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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045678
UUCD1 version UUC-HoS-00628
Ensembl Protein ID ENSP00000217109.4
UniProt Accession Q05048; Q5QPD8; CSTF1_HUMAN
Genbank Protein ID AAA35691.1; AAP35802.1; BAG35638.1; CAC12718.2; CAI19328.1; EAW75548.1; EAW75549.1; AAH01011.1; AAH07425.1
Protein Name Cleavage stimulation factor subunit 1; CF-1 50 kDa subunit; Cleavage stimulation factor 50 kDa subunit
Genbank Nucleotide ID L02547; BT007138; AK312774; AL121914; AL121914; CH471077; CH471077; BC001011; BC007425
Gene Name CSTF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000101138.11 ENST00000217109.8 ENSP00000217109.4
ENSG00000101138.11 ENST00000493039.5 ENSP00000477958.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Beta-Prp Beta-Prp 21070969
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.20e-27 95.6 172 202
UBD/Beta-Prp 5.10e-73 247.5 102 429
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDl 30
           H d+vtclaf ++  +l+sGs+D t+k++D+
   Q: 172  HVDEVTCLAFhPTeQILASGSRDYTLKLFDY 202
           9**********77799**************7 PP
   

   UBD/Beta-Prp
   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkl.......................lrslsgheaevtavkfspdgkilvtgse 72
           ++ ++hk+++++ ++s+d++l+atgs+d++ik+ d++++ +                       +r+l++h +evt++ f+p+++il++gs+
   Q: 102  CYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAksampievmmnetaqqnmenhpvIRTLYDHVDEVTCLAFHPTEQILASGSR 193
           67889*********************************988*************************************************** PP
   S: 73   Drtikvwdlstgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrt 160
           D+t+k++d+s+++  +++k  ++ ++++s+sf+psgd++++G+++ t+r++d++t qc+ +  ++++h++++++v++++++n++v+Gs+D++
   Q: 194  DYTLKLFDYSKPSAKRAFKyiQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVScnPQDQHTDAICSVNYNSSANMYVTGSKDGC 285
           **************99999999***************************************99***************************** PP
   S: 161  vrlWdlktgkllrtltgghtdsvysls.fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs....pnderlvsgssDgsir 247
           ++lWd  ++++++t++++h+++  + + f++n+k+++s ++d+  klw+++tg+++++++g     ++v+ +    +++e +v   ++++i+
   Q: 286  IKLWDGVSNRCITTFEKAHDGAEVCSAiFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTqavfNHTEDYVLLPDERTIS 377
           ***************9999998777666***********************************99999888877789**************9 PP
   S: 248  i..Wdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkn 297
           +  Wd+r+ +  + l+l +++++ + v+s++++ ++++s+d ++++w  +++
   Q: 378  LccWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRST 429
           888********************************************98765 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.
 Homodimer. The CSTF complex is composed of CSTF1 (50 kDa subunit), CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). Interacts directly with CSTF3. Interacts with BARD1.
Protein Sequence
(Fasta)
MYRTKVGLKD RQQLYKLIIS QLLYDGYISI ANGLINEIKP QSVCAPSEQL LHLIKLGMEN 60
DDTAVQYAIG RSDTVAPGTG IDLEFDADVQ TMSPEASEYE TCYVTSHKGP CRVATYSRDG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045678|UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGAACCCGG AAGTGGTGGA GCCAACGGCC AGCCAGACCT GTGGCAGTCC CAGCCCCAGG 60
GTGCTCTCCG CGGTCGGCCA TTTATCGGTG AAGCAACAGC CCCTTGACGT CAAGCTTGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045678|UBD,Beta-Prp;E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR032028--CSTF1_dimer
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF16699--CSTF1_dimer
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003723--F:RNA binding
GO:0031124--P:mRNA 3'-end processing
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006369--P:termination of RNA polymerase II transcription
KEGG hsa:1477
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002163 Ailuropoda melanoleuca 99.77 0.00e+00 905.00
IUUC-Atr-002687 Amborella trichopoda 38.44 5.00e-68 251.00
IUUC-Apl-003438 Anas platyrhynchos 98.38 0.00e+00 896.00
IUUC-Aca-005178 Anolis carolinensis 97.45 0.00e+00 892.00
IUUC-Aly-005791 Arabidopsis lyrata 37.50 3.00e-80 292.00
IUUC-Ath-006689 Arabidopsis thaliana 38.68 6.00e-81 294.00
IUUC-Ame-011217 Astyanax mexicanus 91.55 5.00e-162 563.00
IUUC-Bta-012619 Bos taurus 99.54 0.00e+00 903.00
IUUC-Bdi-014515 Brachypodium distachyon 43.43 2.00e-79 289.00
IUUC-Bra-017450 Brassica rapa 36.73 5.00e-75 275.00
IUUC-Cel-018151 Caenorhabditis elegans 52.20 9.00e-134 469.00
IUUC-Cja-019304 Callithrix jacchus 100.00 0.00e+00 907.00
IUUC-Cfa-020208 Canis familiaris 99.77 0.00e+00 905.00
IUUC-Cpo-022245 Cavia porcellus 99.77 0.00e+00 905.00
IUUC-Csa-023066 Chlorocebus sabaeus 100.00 0.00e+00 907.00
IUUC-Cho-024770 Choloepus hoffmanni 99.73 0.00e+00 787.00
IUUC-Cin-025621 Ciona intestinalis 57.38 3.00e-152 531.00
IUUC-Csv-026071 Ciona savignyi 60.14 2.00e-162 565.00
IUUC-Dre-028254 Danio rerio 90.02 0.00e+00 830.00
IUUC-Dno-029903 Dasypus novemcinctus 99.77 0.00e+00 905.00
IUUC-Dor-030423 Dipodomys ordii 99.54 0.00e+00 905.00
IUUC-Dme-031993 Drosophila melanogaster 55.11 3.00e-132 464.00
IUUC-Ete-032689 Echinops telfairi 98.66 2.00e-82 299.00
IUUC-Eca-033316 Equus caballus 99.54 0.00e+00 904.00
IUUC-Eeu-035001 Erinaceus europaeus 94.66 0.00e+00 860.00
IUUC-Fca-036447 Felis catus 99.77 0.00e+00 905.00
IUUC-Fal-037601 Ficedula albicollis 98.38 0.00e+00 896.00
IUUC-Gmo-038531 Gadus morhua 88.45 0.00e+00 803.00
IUUC-Gga-040869 Gallus gallus 98.14 0.00e+00 894.00
IUUC-Gac-042380 Gasterosteus aculeatus 89.40 0.00e+00 820.00
IUUC-Gma-043478 Glycine max 39.05 1.00e-83 303.00
IUUC-Ggo-045302 Gorilla gorilla 100.00 0.00e+00 907.00
IUUC-Hvu-047301 Hordeum vulgare 43.92 3.00e-81 295.00
IUUC-Itr-048259 Ictidomys tridecemlineatus 99.77 0.00e+00 905.00
IUUC-Lch-050319 Latimeria chalumnae 94.43 0.00e+00 865.00
IUUC-Lpe-051440 Leersia perrieri 40.76 4.00e-67 248.00
IUUC-Loc-052035 Lepisosteus oculatus 91.65 0.00e+00 840.00
IUUC-Laf-054275 Loxodonta africana 99.77 0.00e+00 905.00
IUUC-Mcc-055857 Macaca mulatta 86.77 0.00e+00 754.00
IUUC-Meu-056194 Macropus eugenii 99.37 4.00e-92 331.00
IUUC-Mtr-058667 Medicago truncatula 38.08 5.00e-76 278.00
IUUC-Mga-059710 Meleagris gallopavo 98.14 0.00e+00 894.00
IUUC-Mmr-060604 Microcebus murinus 99.77 0.00e+00 905.00
IUUC-Mdo-062953 Monodelphis domestica 99.07 0.00e+00 900.00
IUUC-Mmu-064292 Mus musculus 99.54 0.00e+00 905.00
IUUC-Mac-064568 Musa acuminata 44.14 1.00e-78 286.00
IUUC-Mpu-066294 Mustela putorius furo 67.79 5.00e-163 567.00
IUUC-Mlu-067995 Myotis lucifugus 98.84 0.00e+00 895.00
IUUC-Nle-069322 Nomascus leucogenys 100.00 0.00e+00 907.00
IUUC-Opr-070580 Ochotona princeps 99.30 0.00e+00 902.00
IUUC-Ont-072554 Oreochromis niloticus 91.88 0.00e+00 843.00
IUUC-Oan-072856 Ornithorhynchus anatinus 98.61 0.00e+00 897.00
IUUC-Ocu-074150 Oryctolagus cuniculus 87.73 0.00e+00 763.00
IUUC-Oba-075585 Oryza barthii 36.82 6.00e-70 258.00
IUUC-Obr-076069 Oryza brachyantha 41.84 2.00e-75 276.00
IUUC-Ogl-077045 Oryza glaberrima 40.26 3.00e-80 292.00
IUUC-Ogu-078697 Oryza glumaepatula 40.26 5.00e-76 280.00
IUUC-Oin-080119 Oryza indica 40.26 3.00e-80 292.00
IUUC-Olo-081093 Oryza longistaminata 32.15 9.00e-45 176.00
IUUC-Ome-081718 Oryza meridionalis 33.33 8.00e-57 215.00
IUUC-Oni-082072 Oryza nivara 36.82 6.00e-70 258.00
IUUC-Opu-084080 Oryza punctata 35.29 3.00e-57 215.00
IUUC-Oru-085070 Oryza rufipogon 37.38 2.00e-69 258.00
IUUC-Osa-086149 Oryza sativa 40.26 3.00e-80 292.00
IUUC-Ola-086697 Oryzias latipes 91.42 0.00e+00 842.00
IUUC-Oga-088697 Otolemur garnettii 99.77 0.00e+00 905.00
IUUC-Oar-089774 Ovis aries 99.77 0.00e+00 906.00
IUUC-Ptr-090924 Pan troglodytes 100.00 0.00e+00 907.00
IUUC-Pan-092373 Papio anubis 100.00 0.00e+00 906.00
IUUC-Psi-094001 Pelodiscus sinensis 98.14 0.00e+00 895.00
IUUC-Pma-094274 Petromyzon marinus 73.89 0.00e+00 693.00
IUUC-Ppa-095562 Physcomitrella patens 35.94 1.00e-80 293.00
IUUC-Pfo-097235 Poecilia formosa 91.42 0.00e+00 840.00
IUUC-Pab-098608 Pongo abelii 100.00 0.00e+00 907.00
IUUC-Pca-100268 Procavia capensis 99.54 0.00e+00 903.00
IUUC-Ppe-101425 Prunus persica 41.81 4.00e-83 301.00
IUUC-Pva-103183 Pteropus vampyrus 99.77 0.00e+00 905.00
IUUC-Rno-105097 Rattus norvegicus 99.54 0.00e+00 905.00
IUUC-Sha-107642 Sarcophilus harrisii 99.07 0.00e+00 900.00
IUUC-Smo-108680 Selaginella moellendorffii 36.43 7.00e-78 284.00
IUUC-Sit-110471 Setaria italica 41.15 2.00e-82 300.00
IUUC-Sly-111143 Solanum lycopersicum 33.89 2.00e-33 136.00
IUUC-Stu-111926 Solanum tuberosum 45.34 1.00e-33 135.00
IUUC-Sar-112947 Sorex araneus 99.65 5.00e-174 603.00
IUUC-Sbi-113769 Sorghum bicolor 43.03 1.00e-79 290.00
IUUC-Ssc-115736 Sus scrofa 99.77 0.00e+00 905.00
IUUC-Tgu-117457 Taeniopygia guttata 98.38 0.00e+00 896.00
IUUC-Tru-117760 Takifugu rubripes 91.18 0.00e+00 840.00
IUUC-Tsy-118943 Tarsius syrichta 98.84 0.00e+00 890.00
IUUC-Tni-120081 Tetraodon nigroviridis 91.88 0.00e+00 844.00
IUUC-Tca-121190 Theobroma cacao 40.65 9.00e-87 313.00
IUUC-Tae-125535 Triticum aestivum 44.81 4.00e-84 305.00
IUUC-Tur-126329 Triticum urartu 44.81 9.00e-84 304.00
IUUC-Tbe-127878 Tupaia belangeri 98.35 0.00e+00 878.00
IUUC-Ttr-128985 Tursiops truncatus 99.77 0.00e+00 905.00
IUUC-Vpa-130147 Vicugna pacos 99.54 0.00e+00 903.00
IUUC-Vvi-130935 Vitis vinifera 39.53 9.00e-86 310.00
IUUC-Xtr-132482 Xenopus tropicalis 95.13 0.00e+00 867.00
IUUC-Xma-133929 Xiphophorus maculatus 91.42 0.00e+00 840.00
Created Date 25-Jun-2017

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