iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059879

UUCD1 version

UUC-MeG-00836

Ensembl Protein ID

ENSMGAP00000008268.2

UniProt Accession

G1N7R0; G1N7R0_MELGA

Protein Name

Uncharacterized protein

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000008096.2	ENSMGAT00000009060.2	ENSMGAP00000008268.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-114	382.5	605	1334

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelw....kskkkavsprellkalkkeae 82
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ ++++++n +np ++ g+l+  ++ l+++lw    +++++a++p++l+++++++a+
   Q: 605  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrSFESEINYNNPLGTGGRLAIGFAMLLRALWkgthHGTHHAFQPSKLKAIVASKAS 691
           7******************************99*****************************998888999**************** PP
   S: 83   efsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvss 164
           +f+gy+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c +vs 
   Q: 692  QFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCSKVSI 776
           ************************************9999..6666666777*********************************** PP
   S: 165  reepfldlslpvpgkeetkke.................................................................. 185
           +++pfl+l++p+p+k++  +                                                                   
   Q: 777  TFDPFLYLPVPLPQKQKVLTVyyfakephkkpikflvsiskenssamevldsvahsvhvkpdnlrlaeviknrfqrmflpsqsldtv 863
           ****************87555****************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 864  sptdlllcfevlspelakervvelqvqqrpqvpsvpvakcaacqkkqlseeeklrrctrcyrvgycnvtcqkthwpdhkalcrpeni 950
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 951  gfpflisvpesrltyarlaqllegyarysvsvfqppfqlgrmshkleplakgscaaatpapelgdgdrasgllqepplspavpelhp 1037
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1038 emsdtgtvrskvlaarssllsldsgfsehmdlqgdsccekepsyeralkpeaaipgyqhtpdslstratqfyinkidaankeykled 1124
           *************************************************************************************** PP
   S: 186  .....................................................slqdcLesftkeeelegenkyycekckkkqeaek 219
                                                                +l++cL+ ftk+e l  e+++yc+kck+++ea+k
   Q: 1125 kgdtpleltddcslalvwknnerlkefvlveskelecvedpssaseaaraghfTLEQCLNLFTKPEVLAPEEAWYCPKCKQHREASK 1211
           *************************************************************************************** PP
   S: 220  klklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk 305
           +l+l++lP+vLi++LkRfsf++  +++ kin+ v+fp + Ldls+fc+ ++ +q +   Y+L+av++H+G++ +GHY+ay++  ++k
   Q: 1212 QLMLWRLPNVLIIQLKRFSFRSFIWRD-KINDMVDFPVRsLDLSKFCIGRKGEQ-QLPMYDLYAVINHYGGMIGGHYTAYARLPSDK 1296
           ***********************8886.*********************88776.5**************************94444 PP
   S: 306  ........WllfdDskVtevkeeevleetgstaYvlfYkrr 338
                   W lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1297 nsqrsdvgWRLFDDSTVTTVDESQVVT---RYAYVLFYRRR 1334
           44567788*******************...********996 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MSSSTNAPGQ RRVSRGLDDT TNKKKQKDRA NQESKEGESP RAVPQGAGPA GWFLGSAGGS 60
LAAICCRGAG IRCQVSLVPW SDLEAETSQE RDLEEGKSPL VSPRVILWLP CSLELLLDWK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAGCA GCACCAATGC CCCTGGCCAG AGGAGAGTGT CTCGGGGCTT GGATGATACC 60
ACCAACAAGA AGAAGCAAAA GGATCGAGCC AACCAGGAGA GCAAGGAAGG TGAGAGCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	67.30	0.00e+00	1675.00
IUUC-Apl-003368	Anas platyrhynchos	87.87	0.00e+00	2295.00
IUUC-Aca-004267	Anolis carolinensis	75.77	0.00e+00	1865.00
IUUC-Ame-010970	Astyanax mexicanus	71.78	0.00e+00	1368.00
IUUC-Bta-012905	Bos taurus	67.52	0.00e+00	1666.00
IUUC-Cel-018257	Caenorhabditis elegans	43.85	3.00e-88	320.00
IUUC-Cja-018789	Callithrix jacchus	65.48	0.00e+00	1735.00
IUUC-Cfa-021004	Canis familiaris	66.59	0.00e+00	1657.00
IUUC-Cpo-021529	Cavia porcellus	64.79	0.00e+00	1697.00
IUUC-Csa-024035	Chlorocebus sabaeus	69.72	0.00e+00	1660.00
IUUC-Cho-025036	Choloepus hoffmanni	64.29	0.00e+00	868.00
IUUC-Cin-025451	Ciona intestinalis	42.04	9.00e-83	301.00
IUUC-Dre-028556	Danio rerio	71.46	0.00e+00	1363.00
IUUC-Dno-029240	Dasypus novemcinctus	66.94	0.00e+00	1521.00
IUUC-Dor-030495	Dipodomys ordii	72.96	0.00e+00	979.00
IUUC-Ete-032741	Echinops telfairi	76.39	0.00e+00	1480.00
IUUC-Eca-033661	Equus caballus	69.55	0.00e+00	1712.00
IUUC-Eeu-034648	Erinaceus europaeus	75.11	0.00e+00	652.00
IUUC-Fca-035646	Felis catus	67.23	0.00e+00	1653.00
IUUC-Fal-037094	Ficedula albicollis	84.67	0.00e+00	2379.00
IUUC-Gmo-038869	Gadus morhua	67.84	0.00e+00	1259.00
IUUC-Gga-041170	Gallus gallus	93.13	0.00e+00	2441.00
IUUC-Gac-041901	Gasterosteus aculeatus	65.40	0.00e+00	1338.00
IUUC-Ggo-044708	Gorilla gorilla	66.03	0.00e+00	1734.00
IUUC-Hsa-046791	Homo sapiens	73.21	0.00e+00	1552.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	65.48	0.00e+00	1667.00
IUUC-Lch-050456	Latimeria chalumnae	55.80	0.00e+00	1255.00
IUUC-Loc-052861	Lepisosteus oculatus	62.31	0.00e+00	1209.00
IUUC-Laf-053788	Loxodonta africana	69.19	0.00e+00	1658.00
IUUC-Mcc-055693	Macaca mulatta	65.35	0.00e+00	1677.00
IUUC-Meu-055921	Macropus eugenii	80.46	0.00e+00	1354.00
IUUC-Mmr-060802	Microcebus murinus	65.91	0.00e+00	1719.00
IUUC-Mdo-061856	Monodelphis domestica	77.17	0.00e+00	1554.00
IUUC-Mmu-063874	Mus musculus	69.09	0.00e+00	1716.00
IUUC-Mpu-066166	Mustela putorius furo	66.91	0.00e+00	1661.00
IUUC-Nle-070161	Nomascus leucogenys	65.69	0.00e+00	1744.00
IUUC-Opr-071015	Ochotona princeps	76.95	0.00e+00	1496.00
IUUC-Ont-072308	Oreochromis niloticus	70.65	0.00e+00	1405.00
IUUC-Oan-072723	Ornithorhynchus anatinus	67.20	0.00e+00	1605.00
IUUC-Ocu-073938	Oryctolagus cuniculus	67.06	0.00e+00	1657.00
IUUC-Ola-086375	Oryzias latipes	61.51	0.00e+00	1428.00
IUUC-Oga-088297	Otolemur garnettii	65.67	0.00e+00	1683.00
IUUC-Oar-089675	Ovis aries	77.70	0.00e+00	1354.00
IUUC-Ptr-091621	Pan troglodytes	73.12	0.00e+00	1551.00
IUUC-Pan-092118	Papio anubis	66.47	0.00e+00	1698.00
IUUC-Pma-094154	Petromyzon marinus	51.18	5.00e-112	397.00
IUUC-Pfo-097246	Poecilia formosa	62.53	0.00e+00	1476.00
IUUC-Pab-098551	Pongo abelii	74.04	0.00e+00	1529.00
IUUC-Pca-100158	Procavia capensis	65.35	0.00e+00	1599.00
IUUC-Pva-103160	Pteropus vampyrus	69.32	0.00e+00	1649.00
IUUC-Rno-105355	Rattus norvegicus	68.60	0.00e+00	1677.00
IUUC-Sha-107057	Sarcophilus harrisii	68.05	0.00e+00	1746.00
IUUC-Sar-113011	Sorex araneus	72.88	0.00e+00	1122.00
IUUC-Ssc-115761	Sus scrofa	67.55	0.00e+00	1680.00
IUUC-Tgu-116956	Taeniopygia guttata	76.30	0.00e+00	1050.00
IUUC-Tru-118739	Takifugu rubripes	70.07	0.00e+00	1397.00
IUUC-Tsy-118827	Tarsius syrichta	61.62	0.00e+00	899.00
IUUC-Tni-119921	Tetraodon nigroviridis	59.57	0.00e+00	1431.00
IUUC-Tbe-128017	Tupaia belangeri	73.13	0.00e+00	1499.00
IUUC-Ttr-128869	Tursiops truncatus	69.13	0.00e+00	1661.00
IUUC-Vpa-130427	Vicugna pacos	72.84	0.00e+00	699.00
IUUC-Xtr-132734	Xenopus tropicalis	63.70	0.00e+00	1635.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence