iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074286

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02034199

Gene Name

APAF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000011860.3	ENSOCUT00000011868.3	ENSOCUP00000010200.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.20e-64	210.0	545	583
UBD/Beta-Prp	6.30e-94	314.5	416	587

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHt+sv+ ++f +d +ll+s+s Dgt+k+WD+++ + +k
   Q: 545  GHTNSVNHCRFsPDdKLLSSCSADGTLKLWDVKSANEVK 583
           8***********777*****************9988776 PP

UBD/Beta-Prp

   S: 49   sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghd 137
             h+++v+  +fs dg+ +++++ D+t++v+  +tg+ +  +k+hed+vl+++fs + +++++ s dr +++w+  tg+ ++ t ++h+
   Q: 416  RPHTDAVYHACFSADGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCTFSTDENFIATCSVDRKVKIWNSVTGELVR-TYDEHS 503
           5689999999999999999999999999999999999999999999999999999999999999999999999999999999.888888 PP
   S: 138  gvvncvvvhpdg..nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlng 220
           + vnc ++  ++   ll++Gs D +++lWdl+++ +  t+ g ht+sv++  f+++ k l s+s dgt+klwd+++ + v++ n 
   Q: 504  EQVNCCCFTNQSqyLLLATGSSDFFLKLWDLNQNVCRNTMFG-HTNSVNHCRFSPDDKLLSSCSADGTLKLWDVKSANEVKSINV 587
           888888887777345678999999999999999999999987.999999999999999999999999999999998776666554 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MKLQNLCSRL DQDESFFQRL PLNIEEAKDR LRILMLHKHP RSLLILDDVW DPWVLKAFDN 60
QCQILLTTRD KSVTDSVMGP KYVVPVESSL GKEKGLEILS LFVNMKKTDL PEQAHSIIKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCTAACAG TGAAGCCATT ACGAGGAGGG CTGCTGTTCA GAATCCTTGT TTATTTTTTC 60
CTCACCAGGT TGTTTCCCGG GAGGTGTGCA TTGGGTTTCA GTTGGGCAGC AGGACAAAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR009072--Histone-fold
IPR002182--NB-ARC
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00931--NB-ARC
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0043293--C:apoptosome
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0043531--F:ADP binding
GO:0008656--F:cysteine-type endopeptidase activator activity involved in apoptotic process
GO:0008635--P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0030900--P:forebrain development
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001843--P:neural tube closure
GO:0051402--P:neuron apoptotic process
GO:2001235--P:positive regulation of apoptotic signaling pathway
GO:1902510--P:regulation of apoptotic DNA fragmentation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001432	Ailuropoda melanoleuca	91.27	0.00e+00	1976.00
IUUC-Apl-004201	Anas platyrhynchos	70.05	0.00e+00	1556.00
IUUC-Aca-004638	Anolis carolinensis	67.96	0.00e+00	1517.00
IUUC-Ani-009285	Aspergillus nidulans	27.59	6.00e-69	256.00
IUUC-Ame-011062	Astyanax mexicanus	54.50	0.00e+00	1140.00
IUUC-Bta-012865	Bos taurus	89.84	0.00e+00	1991.00
IUUC-Cel-018376	Caenorhabditis elegans	21.22	3.00e-30	128.00
IUUC-Cja-018815	Callithrix jacchus	79.38	0.00e+00	1700.00
IUUC-Cfa-020222	Canis familiaris	85.81	0.00e+00	1839.00
IUUC-Cpo-021524	Cavia porcellus	88.22	0.00e+00	1957.00
IUUC-Csa-023861	Chlorocebus sabaeus	91.55	0.00e+00	1998.00
IUUC-Cho-024484	Choloepus hoffmanni	80.11	0.00e+00	1226.00
IUUC-Dre-028006	Danio rerio	53.22	0.00e+00	1068.00
IUUC-Dno-029591	Dasypus novemcinctus	91.26	0.00e+00	2021.00
IUUC-Dor-030237	Dipodomys ordii	76.52	0.00e+00	1092.00
IUUC-Ete-032620	Echinops telfairi	83.71	0.00e+00	1079.00
IUUC-Eca-033569	Equus caballus	90.79	0.00e+00	1982.00
IUUC-Eeu-035354	Erinaceus europaeus	64.86	4.00e-178	619.00
IUUC-Fca-036337	Felis catus	91.26	0.00e+00	1999.00
IUUC-Fal-037077	Ficedula albicollis	70.18	0.00e+00	1532.00
IUUC-Gmo-039687	Gadus morhua	49.40	0.00e+00	764.00
IUUC-Ggr-039828	Gaeumannomyces graminis	22.61	3.00e-40	161.00
IUUC-Gga-040299	Gallus gallus	69.10	0.00e+00	1540.00
IUUC-Gac-041762	Gasterosteus aculeatus	51.44	0.00e+00	1065.00
IUUC-Ggo-045563	Gorilla gorilla	91.45	0.00e+00	1998.00
IUUC-Hsa-046771	Homo sapiens	90.98	0.00e+00	1992.00
IUUC-Lch-050200	Latimeria chalumnae	64.48	0.00e+00	1365.00
IUUC-Loc-052090	Lepisosteus oculatus	59.25	0.00e+00	1291.00
IUUC-Laf-053861	Loxodonta africana	90.23	0.00e+00	1971.00
IUUC-Mcc-055543	Macaca mulatta	91.83	0.00e+00	2001.00
IUUC-Meu-056688	Macropus eugenii	80.40	0.00e+00	1752.00
IUUC-Mga-059243	Meleagris gallopavo	69.44	0.00e+00	1551.00
IUUC-Mmr-061134	Microcebus murinus	84.52	0.00e+00	1819.00
IUUC-Mdo-062913	Monodelphis domestica	79.55	0.00e+00	1747.00
IUUC-Mmu-063811	Mus musculus	87.84	0.00e+00	1962.00
IUUC-Mpu-066780	Mustela putorius furo	91.26	0.00e+00	1982.00
IUUC-Mlu-067276	Myotis lucifugus	89.85	0.00e+00	1979.00
IUUC-Nfi-068459	Neosartorya fischeri	27.01	2.00e-59	224.00
IUUC-Nle-069129	Nomascus leucogenys	90.79	0.00e+00	1984.00
IUUC-Opr-071007	Ochotona princeps	70.14	0.00e+00	1173.00
IUUC-Ont-071348	Oreochromis niloticus	55.84	0.00e+00	1182.00
IUUC-Oan-072717	Ornithorhynchus anatinus	82.10	0.00e+00	1805.00
IUUC-Ola-086895	Oryzias latipes	50.54	0.00e+00	1017.00
IUUC-Oga-088678	Otolemur garnettii	90.22	0.00e+00	1981.00
IUUC-Oar-089359	Ovis aries	89.17	0.00e+00	1984.00
IUUC-Ptr-091062	Pan troglodytes	90.98	0.00e+00	1994.00
IUUC-Pan-092528	Papio anubis	93.22	0.00e+00	1028.00
IUUC-Psi-093430	Pelodiscus sinensis	74.29	0.00e+00	1646.00
IUUC-Pma-094690	Petromyzon marinus	37.99	4.00e-150	525.00
IUUC-Pfo-097204	Poecilia formosa	55.46	0.00e+00	1192.00
IUUC-Pab-097690	Pongo abelii	91.36	0.00e+00	2002.00
IUUC-Pca-100778	Procavia capensis	71.43	0.00e+00	1194.00
IUUC-Pva-102870	Pteropus vampyrus	87.18	0.00e+00	1922.00
IUUC-Pyt-104620	Pyrenophora triticirepentis	27.22	5.00e-60	226.00
IUUC-Rno-104889	Rattus norvegicus	87.75	0.00e+00	1924.00
IUUC-Sha-107465	Sarcophilus harrisii	79.51	0.00e+00	1782.00
IUUC-Spo-108361	Schizosaccharomyces pombe	21.38	3.00e-31	130.00
IUUC-Sar-113268	Sorex araneus	87.46	0.00e+00	648.00
IUUC-Ssc-115654	Sus scrofa	89.55	0.00e+00	1982.00
IUUC-Tgu-117302	Taeniopygia guttata	70.56	0.00e+00	1549.00
IUUC-Tru-118363	Takifugu rubripes	54.05	0.00e+00	1151.00
IUUC-Tsy-119007	Tarsius syrichta	87.18	0.00e+00	1899.00
IUUC-Tni-120910	Tetraodon nigroviridis	53.44	0.00e+00	1114.00
IUUC-Tbe-127413	Tupaia belangeri	76.46	0.00e+00	1407.00
IUUC-Ttr-129213	Tursiops truncatus	82.62	0.00e+00	1784.00
IUUC-Vpa-130146	Vicugna pacos	84.84	0.00e+00	1628.00
IUUC-Xtr-132559	Xenopus tropicalis	60.42	0.00e+00	1303.00
IUUC-Xma-133445	Xiphophorus maculatus	55.36	0.00e+00	1168.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence