iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021543

Ensembl Protein ID

ENSCPOP00000015987.1

UniProt Accession

H0VZ55; H0VZ55_CAVPO

Genbank Protein ID

ENSCPOP00000015987

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02024180

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000000086.3	ENSCPOT00000000087.2	ENSCPOP00000015987.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.90e-18	64.6	690	741

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 690  ARYNFAARDMRELSLREGDVVKIHSRIGGDQGWWKG--ETNGRIGWFPSTYVEE 741
           67**********************************..9*************86 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

RPFPSEETAE NDDDVYRSLE ELADEHDLGE DIYDCVPCED EGDDIYEDII KVEVQQPMKM 60
GMTEDDKRSC CLLEIQETEA KYYRTLEDIE KNYMGPLRLV LSPADMASIF INLEDLIKVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCCTTTTC CCTCCGAGGA GACGGCAGAG AATGACGACG ATGTGTACCG CAGCCTGGAG 60
GAGCTGGCTG AGTAAGGCAC GGGGAGGATG GTGGGGAGGA CGGTGGGGAG GACGGCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	91.79	0.00e+00	1290.00
IUUC-Apl-003262	Anas platyrhynchos	89.13	0.00e+00	1298.00
IUUC-Aca-004628	Anolis carolinensis	64.95	0.00e+00	889.00
IUUC-Ath-007352	Arabidopsis thaliana	39.22	1.00e-03	38.50
IUUC-Ame-011608	Astyanax mexicanus	76.15	0.00e+00	1167.00
IUUC-Bta-013147	Bos taurus	92.66	0.00e+00	1315.00
IUUC-Cel-018578	Caenorhabditis elegans	26.78	9.00e-73	268.00
IUUC-Cja-018877	Callithrix jacchus	88.62	0.00e+00	1263.00
IUUC-Cfa-020315	Canis familiaris	90.70	0.00e+00	1238.00
IUUC-Csa-024204	Chlorocebus sabaeus	89.39	0.00e+00	1318.00
IUUC-Cho-025069	Choloepus hoffmanni	33.46	7.00e-24	107.00
IUUC-Cin-025115	Ciona intestinalis	33.76	1.00e-111	397.00
IUUC-Csv-025995	Ciona savignyi	36.01	2.00e-119	423.00
IUUC-Dre-028308	Danio rerio	78.03	0.00e+00	1189.00
IUUC-Dno-029584	Dasypus novemcinctus	86.94	0.00e+00	1141.00
IUUC-Dor-031014	Dipodomys ordii	81.82	0.00e+00	1112.00
IUUC-Eca-033448	Equus caballus	89.80	0.00e+00	1299.00
IUUC-Eeu-035182	Erinaceus europaeus	84.26	7.00e-166	577.00
IUUC-Fca-035460	Felis catus	91.28	0.00e+00	1313.00
IUUC-Fal-036684	Ficedula albicollis	86.87	0.00e+00	1282.00
IUUC-Gmo-038816	Gadus morhua	74.53	0.00e+00	1087.00
IUUC-Gga-040999	Gallus gallus	85.77	0.00e+00	1257.00
IUUC-Gac-041353	Gasterosteus aculeatus	75.74	0.00e+00	1118.00
IUUC-Ggo-044558	Gorilla gorilla	91.66	0.00e+00	1328.00
IUUC-Hsa-046208	Homo sapiens	91.66	0.00e+00	1329.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	89.67	0.00e+00	1209.00
IUUC-Loc-052827	Lepisosteus oculatus	77.87	0.00e+00	1207.00
IUUC-Laf-054009	Loxodonta africana	89.41	0.00e+00	1285.00
IUUC-Mcc-055054	Macaca mulatta	91.52	0.00e+00	1327.00
IUUC-Meu-056269	Macropus eugenii	82.04	0.00e+00	735.00
IUUC-Mga-060106	Meleagris gallopavo	88.72	0.00e+00	1290.00
IUUC-Mmr-061118	Microcebus murinus	91.41	0.00e+00	1324.00
IUUC-Mdo-062380	Monodelphis domestica	86.11	0.00e+00	1267.00
IUUC-Mmu-063135	Mus musculus	94.90	0.00e+00	1386.00
IUUC-Mpu-066135	Mustela putorius furo	89.40	0.00e+00	1306.00
IUUC-Nle-069465	Nomascus leucogenys	84.00	0.00e+00	1194.00
IUUC-Ont-071945	Oreochromis niloticus	78.78	0.00e+00	1168.00
IUUC-Oan-073384	Ornithorhynchus anatinus	86.97	0.00e+00	1210.00
IUUC-Ola-087499	Oryzias latipes	75.76	0.00e+00	1080.00
IUUC-Oga-088444	Otolemur garnettii	89.40	0.00e+00	1284.00
IUUC-Oar-089576	Ovis aries	87.12	0.00e+00	1207.00
IUUC-Ptr-090507	Pan troglodytes	92.89	0.00e+00	1336.00
IUUC-Pan-092325	Papio anubis	88.86	0.00e+00	1278.00
IUUC-Psi-094021	Pelodiscus sinensis	86.29	0.00e+00	1255.00
IUUC-Pma-094372	Petromyzon marinus	54.44	0.00e+00	724.00
IUUC-Pfo-096732	Poecilia formosa	78.16	0.00e+00	1170.00
IUUC-Pab-098426	Pongo abelii	74.47	0.00e+00	1007.00
IUUC-Pca-100295	Procavia capensis	91.08	0.00e+00	1339.00
IUUC-Rno-105332	Rattus norvegicus	93.96	0.00e+00	1305.00
IUUC-Sha-106529	Sarcophilus harrisii	90.46	0.00e+00	1244.00
IUUC-Sit-110173	Setaria italica	36.36	4.70e-02	33.10
IUUC-Ssc-116176	Sus scrofa	92.92	0.00e+00	1328.00
IUUC-Tgu-116917	Taeniopygia guttata	88.99	0.00e+00	1290.00
IUUC-Tru-118398	Takifugu rubripes	77.74	0.00e+00	1003.00
IUUC-Tni-120819	Tetraodon nigroviridis	78.71	0.00e+00	1191.00
IUUC-Xtr-132747	Xenopus tropicalis	75.87	0.00e+00	1117.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence