iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000077901.4	ENSDART00000109030.4	ENSDARP00000098798.2
ENSDARG00000077901.4	ENSDART00000173973.1	ENSDARP00000142936.1
ENSDARG00000077901.4	ENSDART00000171300.2	ENSDARP00000140961.2
ENSDARG00000077901.4	ENSDART00000173598.1	ENSDARP00000142740.1
ENSDARG00000077901.4	ENSDART00000173780.1	ENSDARP00000142861.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	6.10e-91	306.2	4499	4833
E3 adaptor/Cullin RING/DCX/DWD	6.60e-17	61.9	3398	3430

Active Site

Position(s)	Description	Evidence
4802	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n  +++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4499 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGVVDLLIPSPNAAAEVGYNRDRFLLNPsacleEHLLQFKFLGILMGVAIRTKK 4585
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l+++++k+l+  +lsledleevd  ++++l++i+++++s i+e +++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4586 PLDLHLAPMVWKQLCCIPLSLEDLEEVDLLYVQTLNSILHLEDSGITEQNFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4672
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG +ei+ve lkk  +y++ + e+++ +qwFw++l +fs+
   Q: 4673 EYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTARQLEQMVCGLPEISVEVLKKVVRYRE-VDEQQQLVQWFWQTLDDFSN 4757
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss++++ e+L+yAi++++++++
   Q: 4758 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQSVMAERLRYAINNCRSIDM 4833
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlrt 32
           H+++v  + + s  +ll+++++Dgt++vW++++
   Q: 3398 HQSRVITCGWcSKkGLLATSGNDGTVRVWNVTK 3430
           899988889*9778****************975 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MAAMIPPVKL KWLEHLNSSW ISEDSESIST REGVALLYGK LLTNKEVVVL PQQVLCLKGP 60
QLPDFERECL SSDEQEHYLD ALLASQLALA KTVCSDSPFA TALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTGACGTG GAGGGTGTAA GGTGGCACCA TGGCTGCGAT GATACCTCCA GTAAAACTCA 60
AATGGCTGGA GCACCTCAAC AGCTCCTGGA TCTCCGAGGA CAGTGAGTCC ATCTCCACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR001870--B30.2/SPRY
IPR016186--C-type_lectin-like/link
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	79.39	0.00e+00	7075.00
IUUC-Apl-003461	Anas platyrhynchos	79.35	0.00e+00	7091.00
IUUC-Aca-004452	Anolis carolinensis	77.05	0.00e+00	3295.00
IUUC-Ame-011268	Astyanax mexicanus	60.21	0.00e+00	2210.00
IUUC-Bta-013213	Bos taurus	79.48	0.00e+00	7063.00
IUUC-Bdi-014791	Brachypodium distachyon	36.15	5.00e-54	205.00
IUUC-Bra-017584	Brassica rapa	34.63	2.00e-47	184.00
IUUC-Cja-019298	Callithrix jacchus	79.06	0.00e+00	7050.00
IUUC-Cfa-021213	Canis familiaris	79.26	0.00e+00	7130.00
IUUC-Cpo-021674	Cavia porcellus	77.55	0.00e+00	4774.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.44	2.00e-50	193.00
IUUC-Csa-023341	Chlorocebus sabaeus	79.28	0.00e+00	7093.00
IUUC-Cho-024567	Choloepus hoffmanni	72.59	0.00e+00	1291.00
IUUC-Dno-029988	Dasypus novemcinctus	79.04	0.00e+00	7041.00
IUUC-Dor-030636	Dipodomys ordii	81.89	0.00e+00	1881.00
IUUC-Ete-032598	Echinops telfairi	81.86	0.00e+00	1329.00
IUUC-Eca-033754	Equus caballus	79.24	0.00e+00	7068.00
IUUC-Eeu-034702	Erinaceus europaeus	70.20	0.00e+00	1090.00
IUUC-Fca-035900	Felis catus	79.41	0.00e+00	7091.00
IUUC-Fal-037034	Ficedula albicollis	77.75	0.00e+00	6093.00
IUUC-Gmo-039260	Gadus morhua	74.45	0.00e+00	1227.00
IUUC-Gga-040321	Gallus gallus	79.30	0.00e+00	7138.00
IUUC-Gac-042444	Gasterosteus aculeatus	57.43	0.00e+00	2189.00
IUUC-Gma-043808	Glycine max	32.64	9.00e-45	176.00
IUUC-Ggo-045134	Gorilla gorilla	73.62	0.00e+00	3635.00
IUUC-Hsa-046516	Homo sapiens	79.10	0.00e+00	7042.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	84.72	0.00e+00	2253.00
IUUC-Lch-049903	Latimeria chalumnae	80.67	0.00e+00	7176.00
IUUC-Lpe-051165	Leersia perrieri	34.33	4.00e-52	198.00
IUUC-Loc-052149	Lepisosteus oculatus	82.11	0.00e+00	7276.00
IUUC-Laf-053426	Loxodonta africana	79.44	0.00e+00	7109.00
IUUC-Mcc-055826	Macaca mulatta	78.98	0.00e+00	7076.00
IUUC-Meu-056521	Macropus eugenii	66.89	0.00e+00	1666.00
IUUC-Mtr-058277	Medicago truncatula	34.65	9.00e-52	197.00
IUUC-Mga-059567	Meleagris gallopavo	87.50	0.00e+00	1925.00
IUUC-Mmr-061512	Microcebus murinus	78.66	0.00e+00	6974.00
IUUC-Mdo-062177	Monodelphis domestica	77.91	0.00e+00	6906.00
IUUC-Mmu-064373	Mus musculus	78.98	0.00e+00	7063.00
IUUC-Mpu-066148	Mustela putorius furo	79.84	0.00e+00	7130.00
IUUC-Mlu-067680	Myotis lucifugus	79.26	0.00e+00	7024.00
IUUC-Nle-069633	Nomascus leucogenys	78.83	0.00e+00	6991.00
IUUC-Opr-070609	Ochotona princeps	83.70	0.00e+00	1201.00
IUUC-Ont-071249	Oreochromis niloticus	81.09	0.00e+00	7424.00
IUUC-Oan-073157	Ornithorhynchus anatinus	78.90	0.00e+00	6985.00
IUUC-Ocu-074841	Oryctolagus cuniculus	79.95	0.00e+00	7180.00
IUUC-Oba-075262	Oryza barthii	34.25	2.00e-50	193.00
IUUC-Obr-076115	Oryza brachyantha	34.61	3.00e-49	189.00
IUUC-Ogl-077586	Oryza glaberrima	34.25	2.00e-50	193.00
IUUC-Ogu-078796	Oryza glumaepatula	34.00	6.00e-50	191.00
IUUC-Oin-079298	Oryza indica	34.00	7.00e-50	191.00
IUUC-Olo-080768	Oryza longistaminata	35.94	1.00e-54	207.00
IUUC-Ome-081908	Oryza meridionalis	33.67	7.00e-49	188.00
IUUC-Oni-082049	Oryza nivara	34.00	6.00e-50	191.00
IUUC-Opu-083608	Oryza punctata	34.17	1.00e-50	194.00
IUUC-Oru-084712	Oryza rufipogon	34.00	6.00e-50	191.00
IUUC-Osa-086078	Oryza sativa	34.00	6.00e-50	191.00
IUUC-Ola-086889	Oryzias latipes	79.14	0.00e+00	7164.00
IUUC-Oga-088459	Otolemur garnettii	78.24	0.00e+00	7006.00
IUUC-Oar-089888	Ovis aries	79.48	0.00e+00	7044.00
IUUC-Ptr-091114	Pan troglodytes	79.04	0.00e+00	7056.00
IUUC-Pan-092442	Papio anubis	79.11	0.00e+00	7083.00
IUUC-Psi-093833	Pelodiscus sinensis	78.28	0.00e+00	4650.00
IUUC-Pma-094275	Petromyzon marinus	78.22	0.00e+00	1732.00
IUUC-Ppa-095790	Physcomitrella patens	36.74	3.00e-56	213.00
IUUC-Pfo-097262	Poecilia formosa	80.87	0.00e+00	7158.00
IUUC-Pab-097760	Pongo abelii	78.52	0.00e+00	4003.00
IUUC-Pop-099121	Populus trichocarpa	36.34	2.00e-51	198.00
IUUC-Pca-100465	Procavia capensis	78.50	0.00e+00	3706.00
IUUC-Ppe-101345	Prunus persica	33.25	5.00e-50	193.00
IUUC-Pva-102950	Pteropus vampyrus	79.11	0.00e+00	3368.00
IUUC-Rno-104892	Rattus norvegicus	78.98	0.00e+00	7034.00
IUUC-Sha-106633	Sarcophilus harrisii	78.47	0.00e+00	6907.00
IUUC-Smo-108827	Selaginella moellendorffii	34.88	3.00e-52	201.00
IUUC-Sit-110415	Setaria italica	36.04	1.00e-54	207.00
IUUC-Sly-111155	Solanum lycopersicum	37.39	4.00e-54	206.00
IUUC-Stu-112166	Solanum tuberosum	31.20	4.00e-47	183.00
IUUC-Sar-113251	Sorex araneus	69.53	0.00e+00	1865.00
IUUC-Ssc-116391	Sus scrofa	79.38	0.00e+00	7093.00
IUUC-Tgu-116554	Taeniopygia guttata	79.10	0.00e+00	7049.00
IUUC-Tru-118695	Takifugu rubripes	80.57	0.00e+00	7318.00
IUUC-Tsy-119647	Tarsius syrichta	70.36	0.00e+00	4195.00
IUUC-Tni-120707	Tetraodon nigroviridis	80.95	0.00e+00	7295.00
IUUC-Tbe-127346	Tupaia belangeri	75.95	0.00e+00	2215.00
IUUC-Ttr-128542	Tursiops truncatus	72.98	0.00e+00	4411.00
IUUC-Vpa-130611	Vicugna pacos	80.33	0.00e+00	3281.00
IUUC-Xtr-131933	Xenopus tropicalis	77.46	0.00e+00	6859.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence