iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028341

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

SMAD-specific E3 ubiquitin protein ligase 1

Genbank Nucleotide ID

BX649559

Gene Name

smurf1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000016086.10	ENSDART00000004923.8	ENSDARP00000003721.7

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.10e-127	424.6	395	730

Active Site

Position(s)	Description	Evidence
699	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ +tlq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 395  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 482
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g+  ++eLkp+G+nipVt+eNk+eYv+l+v+
   Q: 483  GFTLPFYKQLLGKPIQLCDLETVDPELHKSLVWILEN---DITSV-LDHTFCVEHNAFGKFLQHELKPNGKNIPVTEENKKEYVRLYVN 567
           ***********************************99...99998.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G  +id++d+k++t+ k+ + +ds+ ++wFw+++e+f++e r ++LqFv
   Q: 568  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDNKELELIIGGLGKIDLNDWKANTRLKH-CVADSNIVKWFWQAVESFDEERRGRLLQFV 655
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 656  TGSTRVPLQGFKALQgstgsagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 730
           ******************************99999**************************************76 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKV VVDGSGQCHS TDTVKSTLDP 60
KWNQHYDLYI GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTAGCCTGT GTTGTTAAGT CTGAAAGCTA CAGGGGATTT GCCAGACGGA AATAATACCG 60
TTTTATCGCC GAGAAACACA TGCACAGGCC ACACGATCGC GTCGCGTGTT TTTATACGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	85.52	0.00e+00	1313.00
IUUC-Apl-004155	Anas platyrhynchos	87.62	0.00e+00	1362.00
IUUC-Aca-005238	Anolis carolinensis	89.65	0.00e+00	1360.00
IUUC-Ame-010901	Astyanax mexicanus	98.22	0.00e+00	1477.00
IUUC-Bta-013221	Bos taurus	83.46	0.00e+00	1271.00
IUUC-Cja-018985	Callithrix jacchus	88.67	0.00e+00	1392.00
IUUC-Cfa-020568	Canis familiaris	86.51	0.00e+00	1339.00
IUUC-Cpo-022531	Cavia porcellus	88.27	0.00e+00	1386.00
IUUC-Csa-024145	Chlorocebus sabaeus	91.41	0.00e+00	1395.00
IUUC-Cho-024963	Choloepus hoffmanni	76.74	0.00e+00	707.00
IUUC-Dno-029705	Dasypus novemcinctus	86.45	0.00e+00	1324.00
IUUC-Dme-031740	Drosophila melanogaster	71.79	8.00e-176	611.00
IUUC-Eca-034125	Equus caballus	87.85	0.00e+00	1348.00
IUUC-Fca-035905	Felis catus	89.53	0.00e+00	1345.00
IUUC-Fal-037336	Ficedula albicollis	90.79	0.00e+00	1345.00
IUUC-Gmo-039486	Gadus morhua	84.47	0.00e+00	908.00
IUUC-Gga-040218	Gallus gallus	90.71	0.00e+00	1402.00
IUUC-Gac-041707	Gasterosteus aculeatus	88.89	0.00e+00	1342.00
IUUC-Ggo-045408	Gorilla gorilla	82.86	0.00e+00	1249.00
IUUC-Hsa-045878	Homo sapiens	88.67	0.00e+00	1392.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	88.11	0.00e+00	1348.00
IUUC-Loc-052628	Lepisosteus oculatus	89.33	0.00e+00	1421.00
IUUC-Laf-053644	Loxodonta africana	85.64	0.00e+00	1293.00
IUUC-Mcc-055479	Macaca mulatta	83.90	0.00e+00	1248.00
IUUC-Mga-059723	Meleagris gallopavo	87.57	0.00e+00	1326.00
IUUC-Mdo-063005	Monodelphis domestica	91.80	0.00e+00	1408.00
IUUC-Mmu-063634	Mus musculus	91.13	0.00e+00	1377.00
IUUC-Mpu-065898	Mustela putorius furo	90.00	0.00e+00	1347.00
IUUC-Mlu-067584	Myotis lucifugus	87.17	0.00e+00	1345.00
IUUC-Nle-069033	Nomascus leucogenys	88.39	0.00e+00	1355.00
IUUC-Ont-072265	Oreochromis niloticus	87.91	0.00e+00	1362.00
IUUC-Oan-073621	Ornithorhynchus anatinus	85.85	0.00e+00	1357.00
IUUC-Ocu-073960	Oryctolagus cuniculus	86.81	0.00e+00	1319.00
IUUC-Ola-086960	Oryzias latipes	79.74	0.00e+00	1174.00
IUUC-Oga-088579	Otolemur garnettii	88.67	0.00e+00	1392.00
IUUC-Oar-090396	Ovis aries	86.04	0.00e+00	1283.00
IUUC-Ptr-091624	Pan troglodytes	88.67	0.00e+00	1392.00
IUUC-Pan-092479	Papio anubis	88.39	0.00e+00	1355.00
IUUC-Pfo-097203	Poecilia formosa	89.04	0.00e+00	1351.00
IUUC-Pab-097540	Pongo abelii	88.29	0.00e+00	1321.00
IUUC-Rno-105396	Rattus norvegicus	91.13	0.00e+00	1378.00
IUUC-Sha-107216	Sarcophilus harrisii	87.92	0.00e+00	1373.00
IUUC-Ssc-116413	Sus scrofa	88.78	0.00e+00	1330.00
IUUC-Tgu-116723	Taeniopygia guttata	88.14	0.00e+00	1339.00
IUUC-Tru-117843	Takifugu rubripes	86.54	0.00e+00	1332.00
IUUC-Tsy-119455	Tarsius syrichta	87.57	0.00e+00	1263.00
IUUC-Tni-120037	Tetraodon nigroviridis	84.41	0.00e+00	1269.00
IUUC-Tbe-127879	Tupaia belangeri	74.93	0.00e+00	1093.00
IUUC-Ttr-128423	Tursiops truncatus	86.49	0.00e+00	1274.00
IUUC-Xtr-132237	Xenopus tropicalis	85.45	0.00e+00	1348.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence