 32.38 1.00e-12 68.60
IUUC-Sar-113741 Sorex araneus 31.06 3.00e-14 74.70
IUUC-Sre-114990 Sporisorium reilianum 45.00 5.00e-20 92.40
IUUC-Ssc-116267 Sus scrofa 66.67 0.00e+00 872.00
IUUC-Tgu-117155 Taeniopygia guttata 85.50 0.00e+00 1299.00
IUUC-Tru-117958 Takifugu rubripes 75.17 0.00e+00 1493.00
IUUC-Tni-119805 Tetraodon nigroviridis 79.41 0.00e+00 1324.00
IUUC-Tre-122184 Trichoderma reesei 32.00 5.00e-17 82.80
IUUC-Tvi-122676 Trichoderma virens 31.65 4.00e-18 86.30
IUUC-Tme-127201 Tuber melanosporum 31.82 4.00e-17 83.20
IUUC-Tbe-127496 Tupaia belangeri 66.80 2.00e-82 300.00
IUUC-Ttr-128174 Tursiops truncatus 89.18 0.00e+00 1608.00
IUUC-Uma-129415 Ustilago maydis 50.00 1.00e-19 91.30
IUUC-Vda-129911 Verticillium dahliae 40.00 5.00e-17 82.80
IUUC-Xtr-131957 Xenopus tropicalis 74.98 0.00e+00 1357.00
IUUC-Xma-133604 Xiphophorus maculatus 60.19 0.00e+00 824.00
Created Date 25-Jun-2017

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