iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	24586180

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	5.10e-35	118.7	8	35

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +++W+C++CT++N+P+++kC+mC+  ++
   Q: 8    AQKWKCETCTYENYPSSLKCTMCQASKP 35
           79**********************9998 PP

Organism

Drosophila melanogaster

Functional Description
(View)

Positive regulator of the Wnt signaling pathway. Specifically cleaves 'Lys-63'-linked ubiquitin chains. May act by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription (By similarity). Required for an efficient wg response, but not for other signaling responses, in the eye.

Protein Sequence
(Fasta)

MCDTKDDAQK WKCETCTYEN YPSSLKCTMC QASKPLLNED IFRLSPAQES CTVAEEAAAV 60
EVAVMSPTPS STCYSLQPQS QARQSNVADS EKWPCKVCTY LNWPRSLRCV QCCTKRGGEA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGACGGAGC ACCGATAGTT GTCGATAGGC GGACAGAGAA CCAGATGATT GGCCTCGCAA 60
TAATGTAAAA AATAAATAAT TAGCTGTTTC CAAATAATCC AAATTCCAAA TTCCTTGCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003323--OTU_dom
IPR001876--Znf_RanBP2

PROSITE

PS50802--OTU
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF02338--OTU
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016477--P:cell migration
GO:0007010--P:cytoskeleton organization
GO:0030177--P:positive regulation of Wnt signaling pathway
GO:0016579--P:protein deubiquitination
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0016055--P:Wnt signaling pathway

KEGG

dme:Dmel_CG9448

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002329	Ailuropoda melanoleuca	42.36	1.00e-153	536.00
IUUC-Apl-003612	Anas platyrhynchos	43.36	2.00e-154	538.00
IUUC-Aca-004604	Anolis carolinensis	42.28	8.00e-148	516.00
IUUC-Ate-010393	Aspergillus terreus	42.86	1.50e-02	33.10
IUUC-Ame-011865	Astyanax mexicanus	49.36	3.00e-149	521.00
IUUC-Bta-012482	Bos taurus	42.50	7.00e-154	536.00
IUUC-Cel-018468	Caenorhabditis elegans	31.18	2.00e-29	123.00
IUUC-Cja-019268	Callithrix jacchus	42.36	1.00e-153	535.00
IUUC-Cfa-021066	Canis familiaris	41.80	5.00e-154	537.00
IUUC-Cpo-021479	Cavia porcellus	43.16	4.00e-154	537.00
IUUC-Csa-023512	Chlorocebus sabaeus	42.36	1.00e-153	536.00
IUUC-Cho-024615	Choloepus hoffmanni	45.96	7.00e-133	466.00
IUUC-Cin-025238	Ciona intestinalis	52.21	7.00e-129	453.00
IUUC-Csv-026263	Ciona savignyi	55.81	1.00e-22	97.40
IUUC-Cne-027074	Cryptococcus neoformans	28.00	5.50e-02	32.30
IUUC-Dre-028575	Danio rerio	50.36	1.00e-150	525.00
IUUC-Dno-029309	Dasypus novemcinctus	41.37	1.00e-147	516.00
IUUC-Dor-030895	Dipodomys ordii	60.75	2.00e-70	259.00
IUUC-Ete-032769	Echinops telfairi	42.88	2.00e-154	538.00
IUUC-Eca-033523	Equus caballus	42.36	1.00e-153	535.00
IUUC-Eeu-034672	Erinaceus europaeus	48.46	5.00e-130	457.00
IUUC-Fca-036567	Felis catus	42.92	8.00e-153	533.00
IUUC-Fal-037545	Ficedula albicollis	43.54	3.00e-154	538.00
IUUC-Gmo-038762	Gadus morhua	58.43	3.00e-144	504.00
IUUC-Gga-040857	Gallus gallus	43.54	1.00e-154	539.00
IUUC-Gac-042178	Gasterosteus aculeatus	42.64	6.00e-150	523.00
IUUC-Ggo-045078	Gorilla gorilla	42.36	1.00e-153	536.00
IUUC-Hsa-046882	Homo sapiens	42.36	1.00e-153	536.00
IUUC-Hvu-047244	Hordeum vulgare	24.40	6.00e-05	41.20
IUUC-Itr-048983	Ictidomys tridecemlineatus	57.47	8.00e-147	512.00
IUUC-Lch-050317	Latimeria chalumnae	43.71	8.00e-154	536.00
IUUC-Loc-052922	Lepisosteus oculatus	50.18	2.00e-150	525.00
IUUC-Laf-054134	Loxodonta africana	42.70	3.00e-153	535.00
IUUC-Mcc-054889	Macaca mulatta	42.36	1.00e-153	536.00
IUUC-Meu-056035	Macropus eugenii	42.67	6.00e-154	536.00
IUUC-Mga-059653	Meleagris gallopavo	40.11	2.00e-135	475.00
IUUC-Mvi-060474	Microbotryum violaceum	21.90	3.20e-02	32.30
IUUC-Mmr-061487	Microcebus murinus	42.50	3.00e-154	538.00
IUUC-Mdo-061945	Monodelphis domestica	43.28	2.00e-154	538.00
IUUC-Mmu-063923	Mus musculus	42.22	3.00e-153	534.00
IUUC-Mpu-066044	Mustela putorius furo	42.50	1.00e-153	536.00
IUUC-Mlu-067031	Myotis lucifugus	41.53	3.00e-146	511.00
IUUC-Nle-069600	Nomascus leucogenys	42.22	6.00e-153	533.00
IUUC-Opr-070795	Ochotona princeps	38.45	2.00e-119	422.00
IUUC-Ont-071422	Oreochromis niloticus	51.11	8.00e-152	530.00
IUUC-Oan-072942	Ornithorhynchus anatinus	56.85	6.00e-97	346.00
IUUC-Ocu-074481	Oryctolagus cuniculus	41.62	3.00e-143	501.00
IUUC-Obr-076087	Oryza brachyantha	50.00	7.00e-04	36.60
IUUC-Ola-087151	Oryzias latipes	49.64	5.00e-149	520.00
IUUC-Oga-089035	Otolemur garnettii	42.44	2.00e-152	531.00
IUUC-Oar-089948	Ovis aries	42.44	1.00e-152	532.00
IUUC-Ptr-091245	Pan troglodytes	42.36	1.00e-153	536.00
IUUC-Pan-092797	Papio anubis	34.62	4.00e-77	281.00
IUUC-Psi-093759	Pelodiscus sinensis	34.92	8.00e-76	276.00
IUUC-Pfo-096859	Poecilia formosa	43.87	1.00e-151	529.00
IUUC-Pab-098015	Pongo abelii	42.36	1.00e-153	535.00
IUUC-Pca-100282	Procavia capensis	56.69	7.00e-129	453.00
IUUC-Pva-102680	Pteropus vampyrus	41.27	9.00e-137	479.00
IUUC-Rno-105058	Rattus norvegicus	42.22	3.00e-153	534.00
IUUC-Sha-106846	Sarcophilus harrisii	42.44	3.00e-153	534.00
IUUC-Sly-111015	Solanum lycopersicum	22.41	2.00e-04	39.70
IUUC-Stu-112815	Solanum tuberosum	22.41	1.00e-04	40.00
IUUC-Sar-113395	Sorex araneus	40.00	3.00e-30	126.00
IUUC-Sre-114932	Sporisorium reilianum	41.86	4.00e-05	42.40
IUUC-Ssc-116143	Sus scrofa	42.50	9.00e-154	536.00
IUUC-Tgu-117173	Taeniopygia guttata	43.68	2.00e-155	541.00
IUUC-Tru-118266	Takifugu rubripes	49.91	1.00e-149	522.00
IUUC-Tsy-118947	Tarsius syrichta	39.10	8.00e-112	397.00
IUUC-Tni-120090	Tetraodon nigroviridis	49.63	2.00e-144	505.00
IUUC-Tae-124778	Triticum aestivum	32.26	4.00e-04	37.70
IUUC-Tbe-127522	Tupaia belangeri	56.00	6.00e-136	477.00
IUUC-Ttr-128170	Tursiops truncatus	42.64	5.00e-154	537.00
IUUC-Uma-129542	Ustilago maydis	52.17	6.20e-02	31.60
IUUC-Vpa-130143	Vicugna pacos	36.57	8.00e-108	383.00
IUUC-Xtr-132143	Xenopus tropicalis	43.29	2.00e-151	528.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence