iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098666

Ensembl Protein ID

ENSPPYP00000007617.2

UniProt Accession

Q5R7S6; ZFAN6_PONAB

Genbank Protein ID

CAH92184.1

Protein Name

AN1-type zinc finger protein 6; Zinc finger A20 domain-containing protein 3

Genbank Nucleotide ID

CR860033

Gene Name

ZFAND6; ZA20D3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000006712.2	ENSPPYT00000007926.2	ENSPPYP00000007617.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/ZnF_A20	4.00e-20	71.6	9	42

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/ZnF_A20

   S: 2    pskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           ++++lC++gCgfYGnp+tng+CS+Cy+e+l+r++
   Q: 9    QVPMLCSTGCGFYGNPRTNGMCSVCYKEHLQRQN 42
           89******************************95 PP

Organism

Pongo abelii

Functional Description
(View)

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).

Protein Sequence
(Fasta)

MAQETNHSQV PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP PATSVSSLSE 60
SLPVQCTDGS VPEAQSTLDS TSSSMQPSPV SNQSLLSESV ASSQLDSTSV DKAVPETEDL 120

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Nucleotide Sequence
(Fasta)

CATAGGCCGA ACAACCAAAC AGAAAAGTTT AATAAACAGC GGACGGAGGG GCCGGCGGTG 60
GCGGAGCCGG AGCAAGCAGG GGTTCGGCGG CCTTACCTGT ACCCATTCAC CGGCGGCTAT 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002653--Znf_A20
IPR000058--Znf_AN1

PROSITE

PS51036--ZF_A20
PS51039--ZF_AN1

Pfam

PF01754--zf-A20
PF01428--zf-AN1

SMART

SM00259--ZnF_A20
SM00154--ZnF_AN1

Gene Ontology

GO:0005737--C:cytoplasm
GO:0003677--F:DNA binding
GO:0031593--F:polyubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0071356--P:cellular response to tumor necrosis factor
GO:0043066--P:negative regulation of apoptotic process
GO:0006625--P:protein targeting to peroxisome
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling

KEGG

pon:100174596

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001996	Ailuropoda melanoleuca	67.09	6.00e-83	299.00
IUUC-Apl-003230	Anas platyrhynchos	76.89	5.00e-92	330.00
IUUC-Aca-004458	Anolis carolinensis	80.57	3.00e-95	340.00
IUUC-Aly-005845	Arabidopsis lyrata	31.10	7.00e-23	99.80
IUUC-Ath-007039	Arabidopsis thaliana	31.63	6.00e-22	96.70
IUUC-Bol-015417	Brassica oleracea	33.67	5.00e-25	106.00
IUUC-Bra-017534	Brassica rapa	34.85	3.00e-25	107.00
IUUC-Cja-019854	Callithrix jacchus	98.56	3.00e-107	380.00
IUUC-Cfa-020592	Canis familiaris	95.67	1.00e-116	411.00
IUUC-Cpo-022191	Cavia porcellus	88.94	4.00e-93	333.00
IUUC-Cre-022706	Chlamydomonas reinhardtii	31.40	2.00e-23	101.00
IUUC-Csa-023200	Chlorocebus sabaeus	99.52	1.00e-104	371.00
IUUC-Cho-025055	Choloepus hoffmanni	87.42	9.00e-70	255.00
IUUC-Cme-027230	Cyanidioschyzon merolae	60.71	7.00e-07	47.00
IUUC-Dno-029778	Dasypus novemcinctus	97.60	6.00e-109	385.00
IUUC-Dor-030783	Dipodomys ordii	78.85	2.00e-74	271.00
IUUC-Dme-032180	Drosophila melanogaster	40.38	3.00e-35	141.00
IUUC-Ete-033057	Echinops telfairi	93.30	5.00e-105	372.00
IUUC-Eca-033680	Equus caballus	96.63	5.00e-110	389.00
IUUC-Fca-036284	Felis catus	93.72	1.00e-114	405.00
IUUC-Fal-036744	Ficedula albicollis	81.82	4.00e-94	336.00
IUUC-Gga-041083	Gallus gallus	82.30	5.00e-92	330.00
IUUC-Gma-043379	Glycine max	32.69	7.00e-23	99.40
IUUC-Ggo-045187	Gorilla gorilla	99.52	3.00e-108	383.00
IUUC-Hsa-046323	Homo sapiens	99.04	4.00e-111	393.00
IUUC-Itr-048209	Ictidomys tridecemlineatus	91.93	4.00e-107	380.00
IUUC-Lch-049537	Latimeria chalumnae	71.70	1.00e-78	285.00
IUUC-Loc-051871	Lepisosteus oculatus	67.77	3.00e-75	274.00
IUUC-Laf-053415	Loxodonta africana	89.69	6.00e-114	402.00
IUUC-Mcc-055523	Macaca mulatta	99.52	8.00e-105	372.00
IUUC-Meu-056041	Macropus eugenii	79.90	2.00e-89	321.00
IUUC-Mga-059999	Meleagris gallopavo	75.77	1.00e-88	318.00
IUUC-Mmr-061275	Microcebus murinus	88.94	2.00e-105	374.00
IUUC-Mdo-062315	Monodelphis domestica	95.22	7.00e-116	409.00
IUUC-Mmu-063968	Mus musculus	88.34	7.00e-112	395.00
IUUC-Mpu-066705	Mustela putorius furo	92.79	1.00e-112	398.00
IUUC-Mlu-067748	Myotis lucifugus	87.05	7.00e-97	346.00
IUUC-Nle-069143	Nomascus leucogenys	99.04	3.00e-106	377.00
IUUC-Opr-070483	Ochotona princeps	89.90	7.00e-96	342.00
IUUC-Oan-073186	Ornithorhynchus anatinus	85.17	2.00e-100	357.00
IUUC-Ocu-073771	Oryctolagus cuniculus	91.83	6.00e-92	329.00
IUUC-Oga-088957	Otolemur garnettii	96.63	4.00e-109	386.00
IUUC-Oar-089228	Ovis aries	95.19	2.00e-116	410.00
IUUC-Ptr-090990	Pan troglodytes	99.52	4.00e-108	383.00
IUUC-Pan-092389	Papio anubis	99.04	1.00e-104	371.00
IUUC-Psi-093513	Pelodiscus sinensis	85.17	2.00e-93	334.00
IUUC-Ppa-095693	Physcomitrella patens	34.17	8.00e-26	109.00
IUUC-Pca-100099	Procavia capensis	84.62	2.00e-96	344.00
IUUC-Pva-102935	Pteropus vampyrus	94.31	2.00e-104	371.00
IUUC-Rno-104975	Rattus norvegicus	88.34	7.00e-112	395.00
IUUC-Sha-106855	Sarcophilus harrisii	88.44	8.00e-113	399.00
IUUC-Sly-111918	Solanum lycopersicum	36.97	6.00e-27	113.00
IUUC-Ssc-116012	Sus scrofa	87.61	2.00e-107	381.00
IUUC-Tgu-116855	Taeniopygia guttata	82.30	4.00e-95	340.00
IUUC-Tsy-119175	Tarsius syrichta	91.87	2.00e-108	384.00
IUUC-Tae-125099	Triticum aestivum	32.32	1.00e-24	105.00
IUUC-Tbe-127440	Tupaia belangeri	56.96	2.00e-42	164.00
IUUC-Ttr-128188	Tursiops truncatus	96.15	2.00e-87	314.00
IUUC-Vpa-130770	Vicugna pacos	97.12	3.00e-99	353.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence