iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091621

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03025953

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000014911.5	ENSPTRT00000027911.5	ENSPTRP00000046154.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.70e-115	384.7	497	1214

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 497  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 583
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 584  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 668
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 669  FLYLPVPLPQKQKVLPVfyfarephskpikflvsvskenstasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldtvspsd 755
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 756  mllcfellsselakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 842
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 843  lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqspgcttllstgsleagdserdpiqppelqlvtpmaegdtglprv 929
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 930  waapdrgpvpstsgissemlasgpievgslpagervsrpeaavpgyqhpseamnahtplffiykidssnreqrledkgdtplelgdd 1016
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1017 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1103
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1104 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1187
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1188 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1214
           ****************...********996 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSGGASATGP RRGPPGLEDT TSKKKQKDRA NQESKDGGPR KETGSRYVAQ AGLELLASGD 60
PSASASHAAG ITGSRHHTRL FFPSSSGSAS TPQEEQTKEG ACEDPHDLLA TPPPELLLDW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTTGGCGC TCCGCCTCCC TCGGCCTTAG CTAGAAGTCG AAACAAAACA AGCGCTAAGG 60
CGGTGGCGGC GGCGCCGGGA CGGGGGAGGG GCGCGCCGGA ACCGGAACCG ACCTGACGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	94.95	0.00e+00	1954.00
IUUC-Apl-003368	Anas platyrhynchos	73.55	0.00e+00	1484.00
IUUC-Aca-004267	Anolis carolinensis	77.69	0.00e+00	1474.00
IUUC-Ame-010970	Astyanax mexicanus	70.81	0.00e+00	1327.00
IUUC-Bta-012905	Bos taurus	93.20	0.00e+00	1931.00
IUUC-Cel-018257	Caenorhabditis elegans	43.00	1.00e-91	331.00
IUUC-Cja-018789	Callithrix jacchus	97.22	0.00e+00	2119.00
IUUC-Cfa-021004	Canis familiaris	94.17	0.00e+00	1951.00
IUUC-Cpo-021529	Cavia porcellus	90.23	0.00e+00	1966.00
IUUC-Csa-024035	Chlorocebus sabaeus	97.50	0.00e+00	2036.00
IUUC-Cho-025036	Choloepus hoffmanni	86.01	0.00e+00	835.00
IUUC-Cin-025451	Ciona intestinalis	43.15	1.00e-84	308.00
IUUC-Csv-025931	Ciona savignyi	36.43	1.00e-110	393.00
IUUC-Dre-028556	Danio rerio	69.11	0.00e+00	1305.00
IUUC-Dno-029240	Dasypus novemcinctus	89.01	0.00e+00	1899.00
IUUC-Dor-030495	Dipodomys ordii	95.55	0.00e+00	1292.00
IUUC-Ete-032741	Echinops telfairi	92.03	0.00e+00	1851.00
IUUC-Eca-033661	Equus caballus	95.32	0.00e+00	2067.00
IUUC-Eeu-034648	Erinaceus europaeus	82.15	0.00e+00	1024.00
IUUC-Fca-035646	Felis catus	93.97	0.00e+00	1932.00
IUUC-Fal-037094	Ficedula albicollis	73.42	0.00e+00	1580.00
IUUC-Gmo-038869	Gadus morhua	71.94	0.00e+00	843.00
IUUC-Gga-041170	Gallus gallus	72.92	0.00e+00	1548.00
IUUC-Gac-041901	Gasterosteus aculeatus	60.09	0.00e+00	1412.00
IUUC-Ggo-044708	Gorilla gorilla	99.11	0.00e+00	2180.00
IUUC-Hsa-046791	Homo sapiens	99.24	0.00e+00	2556.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	92.46	0.00e+00	1973.00
IUUC-Lch-050456	Latimeria chalumnae	63.51	0.00e+00	1124.00
IUUC-Loc-052861	Lepisosteus oculatus	62.33	0.00e+00	1119.00
IUUC-Laf-053788	Loxodonta africana	92.37	0.00e+00	2006.00
IUUC-Mcc-055693	Macaca mulatta	97.70	0.00e+00	2053.00
IUUC-Meu-055921	Macropus eugenii	78.72	0.00e+00	1516.00
IUUC-Mga-059879	Meleagris gallopavo	73.08	0.00e+00	1535.00
IUUC-Mmr-060802	Microcebus murinus	95.38	0.00e+00	2056.00
IUUC-Mdo-061856	Monodelphis domestica	73.64	0.00e+00	1774.00
IUUC-Mmu-063874	Mus musculus	92.32	0.00e+00	1985.00
IUUC-Mpu-066166	Mustela putorius furo	94.07	0.00e+00	1926.00
IUUC-Nle-070161	Nomascus leucogenys	98.04	0.00e+00	2154.00
IUUC-Opr-071015	Ochotona princeps	86.96	0.00e+00	2072.00
IUUC-Ont-072308	Oreochromis niloticus	70.12	0.00e+00	1352.00
IUUC-Oan-072723	Ornithorhynchus anatinus	71.94	0.00e+00	1516.00
IUUC-Ocu-073938	Oryctolagus cuniculus	94.30	0.00e+00	1905.00
IUUC-Ola-086375	Oryzias latipes	70.61	0.00e+00	1331.00
IUUC-Oga-088297	Otolemur garnettii	95.00	0.00e+00	2024.00
IUUC-Oar-089675	Ovis aries	94.80	0.00e+00	1644.00
IUUC-Pan-092118	Papio anubis	97.88	0.00e+00	2043.00
IUUC-Pma-094154	Petromyzon marinus	52.02	7.00e-115	407.00
IUUC-Pfo-097246	Poecilia formosa	70.36	0.00e+00	1328.00
IUUC-Pab-098551	Pongo abelii	98.33	0.00e+00	2518.00
IUUC-Pca-100158	Procavia capensis	87.84	0.00e+00	1912.00
IUUC-Pva-103160	Pteropus vampyrus	94.76	0.00e+00	2010.00
IUUC-Rno-105355	Rattus norvegicus	92.65	0.00e+00	1985.00
IUUC-Sha-107057	Sarcophilus harrisii	80.12	0.00e+00	1575.00
IUUC-Sar-113011	Sorex araneus	89.79	0.00e+00	1550.00
IUUC-Ssc-115761	Sus scrofa	93.64	0.00e+00	1952.00
IUUC-Tgu-116956	Taeniopygia guttata	62.24	0.00e+00	830.00
IUUC-Tru-118739	Takifugu rubripes	69.15	0.00e+00	1342.00
IUUC-Tsy-118827	Tarsius syrichta	91.73	0.00e+00	939.00
IUUC-Tni-119921	Tetraodon nigroviridis	67.17	0.00e+00	1310.00
IUUC-Tbe-128017	Tupaia belangeri	92.03	0.00e+00	1978.00
IUUC-Ttr-128869	Tursiops truncatus	93.79	0.00e+00	2014.00
IUUC-Vpa-130427	Vicugna pacos	95.51	0.00e+00	926.00
IUUC-Xtr-132734	Xenopus tropicalis	70.84	0.00e+00	1436.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence