iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073157

UUCD1 version

UUC-OrA-00503

Ensembl Protein ID

ENSOANP00000017656.4

UniProt Accession

F7D6H3; F7D6H3_ORNAN

Protein Name

Uncharacterized protein

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000011146.4	ENSOANT00000017659.4	ENSOANP00000017656.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.60e-94	316.1	4521	4855
E3 adaptor/Cullin RING/DCX/DWD	1.20e-15	57.2	3439	3464

Active Site

Position(s)	Description	Evidence
4824	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + lf  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4521 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGVVDLFIPSPNATAEVGYNRDRFLFNPsacsdEHLMQFKFLGILMGVAIRTKK 4607
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l+++++k+l+  +l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4608 PLDLHLAPMVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHIEDSGITEENFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4694
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG++++ip  llsl+t+++le+++cG++ei+ve lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4695 EYVERAIEYRLHE-MDRQVAAVREGMSWIIPVPLLSLLTAKQLEQMVCGMPEISVEVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 4779
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ i+ e+L+yAi++++++++
   Q: 4780 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLIMAERLRYAINNCRSIDM 4855
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf.sd.tllvsGsdDgtikvWDlr 31
            c+ + +  +ll+++++Dgti+vW+++
   Q: 3439 MCV-WcNKkGLLATSGNDGTIRVWNVT 3464
           355.997789***************97 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MTNGKIGLTM AAMVPPVKLK WLEHLNSSWI TEDSESIATR EGVSVLYSKL LSNKEVVPLP 60
QQVLCLKGPQ LPDFERDSLS SDEQDHYLDA LLSSQLALAK MVCSDSPFAG ALRKRLLVLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TATAGGTGCT GGATTTGATA CGATGATCTG GAGATGGTCT GTTACACTAA TAAATGTAAG 60
TCAGTTGAAG GAGCCGCGTG GCTCAATGGA AAGAGCCCGG GCTTGGGAGT CAGAGGTCAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR011989--ARM-like
IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	93.74	0.00e+00	8441.00
IUUC-Atr-003065	Amborella trichopoda	32.77	4.00e-46	179.00
IUUC-Apl-003461	Anas platyrhynchos	93.19	0.00e+00	8383.00
IUUC-Aca-004452	Anolis carolinensis	85.31	0.00e+00	7386.00
IUUC-Aly-006545	Arabidopsis lyrata	35.65	3.00e-47	183.00
IUUC-Ame-011268	Astyanax mexicanus	60.53	0.00e+00	2227.00
IUUC-Bta-013213	Bos taurus	94.17	0.00e+00	8465.00
IUUC-Bdi-014791	Brachypodium distachyon	34.87	6.00e-51	194.00
IUUC-Bol-015203	Brassica oleracea	34.38	7.00e-49	188.00
IUUC-Bra-017584	Brassica rapa	33.33	8.00e-48	185.00
IUUC-Cja-019298	Callithrix jacchus	93.70	0.00e+00	8442.00
IUUC-Cfa-021213	Canis familiaris	93.82	0.00e+00	8528.00
IUUC-Cpo-021674	Cavia porcellus	92.09	0.00e+00	5683.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	37.94	4.00e-49	187.00
IUUC-Csa-023341	Chlorocebus sabaeus	93.37	0.00e+00	8406.00
IUUC-Cho-024567	Choloepus hoffmanni	92.06	0.00e+00	1739.00
IUUC-Dre-028289	Danio rerio	78.77	0.00e+00	7046.00
IUUC-Dno-029988	Dasypus novemcinctus	93.39	0.00e+00	8395.00
IUUC-Dor-030636	Dipodomys ordii	91.00	0.00e+00	2081.00
IUUC-Ete-032598	Echinops telfairi	90.16	0.00e+00	1204.00
IUUC-Eca-033754	Equus caballus	94.00	0.00e+00	8482.00
IUUC-Eeu-034702	Erinaceus europaeus	87.70	0.00e+00	1422.00
IUUC-Fca-035900	Felis catus	94.11	0.00e+00	8497.00
IUUC-Fal-037034	Ficedula albicollis	91.08	0.00e+00	7195.00
IUUC-Gmo-039260	Gadus morhua	75.74	0.00e+00	1271.00
IUUC-Gga-040321	Gallus gallus	93.23	0.00e+00	8451.00
IUUC-Gac-042444	Gasterosteus aculeatus	58.39	0.00e+00	2215.00
IUUC-Gma-043808	Glycine max	32.56	5.00e-44	172.00
IUUC-Ggo-045134	Gorilla gorilla	88.40	0.00e+00	4520.00
IUUC-Hsa-046516	Homo sapiens	93.51	0.00e+00	8396.00
IUUC-Hvu-047529	Hordeum vulgare	34.39	3.00e-47	183.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	94.00	0.00e+00	2496.00
IUUC-Lch-049903	Latimeria chalumnae	87.58	0.00e+00	7890.00
IUUC-Lpe-051165	Leersia perrieri	33.50	1.00e-48	186.00
IUUC-Loc-052149	Lepisosteus oculatus	84.31	0.00e+00	7516.00
IUUC-Laf-053426	Loxodonta africana	93.78	0.00e+00	8509.00
IUUC-Mcc-055826	Macaca mulatta	93.72	0.00e+00	8462.00
IUUC-Meu-056521	Macropus eugenii	84.85	0.00e+00	2217.00
IUUC-Mtr-058277	Medicago truncatula	34.23	7.00e-51	194.00
IUUC-Mga-059567	Meleagris gallopavo	96.68	0.00e+00	2112.00
IUUC-Mmr-061512	Microcebus murinus	93.51	0.00e+00	8368.00
IUUC-Mdo-062177	Monodelphis domestica	91.97	0.00e+00	8220.00
IUUC-Mmu-064373	Mus musculus	93.55	0.00e+00	8421.00
IUUC-Mpu-066148	Mustela putorius furo	93.70	0.00e+00	8452.00
IUUC-Mlu-067680	Myotis lucifugus	93.47	0.00e+00	8386.00
IUUC-Nle-069633	Nomascus leucogenys	93.22	0.00e+00	8362.00
IUUC-Opr-070609	Ochotona princeps	90.51	0.00e+00	1363.00
IUUC-Ont-071249	Oreochromis niloticus	81.48	0.00e+00	7441.00
IUUC-Ocu-074841	Oryctolagus cuniculus	93.70	0.00e+00	8503.00
IUUC-Oba-075262	Oryza barthii	33.58	5.00e-47	181.00
IUUC-Obr-076115	Oryza brachyantha	34.34	7.00e-48	184.00
IUUC-Ogl-077586	Oryza glaberrima	33.58	5.00e-47	181.00
IUUC-Ogu-078796	Oryza glumaepatula	33.33	2.00e-46	179.00
IUUC-Oin-079298	Oryza indica	33.33	1.00e-46	179.00
IUUC-Olo-080768	Oryza longistaminata	34.96	7.00e-52	197.00
IUUC-Ome-081908	Oryza meridionalis	33.00	5.00e-46	177.00
IUUC-Oni-082049	Oryza nivara	33.33	2.00e-46	179.00
IUUC-Opu-083608	Oryza punctata	33.08	9.00e-48	183.00
IUUC-Oru-084712	Oryza rufipogon	33.33	2.00e-46	179.00
IUUC-Osa-086078	Oryza sativa	33.33	2.00e-46	179.00
IUUC-Ola-086889	Oryzias latipes	80.24	0.00e+00	7299.00
IUUC-Oga-088459	Otolemur garnettii	93.04	0.00e+00	8390.00
IUUC-Oar-089888	Ovis aries	94.17	0.00e+00	8432.00
IUUC-Ptr-091114	Pan troglodytes	93.57	0.00e+00	8429.00
IUUC-Pan-092442	Papio anubis	93.59	0.00e+00	8438.00
IUUC-Psi-093833	Pelodiscus sinensis	92.11	0.00e+00	5467.00
IUUC-Pma-094275	Petromyzon marinus	77.89	0.00e+00	1729.00
IUUC-Ppa-095790	Physcomitrella patens	36.04	2.00e-53	202.00
IUUC-Pfo-097262	Poecilia formosa	79.97	0.00e+00	7116.00
IUUC-Pab-097760	Pongo abelii	92.87	0.00e+00	4762.00
IUUC-Pop-099121	Populus trichocarpa	35.63	2.00e-50	194.00
IUUC-Pca-100465	Procavia capensis	92.66	0.00e+00	4451.00
IUUC-Ppe-101345	Prunus persica	32.66	5.00e-50	192.00
IUUC-Pva-102950	Pteropus vampyrus	93.25	0.00e+00	3971.00
IUUC-Rno-104892	Rattus norvegicus	93.22	0.00e+00	8338.00
IUUC-Sha-106633	Sarcophilus harrisii	93.91	0.00e+00	8279.00
IUUC-Smo-108827	Selaginella moellendorffii	33.76	3.00e-49	190.00
IUUC-Sit-110415	Setaria italica	35.45	1.00e-50	193.00
IUUC-Sly-111155	Solanum lycopersicum	35.53	1.00e-50	194.00
IUUC-Stu-112166	Solanum tuberosum	30.89	2.00e-47	183.00
IUUC-Sar-113251	Sorex araneus	85.55	0.00e+00	2441.00
IUUC-Ssc-116391	Sus scrofa	93.72	0.00e+00	8461.00
IUUC-Tgu-116554	Taeniopygia guttata	92.33	0.00e+00	8352.00
IUUC-Tru-118695	Takifugu rubripes	80.84	0.00e+00	7399.00
IUUC-Tsy-119647	Tarsius syrichta	87.03	0.00e+00	5377.00
IUUC-Tni-120707	Tetraodon nigroviridis	80.83	0.00e+00	7355.00
IUUC-Tca-121094	Theobroma cacao	33.81	2.00e-49	190.00
IUUC-Tur-126300	Triticum urartu	34.39	1.00e-47	185.00
IUUC-Tbe-127346	Tupaia belangeri	85.74	0.00e+00	2478.00
IUUC-Ttr-128542	Tursiops truncatus	89.18	0.00e+00	5647.00
IUUC-Vpa-130611	Vicugna pacos	94.03	0.00e+00	3861.00
IUUC-Xtr-131933	Xenopus tropicalis	84.68	0.00e+00	7609.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence