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Tag Content
iUUCD ID IUUC-Apl-004155
Ensembl Protein ID ENSAPLP00000010236.1
UniProt Accession U3ISL3; U3ISL3_ANAPL
Genbank Protein ID ENSAPLP00000010236
Protein Name Uncharacterized protein
Genbank Nucleotide ID ADON01076797
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAPLG00000010476.1 ENSAPLT00000010945.1 ENSAPLP00000010236.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.70e-126 421.9 416 752
Active Site
Position(s) Description Evidence
721 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGv.treflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++dlkkrl+v+f+gEegld+gGv +re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++
   Q: 416  PKDLKKRLMVKFRGEEGLDYGGVaSREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYIN 503
           689*******************9459***********************************9.89************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
             ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+nipVt+eNk+eYv+l+v
   Q: 504  GGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNIPVTEENKKEYVRLYV 588
           ************************************99...9***8.****************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           ++r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqF
   Q: 589  NWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQF 676
           *********************************************************99.***************************** PP
   S: 268  vTgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           vTgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 677  VTGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 752
           *******************************99999**************************************76 PP
   
Organism Anas platyrhynchos
Protein Sequence
(Fasta)
APEPFLVQNL LSARCKMAVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Apl-004155|E3,HECT|Anas platyrhynchos
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCCCCAGAAC CCTTCTTGGT TCAAAACCTG CTTAGTGCTC GTTGTAAAAT GGGTGGGTTC 60
TGAAACAATG GCAGCAAAAT TCTGTTTTAG CACTTGTGTG AGCATGTAAT ATAGAGACTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Apl-004155|E3,HECT|Anas platyrhynchos
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 88.87 0.00e+00 1378.00
IUUC-Aca-005238 Anolis carolinensis 93.40 0.00e+00 1433.00
IUUC-Ame-010901 Astyanax mexicanus 87.47 0.00e+00 1353.00
IUUC-Bta-013221 Bos taurus 87.17 0.00e+00 1322.00
IUUC-Cja-018985 Callithrix jacchus 93.40 0.00e+00 1454.00
IUUC-Cfa-020568 Canis familiaris 93.84 0.00e+00 1431.00
IUUC-Cpo-022531 Cavia porcellus 92.74 0.00e+00 1446.00
IUUC-Csa-024145 Chlorocebus sabaeus 93.08 0.00e+00 1432.00
IUUC-Cho-024963 Choloepus hoffmanni 76.26 0.00e+00 906.00
IUUC-Dre-028341 Danio rerio 87.62 0.00e+00 1362.00
IUUC-Dno-029705 Dasypus novemcinctus 93.94 0.00e+00 1417.00
IUUC-Dme-031740 Drosophila melanogaster 70.62 4.00e-175 608.00
IUUC-Eca-034125 Equus caballus 94.62 0.00e+00 1446.00
IUUC-Fca-035905 Felis catus 92.69 0.00e+00 1418.00
IUUC-Fal-037336 Ficedula albicollis 95.66 0.00e+00 1444.00
IUUC-Gmo-039486 Gadus morhua 78.14 0.00e+00 860.00
IUUC-Gga-040218 Gallus gallus 96.67 0.00e+00 1503.00
IUUC-Gac-041707 Gasterosteus aculeatus 81.75 0.00e+00 1252.00
IUUC-Ggo-045408 Gorilla gorilla 88.42 0.00e+00 1340.00
IUUC-Hsa-045878 Homo sapiens 93.54 0.00e+00 1456.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 94.60 0.00e+00 1437.00
IUUC-Loc-052628 Lepisosteus oculatus 82.38 0.00e+00 1338.00
IUUC-Laf-053644 Loxodonta africana 88.90 0.00e+00 1361.00
IUUC-Mcc-055479 Macaca mulatta 85.49 0.00e+00 1283.00
IUUC-Mga-059723 Meleagris gallopavo 92.49 0.00e+00 1432.00
IUUC-Mdo-063005 Monodelphis domestica 94.53 0.00e+00 1459.00
IUUC-Mmu-063634 Mus musculus 92.68 0.00e+00 1412.00
IUUC-Mpu-065898 Mustela putorius furo 93.03 0.00e+00 1419.00
IUUC-Mlu-067584 Myotis lucifugus 93.87 0.00e+00 1444.00
IUUC-Nle-069033 Nomascus leucogenys 95.02 0.00e+00 1450.00
IUUC-Ont-072265 Oreochromis niloticus 82.96 0.00e+00 1289.00
IUUC-Oan-073621 Ornithorhynchus anatinus 90.12 0.00e+00 1425.00
IUUC-Ocu-073960 Oryctolagus cuniculus 93.69 0.00e+00 1419.00
IUUC-Oga-088579 Otolemur garnettii 93.54 0.00e+00 1456.00
IUUC-Oar-090396 Ovis aries 90.84 0.00e+00 1345.00
IUUC-Ptr-091624 Pan troglodytes 93.54 0.00e+00 1456.00
IUUC-Pan-092479 Papio anubis 94.14 0.00e+00 1448.00
IUUC-Psi-094074 Pelodiscus sinensis 95.16 0.00e+00 1134.00
IUUC-Pfo-097203 Poecilia formosa 81.94 0.00e+00 1263.00
IUUC-Pab-097540 Pongo abelii 93.10 0.00e+00 1384.00
IUUC-Pca-100379 Procavia capensis 72.47 0.00e+00 632.00
IUUC-Rno-105396 Rattus norvegicus 92.68 0.00e+00 1413.00
IUUC-Sha-107216 Sarcophilus harrisii 95.70 0.00e+00 1464.00
IUUC-Ssc-116413 Sus scrofa 93.75 0.00e+00 1385.00
IUUC-Tgu-116723 Taeniopygia guttata 95.56 0.00e+00 1452.00
IUUC-Tru-117843 Takifugu rubripes 79.66 0.00e+00 1242.00
IUUC-Tsy-119455 Tarsius syrichta 93.05 0.00e+00 1352.00
IUUC-Tni-120037 Tetraodon nigroviridis 81.28 0.00e+00 1215.00
IUUC-Tbe-127879 Tupaia belangeri 80.86 0.00e+00 1181.00
IUUC-Ttr-128423 Tursiops truncatus 93.26 0.00e+00 1366.00
IUUC-Xtr-132237 Xenopus tropicalis 88.74 0.00e+00 1379.00
Created Date 25-Jun-2017

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