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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063842
UUCD1 version UUC-MuM-00218
Ensembl Protein ID ENSMUSP00000089173.4
UniProt Accession E0CZ16; F7A5U9; I6L891; KLHL3_MOUSE
Genbank Protein ID ENSMUSP00000089173
Protein Name Kelch-like protein 3
Genbank Nucleotide ID AC142258
Gene Name Klhl3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000014164.14 ENSMUST00000160860.7 ENSMUSP00000123701.1
ENSMUSG00000014164.14 ENSMUST00000091583.4 ENSMUSP00000089173.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 3.50e-21 76.4 103 169
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.50e-11 43.3 202 233
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv++v +++e++ah++vLaa+S++F a+f+++++esk  +++eikdv+ + ++ l++++Yt +++ +
   Q: 103  CDVMIVAEDVEVEAHRVVLAACSPYFCAMFTGDMSESK-AKKIEIKDVDGQTLSKLIDYIYTAEIEVT 169
           8*************************************.************************99876 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           + Nclgi++fAd ++c+dL ++a+ ++++hF+
   Q: 202  PTNCLGIRAFADVHTCTDLLQQANAYAEQHFP 233
           78*****************************6 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron. The BCR(KLHL3) complex acts by mediating ubiquitination of WNK4, an inhibitor of potassium channel KCNJ1, leading to WNK4 degradation (By similarity).
Protein Sequence
(Fasta)
MAYYIMIPCQ VGKRGHRLWT WTRVAARINV ALCFVGGESA WFLLVSRLTS ASGGKGLSVK 60
PSPQPTAQAE DEEKNRRTVT VNAAHMGKAF KVMNELRSKR LLCDVMIVAE DVEVEAHRVV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063842|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGAGGCAGG AGACTGTGGG GTGGGCTAGT CGCTAGGGCT GGGGATGCCT GAGCAGATGT 60
GGAAACAGCT GGAAAGGTGG CACAGCCCTT GGGTCGCCGC CGCCGCCGCC GAAGCTGTGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063842|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011041--Quinoprot_gluc/sorb_DH
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0003824--F:catalytic activity
GO:0072156--P:distal tubule morphogenesis
GO:0050801--P:ion homeostasis
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0070294--P:renal sodium ion absorption
KEGG mmu:100503085
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001632 Ailuropoda melanoleuca 96.75 0.00e+00 1155.00
IUUC-Apl-003965 Anas platyrhynchos 94.35 0.00e+00 1100.00
IUUC-Aca-004912 Anolis carolinensis 94.00 0.00e+00 1094.00
IUUC-Ate-010500 Aspergillus terreus 25.47 4.00e-20 92.80
IUUC-Ame-010670 Astyanax mexicanus 80.77 0.00e+00 939.00
IUUC-Bta-013354 Bos taurus 96.92 0.00e+00 1156.00
IUUC-Bra-017771 Brassica rapa 29.36 1.00e-12 68.60
IUUC-Cel-018136 Caenorhabditis elegans 41.65 2.00e-130 459.00
IUUC-Cja-019183 Callithrix jacchus 93.58 0.00e+00 1023.00
IUUC-Cfa-020465 Canis familiaris 95.88 0.00e+00 1143.00
IUUC-Cpo-022115 Cavia porcellus 97.43 0.00e+00 1166.00
IUUC-Csa-024219 Chlorocebus sabaeus 96.76 0.00e+00 1159.00
IUUC-Csv-026032 Ciona savignyi 60.27 0.00e+00 697.00
IUUC-Cgl-026620 Colletotrichum gloeosporioides 30.10 2.00e-23 103.00
IUUC-Dre-028524 Danio rerio 74.44 0.00e+00 949.00
IUUC-Dno-029075 Dasypus novemcinctus 98.22 0.00e+00 1131.00
IUUC-Dor-030156 Dipodomys ordii 80.96 0.00e+00 946.00
IUUC-Ete-033064 Echinops telfairi 82.39 0.00e+00 856.00
IUUC-Eca-033887 Equus caballus 96.71 0.00e+00 1145.00
IUUC-Eeu-035244 Erinaceus europaeus 76.96 0.00e+00 907.00
IUUC-Fca-035375 Felis catus 96.41 0.00e+00 1152.00
IUUC-Fal-037119 Ficedula albicollis 96.22 0.00e+00 1067.00
IUUC-Fso-038219 Fusarium solani 40.32 2.00e-10 57.00
IUUC-Gga-041094 Gallus gallus 95.28 0.00e+00 1092.00
IUUC-Gac-042585 Gasterosteus aculeatus 76.82 0.00e+00 912.00
IUUC-Ggo-045485 Gorilla gorilla 96.77 0.00e+00 1154.00
IUUC-Hsa-046717 Homo sapiens 97.27 0.00e+00 1163.00
IUUC-Itr-048605 Ictidomys tridecemlineatus 97.43 0.00e+00 1160.00
IUUC-Lch-050246 Latimeria chalumnae 86.30 0.00e+00 993.00
IUUC-Laf-053700 Loxodonta africana 95.91 0.00e+00 1148.00
IUUC-Mcc-054732 Macaca mulatta 99.21 0.00e+00 1021.00
IUUC-Mga-059994 Meleagris gallopavo 94.31 0.00e+00 986.00
IUUC-Mdo-062923 Monodelphis domestica 95.90 0.00e+00 1153.00
IUUC-Mpu-066380 Mustela putorius furo 96.24 0.00e+00 1154.00
IUUC-Mlu-067922 Myotis lucifugus 96.53 0.00e+00 1132.00
IUUC-Nle-069761 Nomascus leucogenys 96.93 0.00e+00 1161.00
IUUC-Opr-070287 Ochotona princeps 88.57 0.00e+00 1033.00
IUUC-Ont-071654 Oreochromis niloticus 79.66 0.00e+00 959.00
IUUC-Ocu-074957 Oryctolagus cuniculus 97.10 0.00e+00 1152.00
IUUC-Ola-086853 Oryzias latipes 77.97 0.00e+00 917.00
IUUC-Oga-088559 Otolemur garnettii 96.43 0.00e+00 1155.00
IUUC-Oar-089925 Ovis aries 96.93 0.00e+00 1158.00
IUUC-Ptr-091487 Pan troglodytes 97.27 0.00e+00 1163.00
IUUC-Pan-091705 Papio anubis 96.76 0.00e+00 1159.00
IUUC-Psi-093478 Pelodiscus sinensis 91.49 0.00e+00 1050.00
IUUC-Pfo-097450 Poecilia formosa 79.48 0.00e+00 899.00
IUUC-Pab-097618 Pongo abelii 97.10 0.00e+00 1160.00
IUUC-Pca-100739 Procavia capensis 88.53 0.00e+00 655.00
IUUC-Sha-106935 Sarcophilus harrisii 98.40 0.00e+00 748.00
IUUC-Ssc-115599 Sus scrofa 97.08 0.00e+00 1157.00
IUUC-Tgu-117001 Taeniopygia guttata 95.22 0.00e+00 1080.00
IUUC-Tru-118078 Takifugu rubripes 78.45 0.00e+00 948.00
IUUC-Tsy-119161 Tarsius syrichta 85.36 0.00e+00 890.00
IUUC-Tni-120888 Tetraodon nigroviridis 76.17 0.00e+00 885.00
IUUC-Tbe-127285 Tupaia belangeri 83.67 0.00e+00 665.00
IUUC-Ttr-128884 Tursiops truncatus 80.65 6.00e-148 517.00
Created Date 25-Jun-2017

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