iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028388

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

CR854897

Gene Name

usp16; si:dkey-121n8.2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000060633.6	ENSDART00000085645.5	ENSDARP00000080080.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-81	275.1	209	813

Active Site

Position(s)	Description	Evidence
217	Nucleophile	ECO:0000255\|HAMAP-Rule:MF_03062}
752	Proton acceptor	ECO:0000255\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp.............kepkgellkslqklfeelwkskkkavsprellk 75
           Gl+NlgNtC++N+v+Q+Ls+++ lrell++  +  ek + +                e+ g+l+ ++ +l++e++++kk++v+p+el++
   Q: 209  GLSNLGNTCFFNAVVQSLSQTQYLRELLKQiaE--EKSSFSITpalsseldplqiqLERPGSLTLAMCQLMNEIQETKKGVVTPKELFT 295
           9*****************************552..44333333457777777777788889**************************** PP
   S: 76   alkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikcle 158
           +++k+a++f+g++qqD+qE+l++lld+++ e  k+ n+ + e+ +++ ++ + e      +e++k+   k++++++F+g ++s+++c+e
   Q: 296  QVCKKAPRFKGFQQQDSQELLRYLLDGMRAEEAKRVNSGILEALKSSGKNFEAEqtkkivKEYEKDGAPKNFVDRVFGGAMSSTVMCKE 384
           ********************************99777777777666666666665566667788888888******************* PP
   S: 159  cdnvssreepfldlslpvpgkeetkke.............................................................. 185
           c++vs  +e fldlslpv ++  +kk+                                                              
   Q: 385  CKTVSLVTEMFLDLSLPVADEAYRKKNqkkavqhrhsvsddgdqdtsslangnedmptgtgskyqqkkakkqakkqaknqrrqqkqggk 473
           *******************99998888999*********************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 474  vtldaitnqsstdpadssmqtqtvsvngsadaqpadtnqedlslekhnedqddeepeqeqaasvnnrftalsedqttediaeqvneded 562
           ***************************************************************************************** PP
   S: 186  ...................................................................slqdcLesftkeeelegenkyy 207
                                                                              s+++cL +ft+ e+l+++n++ 
   Q: 563  eieqncaeeeelveelntmslttpsegdvengedtledvkeytvvnrdpelafralasrtapvkqecSVESCLYQFTEVEHLTENNRLM 651
           ***************************************************************************************** PP
   S: 208  cekckkkqe.............aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke...kkkYeL 280
           c +c+k+q              a k++ ++  P vL+lhLkRf  ++  +s  k+n++v+fp+ Ldl+pfc+ +++++ke   ++ Y+L
   Q: 652  CVTCTKQQPgykdgckkavyrdALKQMLISDPPVVLTLHLKRF--QQVAYSVCKVNRHVQFPQILDLAPFCSLNCTGVKEgetQVLYSL 738
           *****88889999999999999*********************..88889999********************99999988889***** PP
   S: 281  iavvvHsGslssGHYvayvkn.....................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +++v HsG+++sGHY+ayvk+                     +kg+W++++Ds+V++v+e++v++   s+aY+lfY++
   Q: 739  YGIVEHSGTMRSGHYTAYVKSrpsthncvqngtaaasgdaeaSKGSWFHISDSSVHPVPEAKVQS---SQAYLLFYEK 813
           *********************9999999999999999988877889*******************...********97 PP

Organism

Danio rerio

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKKVKDRS AGTDSSSETA GPSCTHIRKG TENSVLKKAC LNEHWSSCQD CEQDKPEEKQ 60
ILEDQTDGES PAVWMCLKCG HRGCGRSGNQ HAIKHYETPR SEPHCLVLSL DVWSVWCYIC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAGCAGTCG GTGAACATGC TGTACGCTGT TGCTTTTAAT GCTGTAAATT TCACCACAAA 60
ATGATTAAAT TACTGCTACT TGAATGGATG TAATTCAGTT TATCATGTTT TAAAGGTTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0016578--P:histone deubiquitination
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:569700

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	33.84	7.00e-25	109.00
IUUC-Aml-001931	Ailuropoda melanoleuca	46.11	0.00e+00	660.00
IUUC-Atr-003015	Amborella trichopoda	29.95	4.00e-32	133.00
IUUC-Apl-004145	Anas platyrhynchos	54.94	9.00e-110	391.00
IUUC-Aca-004314	Anolis carolinensis	45.63	2.00e-177	615.00
IUUC-Aly-006422	Arabidopsis lyrata	29.43	1.00e-27	119.00
IUUC-Ame-011659	Astyanax mexicanus	60.46	7.00e-151	528.00
IUUC-Bta-013362	Bos taurus	45.88	0.00e+00	648.00
IUUC-Bdi-014465	Brachypodium distachyon	36.73	1.00e-26	115.00
IUUC-Cja-019177	Callithrix jacchus	46.30	0.00e+00	661.00
IUUC-Cfa-020051	Canis familiaris	45.90	0.00e+00	657.00
IUUC-Cpo-021886	Cavia porcellus	45.86	0.00e+00	637.00
IUUC-Csa-024103	Chlorocebus sabaeus	46.24	0.00e+00	662.00
IUUC-Cho-024315	Choloepus hoffmanni	68.46	7.00e-47	182.00
IUUC-Cin-025775	Ciona intestinalis	45.71	4.00e-36	143.00
IUUC-Csv-026075	Ciona savignyi	43.41	1.00e-46	181.00
IUUC-Dno-029409	Dasypus novemcinctus	45.77	0.00e+00	662.00
IUUC-Dor-030443	Dipodomys ordii	48.80	2.00e-90	327.00
IUUC-Ete-032807	Echinops telfairi	46.41	5.00e-94	339.00
IUUC-Eca-033479	Equus caballus	45.88	0.00e+00	657.00
IUUC-Eeu-034835	Erinaceus europaeus	52.05	2.00e-68	254.00
IUUC-Fca-036320	Felis catus	46.13	0.00e+00	667.00
IUUC-Fal-037029	Ficedula albicollis	52.58	3.00e-107	383.00
IUUC-Gmo-039480	Gadus morhua	60.14	3.00e-141	496.00
IUUC-Gga-040527	Gallus gallus	45.25	7.00e-176	611.00
IUUC-Gac-042343	Gasterosteus aculeatus	55.19	0.00e+00	812.00
IUUC-Gma-044402	Glycine max	29.31	2.00e-34	141.00
IUUC-Ggo-045598	Gorilla gorilla	46.30	0.00e+00	659.00
IUUC-Hsa-046598	Homo sapiens	46.60	0.00e+00	658.00
IUUC-Hvu-047146	Hordeum vulgare	33.67	1.00e-24	108.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	45.45	0.00e+00	659.00
IUUC-Lch-050536	Latimeria chalumnae	52.66	1.00e-108	387.00
IUUC-Lpe-050703	Leersia perrieri	35.20	6.00e-26	113.00
IUUC-Loc-051814	Lepisosteus oculatus	55.54	0.00e+00	820.00
IUUC-Laf-053732	Loxodonta africana	45.50	0.00e+00	662.00
IUUC-Mcc-054661	Macaca mulatta	46.36	0.00e+00	663.00
IUUC-Meu-055967	Macropus eugenii	49.88	3.00e-99	356.00
IUUC-Mtr-057945	Medicago truncatula	31.30	4.00e-34	140.00
IUUC-Mga-059551	Meleagris gallopavo	54.59	2.00e-116	413.00
IUUC-Mmr-061747	Microcebus murinus	46.55	0.00e+00	652.00
IUUC-Mdo-062220	Monodelphis domestica	53.40	7.00e-119	421.00
IUUC-Mmu-063582	Mus musculus	50.84	2.00e-112	400.00
IUUC-Mac-064941	Musa acuminata	39.20	3.00e-31	130.00
IUUC-Mpu-066339	Mustela putorius furo	45.70	0.00e+00	658.00
IUUC-Mlu-067511	Myotis lucifugus	44.52	0.00e+00	638.00
IUUC-Nle-069252	Nomascus leucogenys	46.60	0.00e+00	662.00
IUUC-Opr-070969	Ochotona princeps	46.19	0.00e+00	633.00
IUUC-Ont-071786	Oreochromis niloticus	54.41	0.00e+00	809.00
IUUC-Ocu-074704	Oryctolagus cuniculus	46.99	0.00e+00	648.00
IUUC-Oba-075094	Oryza barthii	26.47	3.00e-27	117.00
IUUC-Obr-076743	Oryza brachyantha	35.20	6.00e-26	113.00
IUUC-Ogl-077739	Oryza glaberrima	26.33	3.00e-27	117.00
IUUC-Ogu-078851	Oryza glumaepatula	26.72	9.00e-28	119.00
IUUC-Oin-079402	Oryza indica	26.72	1.00e-27	119.00
IUUC-Olo-080431	Oryza longistaminata	27.27	3.00e-27	117.00
IUUC-Ome-081580	Oryza meridionalis	26.33	6.00e-28	120.00
IUUC-Oni-082644	Oryza nivara	26.72	1.00e-27	119.00
IUUC-Opu-083452	Oryza punctata	27.14	2.00e-28	121.00
IUUC-Oru-084546	Oryza rufipogon	26.72	1.00e-27	119.00
IUUC-Osa-085858	Oryza sativa	26.72	1.00e-27	119.00
IUUC-Ola-086795	Oryzias latipes	52.50	0.00e+00	756.00
IUUC-Oga-088713	Otolemur garnettii	45.90	0.00e+00	657.00
IUUC-Oar-089887	Ovis aries	45.76	0.00e+00	652.00
IUUC-Ptr-091670	Pan troglodytes	46.48	0.00e+00	657.00
IUUC-Pan-092293	Papio anubis	46.36	0.00e+00	663.00
IUUC-Psi-093101	Pelodiscus sinensis	53.90	5.00e-113	402.00
IUUC-Ppa-095825	Physcomitrella patens	42.16	7.00e-33	136.00
IUUC-Pfo-097202	Poecilia formosa	54.88	0.00e+00	819.00
IUUC-Pab-098773	Pongo abelii	46.44	8.00e-139	487.00
IUUC-Pop-099136	Populus trichocarpa	31.10	3.00e-34	140.00
IUUC-Pca-101069	Procavia capensis	43.16	2.00e-120	427.00
IUUC-Ppe-101794	Prunus persica	30.95	4.00e-34	140.00
IUUC-Pva-103092	Pteropus vampyrus	42.04	4.00e-68	253.00
IUUC-Rno-105237	Rattus norvegicus	43.35	4.00e-178	618.00
IUUC-Sha-106889	Sarcophilus harrisii	54.37	1.00e-115	410.00
IUUC-Sly-111487	Solanum lycopersicum	30.43	2.00e-33	137.00
IUUC-Stu-112820	Solanum tuberosum	30.72	2.00e-35	144.00
IUUC-Sar-113530	Sorex araneus	52.80	2.00e-119	423.00
IUUC-Sbi-113785	Sorghum bicolor	36.99	4.00e-21	97.40
IUUC-Tgu-117478	Taeniopygia guttata	53.81	2.00e-106	380.00
IUUC-Tru-118640	Takifugu rubripes	54.98	0.00e+00	817.00
IUUC-Tsy-119042	Tarsius syrichta	38.52	2.00e-102	367.00
IUUC-Tni-120015	Tetraodon nigroviridis	53.52	0.00e+00	764.00
IUUC-Tae-125351	Triticum aestivum	34.18	3.00e-23	104.00
IUUC-Tur-126788	Triticum urartu	34.18	2.00e-23	104.00
IUUC-Tbe-127309	Tupaia belangeri	45.70	4.00e-74	273.00
IUUC-Vpa-130674	Vicugna pacos	45.95	4.00e-172	598.00
IUUC-Xtr-131869	Xenopus tropicalis	47.87	2.00e-105	377.00
IUUC-Xma-134195	Xiphophorus maculatus	54.79	0.00e+00	818.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence