iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-044678

Ensembl Protein ID

ENSGGOP00000024611.1

UniProt Accession

G3S946; G3S946_GORGO

Protein Name

Uncharacterized protein

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000027471.1	ENSGGOT00000024206.1	ENSGGOP00000020631.1
ENSGGOG00000027471.1	ENSGGOT00000027156.1	ENSGGOP00000024611.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	8.80e-13	47.9	349	377
ULD/UDP/UBQ/UBQ_Other	6.50e-11	42.4	239	291

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           ++ W+C++CTf+N+P++++CemCs++R+c
   Q: 349  QPSWSCPSCTFINAPDRPGCEMCSTQRPC 377
           578*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 12   eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiL.eddktLadyglkdg 64
           +  l+v+p+ tVa L+e+++++lg+pp+ qr+++ G++L  + ++La+yg++++
   Q: 239  HVALQVHPHRTVAALQEQVFSELGFPPAVQRWVI-GRCLcVPERSLASYGVRQD 291
           66789*****************************.**************99754 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

VFPTGGGGSA ASDLGSAAVL LAVHAAVRPL GAGPDAEAQL RRLQLSADPE RPGRFRLELL 60
GAVNLEWPLE SVSYTIRGPT QHELQPPPGG PGTLSLHFLN PQEAQRWAVL VRGATVEGQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGGGCGT GGCAGGGGCT GGGGCCTGCG GGCGAAGGTG GCAGCCCATT GGAGGTCCCG 60
GGAGCGAAGT CCAGCTGCCG TTAGGCGCTG GGATAGTCGC ACGCCGGCTG CATCTACGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR001876--Znf_RanBP2

PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000111	Aegilops tauschii	38.24	1.90e-02	33.10
IUUC-Aml-001223	Ailuropoda melanoleuca	80.66	2.00e-131	461.00
IUUC-Apl-004151	Anas platyrhynchos	68.09	7.00e-18	81.30
IUUC-Ang-009713	Aspergillus niger	33.33	1.80e-02	33.50
IUUC-Bta-012948	Bos taurus	78.15	1.00e-135	475.00
IUUC-Cel-018155	Caenorhabditis elegans	36.54	6.40e-02	29.30
IUUC-Cja-019031	Callithrix jacchus	87.64	1.00e-144	506.00
IUUC-Cfa-020863	Canis familiaris	73.63	2.00e-106	378.00
IUUC-Cpo-022499	Cavia porcellus	75.00	2.00e-125	441.00
IUUC-Csa-023641	Chlorocebus sabaeus	89.89	3.00e-144	504.00
IUUC-Dno-029459	Dasypus novemcinctus	57.09	1.00e-58	219.00
IUUC-Dor-030914	Dipodomys ordii	60.50	6.00e-83	300.00
IUUC-Ete-032940	Echinops telfairi	68.45	6.00e-96	343.00
IUUC-Eca-033537	Equus caballus	79.17	9.00e-131	459.00
IUUC-Eeu-035176	Erinaceus europaeus	67.80	6.00e-62	231.00
IUUC-Fca-035971	Felis catus	77.78	4.00e-120	424.00
IUUC-Gmo-039219	Gadus morhua	38.06	2.00e-48	186.00
IUUC-Gga-040198	Gallus gallus	46.20	6.00e-30	124.00
IUUC-Gac-041562	Gasterosteus aculeatus	53.52	1.00e-29	124.00
IUUC-Hsa-046578	Homo sapiens	94.78	1.00e-159	555.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	73.78	1.00e-134	473.00
IUUC-Mcc-055686	Macaca mulatta	80.82	1.00e-141	496.00
IUUC-Meu-055912	Macropus eugenii	50.16	3.00e-57	215.00
IUUC-Mmr-060584	Microcebus murinus	77.47	9.00e-138	483.00
IUUC-Mdo-062191	Monodelphis domestica	54.36	7.00e-79	287.00
IUUC-Mmu-063740	Mus musculus	70.33	3.00e-109	388.00
IUUC-Mpu-066878	Mustela putorius furo	73.55	1.00e-112	399.00
IUUC-Mlu-067878	Myotis lucifugus	77.47	2.00e-127	449.00
IUUC-Nle-069748	Nomascus leucogenys	91.82	1.00e-148	518.00
IUUC-Ont-072270	Oreochromis niloticus	39.89	1.00e-51	196.00
IUUC-Oga-088300	Otolemur garnettii	78.66	2.00e-148	518.00
IUUC-Oar-089549	Ovis aries	78.41	1.00e-136	479.00
IUUC-Ptr-090961	Pan troglodytes	95.07	1.00e-147	515.00
IUUC-Pan-092687	Papio anubis	90.41	5.00e-149	520.00
IUUC-Pma-094669	Petromyzon marinus	37.44	5.00e-24	104.00
IUUC-Pab-097872	Pongo abelii	88.56	2.00e-144	505.00
IUUC-Pca-100363	Procavia capensis	66.53	2.00e-66	246.00
IUUC-Pva-102595	Pteropus vampyrus	77.15	2.00e-114	405.00
IUUC-Rno-105856	Rattus norvegicus	70.47	1.00e-110	392.00
IUUC-Sha-106838	Sarcophilus harrisii	52.99	2.00e-68	253.00
IUUC-Sar-113611	Sorex araneus	65.18	5.00e-28	118.00
IUUC-Ssc-116263	Sus scrofa	75.55	2.00e-135	475.00
IUUC-Tru-118089	Takifugu rubripes	43.44	4.00e-60	225.00
IUUC-Tni-120004	Tetraodon nigroviridis	42.62	4.00e-49	188.00
IUUC-Tbe-127471	Tupaia belangeri	69.19	6.00e-102	363.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence