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Tag Content
UUCD2 ID IUUC-Gga-040299
UUCD1 version UUC-GaG-00071
Ensembl Protein ID ENSGALP00000037437.2
UniProt Accession F1P1P3; F1P1P3_CHICK
Genbank Protein ID ENSGALP00000037437
Protein Name Apoptotic protease-activating factor 1
Genbank Nucleotide ID AADN04000027
Gene Name APAF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSGALG00000011531.5 ENSGALT00000038231.3 ENSGALP00000037437.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.60e-62 204.9 654 690
UBD/Beta-Prp 7.60e-130 432.8 612 869
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           H d++ c+ f  +d++++++s D+++k+W+ rtg++l
   Q: 654  HDDEILCCTFsaDDKYVATCSADKKVKIWNSRTGKCL 690
           9**********777*********************98 PP
   

   UBD/Beta-Prp
   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h + ++  +fs+d++ +a+ ++d+t++v+++++g  l ++s h++e+ +++fs d+k+ +t+s D+ +k+w+ +tgkc++++++h+++v
   Q: 612  HRDAVYHACFSRDRQRIASCGADKTLQVFKAESGERLLEISAHDDEILCCTFSADDKYVATCSADKKVKIWNSRTGKCLYVYEEHTEQV 700
           44555669********************************************************************************* PP
   S: 98   lslsfsp.sg.dklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl......... 175
            +++f+   g + l++ s+d +i++wdl+ ++c + t  gh  +v++ +++p++++++s+s+D+tv+lW++ +++ lrt          
   Q: 701  NCCQFNNrRGqYLLATCSDDTYIKLWDLKDKYCRN-TMFGHVNAVSHCRFSPNDDYIASCSTDGTVKLWNVHSANELRTIeikdffrna 788
           *******755689999*******************.***********************************999999999999999996 PP
   S: 176  tgghtdsvysls....fdsngkelvsgsldgtvklwdlqtgec.vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrs 253
            + ++d+v+ l     +++++  ++ ++++ ++ l+d+ t++   +  + h ++++  +f+  de+++++ s+ si +W+++s
   Q: 789  DE-QQDDVEVLVkccsWSRSSDTILVVAKN-KLLLFDVTTSNLlTQVIISHHSTIQYCDFCAGDELVAVALSHCSIELWNIKS 869
           33.5666655555666***99999999887.57799*9977762556678***********9999999999*********986 PP
   
Organism Gallus gallus
Functional Description
(View)

Functional Description


     Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
 Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.
Protein Sequence
(Fasta)
MDENSRMCLI TNRQALEKDI KTSYIMDHMV ADQVLTLQEE EKVKQQNTQK ERAAMLINTL 60
LTKDNNAYRS FYNALLHEGY RDLAALLQDG IPAFSSKNGK NAMDERTSYV KTALCEGGVP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Gga-040299|E3,WD_repeat;UBD,Beta-Prp|Gallus gallus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTTGACTTTC CCCCCCCCCA CCCTAAAGAA ATATGGATGA GAACAGTAGA ATGTGTTTAA 60
TTACGAATCG TCAGGCACTG GAGAAAGACA TCAAAACCTC TTACATTATG GATCATATGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Gga-040299|E3,WD_repeat;UBD,Beta-Prp|Gallus gallus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0053--Apoptosis
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR017251--Apaf-1
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR002469--Peptidase_S9B_N
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom
PROSITE

PS50209--CARD
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00619--CARD
PF00931--NB-ARC
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00114--CARD
SM00320--WD40
Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0005524--F:ATP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001432 Ailuropoda melanoleuca 69.46 0.00e+00 1813.00
IUUC-Apl-004201 Anas platyrhynchos 90.07 0.00e+00 2313.00
IUUC-Aca-004638 Anolis carolinensis 70.24 0.00e+00 1871.00
IUUC-Ani-009285 Aspergillus nidulans 26.35 3.00e-64 240.00
IUUC-Ame-011062 Astyanax mexicanus 54.00 0.00e+00 1370.00
IUUC-Bta-012865 Bos taurus 69.22 0.00e+00 1849.00
IUUC-Cel-018376 Caenorhabditis elegans 22.09 2.00e-25 112.00
IUUC-Cja-018815 Callithrix jacchus 64.36 0.00e+00 1662.00
IUUC-Cfa-020222 Canis familiaris 65.98 0.00e+00 1692.00
IUUC-Cpo-021524 Cavia porcellus 68.59 0.00e+00 1821.00
IUUC-Csa-023861 Chlorocebus sabaeus 69.70 0.00e+00 1836.00
IUUC-Cho-024484 Choloepus hoffmanni 59.52 0.00e+00 915.00
IUUC-Dre-028006 Danio rerio 52.39 0.00e+00 1271.00
IUUC-Dno-029591 Dasypus novemcinctus 70.02 0.00e+00 1852.00
IUUC-Dor-030237 Dipodomys ordii 56.98 0.00e+00 811.00
IUUC-Ete-032620 Echinops telfairi 66.13 0.00e+00 853.00
IUUC-Eca-033569 Equus caballus 69.70 0.00e+00 1826.00
IUUC-Eeu-035354 Erinaceus europaeus 49.90 7.00e-133 468.00
IUUC-Fca-036337 Felis catus 69.41 0.00e+00 1845.00
IUUC-Fal-037077 Ficedula albicollis 86.79 0.00e+00 2246.00
IUUC-Gmo-039687 Gadus morhua 48.60 0.00e+00 905.00
IUUC-Ggr-039828 Gaeumannomyces graminis 25.31 7.00e-39 156.00
IUUC-Gac-041762 Gasterosteus aculeatus 51.34 0.00e+00 1263.00
IUUC-Ggo-045563 Gorilla gorilla 69.86 0.00e+00 1848.00
IUUC-Hsa-046771 Homo sapiens 69.70 0.00e+00 1843.00
IUUC-Lch-050200 Latimeria chalumnae 64.78 0.00e+00 1643.00
IUUC-Loc-052090 Lepisosteus oculatus 58.03 0.00e+00 1521.00
IUUC-Laf-053861 Loxodonta africana 69.25 0.00e+00 1830.00
IUUC-Mcc-055543 Macaca mulatta 69.62 0.00e+00 1833.00
IUUC-Meu-056688 Macropus eugenii 69.22 0.00e+00 1783.00
IUUC-Mga-059243 Meleagris gallopavo 95.43 0.00e+00 2471.00
IUUC-Mmr-061134 Microcebus murinus 66.75 0.00e+00 1575.00
IUUC-Mdo-062913 Monodelphis domestica 68.98 0.00e+00 1798.00
IUUC-Mmu-063811 Mus musculus 68.59 0.00e+00 1823.00
IUUC-Mpu-066780 Mustela putorius furo 69.57 0.00e+00 1802.00
IUUC-Mlu-067276 Myotis lucifugus 69.65 0.00e+00 1843.00
IUUC-Nle-069129 Nomascus leucogenys 69.46 0.00e+00 1833.00
IUUC-Opr-071007 Ochotona princeps 51.05 0.00e+00 835.00
IUUC-Ont-071348 Oreochromis niloticus 53.02 0.00e+00 1381.00
IUUC-Oan-072717 Ornithorhynchus anatinus 71.70 0.00e+00 1897.00
IUUC-Ocu-074286 Oryctolagus cuniculus 69.10 0.00e+00 1540.00
IUUC-Ola-086895 Oryzias latipes 48.48 0.00e+00 1180.00
IUUC-Oga-088678 Otolemur garnettii 68.35 0.00e+00 1804.00
IUUC-Oar-089359 Ovis aries 69.30 0.00e+00 1843.00
IUUC-Ptr-091062 Pan troglodytes 69.78 0.00e+00 1846.00
IUUC-Pan-092528 Papio anubis 73.39 0.00e+00 1145.00
IUUC-Psi-093430 Pelodiscus sinensis 77.49 0.00e+00 2006.00
IUUC-Pma-094690 Petromyzon marinus 37.08 7.00e-146 510.00
IUUC-Pfo-097204 Poecilia formosa 52.89 0.00e+00 1363.00
IUUC-Pab-097690 Pongo abelii 69.94 0.00e+00 1850.00
IUUC-Pca-100778 Procavia capensis 54.21 0.00e+00 891.00
IUUC-Pva-102870 Pteropus vampyrus 68.27 0.00e+00 1658.00
IUUC-Rno-104889 Rattus norvegicus 68.75 0.00e+00 1801.00
IUUC-Sha-107465 Sarcophilus harrisii 68.90 0.00e+00 1828.00
IUUC-Sar-113268 Sorex araneus 66.95 2.00e-143 503.00
IUUC-Ssc-115654 Sus scrofa 69.14 0.00e+00 1838.00
IUUC-Tgu-117302 Taeniopygia guttata 87.89 0.00e+00 2278.00
IUUC-Tru-118363 Takifugu rubripes 53.17 0.00e+00 1358.00
IUUC-Tsy-119007 Tarsius syrichta 67.55 0.00e+00 1763.00
IUUC-Tni-120910 Tetraodon nigroviridis 51.70 0.00e+00 1304.00
IUUC-Tur-126636 Triticum urartu 23.75 2.00e-23 105.00
IUUC-Tbe-127413 Tupaia belangeri 60.04 0.00e+00 1097.00
IUUC-Ttr-129213 Tursiops truncatus 63.87 0.00e+00 1657.00
IUUC-Vpa-130146 Vicugna pacos 65.45 0.00e+00 1254.00
IUUC-Xtr-132559 Xenopus tropicalis 59.25 0.00e+00 1542.00
Created Date 25-Jun-2017

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