iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059808

UUCD1 version

UUC-MeG-00864

Ensembl Protein ID

ENSMGAP00000015323.1

UniProt Accession

G1NNS5; G1NNS5_MELGA

Protein Name

Uncharacterized protein

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000014480.1	ENSMGAT00000016277.1	ENSMGAP00000015323.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-63	214.6	169	649
UBD/Alpha-Helix/UBA	7.30e-06	25.7	19	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+     + ++l+++++++++ +++++l+ lf+ l+ sk+k+v+p++ +++lk++ ++ +
   Q: 169  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNfnppANAQDLPRNQKEHRNLPFMRELRYLFALLVGSKRKYVDPSRAVEILKDAFKS-N 256
           6*******************************9999999999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le++++                   + +ee++ +k k+++++lF g++    + +  +++ + +e f +++l
   Q: 257  DSQQQDVSEFTHKLLDWLEDAFQ------------------IKAEEERDGEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 325
           **********************2..................22345678999**************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp  L l++
   Q: 326  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSAKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPPILYLDR 403
           ******.....9**************96...899998754...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 404  YMHKnreltrikrdeikrlkeyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddlgasapssgtlpaqtspstve 492
           ****7777777777777777777777777777777777777777777777777777777777776666666666666666666655555 PP
   S: 268  peekqke.................................................................................. 274
           +     +                                                                                  
   Q: 493  Q-----Qgpsssdvpstspvqrsvihkpftqsrippdlpmhpaprhiteeelsvlegclhrwrtevendtrdlqesisrihrtielmyf 576
           0.....05555555666666666666666666677777777777777777777777888888888888888888999999999999999 PP
   S: 275  .....kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                ++ Y+L+av+vH+G+++ GHY+ay+++++++ W++++D +Vt++++ee ++++      ++aY+l+Y 
   Q: 577  dktmiQVPYRLHAVLVHEGQANAGHYWAYIYDHHQNrWMKYNDISVTKSTWEELERDSFggyrnASAYCLMYI 649
           99999***************************77667*******************8779************6 PP

UBD/Alpha-Helix/UBA

   S: 5    dkleqlve.MGF.dreealqaLraannnleaAveyL 38
             l+ql+e +G+ d +  +qaL ++n+nle Av++L
   Q: 19   TFLNQLREiTGInDIQVLQQALKDSNGNLELAVAFL 54
           569*******************************98 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

ICMYHQVLLF FSSSKHQQTF LNQLREITGI NDIQVLQQAL KDSNGNLELA VAFLTAKNAK 60
VPQQEEASYY QTALPGNDRY ISVGSQADTN VIDLTGDDKD DLQRAIALSL EESNRAFRET 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTGCATGT ACCACCAAGT TCTTCTCTTT TTCTCATCTT CCAAAGGAAG AATGTAACCA 60
TATAGTTTAG AACAGTGGTC AATCTTCTGT GTTTTCATGG TTTTAATGGT GAAGATGGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	83.06	0.00e+00	1794.00
IUUC-Apl-004030	Anas platyrhynchos	95.51	0.00e+00	2058.00
IUUC-Aca-004753	Anolis carolinensis	69.57	0.00e+00	1074.00
IUUC-Acl-008164	Aspergillus clavatus	25.13	2.00e-14	75.10
IUUC-Ani-009503	Aspergillus nidulans	34.58	4.00e-11	63.50
IUUC-Ame-010624	Astyanax mexicanus	73.60	0.00e+00	1144.00
IUUC-Bta-013166	Bos taurus	85.27	0.00e+00	1792.00
IUUC-Cja-019150	Callithrix jacchus	84.86	0.00e+00	1302.00
IUUC-Cfa-020649	Canis familiaris	84.97	0.00e+00	1301.00
IUUC-Cpo-021807	Cavia porcellus	82.96	0.00e+00	1857.00
IUUC-Csa-023388	Chlorocebus sabaeus	85.34	0.00e+00	1320.00
IUUC-Cho-024343	Choloepus hoffmanni	73.48	0.00e+00	902.00
IUUC-Cin-025302	Ciona intestinalis	37.77	5.00e-97	348.00
IUUC-Csv-025911	Ciona savignyi	36.74	5.00e-138	484.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	55.56	1.00e-10	62.00
IUUC-Cme-027167	Cyanidioschyzon merolae	31.34	5.00e-13	70.10
IUUC-Dre-028016	Danio rerio	77.17	0.00e+00	1192.00
IUUC-Dno-029495	Dasypus novemcinctus	81.98	0.00e+00	1299.00
IUUC-Dor-030948	Dipodomys ordii	70.92	0.00e+00	1263.00
IUUC-Fca-035876	Felis catus	85.66	0.00e+00	1823.00
IUUC-Fal-036762	Ficedula albicollis	97.19	0.00e+00	1246.00
IUUC-Fox-037752	Fusarium oxysporum	25.78	1.00e-18	88.60
IUUC-Gmo-039490	Gadus morhua	74.53	0.00e+00	1586.00
IUUC-Gga-040817	Gallus gallus	98.82	0.00e+00	1506.00
IUUC-Gac-042473	Gasterosteus aculeatus	75.00	0.00e+00	1620.00
IUUC-Ggo-044939	Gorilla gorilla	80.94	0.00e+00	1734.00
IUUC-Hsa-046204	Homo sapiens	85.13	0.00e+00	1803.00
IUUC-Kpa-049349	Komagataella pastoris	27.75	1.00e-08	55.50
IUUC-Lch-049572	Latimeria chalumnae	83.42	0.00e+00	1269.00
IUUC-Loc-052070	Lepisosteus oculatus	81.18	0.00e+00	1224.00
IUUC-Laf-054426	Loxodonta africana	85.30	0.00e+00	1688.00
IUUC-Mcc-055858	Macaca mulatta	84.86	0.00e+00	1325.00
IUUC-Mmr-060987	Microcebus murinus	84.84	0.00e+00	1288.00
IUUC-Mmu-064245	Mus musculus	83.70	0.00e+00	1802.00
IUUC-Mpu-066304	Mustela putorius furo	84.14	0.00e+00	1301.00
IUUC-Mlu-067139	Myotis lucifugus	85.47	0.00e+00	1854.00
IUUC-Nfi-068458	Neosartorya fischeri	25.11	4.00e-15	77.40
IUUC-Nle-069075	Nomascus leucogenys	84.84	0.00e+00	1792.00
IUUC-Ont-072150	Oreochromis niloticus	76.73	0.00e+00	1213.00
IUUC-Oan-073054	Ornithorhynchus anatinus	80.78	0.00e+00	1711.00
IUUC-Ocu-074102	Oryctolagus cuniculus	82.50	0.00e+00	1301.00
IUUC-Ola-086529	Oryzias latipes	71.07	0.00e+00	1545.00
IUUC-Oga-088939	Otolemur garnettii	85.91	0.00e+00	1804.00
IUUC-Oar-090266	Ovis aries	84.46	0.00e+00	1294.00
IUUC-Ptr-090546	Pan troglodytes	84.94	0.00e+00	1799.00
IUUC-Pan-092311	Papio anubis	84.86	0.00e+00	1325.00
IUUC-Psi-093459	Pelodiscus sinensis	93.38	0.00e+00	1239.00
IUUC-Pno-095093	Phaeosphaeria nodorum	40.74	4.00e-12	67.00
IUUC-Pfo-096726	Poecilia formosa	75.43	0.00e+00	1198.00
IUUC-Pab-097608	Pongo abelii	83.02	0.00e+00	1777.00
IUUC-Pca-100718	Procavia capensis	79.28	0.00e+00	1106.00
IUUC-Pva-103150	Pteropus vampyrus	80.78	0.00e+00	1362.00
IUUC-Pte-104300	Pyrenophora teres	24.00	3.00e-14	74.30
IUUC-Rno-105727	Rattus norvegicus	83.60	0.00e+00	1770.00
IUUC-Sha-107051	Sarcophilus harrisii	89.55	0.00e+00	1890.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	35.44	5.00e-09	57.00
IUUC-Sar-113097	Sorex araneus	78.22	0.00e+00	1682.00
IUUC-Ssc-115877	Sus scrofa	81.95	0.00e+00	1785.00
IUUC-Tgu-117473	Taeniopygia guttata	90.05	0.00e+00	1902.00
IUUC-Tru-118135	Takifugu rubripes	68.07	0.00e+00	1426.00
IUUC-Tsy-119471	Tarsius syrichta	78.88	0.00e+00	1605.00
IUUC-Tni-120139	Tetraodon nigroviridis	69.44	0.00e+00	1342.00
IUUC-Tbe-127549	Tupaia belangeri	79.83	0.00e+00	1709.00
IUUC-Ttr-128896	Tursiops truncatus	78.87	0.00e+00	1695.00
IUUC-Vpa-130500	Vicugna pacos	85.49	0.00e+00	1217.00
IUUC-Xtr-132896	Xenopus tropicalis	84.39	0.00e+00	1822.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence