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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045958
UUCD1 version UUC-HoS-00176
Ensembl Protein ID ENSP00000362555.7
UniProt Accession Q6ZMZ0; B7ZLB2; E9PAW6; G3XA82; Q0VG77; Q5TH44; Q5TH45; Q6P6A4; Q8N2S8; Q8WUF3; RN19B_HUMAN
Genbank Protein ID BAC11017.1; BAD18585.1; EAX07490.1; EAX07491.1; AAH20595.2; AAH62374.1; AAI13561.1; AAI43688.1
Protein Name E3 ubiquitin-protein ligase RNF19B; IBR domain-containing protein 3; Natural killer lytic-associated molecule; RING finger protein 19B
Genbank Nucleotide ID AK074486; AK131439; AL031602; CH471059; BC020595; BC062374; BC113560; BC143687
Gene Name RNF19B; IBRDC3; NKLAM
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116514.16 ENST00000373456.11 ENSP00000362555.7
ENSG00000116514.16 ENST00000356990.9 ENSP00000349482.5
ENSG00000116514.16 ENST00000235150.4 ENSP00000235150.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RBR RBR 16709802; 23269922
Classification
Family E-value Score Start End
E3 activity/RBR 2.70e-53 181.4 119 318
Active Site
Position(s) Description Evidence
302 N/A {ECO:0000250|UniProtKB:Q9Y4X5}
Domain Profile

   E3 activity/RBR
   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++Cl++l++e+++ ll+C h+ C++Cl++yl+l+i+e++ + iscp  ec+e+l++++i+ ll+++ l+++ye+++l++++++d++++w
   Q: 119  CPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESR-VPISCP--ECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRW 205
           ****************************************.9*****..89*************************************** PP
   S: 91   cpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeek......eeaeskelleanskkCpkCkvyie 172
           cpapdC ++v++  +a  +kl++e+e+c++efC++Ck++wH++++C+++++++a+t + +       ++ +++  ++++k+Cp+C++yi+
   Q: 206  CPAPDCGYAVIAYGCAscPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRtkhtsgLSYGQESGPADDIKPCPRCSAYII 295
           *************999899************************************99988888888888899999*************** PP
   S: 173  k..negCnhmtCakCkaefCwlC 193
           k  +++CnhmtCa C++efCwlC
   Q: 296  KmnDGSCNHMTCAVCGCEFCWLC 318
           997889***************** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
 E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
Protein Sequence
(Fasta)
MGSEKDSESP RSTSLHAAAP DPKCRSGGRR RRLTLHSVFS ASARGRRARA KPQAEPPPPA 60
AQPPPAPAPA AAQGPPPEAL PAEPAAEAEA EAAAAAAEPG FDDEEAAEGG GPGAEEVECP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045958|E3,RBR|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGCTCCG AGAAGGACTC CGAGTCGCCG CGCTCCACAT CGCTACATGC GGCCGCACCC 60
GACCCTAAGT GCCGCAGCGG CGGCCGGCGC CGGCGCCTCA CCTTGCACAG CGTCTTCTCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045958|E3,RBR|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0391--Immunity
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF01485--IBR
SMART

SM00647--IBR
SM00184--RING
Gene Ontology

GO:0044194--C:cytolytic granule
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:127544
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002183 Ailuropoda melanoleuca 94.92 0.00e+00 1070.00
IUUC-Apl-003468 Anas platyrhynchos 89.89 0.00e+00 852.00
IUUC-Aca-004324 Anolis carolinensis 87.60 0.00e+00 964.00
IUUC-Ame-011813 Astyanax mexicanus 65.97 0.00e+00 684.00
IUUC-Bta-013135 Bos taurus 95.64 0.00e+00 1117.00
IUUC-Cja-019264 Callithrix jacchus 87.86 0.00e+00 987.00
IUUC-Cpo-022502 Cavia porcellus 95.61 0.00e+00 964.00
IUUC-Cho-025032 Choloepus hoffmanni 75.73 0.00e+00 741.00
IUUC-Dre-028769 Danio rerio 67.96 0.00e+00 735.00
IUUC-Dor-030551 Dipodomys ordii 96.98 5.00e-119 421.00
IUUC-Ete-033008 Echinops telfairi 83.30 0.00e+00 803.00
IUUC-Eca-033267 Equus caballus 97.13 0.00e+00 929.00
IUUC-Fca-035520 Felis catus 96.37 0.00e+00 923.00
IUUC-Fal-037090 Ficedula albicollis 89.48 0.00e+00 761.00
IUUC-Gga-041229 Gallus gallus 87.37 0.00e+00 742.00
IUUC-Gac-041619 Gasterosteus aculeatus 67.64 0.00e+00 726.00
IUUC-Itr-048425 Ictidomys tridecemlineatus 96.14 0.00e+00 970.00
IUUC-Lch-049552 Latimeria chalumnae 83.11 0.00e+00 912.00
IUUC-Loc-051738 Lepisosteus oculatus 69.35 0.00e+00 769.00
IUUC-Laf-054252 Loxodonta africana 93.81 0.00e+00 933.00
IUUC-Meu-055920 Macropus eugenii 92.77 0.00e+00 947.00
IUUC-Mga-059587 Meleagris gallopavo 87.22 0.00e+00 796.00
IUUC-Mdo-061985 Monodelphis domestica 93.09 0.00e+00 1085.00
IUUC-Mmu-064262 Mus musculus 95.62 0.00e+00 1097.00
IUUC-Mpu-066101 Mustela putorius furo 96.38 0.00e+00 1117.00
IUUC-Mlu-067347 Myotis lucifugus 96.92 0.00e+00 930.00
IUUC-Ont-071298 Oreochromis niloticus 66.95 0.00e+00 744.00
IUUC-Oan-073219 Ornithorhynchus anatinus 89.08 0.00e+00 860.00
IUUC-Ocu-073792 Oryctolagus cuniculus 95.36 0.00e+00 892.00
IUUC-Ola-086499 Oryzias latipes 68.52 0.00e+00 751.00
IUUC-Oga-088812 Otolemur garnettii 98.64 0.00e+00 1081.00
IUUC-Oar-090353 Ovis aries 94.46 0.00e+00 981.00
IUUC-Psi-092988 Pelodiscus sinensis 90.08 0.00e+00 844.00
IUUC-Pfo-096268 Poecilia formosa 66.17 0.00e+00 743.00
IUUC-Pca-100597 Procavia capensis 96.92 0.00e+00 915.00
IUUC-Pva-102542 Pteropus vampyrus 85.04 0.00e+00 873.00
IUUC-Sha-106512 Sarcophilus harrisii 92.19 0.00e+00 1058.00
IUUC-Sar-113233 Sorex araneus 95.40 0.00e+00 889.00
IUUC-Ssc-115781 Sus scrofa 96.10 0.00e+00 1156.00
IUUC-Tgu-117384 Taeniopygia guttata 95.68 0.00e+00 773.00
IUUC-Tru-117919 Takifugu rubripes 67.71 0.00e+00 728.00
IUUC-Tsy-119275 Tarsius syrichta 93.80 0.00e+00 917.00
IUUC-Tbe-127335 Tupaia belangeri 99.73 0.00e+00 669.00
IUUC-Ttr-128554 Tursiops truncatus 95.78 0.00e+00 909.00
IUUC-Vpa-130407 Vicugna pacos 89.49 0.00e+00 917.00
IUUC-Xtr-132325 Xenopus tropicalis 84.98 0.00e+00 725.00
Created Date 25-Jun-2017

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