iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cja-019880

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACFV01088247

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000007768.3	ENSCJAT00000015211.2	ENSCJAP00000014433.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.40e-112	374.7	1096	1426

Active Site

Position(s)	Description	Evidence
1394	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++re +   +     p++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1096 ELQRNKLYVTFVGEEGLDYSGPSREII---LPSSSIPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1178
           567899*******************85...566678**********************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1179 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1261
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketky.kggytedspaiqwFwevleefsseerk 262
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y   gy++ + +i+wFw ++e+f++e+r 
   Q: 1262 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYrGAGYHDGHLVIRWFWAAVERFNNEQRL 1348
           ***********************************************************6679************************ PP
   S: 263  afLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           ++LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1349 RLLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1426
           *************************999***********************************************985 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

LICTSNHNSY SIKNKIFKSI GSDETVQGQG SRRLISFSLS DFQAMGLKKG MFFNPDPYLK 60
ISIQPGKHSI FPALPHHGQE RRSKIIGNTV NPIWQAEQFS FVSLPTDVLE IEVKDKFAKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGATATGCA CATCCAATCA CAACTCTTAC AGCATCAAGA ATAGTAAGAG AAGAAAGAAA 60
GAGACTGAAC CCACACAGTC TACAAACAGA TTCTGAACAA GAGATTATGG ACATTTTCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	82.65	0.00e+00	2096.00
IUUC-Apl-003299	Anas platyrhynchos	74.97	0.00e+00	2008.00
IUUC-Aca-005024	Anolis carolinensis	73.42	0.00e+00	1977.00
IUUC-Bta-012604	Bos taurus	83.61	0.00e+00	2230.00
IUUC-Cfa-021216	Canis familiaris	86.48	0.00e+00	1704.00
IUUC-Cpo-021466	Cavia porcellus	90.56	0.00e+00	1611.00
IUUC-Csa-023080	Chlorocebus sabaeus	91.78	0.00e+00	2419.00
IUUC-Cho-024740	Choloepus hoffmanni	83.57	0.00e+00	1021.00
IUUC-Dre-028750	Danio rerio	69.05	0.00e+00	1418.00
IUUC-Dno-030019	Dasypus novemcinctus	85.31	0.00e+00	2251.00
IUUC-Dor-031030	Dipodomys ordii	76.95	0.00e+00	842.00
IUUC-Ete-032352	Echinops telfairi	85.74	0.00e+00	1147.00
IUUC-Eca-033948	Equus caballus	84.26	0.00e+00	2142.00
IUUC-Eeu-034474	Erinaceus europaeus	79.19	0.00e+00	822.00
IUUC-Fca-036148	Felis catus	89.99	0.00e+00	1791.00
IUUC-Fal-036957	Ficedula albicollis	75.60	0.00e+00	2008.00
IUUC-Gmo-038714	Gadus morhua	64.26	0.00e+00	926.00
IUUC-Gga-041194	Gallus gallus	74.59	0.00e+00	1999.00
IUUC-Gac-041366	Gasterosteus aculeatus	72.43	0.00e+00	1242.00
IUUC-Ggo-045442	Gorilla gorilla	77.00	0.00e+00	2056.00
IUUC-Hsa-045730	Homo sapiens	91.85	0.00e+00	2427.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	86.68	0.00e+00	2301.00
IUUC-Lch-050185	Latimeria chalumnae	63.29	0.00e+00	1566.00
IUUC-Loc-052744	Lepisosteus oculatus	69.45	0.00e+00	1742.00
IUUC-Laf-054368	Loxodonta africana	91.01	0.00e+00	1392.00
IUUC-Mcc-055487	Macaca mulatta	91.71	0.00e+00	2426.00
IUUC-Meu-056751	Macropus eugenii	78.07	0.00e+00	730.00
IUUC-Mga-059545	Meleagris gallopavo	75.64	0.00e+00	2005.00
IUUC-Mmr-061078	Microcebus murinus	84.82	0.00e+00	2140.00
IUUC-Mdo-062176	Monodelphis domestica	79.40	0.00e+00	1597.00
IUUC-Mmu-063513	Mus musculus	81.66	0.00e+00	2116.00
IUUC-Mpu-065786	Mustela putorius furo	84.84	0.00e+00	2207.00
IUUC-Mlu-067780	Myotis lucifugus	77.90	0.00e+00	1952.00
IUUC-Nle-069213	Nomascus leucogenys	91.37	0.00e+00	2364.00
IUUC-Opr-070208	Ochotona princeps	89.92	0.00e+00	1383.00
IUUC-Ont-072132	Oreochromis niloticus	75.15	0.00e+00	1237.00
IUUC-Oan-072807	Ornithorhynchus anatinus	82.37	0.00e+00	1679.00
IUUC-Ocu-074745	Oryctolagus cuniculus	83.84	0.00e+00	2128.00
IUUC-Ola-086981	Oryzias latipes	69.62	0.00e+00	1360.00
IUUC-Oga-087965	Otolemur garnettii	90.35	0.00e+00	1762.00
IUUC-Oar-089749	Ovis aries	85.81	0.00e+00	1771.00
IUUC-Ptr-091243	Pan troglodytes	91.85	0.00e+00	2425.00
IUUC-Pan-092201	Papio anubis	92.35	0.00e+00	2432.00
IUUC-Psi-093511	Pelodiscus sinensis	73.95	0.00e+00	1962.00
IUUC-Pfo-097001	Poecilia formosa	62.09	0.00e+00	1449.00
IUUC-Pab-098728	Pongo abelii	89.16	0.00e+00	2308.00
IUUC-Pca-100129	Procavia capensis	75.61	0.00e+00	1142.00
IUUC-Pva-102250	Pteropus vampyrus	73.93	0.00e+00	1866.00
IUUC-Rno-105031	Rattus norvegicus	82.07	0.00e+00	2158.00
IUUC-Tgu-117515	Taeniopygia guttata	76.14	0.00e+00	2002.00
IUUC-Tru-117914	Takifugu rubripes	70.76	0.00e+00	1248.00
IUUC-Tsy-119379	Tarsius syrichta	90.97	0.00e+00	720.00
IUUC-Tni-120178	Tetraodon nigroviridis	61.74	0.00e+00	1575.00
IUUC-Tbe-127762	Tupaia belangeri	80.10	0.00e+00	1904.00
IUUC-Ttr-128806	Tursiops truncatus	86.75	0.00e+00	1627.00
IUUC-Xtr-132903	Xenopus tropicalis	71.76	0.00e+00	1738.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence