iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPSIG00000004770.1	ENSPSIT00000005203.1	ENSPSIP00000005174.1
ENSPSIG00000004770.1	ENSPSIT00000005208.1	ENSPSIP00000005178.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.40e-101	340.2	733	1056

Active Site

Position(s)	Description	Evidence
1025	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 733  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEESRLIWFSDKTF-----EDSDLFHLIGVVCGLAIYNFTIVDL 814
           78999***********************************************98877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk sl+dl+e++p++ +s+++++++ e+diee+ ++l+f+++ e++g+t+++eL+p+G++ipV ++N++e+v+++
   Q: 815  HFPLALYKKLLNKKPSLDDLKELMPDVGRSMQQLLDYPEDDIEET-FCLNFTITVENFGTTEVKELVPKGADIPVVKQNRQEFVDAY 900
           ***************************************9**998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l+k+t+ykg+y +d+p+i++Fw+v++e+  e++k+f
   Q: 901  VDYIFTKSVASLFDAFHAGFHKVCGGKVLQLFQPSELQAMVIGNTNYDWKELEKNTEYKGDYWADHPTIKMFWDVFHELPLEKKKQF 987
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G++ lk    vi+   + +  lP s+TCfn+L+LP+Y+ ke+lk+kL+ Ai++++gF+l
   Q: 988  LLFLTGSDRIPILGMKCLK---LVIQPtGGGEGYLPVSHTCFNLLDLPKYTDKETLKSKLIQAIDHNEGFSL 1056
           *******************...6666658899**************************************97 PP

Organism

Pelodiscus sinensis

Protein Sequence
(Fasta)

MLCWGNASFG QLGLGGIDEE IVLEPRKSDF FINKRVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK ARKRPEHVGA LDAQNIVAVS CGEAHTLALN DKGQVYSWGL ATDGQLGLPG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTTCTTGC CATATTACTT GATTGTGGAA ACCTTGGATC GCTACAATTG TATATCTGAT 60
CTATTATTTT GTGTTGCAGG TTGAAACTTG TATGGCAGTC ATTTATTTGG ATCTTTGATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007283--P:spermatogenesis

KEGG

pss:102445819

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	89.69	0.00e+00	1862.00
IUUC-Apl-003295	Anas platyrhynchos	91.49	0.00e+00	1983.00
IUUC-Aca-004336	Anolis carolinensis	87.55	0.00e+00	1893.00
IUUC-Ame-010768	Astyanax mexicanus	72.52	0.00e+00	1585.00
IUUC-Bta-013279	Bos taurus	89.97	0.00e+00	1868.00
IUUC-Cja-019023	Callithrix jacchus	89.50	0.00e+00	1853.00
IUUC-Cfa-021074	Canis familiaris	89.78	0.00e+00	1864.00
IUUC-Cpo-021461	Cavia porcellus	87.44	0.00e+00	1811.00
IUUC-Csa-024261	Chlorocebus sabaeus	90.26	0.00e+00	1869.00
IUUC-Cho-024513	Choloepus hoffmanni	71.24	0.00e+00	1370.00
IUUC-Cin-025232	Ciona intestinalis	42.59	0.00e+00	834.00
IUUC-Dre-028829	Danio rerio	74.48	0.00e+00	1550.00
IUUC-Dno-029445	Dasypus novemcinctus	87.26	0.00e+00	1509.00
IUUC-Dor-030158	Dipodomys ordii	89.45	0.00e+00	831.00
IUUC-Dme-032103	Drosophila melanogaster	45.07	0.00e+00	899.00
IUUC-Ete-033072	Echinops telfairi	80.04	0.00e+00	1632.00
IUUC-Eca-033317	Equus caballus	88.36	0.00e+00	1838.00
IUUC-Fca-035682	Felis catus	89.12	0.00e+00	1843.00
IUUC-Fal-036969	Ficedula albicollis	90.73	0.00e+00	1962.00
IUUC-Gmo-038671	Gadus morhua	73.48	0.00e+00	1579.00
IUUC-Gga-041174	Gallus gallus	91.30	0.00e+00	1979.00
IUUC-Gac-042600	Gasterosteus aculeatus	73.42	0.00e+00	1523.00
IUUC-Ggo-044589	Gorilla gorilla	89.59	0.00e+00	1880.00
IUUC-Hsa-046772	Homo sapiens	89.59	0.00e+00	1878.00
IUUC-Lch-050147	Latimeria chalumnae	80.79	0.00e+00	1441.00
IUUC-Loc-052684	Lepisosteus oculatus	80.32	0.00e+00	1698.00
IUUC-Laf-053844	Loxodonta africana	89.12	0.00e+00	1851.00
IUUC-Mcc-055531	Macaca mulatta	88.16	0.00e+00	1853.00
IUUC-Mga-060151	Meleagris gallopavo	90.70	0.00e+00	1651.00
IUUC-Mmr-060954	Microcebus murinus	89.97	0.00e+00	1868.00
IUUC-Mdo-062246	Monodelphis domestica	87.47	0.00e+00	1699.00
IUUC-Mmu-063369	Mus musculus	87.80	0.00e+00	1863.00
IUUC-Mpu-065936	Mustela putorius furo	89.51	0.00e+00	1716.00
IUUC-Mlu-067326	Myotis lucifugus	89.50	0.00e+00	1827.00
IUUC-Nle-069453	Nomascus leucogenys	89.03	0.00e+00	1835.00
IUUC-Ont-071720	Oreochromis niloticus	74.36	0.00e+00	1562.00
IUUC-Oan-073464	Ornithorhynchus anatinus	88.70	0.00e+00	1727.00
IUUC-Ocu-074207	Oryctolagus cuniculus	86.96	0.00e+00	1697.00
IUUC-Ola-086762	Oryzias latipes	73.89	0.00e+00	1518.00
IUUC-Oga-088435	Otolemur garnettii	89.88	0.00e+00	1863.00
IUUC-Oar-089233	Ovis aries	89.97	0.00e+00	1869.00
IUUC-Ptr-091368	Pan troglodytes	89.88	0.00e+00	1883.00
IUUC-Pan-092300	Papio anubis	90.26	0.00e+00	1869.00
IUUC-Pma-094113	Petromyzon marinus	70.93	0.00e+00	1149.00
IUUC-Ppa-095354	Physcomitrella patens	33.21	5.00e-151	528.00
IUUC-Pfo-097021	Poecilia formosa	73.04	0.00e+00	1597.00
IUUC-Pab-098327	Pongo abelii	89.88	0.00e+00	1887.00
IUUC-Pca-101075	Procavia capensis	84.38	0.00e+00	743.00
IUUC-Pva-102909	Pteropus vampyrus	79.56	0.00e+00	1571.00
IUUC-Rno-105457	Rattus norvegicus	88.84	0.00e+00	1890.00
IUUC-Sha-106632	Sarcophilus harrisii	88.08	0.00e+00	1857.00
IUUC-Sar-113679	Sorex araneus	79.18	0.00e+00	1030.00
IUUC-Tgu-116849	Taeniopygia guttata	86.38	0.00e+00	1852.00
IUUC-Tru-118206	Takifugu rubripes	72.51	0.00e+00	1475.00
IUUC-Tsy-119521	Tarsius syrichta	76.06	0.00e+00	1477.00
IUUC-Tni-120233	Tetraodon nigroviridis	72.24	0.00e+00	1467.00
IUUC-Tbe-127941	Tupaia belangeri	73.38	0.00e+00	1243.00
IUUC-Vpa-130448	Vicugna pacos	89.31	0.00e+00	1855.00
IUUC-Xtr-132719	Xenopus tropicalis	71.43	0.00e+00	1411.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence