iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-063017

UUCD1 version

UUC-MoD-00698

Ensembl Protein ID

ENSMODP00000015243.2

UniProt Accession

F7CY98; F7CY98_MONDO

Protein Name

Uncharacterized protein

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000012170.3	ENSMODT00000015528.2	ENSMODP00000015243.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-121	406.5	1238	1570

Active Site

Position(s)	Description	Evidence
1538	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1238 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1323
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1324 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1406
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1407 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1493
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1494 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1570
           **************************************************************************985 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LASQGSMPEN MNLQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPTD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTGTTTGT CTATTTCTTG CAGATCCTTA GGAAGCTAAC TTCAAGGAGG TAGACAGCAT 60
GGCTAGCTCA GCCCGGGAGC ACCTGCTTTT TGTGAGAAGG CGCAACCCTC AGATGCGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

KEGG

mdo:100022096

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	92.32	0.00e+00	2848.00
IUUC-Apl-003935	Anas platyrhynchos	86.92	0.00e+00	2709.00
IUUC-Aca-004558	Anolis carolinensis	84.78	0.00e+00	2665.00
IUUC-Ame-010893	Astyanax mexicanus	88.61	0.00e+00	1286.00
IUUC-Bta-013093	Bos taurus	95.71	0.00e+00	1546.00
IUUC-Cja-019651	Callithrix jacchus	91.13	0.00e+00	2705.00
IUUC-Cfa-021232	Canis familiaris	98.61	0.00e+00	1597.00
IUUC-Cpo-021770	Cavia porcellus	87.40	0.00e+00	2722.00
IUUC-Csa-023970	Chlorocebus sabaeus	91.68	0.00e+00	2809.00
IUUC-Cho-024512	Choloepus hoffmanni	84.57	0.00e+00	2525.00
IUUC-Csv-026127	Ciona savignyi	66.67	8.00e-155	540.00
IUUC-Dre-028275	Danio rerio	86.27	0.00e+00	1467.00
IUUC-Dno-029963	Dasypus novemcinctus	90.68	0.00e+00	2669.00
IUUC-Dor-030282	Dipodomys ordii	83.99	0.00e+00	1858.00
IUUC-Dme-032217	Drosophila melanogaster	71.57	0.00e+00	650.00
IUUC-Ete-033132	Echinops telfairi	82.52	0.00e+00	1245.00
IUUC-Eca-033978	Equus caballus	91.04	0.00e+00	2792.00
IUUC-Eeu-035278	Erinaceus europaeus	62.85	0.00e+00	1152.00
IUUC-Fca-036157	Felis catus	91.87	0.00e+00	2799.00
IUUC-Fal-037110	Ficedula albicollis	89.99	0.00e+00	1703.00
IUUC-Gmo-039291	Gadus morhua	80.31	0.00e+00	1011.00
IUUC-Gga-040821	Gallus gallus	87.11	0.00e+00	2696.00
IUUC-Gac-042456	Gasterosteus aculeatus	65.02	0.00e+00	1894.00
IUUC-Ggo-044862	Gorilla gorilla	91.80	0.00e+00	2719.00
IUUC-Hsa-046219	Homo sapiens	92.06	0.00e+00	2872.00
IUUC-Lch-050526	Latimeria chalumnae	78.27	0.00e+00	2440.00
IUUC-Loc-052648	Lepisosteus oculatus	78.54	0.00e+00	1515.00
IUUC-Laf-054005	Loxodonta africana	91.67	0.00e+00	2838.00
IUUC-Mcc-055314	Macaca mulatta	91.68	0.00e+00	2804.00
IUUC-Meu-056356	Macropus eugenii	76.71	0.00e+00	1266.00
IUUC-Mga-060074	Meleagris gallopavo	86.06	0.00e+00	2587.00
IUUC-Mmr-061526	Microcebus murinus	91.37	0.00e+00	2806.00
IUUC-Mmu-064165	Mus musculus	90.33	0.00e+00	2747.00
IUUC-Mpu-065835	Mustela putorius furo	82.17	0.00e+00	1534.00
IUUC-Mlu-067709	Myotis lucifugus	87.12	0.00e+00	2639.00
IUUC-Nle-069308	Nomascus leucogenys	91.81	0.00e+00	2835.00
IUUC-Opr-070330	Ochotona princeps	78.79	0.00e+00	2286.00
IUUC-Ont-071918	Oreochromis niloticus	72.66	0.00e+00	1370.00
IUUC-Ocu-074775	Oryctolagus cuniculus	90.37	0.00e+00	2524.00
IUUC-Ola-087225	Oryzias latipes	64.49	0.00e+00	1847.00
IUUC-Oga-088177	Otolemur garnettii	89.48	0.00e+00	2669.00
IUUC-Oar-089452	Ovis aries	91.75	0.00e+00	2828.00
IUUC-Ptr-090806	Pan troglodytes	91.94	0.00e+00	2846.00
IUUC-Pan-091838	Papio anubis	91.47	0.00e+00	2687.00
IUUC-Psi-094090	Pelodiscus sinensis	87.55	0.00e+00	2724.00
IUUC-Pfo-096520	Poecilia formosa	68.36	0.00e+00	1502.00
IUUC-Pab-098405	Pongo abelii	91.94	0.00e+00	2840.00
IUUC-Pca-100441	Procavia capensis	84.86	0.00e+00	2145.00
IUUC-Pva-102324	Pteropus vampyrus	98.11	0.00e+00	1590.00
IUUC-Rno-105943	Rattus norvegicus	89.94	0.00e+00	2826.00
IUUC-Sha-106985	Sarcophilus harrisii	93.12	0.00e+00	2459.00
IUUC-Sar-113505	Sorex araneus	94.57	0.00e+00	1502.00
IUUC-Ssc-115439	Sus scrofa	88.37	0.00e+00	1853.00
IUUC-Tgu-117078	Taeniopygia guttata	91.50	0.00e+00	1744.00
IUUC-Tru-118671	Takifugu rubripes	84.90	0.00e+00	1437.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.22	0.00e+00	1410.00
IUUC-Tbe-127975	Tupaia belangeri	88.10	0.00e+00	2303.00
IUUC-Ttr-128469	Tursiops truncatus	86.16	0.00e+00	2545.00
IUUC-Vpa-130498	Vicugna pacos	81.97	0.00e+00	2380.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence