iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045719

UUCD1 version

UUC-HoS-00382

Ensembl Protein ID

ENSP00000411949.1

UniProt Accession

Q9HCM9; Q5STG3; Q5STG4; Q76BL3; Q8IYT9; Q96IB6; TRI39_HUMAN

Genbank Protein ID

BAB16374.1; AAP36034.1; BAD13703.1; BAF85201.1; BAD13704.1; BAE78608.1; CAI17501.1; CAI18251.1; CAI41818.1; CAI41819.1; CAM25899.1; CAM25900.1; CAQ08313.1; CAQ08314.1; CAQ08383.1; CAQ08384.1; CAQ09020.1; CAQ09021.1; EAX03283.1; EAX03284.1; AAH07661.1; AAH34985.1

Protein Name

E3 ubiquitin-protein ligase TRIM39; RING finger protein 23; RING-type E3 ubiquitin transferase TRIM39; Testis-abundant finger protein; Tripartite motif-containing protein 39

Genbank Nucleotide ID

AB046381; BT007370; AB110937; AK292512; AB110938; AB202089; AL662832; AL662795; AL773535; AL773535; BX248580; BX248580; CR759928; CR759928; BX927214; BX927214; CR759281; CR759281; CH471081; CH471081; BC007661; BC034985

Gene Name

TRIM39; RNF23; TFP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000224994.9	ENST00000440117.5	ENSP00000392130.1
ENSG00000224994.9	ENST00000413715.5	ENSP00000411949.1
ENSG00000224994.9	ENST00000437257.5	ENSP00000388149.1
ENSG00000224994.9	ENST00000552950.4	ENSP00000446993.2

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	CircNet	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	PINA	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	2.40e-07	32.4	27	87
E3 activity/RING/RING	9.70e-08	34.1	29	70

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 6    flCpIslelMrdPvvlpsGitydrssIekwlasggk..tcPvtrqplteedlvPnltlrrl 64
             C++ le  ++Pv++++G+ + +++I +w ++ ++   cPv+r++ + ++l Pn  l ++
   Q: 27   ASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERdfPCPVCRKTSRYRSLRPNRQLGSM 87
           68*****************************88887799****************998666 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle +k+ p++  CgH f++ C+ +w        + f CP+Cr
   Q: 29   CSVCLEYLKE-PVIIECGHNFCKACITRW---WEDLERDFPCPVCR 70
           ********99.999************999...666889999****8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1.

Protein Sequence
(Fasta)

MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL 60
ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGAGAGGA AAAGTGTGGA AGTCCACAAG CCGCCCCCGC CCCGCCCTCT TCGTCGACTT 60
TCAGCTGCAC CGGGAGGCGG CGGCGCCTGG CCAGAGCCGG GGCCTGGAGC CTGGACTAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0496--Mitochondrion
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0042802--F:identical protein binding
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:2000059--P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:0016567--P:protein ubiquitination

KEGG

hsa:56658

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001603	Ailuropoda melanoleuca	93.44	0.00e+00	947.00
IUUC-Apl-003354	Anas platyrhynchos	40.87	1.00e-104	373.00
IUUC-Aca-005381	Anolis carolinensis	71.97	0.00e+00	696.00
IUUC-Cja-019323	Callithrix jacchus	93.76	0.00e+00	926.00
IUUC-Cfa-020342	Canis familiaris	93.36	0.00e+00	944.00
IUUC-Csa-023186	Chlorocebus sabaeus	93.96	0.00e+00	948.00
IUUC-Cho-024697	Choloepus hoffmanni	89.34	0.00e+00	887.00
IUUC-Dor-031021	Dipodomys ordii	90.79	2.00e-153	535.00
IUUC-Ete-032936	Echinops telfairi	87.46	3.00e-156	544.00
IUUC-Eeu-034957	Erinaceus europaeus	94.21	1.00e-133	469.00
IUUC-Fca-035406	Felis catus	93.16	0.00e+00	942.00
IUUC-Fal-036705	Ficedula albicollis	43.83	3.00e-95	342.00
IUUC-Gmo-038505	Gadus morhua	33.54	2.00e-68	253.00
IUUC-Gac-041919	Gasterosteus aculeatus	35.37	3.00e-70	259.00
IUUC-Ggo-044526	Gorilla gorilla	99.80	0.00e+00	1027.00
IUUC-Itr-048404	Ictidomys tridecemlineatus	91.88	0.00e+00	936.00
IUUC-Lch-050632	Latimeria chalumnae	38.87	2.00e-86	312.00
IUUC-Loc-052206	Lepisosteus oculatus	36.22	2.00e-83	303.00
IUUC-Laf-054295	Loxodonta africana	92.59	0.00e+00	940.00
IUUC-Mcc-055765	Macaca mulatta	98.39	0.00e+00	1002.00
IUUC-Mdo-062936	Monodelphis domestica	84.62	0.00e+00	840.00
IUUC-Mmu-063767	Mus musculus	91.75	0.00e+00	929.00
IUUC-Mpu-066160	Mustela putorius furo	93.44	0.00e+00	947.00
IUUC-Opr-070394	Ochotona princeps	94.97	0.00e+00	956.00
IUUC-Oan-072828	Ornithorhynchus anatinus	54.69	1.00e-158	553.00
IUUC-Ola-086686	Oryzias latipes	32.81	4.00e-66	245.00
IUUC-Oga-088422	Otolemur garnettii	88.50	0.00e+00	889.00
IUUC-Oar-089277	Ovis aries	88.33	0.00e+00	868.00
IUUC-Ptr-090853	Pan troglodytes	99.80	0.00e+00	1027.00
IUUC-Pan-091993	Papio anubis	93.96	0.00e+00	948.00
IUUC-Psi-092975	Pelodiscus sinensis	70.78	0.00e+00	637.00
IUUC-Pfo-096831	Poecilia formosa	32.36	2.00e-67	249.00
IUUC-Pab-097944	Pongo abelii	93.96	0.00e+00	948.00
IUUC-Pca-100795	Procavia capensis	89.92	0.00e+00	647.00
IUUC-Pva-103180	Pteropus vampyrus	94.99	0.00e+00	955.00
IUUC-Rno-105736	Rattus norvegicus	90.10	0.00e+00	918.00
IUUC-Sha-107411	Sarcophilus harrisii	50.50	1.00e-144	506.00
IUUC-Sar-113371	Sorex araneus	92.48	0.00e+00	782.00
IUUC-Ssc-116025	Sus scrofa	93.76	0.00e+00	947.00
IUUC-Tgu-116998	Taeniopygia guttata	44.66	3.00e-98	352.00
IUUC-Tru-117532	Takifugu rubripes	32.99	4.00e-71	262.00
IUUC-Tsy-119072	Tarsius syrichta	91.01	0.00e+00	669.00
IUUC-Tbe-127820	Tupaia belangeri	90.82	8.00e-146	510.00
IUUC-Ttr-128310	Tursiops truncatus	81.49	0.00e+00	807.00
IUUC-Vpa-130803	Vicugna pacos	95.98	0.00e+00	979.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence