iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036749

Ensembl Protein ID

ENSFALP00000011027.1

UniProt Accession

U3K7M3; U3K7M3_FICAL

Genbank Protein ID

ENSFALP00000011027

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AGTO01021662

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000010571.1	ENSFALT00000011072.1	ENSFALP00000011027.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-100	335.1	154	505
UBD/ZnF/ZnF_UBP	1.70e-25	88.7	25	99

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 154  TGLRNLGNTCFMNAILQSLSNIQQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGNQTAFSPESLFYVVW 242
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    +   +++s+ls + ++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 243  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSVILQENSNLSAS-NKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 330
           *****************************7744544444444444455444.678899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         +l+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 331  PFLDLSLDIPSQFRNKRTknqesgpmcTLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 417
           **********66654444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L+avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v +   ++aY+lf
   Q: 418  KVDTYVEFPLRgLDMKCYLLEPENSGPESCLYDLVAVVVHHGsGVGSGHYTAYAAH-EGRWFHFNDSTVTLTDEETVGK---AKAYILF 502
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 503  YVE 505
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 4    svcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           svc++++++W+cLtc+sv+CGRyv+gHa+kHye++q p+                ++++s++s+ycY+cdd+v++
   Q: 25   SVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQIPItnhkktekqekvqhtvCMDCSSYSTYCYRCDDFVVN 99
           78***********************************************************************85 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MCWALQGPAR SVKSCALTRA LYSHSVCRSN KSPWVCLTCS SVHCGRYVNG HAKKHYEDAQ 60
IPITNHKKTE KQEKVQHTVC MDCSSYSTYC YRCDDFVVND TKLGLVQKVR EHLQNLENSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGTGTCTC CGAGGGGAAC TGTGATTGTG TAATCCCAAT GCTGAACTGA AGCCAGTTCG 60
GTTGAGTGTA GGGGAGGGGA ATTCCAGGCA GTTGAAGCTG AGCACGTTGT TCTCTGACAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

fab:101809990

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	94.50	0.00e+00	867.00
IUUC-Apl-003358	Anas platyrhynchos	96.75	0.00e+00	905.00
IUUC-Aca-004454	Anolis carolinensis	93.37	0.00e+00	810.00
IUUC-Ame-011544	Astyanax mexicanus	77.59	0.00e+00	692.00
IUUC-Bta-012738	Bos taurus	94.70	0.00e+00	852.00
IUUC-Cel-018186	Caenorhabditis elegans	36.52	5.00e-55	208.00
IUUC-Cja-018893	Callithrix jacchus	94.50	0.00e+00	864.00
IUUC-Cfa-020607	Canis familiaris	94.70	0.00e+00	851.00
IUUC-Cpo-021828	Cavia porcellus	93.28	0.00e+00	839.00
IUUC-Csa-023884	Chlorocebus sabaeus	95.29	0.00e+00	756.00
IUUC-Cho-024863	Choloepus hoffmanni	84.52	0.00e+00	728.00
IUUC-Dre-028452	Danio rerio	74.14	0.00e+00	702.00
IUUC-Dno-029531	Dasypus novemcinctus	94.49	0.00e+00	850.00
IUUC-Dor-030913	Dipodomys ordii	87.13	6.00e-175	606.00
IUUC-Ete-032611	Echinops telfairi	89.41	0.00e+00	803.00
IUUC-Eca-033622	Equus caballus	94.69	0.00e+00	850.00
IUUC-Eeu-035268	Erinaceus europaeus	90.18	0.00e+00	783.00
IUUC-Fca-035801	Felis catus	94.29	0.00e+00	882.00
IUUC-Gmo-039598	Gadus morhua	78.22	0.00e+00	731.00
IUUC-Gga-040883	Gallus gallus	96.96	0.00e+00	871.00
IUUC-Gac-042235	Gasterosteus aculeatus	77.24	0.00e+00	703.00
IUUC-Ggo-044767	Gorilla gorilla	89.00	0.00e+00	814.00
IUUC-Hsa-046581	Homo sapiens	94.70	0.00e+00	887.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	94.70	0.00e+00	850.00
IUUC-Lch-049732	Latimeria chalumnae	90.02	0.00e+00	848.00
IUUC-Loc-052371	Lepisosteus oculatus	88.59	0.00e+00	835.00
IUUC-Laf-054565	Loxodonta africana	94.50	0.00e+00	850.00
IUUC-Mcc-055522	Macaca mulatta	94.91	0.00e+00	889.00
IUUC-Meu-056754	Macropus eugenii	86.90	1.00e-160	559.00
IUUC-Mga-060095	Meleagris gallopavo	97.63	0.00e+00	651.00
IUUC-Mmr-060839	Microcebus murinus	94.91	0.00e+00	851.00
IUUC-Mdo-062339	Monodelphis domestica	96.55	0.00e+00	750.00
IUUC-Mmu-063638	Mus musculus	94.50	0.00e+00	831.00
IUUC-Mpu-066647	Mustela putorius furo	95.17	0.00e+00	740.00
IUUC-Mlu-067921	Myotis lucifugus	93.06	0.00e+00	864.00
IUUC-Nle-069752	Nomascus leucogenys	95.11	0.00e+00	890.00
IUUC-Opr-070636	Ochotona princeps	84.05	0.00e+00	711.00
IUUC-Ont-071638	Oreochromis niloticus	77.05	0.00e+00	705.00
IUUC-Oan-073417	Ornithorhynchus anatinus	90.02	0.00e+00	827.00
IUUC-Ocu-074620	Oryctolagus cuniculus	93.48	0.00e+00	845.00
IUUC-Ola-087281	Oryzias latipes	79.26	0.00e+00	633.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.33	9.00e-49	186.00
IUUC-Oga-088448	Otolemur garnettii	93.89	0.00e+00	877.00
IUUC-Oar-090132	Ovis aries	94.70	0.00e+00	851.00
IUUC-Ptr-090696	Pan troglodytes	94.50	0.00e+00	886.00
IUUC-Pan-092124	Papio anubis	94.70	0.00e+00	885.00
IUUC-Psi-093801	Pelodiscus sinensis	96.32	0.00e+00	746.00
IUUC-Pma-094472	Petromyzon marinus	73.25	2.00e-95	340.00
IUUC-Pfo-096330	Poecilia formosa	78.46	0.00e+00	733.00
IUUC-Pab-098191	Pongo abelii	94.91	0.00e+00	889.00
IUUC-Pca-100341	Procavia capensis	93.84	0.00e+00	651.00
IUUC-Pva-103177	Pteropus vampyrus	94.09	0.00e+00	838.00
IUUC-Rno-105048	Rattus norvegicus	92.70	0.00e+00	811.00
IUUC-Sha-107429	Sarcophilus harrisii	96.73	0.00e+00	865.00
IUUC-Sar-113024	Sorex araneus	92.54	0.00e+00	790.00
IUUC-Ssc-115749	Sus scrofa	93.95	9.00e-149	518.00
IUUC-Tgu-117277	Taeniopygia guttata	98.57	0.00e+00	916.00
IUUC-Tru-117844	Takifugu rubripes	78.46	0.00e+00	731.00
IUUC-Tsy-119456	Tarsius syrichta	91.82	0.00e+00	840.00
IUUC-Tni-120251	Tetraodon nigroviridis	75.25	0.00e+00	750.00
IUUC-Tbe-127423	Tupaia belangeri	88.59	0.00e+00	770.00
IUUC-Ttr-128401	Tursiops truncatus	88.14	0.00e+00	769.00
IUUC-Vpa-130549	Vicugna pacos	85.03	2.00e-160	557.00
IUUC-Xtr-131892	Xenopus tropicalis	83.40	0.00e+00	749.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence